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Aliases for RPS18 Gene

Aliases for RPS18 Gene

  • Ribosomal Protein S18 2 3 5
  • D6S218E 3 4
  • KE-3 3 4
  • KE3 3 4
  • Rhabdomyosarcoma Antigen MU-RMS-40.21 3
  • HKE3 3
  • S18 3

External Ids for RPS18 Gene

Previous HGNC Symbols for RPS18 Gene

  • D6S218E

Previous GeneCards Identifiers for RPS18 Gene

  • GC06P033243
  • GC06P033236
  • GC06P033232
  • GC06P033286
  • GC06P033347
  • GC06Pf33317
  • GC06P033240
  • GC06P032981

Summaries for RPS18 Gene

Entrez Gene Summary for RPS18 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS18 Gene

RPS18 (Ribosomal Protein S18) is a Protein Coding gene. Diseases associated with RPS18 include bowen-conradi syndrome. Among its related pathways are Viral mRNA Translation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for RPS18 Gene

  • Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.

Gene Wiki entry for RPS18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS18 Gene

Genomics for RPS18 Gene

Regulatory Elements for RPS18 Gene

Enhancers for RPS18 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS18 on UCSC Golden Path with GeneCards custom track

Promoters for RPS18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS18 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS18 Gene

Chromosome:
6
Start:
33,272,010 bp from pter
End:
33,276,510 bp from pter
Size:
4,501 bases
Orientation:
Plus strand

Genomic View for RPS18 Gene

Genes around RPS18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for RPS18 Gene

  • Protein details for RPS18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62269-RS18_HUMAN
    Recommended name:
    40S ribosomal protein S18
    Protein Accession:
    P62269
    Secondary Accessions:
    • P25232
    • Q5SUJ3
    • Q6IPF8

    Protein attributes for RPS18 Gene

    Size:
    152 amino acids
    Molecular mass:
    17719 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS18 Gene

neXtProt entry for RPS18 Gene

Proteomics data for RPS18 Gene at MOPED

Post-translational modifications for RPS18 Gene

  • Ubiquitination at Lys 78
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS18 Gene

Domains & Families for RPS18 Gene

Gene Families for RPS18 Gene

Protein Domains for RPS18 Gene

Suggested Antigen Peptide Sequences for RPS18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62269

UniProtKB/Swiss-Prot:

RS18_HUMAN :
  • Belongs to the ribosomal protein S13P family.
Family:
  • Belongs to the ribosomal protein S13P family.
genes like me logo Genes that share domains with RPS18: view

Function for RPS18 Gene

Molecular function for RPS18 Gene

GENATLAS Biochemistry:
40S ribosomal protein S18,17kDa
UniProtKB/Swiss-Prot Function:
Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.

Gene Ontology (GO) - Molecular Function for RPS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 22720776
genes like me logo Genes that share ontologies with RPS18: view
genes like me logo Genes that share phenotypes with RPS18: view

Animal Model Products

miRNA for RPS18 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS18 Gene

Localization for RPS18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS18 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS18 Gene COMPARTMENTS Subcellular localization image for RPS18 gene
Compartment Confidence
cytosol 3
chloroplast 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0015935 small ribosomal subunit IDA 15883184
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RPS18: view

Pathways & Interactions for RPS18 Gene

SuperPathways for RPS18 Gene

Superpath Contained pathways
1 Viral mRNA Translation
.60
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 Infectious disease
.48
5 rRNA processing
genes like me logo Genes that share pathways with RPS18: view

Gene Ontology (GO) - Biological Process for RPS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0016032 viral process TAS --
GO:0019058 viral life cycle TAS --
GO:0019083 viral transcription TAS --
genes like me logo Genes that share ontologies with RPS18: view

No data available for SIGNOR curated interactions for RPS18 Gene

Drugs & Compounds for RPS18 Gene

No Compound Related Data Available

Transcripts for RPS18 Gene

Unigene Clusters for RPS18 Gene

Ribosomal protein S18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS18 Gene

No ASD Table

Relevant External Links for RPS18 Gene

GeneLoc Exon Structure for
RPS18
ECgene alternative splicing isoforms for
RPS18

Expression for RPS18 Gene

mRNA expression in normal human tissues for RPS18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS18 Gene

