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Aliases for RPS6KB2 Gene

Aliases for RPS6KB2 Gene

  • Ribosomal Protein S6 Kinase B2 2 3
  • Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 3 5
  • 70 KDa Ribosomal Protein S6 Kinase 2 3 4
  • Serine/Threonine-Protein Kinase 14B 3 4
  • P70 Ribosomal S6 Kinase Beta 3 4
  • S6 Kinase-Related Kinase 3 4
  • P70 S6 Kinase Beta 3 4
  • P70 S6K-Beta 3 4
  • EC 4 63
  • S6K-Beta-2 3 4
  • P70-S6K 2 3 4
  • P70 S6KB 3 4
  • P70-Beta 3 4
  • S6K-Beta 3 4
  • P70S6K2 3 4
  • STK14B 3 4
  • S6K2 3 4
  • SRK 3 4
  • Ribosomal Protein S6 Kinase, 70kD, Polypeptide 2 2
  • Serine/Threonine-Protein Kinase 14 Beta 3
  • P70(S6K)-Beta 3
  • P70-Beta-1 3
  • P70-Beta-2 3
  • S6K-Beta2 3
  • EC 2.7.11 63
  • P70S6Kb 3
  • KLS 3

External Ids for RPS6KB2 Gene

Previous GeneCards Identifiers for RPS6KB2 Gene

  • GC11P069692
  • GC11P068892
  • GC11P067445
  • GC11P066971
  • GC11P066932
  • GC11P066952
  • GC11P067195
  • GC11P063523

Summaries for RPS6KB2 Gene

Entrez Gene Summary for RPS6KB2 Gene

  • This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015]

GeneCards Summary for RPS6KB2 Gene

RPS6KB2 (Ribosomal Protein S6 Kinase B2) is a Protein Coding gene. Diseases associated with RPS6KB2 include Recurrent Hypersomnia and Kleine-Levin Syndrome. Among its related pathways are Constitutive Signaling by AKT1 E17K in Cancer and ErbB signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot for RPS6KB2 Gene

  • Phosphorylates specifically ribosomal protein S6.

Gene Wiki entry for RPS6KB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KB2 Gene

Genomics for RPS6KB2 Gene

Regulatory Elements for RPS6KB2 Gene

Enhancers for RPS6KB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS6KB2 on UCSC Golden Path with GeneCards custom track

Promoters for RPS6KB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS6KB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS6KB2 Gene

67,428,460 bp from pter
67,435,408 bp from pter
6,949 bases
Plus strand

Genomic View for RPS6KB2 Gene

Genes around RPS6KB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS6KB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS6KB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KB2 Gene

Proteins for RPS6KB2 Gene

  • Protein details for RPS6KB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosomal protein S6 kinase beta-2
    Protein Accession:
    Secondary Accessions:
    • B2RMZ9
    • B4DML8
    • O94809
    • Q9UEC1

    Protein attributes for RPS6KB2 Gene

    482 amino acids
    Molecular mass:
    53455 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA34402.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RPS6KB2 Gene


neXtProt entry for RPS6KB2 Gene

Proteomics data for RPS6KB2 Gene at MOPED

Post-translational modifications for RPS6KB2 Gene

  • Phosphorylated and activated by MTOR. Phosphorylation by PKC within the NLS in response to mitogenic stimuli causes cytoplasmic retention.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPS6KB2 Gene

Antibody Products

  • R&D Systems Antibodies for RPS6KB2 (p70 S6 Kinase beta)
  • Cell Signaling Technology (CST) Antibodies for RPS6KB2 (P70S6KB)
  • Cloud-Clone Corp. Antibodies for RPS6KB2

Domains & Families for RPS6KB2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KB2: view

Function for RPS6KB2 Gene

Molecular function for RPS6KB2 Gene

GENATLAS Biochemistry:
ribosomal protein S6 kinase,70kDa,polypeptide 2,widely expressed,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essential regulatory role in protein synthesis during cell proliferation
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Phosphorylates specifically ribosomal protein S6.

Enzyme Numbers (IUBMB) for RPS6KB2 Gene

Gene Ontology (GO) - Molecular Function for RPS6KB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004711 ribosomal protein S6 kinase activity IBA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with RPS6KB2: view
genes like me logo Genes that share phenotypes with RPS6KB2: view

Animal Models for RPS6KB2 Gene

MGI Knock Outs for RPS6KB2:

Animal Model Products

  • Taconic Biosciences Mouse Models for RPS6KB2

miRNA for RPS6KB2 Gene

miRTarBase miRNAs that target RPS6KB2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPS6KB2 Gene

Localization for RPS6KB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KB2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for RPS6KB2 Gene COMPARTMENTS Subcellular localization image for RPS6KB2 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for RPS6KB2 Gene

Pathways & Interactions for RPS6KB2 Gene

SuperPathways for RPS6KB2 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 PI3K events in ERBB4 signaling
3 Translation Insulin regulation of translation
4 Immune System
5 Downstream signaling events of B Cell Receptor (BCR)
genes like me logo Genes that share pathways with RPS6KB2: view

SIGNOR curated interactions for RPS6KB2 Gene

Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for RPS6KB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9804755
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0035556 intracellular signal transduction IBA --
GO:0045087 innate immune response TAS --
GO:0048011 neurotrophin TRK receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with RPS6KB2: view

Drugs & Compounds for RPS6KB2 Gene

(7) Drugs for RPS6KB2 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
BI-D1870 Pharma P90 RSK inhibitor,ATP-competitive and cell-permeable 0
PF-4708671 Pharma P70 S6K1 isoform inhibitor,cell-permeable, S6K1 inhibitor 0

