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Aliases for RPS18 Gene

Aliases for RPS18 Gene

  • Ribosomal Protein S18 2 3 5
  • Small Ribosomal Subunit Protein US13 3 4
  • D6S218E 3 4
  • KE-3 3 4
  • KE3 3 4
  • Rhabdomyosarcoma Antigen MU-RMS-40.21 3
  • 40S Ribosomal Protein S18 3
  • HKE3 3
  • S18 3

External Ids for RPS18 Gene

Previous HGNC Symbols for RPS18 Gene

  • D6S218E

Previous GeneCards Identifiers for RPS18 Gene

  • GC06P033243
  • GC06P033236
  • GC06P033232
  • GC06P033286
  • GC06P033347
  • GC06Pf33317
  • GC06P033240
  • GC06P032981
  • GC06P033273
  • GC06P033274

Summaries for RPS18 Gene

Entrez Gene Summary for RPS18 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS18 Gene

RPS18 (Ribosomal Protein S18) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for RPS18 Gene

  • Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.

Gene Wiki entry for RPS18 Gene

Additional gene information for RPS18 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS18 Gene

Genomics for RPS18 Gene

GeneHancer (GH) Regulatory Elements for RPS18 Gene

Promoters and enhancers for RPS18 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I033270 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 623.6 +3.1 3119 8.4 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 RPS18 VPS52 B3GALT4 PIR43330 BRD2 LEMD2 DAXX RXRB RING1 WDR46
GH06I032965 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 26 -301.3 -301341 10.4 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 BRD2 HLA-DMA ENSG00000223837 LEMD2 VPS52 RXRB ATF6B DAXX HCG25 RING1
GH06I033743 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.1 +473.8 473789 5.2 HDGF CLOCK ARNT ZFP64 ARID4B SIN3A YBX1 FEZF1 ZNF2 YY1 IP6K3 LEMD2 BRD2 DAXX WDR46 RPS18 VPS52 RPS10 RXRB UQCC2
GH06I033198 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 23.3 -71.0 -71009 4 MLX FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 RXRB RNY4P10 SLC39A7 GC06P033199 DAXX BRD2 WDR46 RGL2 LEMD2 RPS18
GH06I034233 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 18 +970.2 970246 17.1 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SMIM29 MIR6835 HMGA1 LEMD2 DAXX WDR46 VPS52 TAF11 RGL2 HCG25
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RPS18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RPS18 gene promoter:

Genomic Locations for RPS18 Gene

Genomic Locations for RPS18 Gene
4,501 bases
Plus strand

Genomic View for RPS18 Gene

Genes around RPS18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for RPS18 Gene

  • Protein details for RPS18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S18
    Protein Accession:
    Secondary Accessions:
    • P25232
    • Q5SUJ3
    • Q6IPF8

    Protein attributes for RPS18 Gene

    152 amino acids
    Molecular mass:
    17719 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS18 Gene

neXtProt entry for RPS18 Gene

Post-translational modifications for RPS18 Gene

Other Protein References for RPS18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS18 Gene

Domains & Families for RPS18 Gene

Gene Families for RPS18 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RPS18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uS13 family.
  • Belongs to the universal ribosomal protein uS13 family.
genes like me logo Genes that share domains with RPS18: view

Function for RPS18 Gene

Molecular function for RPS18 Gene

GENATLAS Biochemistry:
40S ribosomal protein S18,17kDa
UniProtKB/Swiss-Prot Function:
Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.

Phenotypes From GWAS Catalog for RPS18 Gene

Gene Ontology (GO) - Molecular Function for RPS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA,IEA 22658674
GO:0003735 structural constituent of ribosome IBA,IEA --
GO:0005515 protein binding IPI 22720776
GO:0019843 rRNA binding IEA --
genes like me logo Genes that share ontologies with RPS18: view
genes like me logo Genes that share phenotypes with RPS18: view

miRNA for RPS18 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS18 Gene

Localization for RPS18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS18 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS18 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RPS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 22720776
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RPS18: view

Pathways & Interactions for RPS18 Gene

SuperPathways for RPS18 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
genes like me logo Genes that share pathways with RPS18: view

