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Aliases for RPS16 Gene

Aliases for RPS16 Gene

  • Ribosomal Protein S16 2 3 5
  • 40S Ribosomal Protein S16 2
  • S16 3

External Ids for RPS16 Gene

Previous GeneCards Identifiers for RPS16 Gene

  • GC19M040561
  • GC19M040315
  • GC19M044596
  • GC19M044615
  • GC19M039923
  • GC19M036370

Summaries for RPS16 Gene

Entrez Gene Summary for RPS16 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S9P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS16 Gene

RPS16 (Ribosomal Protein S16) is a Protein Coding gene. Diseases associated with RPS16 include Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS16 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS16 Gene

Genomics for RPS16 Gene

Regulatory Elements for RPS16 Gene

Enhancers for RPS16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS16 on UCSC Golden Path with GeneCards custom track

Promoters for RPS16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS16 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS16 Gene

39,433,207 bp from pter
39,436,020 bp from pter
2,814 bases
Minus strand

Genomic View for RPS16 Gene

Genes around RPS16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS16 Gene

Proteins for RPS16 Gene

  • Protein details for RPS16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S16
    Protein Accession:
    Secondary Accessions:
    • B2RDD5
    • P17008

    Protein attributes for RPS16 Gene

    146 amino acids
    Molecular mass:
    16445 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS16 Gene

neXtProt entry for RPS16 Gene

Proteomics data for RPS16 Gene at MOPED

Post-translational modifications for RPS16 Gene

  • Ubiquitination at Lys 4, Lys 33, Lys 50, Lys 73, Lys 90, Lys 98, and Lys 109
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS16 Gene

No data available for DME Specific Peptides for RPS16 Gene

Domains & Families for RPS16 Gene

Gene Families for RPS16 Gene

Suggested Antigen Peptide Sequences for RPS16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S9P family.
  • Belongs to the ribosomal protein S9P family.
genes like me logo Genes that share domains with RPS16: view

Function for RPS16 Gene

Molecular function for RPS16 Gene

GENATLAS Biochemistry:
40S ribosomal protein S16,16kDa

Gene Ontology (GO) - Molecular Function for RPS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24725412
genes like me logo Genes that share ontologies with RPS16: view
genes like me logo Genes that share phenotypes with RPS16: view

Animal Model Products

miRNA for RPS16 Gene

miRTarBase miRNAs that target RPS16

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS16 Gene

Localization for RPS16 Gene

Subcellular locations from

Jensen Localization Image for RPS16 Gene COMPARTMENTS Subcellular localization image for RPS16 gene
Compartment Confidence
cytosol 5
extracellular 5
chloroplast 3
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with RPS16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS16 Gene

Pathways & Interactions for RPS16 Gene

SuperPathways for RPS16 Gene

Superpath Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 Infectious disease
5 rRNA processing
genes like me logo Genes that share pathways with RPS16: view

Gene Ontology (GO) - Biological Process for RPS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing IMP,TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0016032 viral process TAS --
genes like me logo Genes that share ontologies with RPS16: view

No data available for SIGNOR curated interactions for RPS16 Gene

Drugs & Compounds for RPS16 Gene

No Compound Related Data Available

Transcripts for RPS16 Gene

Unigene Clusters for RPS16 Gene

Ribosomal protein S16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS16 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - -
SP7: -

Relevant External Links for RPS16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS16 Gene

mRNA expression in normal human tissues for RPS16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS16 Gene

This gene is overexpressed in Nasal epithelium (14.2) and Bone marrow mesenchymal stem cell (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS16 Gene

SOURCE GeneReport for Unigene cluster for RPS16 Gene Hs.397609

genes like me logo Genes that share expression patterns with RPS16: view

Protein tissue co-expression partners for RPS16 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS16 Gene

