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Aliases for RPS5 Gene

Aliases for RPS5 Gene

  • Ribosomal Protein S5 2 3 5
  • 40S Ribosomal Protein S5 2
  • S5 3

External Ids for RPS5 Gene

Previous GeneCards Identifiers for RPS5 Gene

  • GC19P059797
  • GC19P059352
  • GC19P063574
  • GC19P063590
  • GC19P059040
  • GC19P059053
  • GC19P055207
  • GC19P059076
  • GC19P059095
  • GC19P059106
  • GC19P059149
  • GC19P059205
  • GC19P059246
  • GC19P059295

Summaries for RPS5 Gene

Entrez Gene Summary for RPS5 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS5 Gene

RPS5 (Ribosomal Protein S5) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS5 Gene

Genomics for RPS5 Gene

Regulatory Elements for RPS5 Gene

Enhancers for RPS5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS5 on UCSC Golden Path with GeneCards custom track

Promoters for RPS5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS5 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS5 Gene

58,386,400 bp from pter
58,394,806 bp from pter
8,407 bases
Plus strand

Genomic View for RPS5 Gene

Genes around RPS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS5 Gene

Proteins for RPS5 Gene

  • Protein details for RPS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S5
    Protein Accession:
    Secondary Accessions:
    • B2R4T2
    • Q96BN0

    Protein attributes for RPS5 Gene

    204 amino acids
    Molecular mass:
    22876 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS5 Gene

neXtProt entry for RPS5 Gene

Proteomics data for RPS5 Gene at MOPED

Post-translational modifications for RPS5 Gene

  • Ubiquitination at Lys 18, Lys 22, Lys 47, Lys 63, Lys 167, and Lys 182
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS5 Gene

No data available for DME Specific Peptides for RPS5 Gene

Domains & Families for RPS5 Gene

Gene Families for RPS5 Gene

Protein Domains for RPS5 Gene

Suggested Antigen Peptide Sequences for RPS5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S7P family.
  • Belongs to the ribosomal protein S7P family.
genes like me logo Genes that share domains with RPS5: view

Function for RPS5 Gene

Molecular function for RPS5 Gene

GENATLAS Biochemistry:
40S ribosomal protein S5

Gene Ontology (GO) - Molecular Function for RPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 24965446
genes like me logo Genes that share ontologies with RPS5: view
genes like me logo Genes that share phenotypes with RPS5: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS5 Gene

Localization for RPS5 Gene

Subcellular locations from

Jensen Localization Image for RPS5 Gene COMPARTMENTS Subcellular localization image for RPS5 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with RPS5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS5 Gene

Pathways & Interactions for RPS5 Gene

SuperPathways for RPS5 Gene

Superpath Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 Infectious disease
5 rRNA processing
genes like me logo Genes that share pathways with RPS5: view

Gene Ontology (GO) - Biological Process for RPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 7772601
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
genes like me logo Genes that share ontologies with RPS5: view

No data available for SIGNOR curated interactions for RPS5 Gene

Drugs & Compounds for RPS5 Gene

No Compound Related Data Available

Transcripts for RPS5 Gene

Unigene Clusters for RPS5 Gene

Ribosomal protein S5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -
SP2: - -

Relevant External Links for RPS5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS5 Gene

mRNA expression in normal human tissues for RPS5 Gene

Protein differential expression in normal tissues from HIPED for RPS5 Gene

This gene is overexpressed in Tlymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS5 Gene

SOURCE GeneReport for Unigene cluster for RPS5 Gene Hs.378103

genes like me logo Genes that share expression patterns with RPS5: view

Protein tissue co-expression partners for RPS5 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS5 Gene

