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Aliases for RPS21 Gene

Aliases for RPS21 Gene

  • Ribosomal Protein S21 2 3 5
  • Small Ribosomal Subunit Protein ES21 3 4
  • 8.2 KDa Differentiation Factor 2 3
  • Human Leukemia Differentiation Factor 3
  • 40S Ribosomal Protein S21 3
  • HLDF 3
  • S21 3

External Ids for RPS21 Gene

Previous GeneCards Identifiers for RPS21 Gene

  • GC20P060725
  • GC20P061600
  • GC20P061647
  • GC20P060395
  • GC20P060962

Summaries for RPS21 Gene

Entrez Gene Summary for RPS21 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S21E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants that encode different protein isoforms have been described, but their existence has not been verified. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS21 Gene

RPS21 (Ribosomal Protein S21) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include poly(A) RNA binding and protein N-terminus binding.

Gene Wiki entry for RPS21 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS21 Gene

Genomics for RPS21 Gene

Regulatory Elements for RPS21 Gene

Enhancers for RPS21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G062293 0.6 ENCODE 11.7 -93.0 -93037 1.7 RAD51 PKNOX1 SMC3 CREB1 ATF2 EP300 EZH2 LAMA5 RPS21 HRH3 OSBPL2 LAMA5-AS1 GC20M062290 ADRM1
GH20G062344 0.5 ENCODE 12.1 -42.1 -42146 0.2 FOXA2 BHLHE40 EP300 LAMA5 RPS21 ENSG00000226332 ADRM1 LAMA5-AS1 MIR4758
GH20G062291 0.5 ENCODE 11.5 -94.7 -94658 1.1 KLF1 CEBPB ZNF394 ZNF18 LAMA5 RPS21 HRH3 LAMA5-AS1 ENSG00000226332 GC20M062290 ADRM1
GH20G062385 1.4 ENCODE dbSUPER 0.7 +0.3 261 3.9 HNRNPUL1 HDGF PKNOX1 AGO1 ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 ZNF416 CABLES2 LAMA5 ENSG00000226332 OSBPL2 GC20M062395 PIR58957 RPS21
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPS21 on UCSC Golden Path with GeneCards custom track

Promoters for RPS21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000139711 -265 2001 HDGF PKNOX1 AGO1 ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 ZNF416 ZNF143

Genomic Location for RPS21 Gene

62,387,065 bp from pter
62,388,520 bp from pter
1,456 bases
Plus strand

Genomic View for RPS21 Gene

Genes around RPS21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS21 Gene

Proteins for RPS21 Gene

  • Protein details for RPS21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S21
    Protein Accession:
    Secondary Accessions:
    • P35265

    Protein attributes for RPS21 Gene

    83 amino acids
    Molecular mass:
    9111 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS21 Gene

neXtProt entry for RPS21 Gene

Post-translational modifications for RPS21 Gene

  • Ubiquitination at isoforms=27, Lys51, and Lys74
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS21 Gene

No data available for DME Specific Peptides for RPS21 Gene

Domains & Families for RPS21 Gene

Gene Families for RPS21 Gene

Protein Domains for RPS21 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eS21 family.
  • Belongs to the eukaryotic ribosomal protein eS21 family.
genes like me logo Genes that share domains with RPS21: view

Function for RPS21 Gene

Molecular function for RPS21 Gene

GENATLAS Biochemistry:
40S ribosomal protein S21,9kDa

Gene Ontology (GO) - Molecular Function for RPS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003735 structural constituent of ribosome IBA,IEA --
GO:0005515 protein binding IPI --
GO:0047485 protein N-terminus binding IPI 10079194
genes like me logo Genes that share ontologies with RPS21: view
genes like me logo Genes that share phenotypes with RPS21: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS21 Gene

Localization for RPS21 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS21 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0015935 small ribosomal subunit IDA 15883184
genes like me logo Genes that share ontologies with RPS21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS21 Gene

Pathways & Interactions for RPS21 Gene

SuperPathways for RPS21 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
genes like me logo Genes that share pathways with RPS21: view

Gene Ontology (GO) - Biological Process for RPS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000461 endonucleolytic cleavage to generate mature 3-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 8332502
genes like me logo Genes that share ontologies with RPS21: view

No data available for SIGNOR curated interactions for RPS21 Gene

Drugs & Compounds for RPS21 Gene

No Compound Related Data Available

Transcripts for RPS21 Gene

Unigene Clusters for RPS21 Gene

Ribosomal protein S21:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS21 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - -
SP2: - -
SP3: - -