Orthologs for RPS16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS16 35
  • 91.1 (n)
  • 100 (a)
RPS16 36
  • 100 (a)
(Canis familiaris)
Mammalia RPS16 35
  • 90.18 (n)
  • 100 (a)
RPS16 36
  • 91 (a)
(Mus musculus)
Mammalia Rps16 35
  • 89.5 (n)
  • 100 (a)
Rps16 16
Rps16 36
  • 100 (a)
(Pan troglodytes)
Mammalia RPS16 35
  • 99.32 (n)
  • 100 (a)
RPS16 36
  • 60 (a)
(Rattus norvegicus)
Mammalia Rps16 35
  • 89.04 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia RPS16 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia RPS16 36
  • 96 (a)
(Gallus gallus)
Aves RPS16 35
  • 79.91 (n)
  • 98.63 (a)
RPS16 36
  • 99 (a)
(Anolis carolinensis)
Reptilia RPS16 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps16 35
  • 79 (n)
  • 96.58 (a)
Str.1030 35
(Danio rerio)
Actinopterygii rps16 35
  • 82.65 (n)
  • 96.58 (a)
rps16 36
  • 96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4046 37
  • 88 (a)
RpS16 35
  • 78.49 (n)
  • 88.65 (a)
RpS16 36
  • 84 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011424 35
  • 74.36 (n)
  • 81.82 (a)
(Caenorhabditis elegans)
Secernentea rps-16 37
  • 77 (a)
rps-16 35
  • 71.43 (n)
  • 77.14 (a)
rps-16 36
  • 74 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR258W 35
  • 61.35 (n)
  • 65.94 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21979g 35
  • 57.25 (n)
  • 64.49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS16A 35
  • 57.97 (n)
  • 65.94 (a)
RPS16A 36
  • 63 (a)
RPS16B 36
  • 63 (a)
RPS16B 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G18380 35
  • 68.26 (n)
  • 73.97 (a)
(Oryza sativa)
Liliopsida Os11g0127900 35
  • 66.2 (n)
  • 69.44 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08620 35
  • 66.67 (n)
  • 69.06 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1601 35
  • 65 (n)
  • 72.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 76 (a)
Species with no ortholog for RPS16:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS16 Gene

Gene Tree for RPS16 (if available)
Gene Tree for RPS16 (if available)

Paralogs for RPS16 Gene

genes like me logo Genes that share paralogs with RPS16: view

No data available for Paralogs for RPS16 Gene

Variants for RPS16 Gene

Sequence variations from dbSNP and Humsavar for RPS16 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs8105332 -- 39,436,085(+) CCCTT(A/C)GGCGC upstream-variant-2KB
rs66667783 -- 39,437,059(+) CTCCC(A/G)GGTTC upstream-variant-2KB
rs140094490 -- 39,435,348(+) TTTGG(C/G)TCCCC intron-variant
rs73033380 -- 39,434,981(+) GAACC(C/T)CTTTT intron-variant
rs8111779 -- 39,434,077(+) GAACA(A/G)TAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS16 Gene

Variant ID Type Subtype PubMed ID
nsv911679 CNV Loss 21882294
nsv911680 CNV Loss 21882294
dgv3860n71 CNV Loss 21882294
dgv3861n71 CNV Loss 21882294
nsv911685 CNV Loss 21882294
dgv3863n71 CNV Loss 21882294
nsv523856 CNV Loss 19592680

Variation tolerance for RPS16 Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RPS16 Gene

Disorders for RPS16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS16 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia
  • blackfan - diamond syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPS16 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS16

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPS16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS16 Gene

Publications for RPS16 Gene

  1. Molecular cloning and sequence analysis of the human ribosomal protein S16. (PMID: 2016298) Batra S.K. … Hollingsworth M.A. (J. Biol. Chem. 1991) 2 3 4 23 67
  2. [Human ribosomal protein S16 inhibites excision of the first intron from its own]. (PMID: 20198863) Ivanov A.V. … Karpova G.G. (Mol. Biol. (Mosk.) 2010) 3 23
  3. Interactions of human ribosomal proteins S16 and S5 with an 18S rRNA fragment containing their binding sites. (PMID: 19559069) Malygin A.A. … Karpova G.G. (Biochimie 2009) 3 23
  4. [Binding of human ribosomal protein S16 with the 18S rRNA fragment 1203-1236/1521-1698]. (PMID: 18318121) Ian'shina D.D. … Karpova G.G. (Mol. Biol. (Mosk.) 2007) 3 23
  5. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3

Products for RPS16 Gene

Sources for RPS16 Gene