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Aliases for RPL35A Gene

Aliases for RPL35A Gene

  • Ribosomal Protein L35a 2 3 5
  • Cell Growth-Inhibiting Gene 33 Protein 3 4
  • DBA5 3
  • L35A 3

External Ids for RPL35A Gene

Previous GeneCards Identifiers for RPL35A Gene

  • GC03U990068
  • GC03P199076
  • GC03P199003
  • GC03P199165
  • GC03P197676
  • GC03P194979

Summaries for RPL35A Gene

Entrez Gene Summary for RPL35A Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L35AE family of ribosomal proteins. It is located in the cytoplasm. The rat protein has been shown to bind to both initiator and elongator tRNAs, and thus, it is located at the P site, or P and A sites, of the ribosome. Although this gene was originally mapped to chromosome 18, it has been established that it is located at 3q29-qter. Alternative splicing results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Oct 2015]

GeneCards Summary for RPL35A Gene

RPL35A (Ribosomal Protein L35a) is a Protein Coding gene. Diseases associated with RPL35A include Diamond-Blackfan Anemia 5 and Diamond-Blackfan Anemia. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and tRNA binding.

UniProtKB/Swiss-Prot for RPL35A Gene

  • Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site.

Gene Wiki entry for RPL35A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL35A Gene

Genomics for RPL35A Gene

Regulatory Elements for RPL35A Gene

Enhancers for RPL35A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPL35A on UCSC Golden Path with GeneCards custom track

Promoters for RPL35A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL35A on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL35A Gene

Chromosome:
3
Start:
197,949,987 bp from pter
End:
197,956,610 bp from pter
Size:
6,624 bases
Orientation:
Plus strand

Genomic View for RPL35A Gene

Genes around RPL35A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL35A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL35A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL35A Gene

Proteins for RPL35A Gene

  • Protein details for RPL35A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18077-RL35A_HUMAN
    Recommended name:
    60S ribosomal protein L35a
    Protein Accession:
    P18077
    Secondary Accessions:
    • Q08ES9
    • Q9BVN7

    Protein attributes for RPL35A Gene

    Size:
    110 amino acids
    Molecular mass:
    12538 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Knockdown of RPL35A in hematopoietic cell lines results in decreased cell proliferation, increased apoptosis, decreased biogenesis of mature 60S ribosomal subunit, and abnormal processing of large ribosomal subunit rRNA.

    Three dimensional structures from OCA and Proteopedia for RPL35A Gene

neXtProt entry for RPL35A Gene

Proteomics data for RPL35A Gene at MOPED

Post-translational modifications for RPL35A Gene

  • Ubiquitination at Lys 8, Lys 45, and Lys 95
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL35A Gene

No data available for DME Specific Peptides for RPL35A Gene

Domains & Families for RPL35A Gene

Gene Families for RPL35A Gene

Protein Domains for RPL35A Gene

Suggested Antigen Peptide Sequences for RPL35A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18077

UniProtKB/Swiss-Prot:

RL35A_HUMAN :
  • Belongs to the ribosomal protein L35Ae family.
Family:
  • Belongs to the ribosomal protein L35Ae family.
genes like me logo Genes that share domains with RPL35A: view

Function for RPL35A Gene

Molecular function for RPL35A Gene

GENATLAS Biochemistry:
60S ribosomal protein L35A,12kDa
UniProtKB/Swiss-Prot Function:
Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site.

Gene Ontology (GO) - Molecular Function for RPL35A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24965446
genes like me logo Genes that share ontologies with RPL35A: view
genes like me logo Genes that share phenotypes with RPL35A: view

Human Phenotype Ontology for RPL35A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL35A Gene

Localization for RPL35A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL35A Gene COMPARTMENTS Subcellular localization image for RPL35A gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 3

Gene Ontology (GO) - Cellular Components for RPL35A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL35A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL35A Gene

Pathways & Interactions for RPL35A Gene

genes like me logo Genes that share pathways with RPL35A: view

Pathways by source for RPL35A Gene

1 KEGG pathway for RPL35A Gene
1 GeneGo (Thomson Reuters) pathway for RPL35A Gene

Gene Ontology (GO) - Biological Process for RPL35A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing IMP,TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL35A: view

No data available for SIGNOR curated interactions for RPL35A Gene

Drugs & Compounds for RPL35A Gene

No Compound Related Data Available

Transcripts for RPL35A Gene

Unigene Clusters for RPL35A Gene

Ribosomal protein L35a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL35A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2:
SP3: -

Relevant External Links for RPL35A Gene

GeneLoc Exon Structure for
RPL35A
ECgene alternative splicing isoforms for
RPL35A

