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Aliases for RPS6KB1 Gene

Aliases for RPS6KB1 Gene

  • Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 2 3
  • S6K1 3 4 6
  • Serine/Threonine-Protein Kinase 14A 3 4
  • Ribosomal Protein S6 Kinase I 3 4
  • EC 2.7.11.1 4 63
  • S6K-Beta-1 3 4
  • P70 S6KA 3 4
  • STK14A 3 4
  • Ribosomal Protein S6 Kinase, 70kD, Polypeptide 1 2
  • 70 KDa Ribosomal Protein S6 Kinase 1 4
  • Ribosomal Protein S6 Kinase Beta-1 3
  • Serine/Threonine Kinase 14 Alpha 3
  • P70 Ribosomal S6 Kinase Alpha 4
  • P70 S6 Kinase, Alpha 3
  • P70 S6 Kinase Alpha 4
  • P70(S6K)-Alpha 3
  • P70 S6K-Alpha 4
  • P70-Alpha 3
  • P70-S6K 1 4
  • EC 2.7.11 63
  • P70-S6K 3
  • P70S6K1 4
  • PS6K 3
  • S6K 3

External Ids for RPS6KB1 Gene

Previous HGNC Symbols for RPS6KB1 Gene

  • STK14A

Previous GeneCards Identifiers for RPS6KB1 Gene

  • GC17M060023
  • GC17P060420
  • GC17P058312
  • GC17P058444
  • GC17P055325
  • GC17P057970
  • GC17P053343

Summaries for RPS6KB1 Gene

Entrez Gene Summary for RPS6KB1 Gene

  • This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]

GeneCards Summary for RPS6KB1 Gene

RPS6KB1 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1) is a Protein Coding gene. Diseases associated with RPS6KB1 include tuberous sclerosis and muscle hypertrophy. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include protein kinase activity and ribosomal protein S6 kinase activity. An important paralog of this gene is AKT1.

UniProtKB/Swiss-Prot for RPS6KB1 Gene

  • Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin. Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR.

Tocris Summary for RPS6KB1 Gene

  • p70 ribosomal S6 kinase (S6K) exists as two isoforms - S6K1 and S6K2 - which are activated by mitogenic stimuli such as growth factors, insulin and cytokines. In turn, p70 S6K phosphorylates the ribosomal protein S6. The S6K1 isoform also phosphorylates other proteins involved in the cell's translational machinery, including elF4B (initiation factor); eEF2K (elongation factor 2 kinase); and SKAR (RNA binding protein). As such, it is thought that S6K1 may be directly involved in cell growth and when considered alongside its position downstream of the PI3K and mTOR pathways, this activity makes S6K1 a potential target for cancer therapy.

Gene Wiki entry for RPS6KB1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KB1 Gene

Genomics for RPS6KB1 Gene

Regulatory Elements for RPS6KB1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPS6KB1 Gene

Start:
59,893,046 bp from pter
End:
59,950,564 bp from pter
Size:
57,519 bases
Orientation:
Plus strand

Genomic View for RPS6KB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS6KB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KB1 Gene

Proteins for RPS6KB1 Gene

  • Protein details for RPS6KB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23443-KS6B1_HUMAN
    Recommended name:
    Ribosomal protein S6 kinase beta-1
    Protein Accession:
    P23443
    Secondary Accessions:
    • B2R779
    • B4DLT4
    • B4DTG1
    • E7ESB8
    • F6UYM1
    • Q7Z721

    Protein attributes for RPS6KB1 Gene

    Size:
    525 amino acids
    Molecular mass:
    59140 Da
    Quaternary structure:
    • Interacts with PPP1R9A/neurabin-1 (By similarity). Interacts with RPTOR. Interacts with IRS1. Interacts with EIF3B and EIF3C. Interacts with POLDIP3 and TRAF4.

    Three dimensional structures from OCA and Proteopedia for RPS6KB1 Gene

    Alternative splice isoforms for RPS6KB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPS6KB1 Gene

Proteomics data for RPS6KB1 Gene at MOPED

Post-translational modifications for RPS6KB1 Gene

  • Phosphorylation at Thr-412 is regulated by mTORC1. The phosphorylation at this site is maintained by an agonist-dependent autophosphorylation mechanism (By similarity). Activated by phosphorylation at Thr-252 by PDPK1. Dephosphorylation by PPP1CC at Thr-412 in mitochondrion.
  • Ubiquitination at Lys104
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for RPS6KB1 (p70 S6 Kinase)
  • Cell Signaling Technology (CST) Antibodies for RPS6KB1 (p70S6K)

Domains for RPS6KB1 Gene

Graphical View of Domain Structure for InterPro Entry

P23443

UniProtKB/Swiss-Prot:

KS6B1_HUMAN :
  • P23443
Domain:
  • The autoinhibitory domain is believed to block phosphorylation within the AGC-kinase C-terminal domain and the activation loop
  • The TOS (TOR signaling) motif is essential for activation by mTORC1.
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KB1: view

