Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPS6KA2 Gene

Aliases for RPS6KA2 Gene

  • Ribosomal Protein S6 Kinase A2 2 3 5
  • MAP Kinase-Activated Protein Kinase 1c 3 4
  • MAPK-Activated Protein Kinase 1c 3 4
  • Ribosomal S6 Kinase 3 3 4
  • EC 4 58
  • MAPKAPK1C 3 4
  • Pp90RSK3 3 4
  • P90RSK2 3 4
  • RSK3 3 4
  • Mitogen-Activated Protein Kinase-Activated Protein Kinase 1C 3
  • Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 3
  • Ribosomal Protein S6 Kinase, 90kD, Polypeptide 2 2
  • 90 KDa Ribosomal Protein S6 Kinase 2 4
  • Ribosomal Protein S6 Kinase Alpha-2 3
  • MAPKAP Kinase 1C 3
  • MAPKAP Kinase 1c 4
  • S6K-Alpha-2 4
  • S6K-Alpha2 3
  • MAPKAPK-1c 4
  • S6K-Alpha 3
  • P90-RSK 2 4
  • EC 2.7.11 58
  • P90-RSK3 3
  • RSK-3 4
  • HU-2 3
  • RSK 3

External Ids for RPS6KA2 Gene

Previous GeneCards Identifiers for RPS6KA2 Gene

  • GC06M166179
  • GC06M166698
  • GC06M166734
  • GC06M166733
  • GC06M166795
  • GC06M166742
  • GC06M164294
  • GC06M166822

Summaries for RPS6KA2 Gene

Entrez Gene Summary for RPS6KA2 Gene

  • This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]

GeneCards Summary for RPS6KA2 Gene

RPS6KA2 (Ribosomal Protein S6 Kinase A2) is a Protein Coding gene. Among its related pathways are Activated TLR4 signalling and Long-term potentiation. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RPS6KA3.

UniProtKB/Swiss-Prot for RPS6KA2 Gene

  • Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.

Tocris Summary for RPS6KA2 Gene

  • Ribosomal S6 protein kinases (RSKs) are a family of protein serine/threonine kinases that regulate diverse cellular processes such as cellular growth, motility, survival and proliferation. The RSK family can be divided into two subfamilies, namely p90 RSK and p70 S6K.

Gene Wiki entry for RPS6KA2 Gene

Additional gene information for RPS6KA2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KA2 Gene

Genomics for RPS6KA2 Gene

Regulatory Elements for RPS6KA2 Gene

Enhancers for RPS6KA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H166552 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12 +349.9 349920 7.3 TBP FOXA2 JUN MAX RAD21 YY1 POLR2A FOS ZNF687 MNT MIR1913 RPS6KA2 PRR18 GC06M166586
GH06H167150 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10 -246.1 -246089 3.4 PKNOX1 TBL1XR1 SIN3A BATF ATF7 ETV6 RUNX3 CREM IKZF2 CBFB GPR31 RNASET2 CCR6 LOC105378120 FGFR1OP ENSG00000249141 UNC93A RPS6KA2 RPS6KA2-AS1 AFDN
GH06H167129 1.2 ENCODE dbSUPER 9.7 -224.1 -224101 2.7 PKNOX1 FOXA2 MLX ARID4B TCF12 SLC30A9 FOS ATF7 RUNX3 SP5 FGFR1OP LOC105378120 GPR31 RPS6KA2-AS1 RPS6KA2 RNASET2 LOC105378122 TCP10L2 LOC105378124
GH06H166656 1.2 FANTOM5 Ensembl ENCODE 9.4 +249.3 249274 1.6 NFIA RAD21 ZIC2 RARA POLR2A ZKSCAN8 ETV4 SMAD4 BCL6 RXRB RPS6KA2 PRR18 GC06P166651 LOC645468
GH06H166639 1.1 Ensembl ENCODE dbSUPER 9.3 +265.9 265904 1.2 L3MBTL2 ZNF341 GLIS1 MNT FOXP2 ZIC2 RPS6KA2 GC06M166644 FAM103A2P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPS6KA2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RPS6KA2 Gene

Genomic Locations for RPS6KA2 Gene
497,088 bases
Minus strand

Genomic View for RPS6KA2 Gene

Genes around RPS6KA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS6KA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS6KA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KA2 Gene

