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Aliases for RPL39 Gene

Aliases for RPL39 Gene

  • Ribosomal Protein L39 2 3 5
  • Ribosomal Protein L39 Pseudogene 42 2
  • RPL39_23_1806 3
  • RPL39P42 3
  • L39 3

External Ids for RPL39 Gene

Previous HGNC Symbols for RPL39 Gene

  • RPL39P42

Previous GeneCards Identifiers for RPL39 Gene

  • GC0XM113738
  • GC0XM115906
  • GC0XM116895
  • GC0XM117674
  • GC0XM118702
  • GC0XM118804
  • GC0XM118920
  • GC0XM108414

Summaries for RPL39 Gene

Entrez Gene Summary for RPL39 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the S39E family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein is the smallest, and one of the most basic, proteins of the ribosome. This gene is co-transcribed with the U69 small nucleolar RNA gene, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL39 Gene

RPL39 (Ribosomal Protein L39) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include RNA binding and structural constituent of ribosome. An important paralog of this gene is RPL39L.

Gene Wiki entry for RPL39 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL39 Gene

Genomics for RPL39 Gene

Regulatory Elements for RPL39 Gene

Promoters for RPL39 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL39 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL39 Gene

Chromosome:
X
Start:
119,786,504 bp from pter
End:
119,791,659 bp from pter
Size:
5,156 bases
Orientation:
Minus strand

Genomic View for RPL39 Gene

Genes around RPL39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL39 Gene

Proteins for RPL39 Gene

  • Protein details for RPL39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62891-RL39_HUMAN
    Recommended name:
    60S ribosomal protein L39
    Protein Accession:
    P62891
    Secondary Accessions:
    • P02404
    • P39025
    • Q9BYF2

    Protein attributes for RPL39 Gene

    Size:
    51 amino acids
    Molecular mass:
    6407 Da
    Quaternary structure:
    • Interacts with IMPACT.
    Miscellaneous:
    • This protein is the smallest and one of the most basic of the proteins in liver ribosomes.

    Three dimensional structures from OCA and Proteopedia for RPL39 Gene

neXtProt entry for RPL39 Gene

Proteomics data for RPL39 Gene at MOPED

Post-translational modifications for RPL39 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPL39 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RPL39 Gene

Domains & Families for RPL39 Gene

Gene Families for RPL39 Gene

Protein Domains for RPL39 Gene

Suggested Antigen Peptide Sequences for RPL39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62891

UniProtKB/Swiss-Prot:

RL39_HUMAN :
  • Belongs to the ribosomal protein L39e family.
Family:
  • Belongs to the ribosomal protein L39e family.
genes like me logo Genes that share domains with RPL39: view

Function for RPL39 Gene

genes like me logo Genes that share phenotypes with RPL39: view

miRNA for RPL39 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL39 Gene

Localization for RPL39 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL39 Gene COMPARTMENTS Subcellular localization image for RPL39 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RPL39 Gene

Pathways & Interactions for RPL39 Gene

genes like me logo Genes that share pathways with RPL39: view

Pathways by source for RPL39 Gene

1 BioSystems pathway for RPL39 Gene
1 KEGG pathway for RPL39 Gene
1 GeneGo (Thomson Reuters) pathway for RPL39 Gene

Interacting Proteins for RPL39 Gene

Gene Ontology (GO) - Biological Process for RPL39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,TAS 8764829
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL39: view

No data available for SIGNOR curated interactions for RPL39 Gene

Drugs & Compounds for RPL39 Gene

No Compound Related Data Available

Transcripts for RPL39 Gene

mRNA/cDNA for RPL39 Gene

Unigene Clusters for RPL39 Gene

Ribosomal protein L39:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL39 Gene

No ASD Table

Relevant External Links for RPL39 Gene

GeneLoc Exon Structure for
RPL39
ECgene alternative splicing isoforms for
RPL39

Expression for RPL39 Gene

mRNA expression in normal human tissues for RPL39 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for RPL39 Gene Hs.300141

genes like me logo Genes that share expression patterns with RPL39: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RPL39 Gene

Orthologs for RPL39 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL39 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPL39 35
  • 94.77 (n)
  • 100 (a)
RPL39 36
  • 100 (a)
ManyToMany
RPL39 36
  • 100 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia RPL39 35
  • 93.46 (n)
  • 100 (a)
-- 36
  • 100 (a)
ManyToMany
-- 36
  • 100 (a)
ManyToMany
-- 36
  • 100 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Rpl39 35
  • 89.54 (n)
  • 100 (a)
Rpl39 16
Rpl39 36
  • 100 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC100614664 35
  • 99.35 (n)
  • 98.04 (a)
RPL39 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl39 35
  • 90.85 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RPL39 35
  • 83.66 (n)
  • 98.04 (a)
RPL39 36
  • 98 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 96 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl39 35
  • 79.08 (n)
  • 98.04 (a)
zebrafish
(Danio rerio)
Actinopterygii rpl39 35
  • 81.7 (n)
  • 98.04 (a)
rpl39 36
  • 98 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta RpL39 36
  • 73 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rpl-39 36
  • 75 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL39 36
  • 63 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.8290 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5449 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6039 36
  • 84 (a)
OneToMany
Species with no ortholog for RPL39:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL39 Gene

ENSEMBL:
Gene Tree for RPL39 (if available)
TreeFam:
Gene Tree for RPL39 (if available)

Paralogs for RPL39 Gene

Paralogs for RPL39 Gene

(2) SIMAP similar genes for RPL39 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RPL39: view

Variants for RPL39 Gene

Sequence variations from dbSNP and Humsavar for RPL39 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs2496199 -- 119,790,798(+) GAACA(C/T)ACCCT intron-variant
rs2496204 -- 119,792,456(+) TTGAA(A/G)CGAGG upstream-variant-2KB
rs2496211 -- 119,793,322(+) caagt(A/G)atccg upstream-variant-2KB
rs2496215 -- 119,793,415(+) attag(A/G)gcttc upstream-variant-2KB
rs2240448 -- 119,791,742(-) GCCAC(A/G)GGAGC upstream-variant-2KB

Variation tolerance for RPL39 Gene

Residual Variation Intolerance Score: 58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL39 Gene

HapMap Linkage Disequilibrium report
RPL39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RPL39 Gene

Disorders for RPL39 Gene

Relevant External Links for RPL39

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL39

No disorders were found for RPL39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL39 Gene

Publications for RPL39 Gene

  1. Molecular cloning of a cDNA encoding human ribosomal protein L39. (PMID: 8764829) Otsuka S. … Itakura M. (Biochim. Biophys. Acta 1996) 2 3 4 23 67
  2. Primary structures and sequence analysis of human ribosomal proteins L39 and S27. (PMID: 8908372) Tsui S.K.W. … Lee C.Y. (Biochem. Mol. Biol. Int. 1996) 3 23
  3. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Knockdown of ribosomal protein L39 by RNA interference inhibits the growth of human pancreatic cancer cells in vitro and in vivo. (PMID: 24799381) Li C. … Zhu J. (Biotechnol J 2014) 3

Products for RPL39 Gene

Sources for RPL39 Gene

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