Orthologs for RPS5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS5 35
  • 89.38 (n)
  • 100 (a)
RPS5 36
  • 100 (a)
(Canis familiaris)
Mammalia RPS5 35
  • 89.71 (n)
  • 100 (a)
RPS5 36
  • 100 (a)
(Mus musculus)
Mammalia Rps5 35
  • 90.52 (n)
  • 99.02 (a)
Rps5 16
Rps5 36
  • 99 (a)
(Pan troglodytes)
Mammalia RPS5 35
  • 100 (n)
  • 100 (a)
RPS5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rps5 35
  • 90.03 (n)
  • 99.51 (a)
(Ornithorhynchus anatinus)
Mammalia RPS5 36
  • 100 (a)
(Anolis carolinensis)
Reptilia RPS5 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps5 35
  • 79.64 (n)
  • 94.58 (a)
Str.1676 35
African clawed frog
(Xenopus laevis)
Amphibia MGC64490 35
(Danio rerio)
Actinopterygii -- 35
rps5 35
  • 84.41 (n)
  • 96.52 (a)
rps5 36
  • 96 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9001 35
fruit fly
(Drosophila melanogaster)
Insecta CG7014 37
  • 86 (a)
RpS5 37
  • 88 (a)
RpS5a 35
  • 77.5 (n)
  • 87.68 (a)
RpS5a 36
  • 79 (a)
RpS5b 36
  • 76 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008329 35
  • 78.34 (n)
  • 89.34 (a)
(Caenorhabditis elegans)
Secernentea rps-5 37
  • 86 (a)
rps-5 35
  • 73.6 (n)
  • 86.8 (a)
rps-5 36
  • 81 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR171W 35
  • 68.33 (n)
  • 71.14 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10659g 35
  • 65.95 (n)
  • 76.47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS5 35
  • 63.97 (n)
  • 71.21 (a)
RPS5 36
  • 63 (a)
RPS5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons RPS5B 35
  • 68.59 (n)
  • 79.58 (a)
(Oryza sativa)
Liliopsida Os11g0482000 35
  • 76.19 (n)
  • 82.54 (a)
(Triticum aestivum)
Liliopsida Ta.3277 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5398 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09475 35
  • 72.92 (n)
  • 79.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps502 35
  • 67.02 (n)
  • 74.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6156 36
  • 81 (a)
Species with no ortholog for RPS5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS5 Gene

Gene Tree for RPS5 (if available)
Gene Tree for RPS5 (if available)

Paralogs for RPS5 Gene

genes like me logo Genes that share paralogs with RPS5: view

No data available for Paralogs for RPS5 Gene

Variants for RPS5 Gene

Sequence variations from dbSNP and Humsavar for RPS5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12984898 -- 58,390,454(+) ttttt(A/T)tgaga intron-variant
rs8105186 -- 58,389,248(+) TATTC(A/C)CTTTC intron-variant
rs13382065 -- 58,392,331(+) ggggg(A/G)aaaaa intron-variant
rs8105899 -- 58,390,823(+) GCCCT(A/G)CGTGA intron-variant
rs8106092 -- 58,391,195(+) gggag(A/G)ctgag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS5 Gene

Variant ID Type Subtype PubMed ID
nsv833887 CNV Loss 17160897
nsv515731 CNV Gain+Loss 19592680
dgv4030n71 CNV Loss 21882294
nsv833888 CNV Loss 17160897
nsv817878 CNV Loss 17921354
essv17855 CNV CNV 17122850
dgv1136e1 CNV Complex 17122850

Variation tolerance for RPS5 Gene

Residual Variation Intolerance Score: 32.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RPS5 Gene

Disorders for RPS5 Gene

Relevant External Links for RPS5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPS5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS5 Gene

Publications for RPS5 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 67
  2. [Mutual effect of human ribosomal proteins S5 and S16 on their binding with 18S rRNA fragment 1203-1236/1521-1698]. (PMID: 19807034) Ian'shina D.D. … Karpova G.G. (Mol. Biol. (Mosk.) 2009) 3 23
  3. Roles of the negatively charged N-terminal extension of Saccharomyces cerevisiae ribosomal protein S5 revealed by characterization of a yeast strain containing human ribosomal protein S5. (PMID: 17901157) Galkin O. … Komar A.A. (RNA 2007) 3 23
  4. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio J.-M. … Iovanna J.L. (Biochim. Biophys. Acta 1995) 2 3
  5. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3

Products for RPS5 Gene

Sources for RPS5 Gene