Proteins for RPS6KA2 Gene

  • Protein details for RPS6KA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosomal protein S6 kinase alpha-2
    Protein Accession:
    Secondary Accessions:
    • B3KTK9
    • Q15419
    • Q59GJ3
    • Q5TI68
    • Q96J38
    • Q9UJN5

    Protein attributes for RPS6KA2 Gene

    733 amino acids
    Molecular mass:
    83239 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).
    • Sequence=AAC82496.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD92353.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG53121.1; Type=Frameshift; Positions=527; Evidence={ECO:0000305};

    Alternative splice isoforms for RPS6KA2 Gene


neXtProt entry for RPS6KA2 Gene

Selected DME Specific Peptides for RPS6KA2 Gene


Post-translational modifications for RPS6KA2 Gene

  • Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity).
  • N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
  • Ubiquitination at Lys630
  • Modification sites at PhosphoSitePlus

Domains & Families for RPS6KA2 Gene

Suggested Antigen Peptide Sequences for RPS6KA2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
genes like me logo Genes that share domains with RPS6KA2: view

Function for RPS6KA2 Gene

Molecular function for RPS6KA2 Gene

GENATLAS Biochemistry:
ribosomal S6 kinase,90kDa,polypeptide 2,growth factor regulated serine/threonine kinase family,predominantly expressed in lung and skeletal muscle,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors,maybe playing an essentilal regulatory role in protein synthesis during cell proliferation
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-570 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-377, allowing binding of PDPK1, which in turn phosphorylates Ser-218 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.

Enzyme Numbers (IUBMB) for RPS6KA2 Gene

Phenotypes From GWAS Catalog for RPS6KA2 Gene

Gene Ontology (GO) - Molecular Function for RPS6KA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS,IEA --
GO:0004711 ribosomal protein S6 kinase activity IEA --
GO:0004712 protein serine/threonine/tyrosine kinase activity IDA 22797923
genes like me logo Genes that share ontologies with RPS6KA2: view
genes like me logo Genes that share phenotypes with RPS6KA2: view

Animal Models for RPS6KA2 Gene

MGI Knock Outs for RPS6KA2:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RPS6KA2 Gene

Localization for RPS6KA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KA2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS6KA2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 1
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RPS6KA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS 16878154
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 16878154
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPS6KA2: view

Pathways & Interactions for RPS6KA2 Gene

SuperPathways for RPS6KA2 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 Post NMDA receptor activation events
3 Nuclear Events (kinase and transcription factor activation)
4 mTOR Pathway
5 GDNF-Family Ligands and Receptor Interactions
genes like me logo Genes that share pathways with RPS6KA2: view

SIGNOR curated interactions for RPS6KA2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RPS6KA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001556 oocyte maturation IEA --
GO:0002035 brain renin-angiotensin system IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction NAS 7623830
GO:0007507 heart development IEA --
genes like me logo Genes that share ontologies with RPS6KA2: view

Drugs & Compounds for RPS6KA2 Gene

(7) Drugs for RPS6KA2 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
BI-D1870 Pharma P90 RSK inhibitor,ATP-competitive and cell-permeable 0
BRD 7389 Pharma P90 RSK inhibitor 0
PF-4708671 Pharma P70 S6K1 isoform inhibitor,cell-permeable 0
SL 0101-1 Pharma 0
Magnesium Nutra 0

(4) Tocris Compounds for RPS6KA2 Gene

Compound Action Cas Number
BRD 7389 Ribosomal S6 kinase inhibitor 376382-11-5
PF 4708671 S6K1 inhibitor 1255517-76-0
RMM 46 MSK/RSK family kinase inhibitor 1307896-46-3
SL 0101-1 Selective ribosomal S6 kinase (RSK) inhibitor 77307-50-7

(4) ApexBio Compounds for RPS6KA2 Gene

Compound Action Cas Number
BI-D1870 P90 RSK inhibitor,ATP-competitive and cell-permeable 501437-28-1
BRD 7389 P90 RSK inhibitor 376382-11-5
PF-4708671 P70 S6K1 isoform inhibitor,cell-permeable 1255517-76-0
SL 0101-1 77307-50-7
genes like me logo Genes that share compounds with RPS6KA2: view

Drug Products

Transcripts for RPS6KA2 Gene

Unigene Clusters for RPS6KA2 Gene

Ribosomal protein S6 kinase, 90kDa, polypeptide 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA2 Gene

No ASD Table

Relevant External Links for RPS6KA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS6KA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS6KA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS6KA2 Gene

This gene is overexpressed in Brain (21.3), Adipocyte (14.3), and Frontal cortex (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS6KA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RPS6KA2 Gene:


SOURCE GeneReport for Unigene cluster for RPS6KA2 Gene:


mRNA Expression by UniProt/SwissProt for RPS6KA2 Gene:

Tissue specificity: Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.

