Aliases for RPN2 Gene
External Ids for RPN2 Gene
Previous GeneCards Identifiers for RPN2 Gene
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
GeneCards Summary for RPN2 Gene
RPN2 (Ribophorin II) is a Protein Coding gene. Among its related pathways are Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include ribosome binding and dolichyl-diphosphooligosaccharide-protein glycotransferase activity.
UniProtKB/Swiss-Prot for RPN2 Gene
Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.