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Aliases for RPS4Y1 Gene

Aliases for RPS4Y1 Gene

  • Ribosomal Protein S4, Y-Linked 1 2 3
  • Ribosomal Protein S4Y 2 3
  • RPS4Y 3 4
  • 40S Ribosomal Protein S4, Y Isoform 1 3
  • Ribosomal Protein S4, Y-Linked 2
  • 40S Ribosomal Protein S4, Y 3
  • 40S Ribosomal Protein S4 2
  • S4 3
  • Y 2

External Ids for RPS4Y1 Gene

Previous HGNC Symbols for RPS4Y1 Gene

  • RPS4Y

Previous GeneCards Identifiers for RPS4Y1 Gene

  • GC0YP002356
  • GC0YP002753
  • GC0YP002769
  • GC0YP002709
  • GC0YP000062

Summaries for RPS4Y1 Gene

Entrez Gene Summary for RPS4Y1 Gene

  • Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, X-linked (RPS4X). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS4Y1 Gene

RPS4Y1 (Ribosomal Protein S4, Y-Linked 1) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and rRNA binding.

Gene Wiki entry for RPS4Y1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS4Y1 Gene

Genomics for RPS4Y1 Gene

Regulatory Elements for RPS4Y1 Gene

Genomic Location for RPS4Y1 Gene

2,841,582 bp from pter
2,866,956 bp from pter
25,375 bases
Plus strand

Genomic View for RPS4Y1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS4Y1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS4Y1 Gene

Proteins for RPS4Y1 Gene

  • Protein details for RPS4Y1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S4, Y isoform 1
    Protein Accession:
    Secondary Accessions:
    • A8K9V4

    Protein attributes for RPS4Y1 Gene

    263 amino acids
    Molecular mass:
    29456 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RPS4Y1 Gene

Proteomics data for RPS4Y1 Gene at MOPED

Post-translational modifications for RPS4Y1 Gene

  • Ubiquitination at Lys16, Lys22, Lys37, Lys53, Lys62, Lys63, Lys134, Lys168, Lys211, and Lys233
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS4Y1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RPS4Y1 Gene

Domains for RPS4Y1 Gene

Gene Families for RPS4Y1 Gene

  • RPS :S ribosomal proteins

Suggested Antigen Peptide Sequences for RPS4Y1 Gene

Graphical View of Domain Structure for InterPro Entry



  • P22090
  • Contains 1 S4 RNA-binding domain.
  • Belongs to the ribosomal protein S4e family.
genes like me logo Genes that share domains with RPS4Y1: view

Function for RPS4Y1 Gene

Gene Ontology (GO) - Molecular Function for RPS4Y1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 2124517
GO:0003735 structural constituent of ribosome IMP 8358435
GO:0019843 rRNA binding IEA --
genes like me logo Genes that share ontologies with RPS4Y1: view

Phenotypes for RPS4Y1 Gene

genes like me logo Genes that share phenotypes with RPS4Y1: view

Animal Model Products

miRNA for RPS4Y1 Gene

miRTarBase miRNAs that target RPS4Y1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS4Y1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS4Y1 Gene

Localization for RPS4Y1 Gene

Subcellular locations from

Jensen Localization Image for RPS4Y1 Gene COMPARTMENTS Subcellular localization image for RPS4Y1 gene
Compartment Confidence
cytosol 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RPS4Y1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 21630459
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
GO:0005844 polysome IDA 8139551
genes like me logo Genes that share ontologies with RPS4Y1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS4Y1 Gene

Pathways for RPS4Y1 Gene

SuperPathways for RPS4Y1 Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 CFTR translational fidelity (class I mutations)
4 Disease
5 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
genes like me logo Genes that share pathways with RPS4Y1: view

Pathways by source for RPS4Y1 Gene

1 KEGG pathway for RPS4Y1 Gene
1 GeneGo (Thomson Reuters) pathway for RPS4Y1 Gene

Interacting Proteins for RPS4Y1 Gene

Selected Interacting proteins: P22090-RS4Y1_HUMAN for RPS4Y1 Gene via I2D

Gene Ontology (GO) - Biological Process for RPS4Y1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPS4Y1: view

Transcripts for RPS4Y1 Gene

mRNA/cDNA for RPS4Y1 Gene

(558) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RPS4Y1 Gene

Ribosomal protein S4, Y-linked 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPS4Y1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPS4Y1 Gene

No ASD Table

Relevant External Links for RPS4Y1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS4Y1 Gene

mRNA expression in normal human tissues for RPS4Y1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RPS4Y1 Gene

This gene is overexpressed in Heart (21.4) and Testis (9.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for RPS4Y1 Gene

SOURCE GeneReport for Unigene cluster for RPS4Y1 Gene Hs.282376

genes like me logo Genes that share expressions with RPS4Y1: view

Expression partners for RPS4Y1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS4Y1 Gene

Orthologs for RPS4Y1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS4Y1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100850611 35
  • 79.72 (n)
  • 90.08 (a)
(Mus musculus)
Mammalia Rps4x 35
  • 80.99 (n)
  • 92.78 (a)
(Pan troglodytes)
Mammalia RPS4Y1 35
  • 99.24 (n)
  • 99.62 (a)
(Rattus norvegicus)
Mammalia Rps4x 35
  • 80.35 (n)
  • 92.78 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2819 35
(Oryza sativa)
Liliopsida Os.12238 35
Species with no ortholog for RPS4Y1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RPS4Y1 Gene

Gene Tree for RPS4Y1 (if available)
Gene Tree for RPS4Y1 (if available)

Paralogs for RPS4Y1 Gene

Selected SIMAP similar genes for RPS4Y1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RPS4Y1: view

No data available for Paralogs for RPS4Y1 Gene

Variants for RPS4Y1 Gene

Sequence variations from dbSNP and Humsavar for RPS4Y1 Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs2075640 -- 2,854,465(+) TTAAT(A/G)TAGTT intron-variant
rs2299942 -- 2,863,846(+) GGGTA(C/T)TTTCT intron-variant
rs7067518 -- 2,859,817(+) ctttt(G/T)tttca intron-variant
rs11538308 -- 2,854,666(-) CTCAT(C/G)ATGCT missense, reference
rs11538309 -- 2,844,196(+) ATGCA(A/G)CGTTT reference, synonymous-codon

Relevant External Links for RPS4Y1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RPS4Y1 Gene

Disorders for RPS4Y1 Gene

(2) University of Copenhagen DISEASES for RPS4Y1 Gene

(1) Novoseek inferred disease relationships for RPS4Y1 Gene

Disease -log(P) Hits PubMed IDs
turners syndrome 82 1
genes like me logo Genes that share disorders with RPS4Y1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for RPS4Y1 Gene

Publications for RPS4Y1 Gene

  1. Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome. (PMID: 2124517) Fisher E.M.C. … Page D.C. (Cell 1990) 3 4 23
  2. Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes. (PMID: 8139551) Zinn A.R. … Page D.C. (Mol. Cell. Biol. 1994) 3 23
  3. Functional equivalence of human X- and Y-encoded isoforms of ribosomal protein S4 consistent with a role in Turner syndrome. (PMID: 8358435) Watanabe M. … Nishimoto T. (Nat. Genet. 1993) 3 23
  4. Relationship between the monosomy X phenotype and Y-linked ribosomal protein S4 (Rps4) in several species of mammals: a molecular evolutionary analysis of Rps4 homologs. (PMID: 8808278) Omoe K. … Endo A. (Genomics 1996) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RPS4Y1 Gene

Sources for RPS4Y1 Gene

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