Evidence on tissue expression from TISSUES for RPS6KA2 Gene

  • Nervous system(4.9)
  • Muscle(4.5)
  • Heart(2.5)
genes like me logo Genes that share expression patterns with RPS6KA2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS6KA2 Gene

Orthologs for RPS6KA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS6KA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPS6KA2 34 33
  • 95.32 (n)
(Monodelphis domestica)
Mammalia RPS6KA2 34
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 92 (a)
-- 34
  • 87 (a)
(Canis familiaris)
Mammalia RPS6KA2 34 33
  • 89.25 (n)
(Bos Taurus)
Mammalia RPS6KA2 34 33
  • 88.86 (n)
(Mus musculus)
Mammalia Rps6ka2 34 16 33
  • 87.72 (n)
(Rattus norvegicus)
Mammalia Rps6ka2 33
  • 86.99 (n)
(Gallus gallus)
Aves RPS6KA2 34 33
  • 81.63 (n)
(Anolis carolinensis)
Reptilia RPS6KA2 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps6ka2 33
  • 73.99 (n)
(Danio rerio)
Actinopterygii RPS6KA2 34
  • 86 (a)
rps6ka2 33
  • 75.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta S6kII 35 34
  • 58 (a)
Pk17E 35
  • 41 (a)
(Caenorhabditis elegans)
Secernentea T01H8.1b 35
  • 62 (a)
rskn-1 34
  • 53 (a)
R04A9.5 35
  • 44 (a)
F28C10.3 35
  • 36 (a)
(Glycine max)
eudicotyledons Gma.186 33
(Oryza sativa)
Liliopsida Os.6126 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 68 (a)
Species where no ortholog for RPS6KA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS6KA2 Gene

Gene Tree for RPS6KA2 (if available)
Gene Tree for RPS6KA2 (if available)

Paralogs for RPS6KA2 Gene

(229) SIMAP similar genes for RPS6KA2 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with RPS6KA2: view

Variants for RPS6KA2 Gene

Sequence variations from dbSNP and Humsavar for RPS6KA2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs267600891 A metastatic melanoma sample 166,469,882(+) AATTT(C/T)CTCCA reference, missense
rs376029388 A colorectal adenocarcinoma sample 166,412,769(+) ACAGC(C/T)GCGTG reference, missense
rs1000009543 -- 166,469,971(+) CCAAT(A/G)CAGCA intron-variant
rs1000011298 -- 166,520,497(+) CCTGT(A/G)ACAAA intron-variant
rs1000015702 -- 166,671,370(+) GTCGA(A/C)AGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS6KA2 Gene

