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Aliases for RPS21 Gene

Aliases for RPS21 Gene

  • Ribosomal Protein S21 2 3 5
  • 8.2 KDa Differentiation Factor 2 3
  • Human Leukemia Differentiation Factor 3
  • HLDF 3
  • S21 3

External Ids for RPS21 Gene

Previous GeneCards Identifiers for RPS21 Gene

  • GC20P060725
  • GC20P061600
  • GC20P061647
  • GC20P060395
  • GC20P060962

Summaries for RPS21 Gene

Entrez Gene Summary for RPS21 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S21E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants that encode different protein isoforms have been described, but their existence has not been verified. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS21 Gene

RPS21 (Ribosomal Protein S21) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and protein N-terminus binding.

Gene Wiki entry for RPS21 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS21 Gene

Genomics for RPS21 Gene

Regulatory Elements for RPS21 Gene

Enhancers for RPS21 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS21 on UCSC Golden Path with GeneCards custom track

Promoters for RPS21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS21 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS21 Gene

62,387,065 bp from pter
62,388,520 bp from pter
1,456 bases
Plus strand

Genomic View for RPS21 Gene

Genes around RPS21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS21 Gene

Proteins for RPS21 Gene

  • Protein details for RPS21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S21
    Protein Accession:
    Secondary Accessions:
    • P35265

    Protein attributes for RPS21 Gene

    83 amino acids
    Molecular mass:
    9111 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS21 Gene

neXtProt entry for RPS21 Gene

Proteomics data for RPS21 Gene at MOPED

Post-translational modifications for RPS21 Gene

  • Ubiquitination at Lys 27, Lys 51, and Lys 74
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS21 Gene

No data available for DME Specific Peptides for RPS21 Gene

Domains & Families for RPS21 Gene

Gene Families for RPS21 Gene

Protein Domains for RPS21 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S21e family.
  • Belongs to the ribosomal protein S21e family.
genes like me logo Genes that share domains with RPS21: view

Function for RPS21 Gene

Molecular function for RPS21 Gene

GENATLAS Biochemistry:
40S ribosomal protein S21,9kDa

Gene Ontology (GO) - Molecular Function for RPS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with RPS21: view
genes like me logo Genes that share phenotypes with RPS21: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS21 Gene

Localization for RPS21 Gene

Subcellular locations from

Jensen Localization Image for RPS21 Gene COMPARTMENTS Subcellular localization image for RPS21 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015935 small ribosomal subunit IDA 15883184
genes like me logo Genes that share ontologies with RPS21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS21 Gene

Pathways & Interactions for RPS21 Gene

SuperPathways for RPS21 Gene

Superpath Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 Infectious disease
5 rRNA processing
genes like me logo Genes that share pathways with RPS21: view

Gene Ontology (GO) - Biological Process for RPS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS21: view

No data available for SIGNOR curated interactions for RPS21 Gene

Drugs & Compounds for RPS21 Gene

No Compound Related Data Available

Transcripts for RPS21 Gene

Unigene Clusters for RPS21 Gene

Ribosomal protein S21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS21 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - -
SP2: - -
SP3: - -

Relevant External Links for RPS21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS21 Gene

mRNA expression in normal human tissues for RPS21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS21 Gene

This gene is overexpressed in Nasal epithelium (10.2) and Tlymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS21 Gene

SOURCE GeneReport for Unigene cluster for RPS21 Gene Hs.190968

genes like me logo Genes that share expression patterns with RPS21: view

Protein tissue co-expression partners for RPS21 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS21 Gene