This gene is overexpressed in Bone (7.4) and Tlymphocyte (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS18 Gene



SOURCE GeneReport for Unigene cluster for RPS18 Gene Hs.448854

genes like me logo Genes that share expression patterns with RPS18: view

Protein tissue co-expression partners for RPS18 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS18 Gene

Orthologs for RPS18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS18 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPS18 35
  • 93.2 (n)
  • 100 (a)
RPS18 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS18 35
  • 93.2 (n)
  • 100 (a)
RPS18 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps18 35
  • 91.89 (n)
  • 100 (a)
Rps18 16
Gm10260 36
  • 99 (a)
OneToMany
Rps18 36
  • 100 (a)
OneToMany
Rps18-ps3 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rps18 35
  • 89.91 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RPS18 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia RPS18 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps18 35
  • 82.24 (n)
  • 98.03 (a)
zebrafish
(Danio rerio)
Actinopterygii rps18 35
  • 81.58 (n)
  • 98.03 (a)
rps18 36
  • 98 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RpS18 37
  • 74 (a)
RpS18 35
  • 72.37 (n)
  • 77.63 (a)
RpS18 36
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010375 35
  • 69.76 (n)
  • 77.48 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-18 37
  • 76 (a)
rps-18 35
  • 70.61 (n)
  • 76.32 (a)
rps-18 36
  • 75 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER315C 35
  • 68.78 (n)
  • 73.94 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B01562g 35
  • 66.43 (n)
  • 71.83 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS18B 35
  • 64.55 (n)
  • 71.83 (a)
RPS18A 36
  • 69 (a)
OneToMany
RPS18B 36
  • 69 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PFL 35
  • 70.18 (n)
  • 74.34 (a)
rice
(Oryza sativa)
Liliopsida Os07g0173700 35
  • 68.64 (n)
  • 71.71 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00475 35
  • 70.18 (n)
  • 75.66 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1802 35
  • 67.54 (n)
  • 73.68 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 72 (a)
OneToOne
Species with no ortholog for RPS18:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS18 Gene

ENSEMBL:
Gene Tree for RPS18 (if available)
TreeFam:
Gene Tree for RPS18 (if available)

Paralogs for RPS18 Gene

No data available for Paralogs for RPS18 Gene

Variants for RPS18 Gene

Sequence variations from dbSNP and Humsavar for RPS18 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10080929 -- 33,274,074(+) gcaca(C/T)gccca intron-variant
rs458434 -- 33,275,048(-) TCACT(G/T)TATCC intron-variant
rs458679 -- 33,274,715(-) agaga(C/G)acacg intron-variant
rs13201994 -- 33,274,057(+) agtag(C/T)tgaga intron-variant
rs7771360 -- 33,275,103(+) AGCCC(A/C)ATACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS18 Gene

Variant ID Type Subtype PubMed ID
nsv830634 CNV Loss 17160897
nsv5249 CNV Loss 18451855
nsv830635 CNV Loss 17160897

Variation tolerance for RPS18 Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS18 Gene

HapMap Linkage Disequilibrium report
RPS18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS18 Gene

Disorders for RPS18 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS18 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bowen-conradi syndrome
  • bowen hutterite syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPS18 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS18

Genetic Association Database (GAD)
RPS18
Human Genome Epidemiology (HuGE) Navigator
RPS18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS18
genes like me logo Genes that share disorders with RPS18: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS18 Gene

Publications for RPS18 Gene

  1. The human homolog of ribosomal protein S18. (PMID: 8441687) Chassin D. … Koman A. (Nucleic Acids Res. 1993) 2 3 4 23 67
  2. Ribosomal protein S18 identified as a cofilin-binding protein by using phage display library. (PMID: 15532723) Kusui K. … Suzuki K. (Mol. Cell. Biochem. 2004) 3 23
  3. The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II. (PMID: 12145273) Mishra-Gorur K. … Castellot J.J. (J. Biol. Chem. 2002) 3 23
  4. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3
  5. Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control. (PMID: 25817432) Gallina I. … Lisby M. (Nat Commun 2015) 3

Products for RPS18 Gene

Sources for RPS18 Gene

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