Variant ID Type Subtype PubMed ID
nsv476275 CNV novel sequence insertion 20440878
nsv476238 CNV novel sequence insertion 20440878
nsv473725 CNV novel sequence insertion 20440878
nsv473496 CNV novel sequence insertion 20440878
nsv349126 CNV deletion 16902084
nsv348883 CNV deletion 16902084
nsv1153547 CNV insertion 26484159
nsv1147339 CNV insertion 26484159
nsv1117452 CNV tandem duplication 24896259
nsv1110802 CNV insertion 24896259
nsv1074976 CNV deletion 25765185
nsv1023649 CNV gain 25217958
esv7295 CNV gain 19470904
esv3720 CNV loss 18987735
esv3611635 CNV loss 21293372
esv3540868 CNV deletion 23714750
esv3540864 CNV deletion 23714750
esv3431830 CNV duplication 20981092
esv3412414 CNV duplication 20981092
esv3354794 CNV insertion 20981092
esv3351998 CNV duplication 20981092
esv3333565 CNV duplication 20981092
esv3324966 CNV insertion 20981092
esv3307232 CNV mobile element insertion 20981092
esv3304797 CNV mobile element insertion 20981092
esv29465 CNV gain+loss 19812545
esv2761039 CNV loss 21179565
esv2733203 CNV deletion 23290073
esv2733202 CNV deletion 23290073
esv2733201 CNV deletion 23290073
esv2733200 CNV deletion 23290073
esv2733199 CNV deletion 23290073
esv2733198 CNV deletion 23290073
esv2733197 CNV deletion 23290073
esv2733196 CNV deletion 23290073
esv2733194 CNV deletion 23290073
esv2733193 CNV deletion 23290073
esv2733192 CNV deletion 23290073
esv2733191 CNV deletion 23290073
esv2733190 CNV deletion 23290073
esv2733189 CNV deletion 23290073
esv2733188 CNV deletion 23290073
esv2733187 CNV deletion 23290073
esv2733186 CNV deletion 23290073
esv2733185 CNV deletion 23290073
esv2678517 CNV deletion 23128226
esv2677188 CNV deletion 23128226
esv2673126 CNV deletion 23128226
esv2672309 CNV deletion 23128226
esv2666760 CNV deletion 23128226
esv2662308 CNV deletion 23128226
esv2580547 CNV deletion 19546169
esv2507832 CNV deletion 19546169
esv25052 CNV loss 19812545
esv2485852 CNV insertion 19546169
esv24794 CNV gain+loss 19812545
esv23654 CNV loss 19812545
esv22598 CNV loss 19812545
esv2182887 CNV deletion 18987734
esv1965634 CNV deletion 18987734
esv1742910 CNV insertion 17803354
esv1684843 CNV insertion 17803354
esv1538758 CNV deletion 17803354
esv1002461 CNV deletion 20482838
dgv400n21 CNV loss 19592680
dgv3440n106 CNV deletion 24896259
dgv3439n106 CNV tandem duplication 24896259
dgv1851e212 CNV loss 25503493
dgv1170e199 CNV deletion 23128226
dgv11054n54 CNV loss 21841781
dgv11053n54 CNV loss 21841781
dgv11052n54 CNV loss 21841781
dgv11051n54 CNV loss 21841781
dgv11050n54 CNV gain+loss 21841781
dgv11049n54 CNV loss 21841781
dgv11048n54 CNV loss 21841781
dgv11047n54 CNV gain 21841781
dgv11046n54 CNV gain+loss 21841781
dgv11045n54 CNV loss 21841781
dgv11044n54 CNV gain+loss 21841781
dgv11043n54 CNV gain 21841781
dgv11042n54 CNV gain 21841781
dgv11041n54 CNV gain+loss 21841781
dgv11040n54 CNV gain 21841781
nsv981206 CNV duplication 23825009
nsv969468 CNV duplication 23825009
nsv965786 CNV duplication 23825009
nsv949890 CNV deletion 24416366
nsv949889 CNV deletion 24416366
nsv930495 CNV deletion 23359205
nsv823928 CNV loss 20364138
nsv7388 OTHER inversion 18451855
nsv605333 CNV loss 21841781
nsv605326 CNV loss 21841781
nsv605325 CNV loss 21841781
nsv605323 CNV loss 21841781
nsv605320 CNV loss 21841781
nsv605318 CNV loss 21841781
nsv605316 CNV loss 21841781
nsv605305 CNV loss 21841781
nsv605300 CNV gain+loss 21841781
nsv605294 CNV gain+loss 21841781
nsv605286 CNV loss 21841781
nsv605268 CNV loss 21841781
nsv605261 CNV gain 21841781
nsv605260 CNV gain 21841781
nsv605259 CNV loss 21841781
nsv5592 CNV deletion 18451855
nsv5591 CNV insertion 18451855
nsv518561 CNV loss 19592680
nsv476602 CNV novel sequence insertion 20440878

Variation tolerance for RPS6KA2 Gene

Residual Variation Intolerance Score: 2.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS6KA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS6KA2 Gene

Disorders for RPS6KA2 Gene

Relevant External Links for RPS6KA2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPS6KA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS6KA2 Gene

Publications for RPS6KA2 Gene

  1. Human rsk isoforms: cloning and characterization of tissue-specific expression. (PMID: 8141249) Moller DE … Jakubowski M (The American journal of physiology 1994) 2 3 4 22 60
  2. RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer. (PMID: 16878154) Bignone PA … Ganesan TS (Oncogene 2007) 3 4 22 60
  3. 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1. (PMID: 10480933) Jensen CJ … Frödin M (The Journal of biological chemistry 1999) 3 4 22 60
  4. RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. (PMID: 7623830) Zhao Y … Moller DE (Molecular and cellular biology 1995) 3 4 22 60
  5. Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer. (PMID: 21035469) Slattery ML … Wolff RK (Mutation research 2011) 3 45 60

Products for RPS6KA2 Gene

Sources for RPS6KA2 Gene

Loading form....