Function for RPS6KB1 Gene

Molecular function for RPS6KB1 Gene

GENATLAS Biochemistry: ribosomal protein S6 kinase,70kDa,polypeptide 1,widely expressed,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essential regulatory role in protein synthesis during cell proliferation
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activation requires multiple phosphorylation events on serine/threonine residues. Activation appears to be first mediated by phosphorylation of multiple sites in the autoinhibitory domain, which facilitates phosphorylation at Thr-412, disrupting the autoinhibitory mechanism and allowing phosphorylation of Thr-252 by PDPK1. The active conformation of the kinase is believed to be stabilized by a mechanism involving three conserved phosphorylation sites located in the kinase domain activation loop (Thr-252) and in the AGC-kinase C-terminal domain (Ser-394 in the middle of the tail/linker region and Thr-412 within a hydrophobic motif at its end). Activated by mTORC1; isoform Alpha I and isoform Alpha II are sensitive to rapamycin, which inhibits activating phosphorylation at Thr-412. Activated by PDPK1.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin. Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR.

Enzyme Numbers (IUBMB) for RPS6KB1 Gene

Gene Ontology (GO) - Molecular Function for RPS6KB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 17936702
GO:0004674 protein serine/threonine kinase activity --
GO:0004711 ribosomal protein S6 kinase activity IBA --
GO:0004712 protein serine/threonine/tyrosine kinase activity IDA 22797923
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with RPS6KB1: view
genes like me logo Genes that share phenotypes with RPS6KB1: view

Animal Models for RPS6KB1 Gene

MGI Knock Outs for RPS6KB1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS6KB1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for RPS6KB1 Gene

Localization for RPS6KB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KB1 Gene

Cell junction, synapse, synaptosome. Mitochondrion outer membrane. Mitochondrion. Note=Colocalizes with URI1 at mitochondrion.
Isoform Alpha I: Nucleus. Cytoplasm.
Isoform Alpha II: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS6KB1 Gene COMPARTMENTS Subcellular localization image for RPS6KB1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 4
cytoskeleton 2
extracellular 2
plasma membrane 2
vacuole 2
lysosome 1

Gene Ontology (GO) - Cellular Components for RPS6KB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19085255
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 19085255
GO:0005739 mitochondrion IDA 17936702
GO:0005741 mitochondrial outer membrane IEA --
genes like me logo Genes that share ontologies with RPS6KB1: view

Pathways for RPS6KB1 Gene

SuperPathways for RPS6KB1 Gene

Superpath Contained pathways
1 Insulin receptor signalling cascade
2 IL-9 Signaling Pathways
3 Translation Insulin regulation of translation
4 IL-2 Pathway
5 Development IGF-1 receptor signaling
genes like me logo Genes that share pathways with RPS6KB1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Autophagy in human,mouse,rat
    • Cardiotoxicity in human,mouse,rat
    • Cell Death PathwayFinder in human,mouse,rat
    • EGF / PDGF Signaling Pathway in human,mouse,rat
    • Insulin Resistance in human,mouse,rat

Gene Ontology (GO) - Biological Process for RPS6KB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IMP 14673156
GO:0003009 skeletal muscle contraction IEA --
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction TAS 1922062
genes like me logo Genes that share ontologies with RPS6KB1: view

Compounds for RPS6KB1 Gene

(3) Tocris Compounds for RPS6KB1 Gene

Compound Action Cas Number
BRD 7389 p90 ribosomal S6 kinase inhibitor [376382-11-5]
PF 4708671 S6K1 inhibitor [1255517-76-0]
SL 0101-1 Selective p90 ribosomal S6 kinase (RSK) inhibitor [77307-50-7]

(2) HMDB Compounds for RPS6KB1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(75) Novoseek inferred chemical compound relationships for RPS6KB1 Gene

Compound -log(P) Hits PubMed IDs
rapamycin 95.5 198
wortmannin 82.5 60
ly294002 82.4 34
phosphatidylinositol 81.9 70
everolimus 74 13

(1) PharmGKB related drug/compound annotations for RPS6KB1 Gene

Drug/compound Annotation
everolimus
genes like me logo Genes that share compounds with RPS6KB1: view

Transcripts for RPS6KB1 Gene

Unigene Clusters for RPS6KB1 Gene

Ribosomal protein S6 kinase, 70kDa, polypeptide 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS6KB1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KB1 Gene

No ASD Table

Relevant External Links for RPS6KB1 Gene

GeneLoc Exon Structure for
RPS6KB1
ECgene alternative splicing isoforms for
RPS6KB1

Expression for RPS6KB1 Gene

mRNA expression in normal human tissues for RPS6KB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS6KB1 Gene

SOURCE GeneReport for Unigene cluster for RPS6KB1 Gene Hs.463642

mRNA Expression by UniProt/SwissProt for RPS6KB1 Gene

P23443-KS6B1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with RPS6KB1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RPS6KB1 Gene