Gene Ontology (GO) - Biological Process for RPS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IC,IEA 8706699
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS18: view

No data available for SIGNOR curated interactions for RPS18 Gene

Drugs & Compounds for RPS18 Gene

No Compound Related Data Available

Transcripts for RPS18 Gene

Unigene Clusters for RPS18 Gene

Ribosomal protein S18:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS18 Gene

No ASD Table

Relevant External Links for RPS18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS18 Gene

This gene is overexpressed in Bone (7.4) and Tlymphocyte (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS18 Gene

Protein tissue co-expression partners for RPS18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS18 Gene:


SOURCE GeneReport for Unigene cluster for RPS18 Gene:


Evidence on tissue expression from TISSUES for RPS18 Gene

  • Liver(4.6)
  • Nervous system(4.4)
  • Bone(4)
  • Intestine(3.4)
  • Skin(2.9)
  • Lung(2.8)
  • Lymph node(2.8)
  • Spleen(2.8)
  • Thyroid gland(2.8)
  • Blood(2.7)
  • Pancreas(2.7)
  • Adrenal gland(2.6)
  • Bone marrow(2.5)
  • Eye(2.5)
  • Heart(2.5)
  • Kidney(2.4)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with RPS18: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS18 Gene

Orthologs for RPS18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
-- 34
  • 100 (a)
(Mus musculus)
Mammalia Gm10260 34
  • 99 (a)
Rps18-ps3 34
  • 99 (a)
Rps18 16 34 33
  • 91.89 (n)
(Monodelphis domestica)
Mammalia RPS18 34
  • 95 (a)
(Canis familiaris)
Mammalia RPS18 33 34
  • 93.2 (n)
(Bos Taurus)
Mammalia RPS18 34 33
  • 93.2 (n)
(Rattus norvegicus)
Mammalia LOC100360679 33
  • 89.91 (n)
(Anolis carolinensis)
Reptilia RPS18 34
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps18 33
  • 82.24 (n)
(Danio rerio)
Actinopterygii rps18 34 33
  • 81.58 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpS18 33 34 35
  • 72.37 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010375 33
  • 69.76 (n)
(Caenorhabditis elegans)
Secernentea rps-18 35 33 34
  • 70.61 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS18A 34
  • 69 (a)
RPS18B 33 34
  • 64.55 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER315C 33
  • 68.78 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B01562g 33
  • 66.43 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PFL 33
  • 70.18 (n)
(Oryza sativa)
Liliopsida Os07g0173700 33
  • 68.64 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 72 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00475 33
  • 70.18 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1802 33
  • 67.54 (n)
Species where no ortholog for RPS18 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS18 Gene

Gene Tree for RPS18 (if available)
Gene Tree for RPS18 (if available)

Paralogs for RPS18 Gene

No data available for Paralogs for RPS18 Gene

Variants for RPS18 Gene

Sequence variations from dbSNP and Humsavar for RPS18 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000382741 -- 33,275,295(+) T/A intron_variant
rs1000874094 -- 33,273,981(+) AGAG/AG intron_variant
rs1000984609 -- 33,276,833(+) C/G/T downstream_transcript_variant
rs1001167353 -- 33,274,701(+) G/A intron_variant
rs1001682491 -- 33,274,401(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RPS18 Gene

Variant ID Type Subtype PubMed ID
dgv10609n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv5249 CNV deletion 18451855
nsv830634 CNV loss 17160897
nsv830635 CNV loss 17160897
nsv970109 CNV duplication 23825009

Variation tolerance for RPS18 Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RPS18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS18 Gene

Disorders for RPS18 Gene

Additional Disease Information for RPS18

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RPS18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS18 Gene

Publications for RPS18 Gene

  1. The human homolog of ribosomal protein S18. (PMID: 8441687) Chassin D … Koman A (Nucleic acids research 1993) 2 3 4 22 58
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 44 58
  4. Ribosomal protein S18 identified as a cofilin-binding protein by using phage display library. (PMID: 15532723) Kusui K … Suzuki K (Molecular and cellular biochemistry 2004) 3 22 58
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58

Products for RPS18 Gene

  • Addgene plasmids for RPS18

Sources for RPS18 Gene

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