Orthologs for RPS21 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS21 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS21 35
  • 91.97 (n)
  • 100 (a)
RPS21 36
  • 100 (a)
(Canis familiaris)
Mammalia RPS21 35
  • 90.76 (n)
  • 100 (a)
RPS21 36
  • 100 (a)
(Mus musculus)
Mammalia Rps21 35
  • 91.57 (n)
  • 95.18 (a)
Rps21 16
Rps21 36
  • 95 (a)
(Pan troglodytes)
Mammalia RPS21 35
  • 100 (n)
  • 100 (a)
RPS21 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rps21 35
  • 89.96 (n)
  • 95.18 (a)
(Monodelphis domestica)
Mammalia RPS21 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia RPS21 36
  • 76 (a)
(Gallus gallus)
Aves RPS21 35
  • 82.88 (n)
  • 94.59 (a)
RPS21 36
  • 94 (a)
(Anolis carolinensis)
Reptilia RPS21 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps21 35
  • 79.92 (n)
  • 92.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29265 35
(Danio rerio)
Actinopterygii rps21 35
  • 79.84 (n)
  • 90.12 (a)
zgc56642 35
rps21 36
  • 90 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009431 35
  • 67.87 (n)
  • 73.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS21 35
  • 67.87 (n)
  • 73.49 (a)
RpS21 36
  • 73 (a)
(Caenorhabditis elegans)
Secernentea rps-21 35
  • 63.82 (n)
  • 68.29 (a)
rps-21 36
  • 64 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR255C 35
  • 57.81 (n)
  • 55.7 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05700g 35
  • 56.96 (n)
  • 56.96 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS21A 35
  • 60.34 (n)
  • 58.23 (a)
RPS21A 36
  • 55 (a)
RPS21B 36
  • 55 (a)
RPS21A 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G53890 35
  • 56.25 (n)
  • 47.5 (a)
(Oryza sativa)
Liliopsida Os03g0345200 35
  • 62.56 (n)
  • 56.16 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08627 35
  • 63.71 (n)
  • 55.7 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps21 35
  • 61.6 (n)
  • 59.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
Species with no ortholog for RPS21:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS21 Gene

Gene Tree for RPS21 (if available)
Gene Tree for RPS21 (if available)

Paralogs for RPS21 Gene

genes like me logo Genes that share paralogs with RPS21: view

No data available for Paralogs for RPS21 Gene

Variants for RPS21 Gene

Sequence variations from dbSNP and Humsavar for RPS21 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1043008 -- 62,387,887(+) ACTTA(A/C/G/T)GCTAT reference, synonymous-codon
rs1079357 -- 62,386,856(+) GGGGC(A/T)CAACC upstream-variant-2KB
rs755726 -- 62,387,568(-) GCGGT(A/G)AGAAT intron-variant
rs1139536 -- 62,387,329(+) GCACC(A/C)AGCCT utr-variant-5-prime
rs1804377 -- 62,387,664(+) GATGA(A/G)CGTGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RPS21 Gene

Variant ID Type Subtype PubMed ID
dgv4599n71 CNV Loss 21882294
nsv518296 CNV Loss 19592680
nsv913047 CNV Loss 21882294
esv2422398 CNV Duplication 17116639
nsv470556 CNV Loss 18288195
nsv834024 CNV Gain 17160897
dgv4602n71 CNV Loss 21882294
nsv913052 CNV Gain 21882294
nsv913053 CNV Gain+Loss 21882294
dgv4603n71 CNV Loss 21882294
nsv470557 CNV Gain 18288195
nsv520024 CNV Loss 19592680
dgv518n27 CNV Loss 19166990
dgv4605n71 CNV Loss 21882294
nsv459065 CNV Gain 19166990
nsv913071 CNV Gain 21882294
dgv4606n71 CNV Loss 21882294
nsv828774 CNV Loss 20364138
nsv459067 CNV Loss 19166990
nsv913073 CNV Loss 21882294

Variation tolerance for RPS21 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RPS21 Gene

Disorders for RPS21 Gene

Relevant External Links for RPS21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPS21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS21 Gene

Publications for RPS21 Gene

  1. Primary structure of human ribosomal protein S21. (PMID: 8332502) Bhat K.S. … Morrison S.G. (Nucleic Acids Res. 1993) 2 3 4 23 67
  2. Cloning and characterization of the human ribosomal protein S21 gene. (PMID: 10900511) Smirnova E.V. … Lipkin V.M. (Bioorg. Khim. 2000) 3 23
  3. Ribosome-associated protein LBP/p40 binds to S21 protein of 40S ribosome: analysis using a yeast two-hybrid system. (PMID: 10079194) Sato M. … Kaneda Y. (Biochem. Biophys. Res. Commun. 1999) 3 23
  4. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3

Products for RPS21 Gene

Sources for RPS21 Gene