Orthologs for RPS6KB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS6KB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS6KB1 35
  • 99.94 (n)
  • 100 (a)
RPS6KB1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPS6KB1 35
  • 96.38 (n)
  • 99.81 (a)
RPS6KB1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS6KB1 35
  • 97.33 (n)
  • 99.81 (a)
RPS6KB1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps6kb1 35
  • 94.6 (n)
  • 99.43 (a)
Rps6kb1 16
Rps6kb1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPS6KB1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS6KB1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps6kb1 35
  • 95.94 (n)
  • 99.43 (a)
chicken
(Gallus gallus)
Aves RPS6KB1 35
  • 88.58 (n)
  • 97.21 (a)
RPS6KB1 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS6KB1 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rps6kb1-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394938 35
rps6kb1 35
  • 83.14 (n)
  • 92.52 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.24528 35
rps6kb1a 36
  • 77 (a)
OneToMany
rps6kb1b 35
  • 74.3 (n)
  • 85.74 (a)
rps6kb1b 36
  • 85 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007333 35
  • 61.86 (n)
  • 66.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta S6k 35
  • 65.85 (n)
  • 73.22 (a)
S6k 36
  • 59 (a)
OneToMany
Pk17E 37
  • 36 (a)
S6k 37
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea rsks-1 35
  • 63.15 (n)
  • 68.38 (a)
rsks-1 36
  • 50 (a)
OneToMany
F28C10.3 37
  • 34 (a)
Y47D3A.16 37
  • 60 (a)
R04A9.5 37
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCH9 36
  • 22 (a)
OneToMany
YPK3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PK1 35
  • 52.08 (n)
  • 49.37 (a)
rice
(Oryza sativa)
Liliopsida Os03g0334000 35
  • 54.9 (n)
  • 48.75 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3064 35
Species with no ortholog for RPS6KB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS6KB1 Gene

ENSEMBL:
Gene Tree for RPS6KB1 (if available)
TreeFam:
Gene Tree for RPS6KB1 (if available)

Paralogs for RPS6KB1 Gene

genes like me logo Genes that share paralogs with RPS6KB1: view

Variants for RPS6KB1 Gene

Sequence variations from dbSNP and Humsavar for RPS6KB1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs25543 -- 59,950,509(-) GTTAA(-/TGAA)AATAA downstream-variant-500B
rs25548 -- 59,946,864(+) GAAAC(A/G)ACTCA utr-variant-3-prime, intron-variant
rs143652 -- 59,945,123(-) CAGGC(C/T)CCATA intron-variant
rs180515 -- 59,946,914(-) GTGTC(C/T)GAAGT utr-variant-3-prime, intron-variant
rs180516 -- 59,943,909(-) tatat(A/G)tgtat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS6KB1 Gene

Variant ID Type Subtype PubMed ID
nsv471702 CNV Gain 15918152
nsv833502 CNV Gain 17160897
dgv996e1 CNV Complex 17122850
nsv428348 CNV Gain 18775914
nsv471544 CNV Duplication 19718026
nsv9576 CNV Gain+Loss 18304495
esv24411 CNV Gain 19812545

Relevant External Links for RPS6KB1 Gene

HapMap Linkage Disequilibrium report
RPS6KB1

PCR Panel Products

  • Copy Number PCR Panels: for RPS6KB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6KB1 Gene

Disorders for RPS6KB1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for RPS6KB1 Gene including...

Search for RPS6KB1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for RPS6KB1 Gene

(44) Novoseek inferred disease relationships for RPS6KB1 Gene

Disease -log(P) Hits PubMed IDs
tuberous sclerosis 75.5 7
tumors 44.3 39
cancer 42.9 20
glioblastoma 37.2 1
rhabdomyosarcoma 36.4 4

Relevant External Links for RPS6KB1

Genetic Association Database (GAD)
RPS6KB1
Human Genome Epidemiology (HuGE) Navigator
RPS6KB1
genes like me logo Genes that share disorders with RPS6KB1: view

No data available for UniProtKB/Swiss-Prot for RPS6KB1 Gene

Publications for RPS6KB1 Gene

  1. mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. (PMID: 14673156) Fingar D.C. … Blenis J. (Mol. Cell. Biol. 2004) 3 4 23
  2. Phosphorylation and activation of p70s6k by PDK1. (PMID: 9445476) Pullen N. … Thomas G. (Science 1998) 3 4 23
  3. SKAR is a specific target of S6 kinase 1 in cell growth control. (PMID: 15341740) Richardson C.J. … Blenis J. (Curr. Biol. 2004) 3 4 23
  4. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. (PMID: 16286006) Holz M.K. … Blenis J. (Cell 2005) 3 4 23
  5. S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. (PMID: 18952604) Zhang J. … Ye J. (J. Biol. Chem. 2008) 3 4 23

Products for RPS6KB1 Gene

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