(3) Additional Compounds for RPS6KB2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(2) ApexBio Compounds for RPS6KB2 Gene

Compound Action Cas Number
BI-D1870 P90 RSK inhibitor,ATP-competitive and cell-permeable 501437-28-1
PF-4708671 P70 S6K1 isoform inhibitor,cell-permeable 1255517-76-0
genes like me logo Genes that share compounds with RPS6KB2: view

Transcripts for RPS6KB2 Gene

Unigene Clusters for RPS6KB2 Gene

Ribosomal protein S6 kinase, 70kDa, polypeptide 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KB2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: -
SP6: -
SP7: -
SP8: - -
SP9: - -
SP10: - - - - -
SP13: - -
SP14: - - - -
SP15: - - -
SP17: -

ExUns: 16 ^ 17a · 17b

Relevant External Links for RPS6KB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS6KB2 Gene

mRNA expression in normal human tissues for RPS6KB2 Gene

Protein differential expression in normal tissues from HIPED for RPS6KB2 Gene

This gene is overexpressed in Adrenal (33.6) and Placenta (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS6KB2 Gene

SOURCE GeneReport for Unigene cluster for RPS6KB2 Gene Hs.534345

genes like me logo Genes that share expression patterns with RPS6KB2: view

Protein tissue co-expression partners for RPS6KB2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS6KB2 Gene

Orthologs for RPS6KB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPS6KB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS6KB2 35
  • 89.9 (n)
  • 94.81 (a)
RPS6KB2 36
  • 95 (a)
(Canis familiaris)
Mammalia RPS6KB2 35
  • 90.35 (n)
  • 93.96 (a)
RPS6KB2 36
  • 95 (a)
(Mus musculus)
Mammalia Rps6kb2 35
  • 88.38 (n)
  • 92.95 (a)
Rps6kb2 16
Rps6kb2 36
  • 92 (a)
(Pan troglodytes)
Mammalia RPS6KB2 35
  • 99.58 (n)
  • 99.17 (a)
RPS6KB2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rps6kb2 35
  • 88.31 (n)
  • 92.95 (a)
(Monodelphis domestica)
Mammalia RPS6KB2 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia RPS6KB2 36
  • 81 (a)
(Gallus gallus)
Aves RPS6KB2 36
  • 90 (a)
(Anolis carolinensis)
Reptilia RPS6KB2 36
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pk17E 37
  • 36 (a)
S6k 37
  • 72 (a)
S6k 36
  • 59 (a)
(Caenorhabditis elegans)
Secernentea F28C10.3 37
  • 34 (a)
R04A9.5 37
  • 51 (a)
Y47D3A.16 37
  • 57 (a)
rsks-1 36
  • 46 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL389W 35
  • 54.98 (n)
  • 48.94 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B03586g 35
  • 50.31 (n)
  • 49.08 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCH9 35
  • 52.72 (n)
  • 49.85 (a)
SCH9 36
  • 21 (a)
Species with no ortholog for RPS6KB2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RPS6KB2 Gene

Gene Tree for RPS6KB2 (if available)
Gene Tree for RPS6KB2 (if available)

Paralogs for RPS6KB2 Gene

genes like me logo Genes that share paralogs with RPS6KB2: view

Variants for RPS6KB2 Gene

Sequence variations from dbSNP and Humsavar for RPS6KB2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs55987642 - 67,433,341(+) CCAGC(A/C/T)GCCCT nc-transcript-variant, reference, missense
VAR_040644 -
VAR_040645 -
VAR_040646 An ovarian mucinous carcinoma sample
rs917570 -- 67,429,073(+) GGGAA(C/G/T)TGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS6KB2 Gene

Variant ID Type Subtype PubMed ID
nsv897797 CNV Loss 21882294
nsv897801 CNV Loss 21882294
nsv897804 CNV Gain 21882294
dgv1193n71 CNV Loss 21882294
dgv1194n71 CNV Loss 21882294
dgv1195n71 CNV Loss 21882294
nsv897811 CNV Loss 21882294
nsv521723 CNV Loss 19592680
nsv524096 CNV Loss 19592680
nsv468604 CNV Loss 19166990

Variation tolerance for RPS6KB2 Gene

Residual Variation Intolerance Score: 43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.07; 93.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS6KB2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6KB2 Gene

Disorders for RPS6KB2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RPS6KB2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
recurrent hypersomnia
  • primary recurrent hypersomnia
kleine-levin syndrome
  • kleine levin syndrome
coffin-lowry syndrome
  • cls
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RPS6KB2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPS6KB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS6KB2 Gene

Publications for RPS6KB2 Gene

  1. Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region. (PMID: 9804755) Gout I. … Yonezawa K. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Histone acetyltransferases interact with and acetylate p70 ribosomal S6 kinases in vitro and in vivo. (PMID: 19961954) Fenton T.R. … Gout I.T. (Int. J. Biochem. Cell Biol. 2010) 3 23
  3. Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway. (PMID: 20308064) Goh E.T. … Gout I. (J. Biol. Chem. 2010) 3 23
  4. Regulation of catalytic activity of S6 kinase 2 during cell cycle. (PMID: 17786541) Boyer D. … Lee-Fruman K.K. (Mol. Cell. Biochem. 2008) 3 23
  5. Receptor association and tyrosine phosphorylation of S6 kinases. (PMID: 16640565) Rebholz H. … Gout I.T. (FEBS J. 2006) 3 23

Products for RPS6KB2 Gene

Sources for RPS6KB2 Gene