Relevant External Links for RPS21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS21 Gene

This gene is overexpressed in Nasal epithelium (10.2) and Tlymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS21 Gene

Protein tissue co-expression partners for RPS21 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS21 Gene:


SOURCE GeneReport for Unigene cluster for RPS21 Gene:


Evidence on tissue expression from TISSUES for RPS21 Gene

  • Liver(4.7)
  • Blood(4.6)
  • Nervous system(4.1)
  • Muscle(3.5)
  • Pancreas(3.4)
  • Lung(3.3)
  • Lymph node(3)
  • Heart(2.9)
  • Skin(2.9)
  • Bone marrow(2.8)
  • Spleen(2.7)
  • Thyroid gland(2.7)
  • Adrenal gland(2.6)
  • Gall bladder(2.6)
  • Intestine(2.6)
  • Stomach(2.6)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with RPS21: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS21 Gene

Orthologs for RPS21 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPS21 34 35
  • 100 (n)
(Bos Taurus)
Mammalia RPS21 34 35
  • 91.97 (n)
(Mus musculus)
Mammalia Rps21 34 16 35
  • 91.57 (n)
(Canis familiaris)
Mammalia RPS21 34 35
  • 90.76 (n)
(Rattus norvegicus)
Mammalia Rps21 34
  • 89.96 (n)
(Monodelphis domestica)
Mammalia RPS21 35
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia RPS21 35
  • 76 (a)
(Gallus gallus)
Aves RPS21 34 35
  • 82.88 (n)
(Anolis carolinensis)
Reptilia RPS21 35
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps21 34
  • 79.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29265 34
(Danio rerio)
Actinopterygii rps21 34 35
  • 79.84 (n)
zgc56642 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009431 34
  • 67.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpS21 34 35
  • 67.87 (n)
(Caenorhabditis elegans)
Secernentea rps-21 34 35
  • 63.82 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS21A 34 35 37
  • 60.34 (n)
RPS21B 35
  • 55 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR255C 34
  • 57.81 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05700g 34
  • 56.96 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G53890 34
  • 56.25 (n)
(Oryza sativa)
Liliopsida Os03g0345200 34
  • 62.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 66 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08627 34
  • 63.71 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps21 34
  • 61.6 (n)
Species where no ortholog for RPS21 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS21 Gene

Gene Tree for RPS21 (if available)
Gene Tree for RPS21 (if available)

Paralogs for RPS21 Gene

No data available for Paralogs for RPS21 Gene

Variants for RPS21 Gene

Sequence variations from dbSNP and Humsavar for RPS21 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000089780 -- 62,386,927(+) CGCCC(A/C)GCGCC upstream-variant-2KB
rs1000833913 -- 62,385,652(+) ACTAA(A/T)AGAGT upstream-variant-2KB
rs1000983455 -- 62,385,343(+) GCACT(C/G)CAGCC upstream-variant-2KB
rs1002038455 -- 62,385,633(+) AATTG(A/C)ACATT upstream-variant-2KB
rs1002291159 -- 62,388,758(+) GCTAC(C/T)GGTGC downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPS21 Gene

Variant ID Type Subtype PubMed ID
dgv518n27 CNV loss 19166990
dgv7650n54 CNV loss 21841781
dgv7651n54 CNV loss 21841781
esv2422398 CNV duplication 17116639
nsv459065 CNV gain 19166990
nsv459067 CNV loss 19166990
nsv470556 CNV loss 18288195
nsv470557 CNV gain 18288195
nsv518296 CNV loss 19592680
nsv520024 CNV loss 19592680
nsv586496 CNV gain 21841781
nsv586497 CNV loss 21841781
nsv586498 CNV loss 21841781
nsv828774 CNV loss 20364138
nsv834024 CNV gain 17160897
nsv953302 CNV deletion 24416366

Variation tolerance for RPS21 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS21 Gene

Disorders for RPS21 Gene

Relevant External Links for RPS21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPS21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS21 Gene

Publications for RPS21 Gene

  1. Primary structure of human ribosomal protein S21. (PMID: 8332502) Bhat K.S. … Morrison S.G. (Nucleic Acids Res. 1993) 2 3 4 22 64
  2. Cloning and characterization of the human ribosomal protein S21 gene. (PMID: 10900511) Smirnova E.V. … Lipkin V.M. (Bioorg. Khim. 2000) 3 4 22 64
  3. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 64
  4. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M. … Kenmochi N. (Genome Res. 2002) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64

Products for RPS21 Gene

Sources for RPS21 Gene

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