Expression for RPL35A Gene

mRNA expression in normal human tissues for RPL35A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL35A Gene

This gene is overexpressed in Nasal epithelium (14.9), Pancreas (7.2), and Lung (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL35A Gene



SOURCE GeneReport for Unigene cluster for RPL35A Gene Hs.529631

genes like me logo Genes that share expression patterns with RPL35A: view

Protein tissue co-expression partners for RPL35A Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL35A Gene

Orthologs for RPL35A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL35A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPL35A 35
  • 91.21 (n)
  • 99.09 (a)
-- 36
  • 95 (a)
OneToMany
RPL35A 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPL35A 35
  • 91.52 (n)
  • 100 (a)
RPL35A 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl35a 35
  • 90.91 (n)
  • 99.09 (a)
Rpl35a 16
Rpl35a 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPL35A 35
  • 99.7 (n)
  • 100 (a)
RPL35A 36
  • 100 (a)
OneToMany
RPL35A 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rpl35a 35
  • 92.12 (n)
  • 99.09 (a)
oppossum
(Monodelphis domestica)
Mammalia RPL35A 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL35A 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL35A 35
  • 81.82 (n)
  • 96.36 (a)
RPL35A 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL35A 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl35a 35
  • 81.82 (n)
  • 98.18 (a)
zebrafish
(Danio rerio)
Actinopterygii rpl35a 35
  • 75.45 (n)
  • 90 (a)
rpl35a 36
  • 90 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2099 37
  • 61 (a)
RpL35A 35
  • 61.73 (n)
  • 62.96 (a)
RpL35A 36
  • 43 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002754 35
  • 62.35 (n)
  • 65.74 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-33 37
  • 59 (a)
rpl-33 35
  • 59.94 (n)
  • 59.63 (a)
rpl-33 36
  • 52 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR120C 35
  • 51.92 (n)
  • 51.92 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D07405g 35
  • 52.24 (n)
  • 50.96 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL33B 35
  • 53.53 (n)
  • 53.85 (a)
RPL33A 36
  • 51 (a)
OneToMany
RPL33B 36
  • 52 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G74270 35
  • 57 (n)
  • 58 (a)
rice
(Oryza sativa)
Liliopsida Os02g0785800 35
  • 55.88 (n)
  • 57.84 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09109 35
  • 52.29 (n)
  • 51.96 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl35b 35
  • 52.29 (n)
  • 50.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 77 (a)
OneToOne
Species with no ortholog for RPL35A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL35A Gene

ENSEMBL:
Gene Tree for RPL35A (if available)
TreeFam:
Gene Tree for RPL35A (if available)

Paralogs for RPL35A Gene

genes like me logo Genes that share paralogs with RPL35A: view

No data available for Paralogs for RPL35A Gene

Variants for RPL35A Gene

Sequence variations from dbSNP and Humsavar for RPL35A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_055447 Diamond-Blackfan anemia 5 (DBA5)

Structural Variations from Database of Genomic Variants (DGV) for RPL35A Gene

Variant ID Type Subtype PubMed ID
esv2751989 CNV Gain 17911159
nsv527527 CNV Gain 19592680
dgv5379n71 CNV Gain 21882294
nsv483023 CNV Gain 15286789
nsv878215 CNV Loss 21882294
nsv878216 CNV Gain 21882294

Variation tolerance for RPL35A Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL35A Gene

Human Gene Mutation Database (HGMD)
RPL35A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL35A Gene

Disorders for RPL35A Gene

MalaCards: The human disease database

(6) MalaCards diseases for RPL35A Gene - From: OMIM, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia 5
  • dba5
diamond-blackfan anemia
  • blackfan - diamond syndrome
rpl35a-related diamond-blackfan anemia
  • diamond-blackfan anemia 5
macrocytic anemia
  • anemia macrocytic
pierre robin syndrome
  • pierre robin sequence
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

RL35A_HUMAN
  • Diamond-Blackfan anemia 5 (DBA5) [MIM:612528]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:18535205}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RPL35A

Genetic Association Database (GAD)
RPL35A
Human Genome Epidemiology (HuGE) Navigator
RPL35A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL35A
genes like me logo Genes that share disorders with RPL35A: view

No data available for Genatlas for RPL35A Gene

Publications for RPL35A Gene

  1. The human L35a ribosomal protein (RPL35A) gene is located at chromosome band 3q29-qter. (PMID: 8786106) Colombo P. … Fried M. (Genomics 1996) 2 3 4 23 67
  2. Inhibition of cell death by ribosomal protein L35a. (PMID: 12175552) Lopez C.D. … Naumovski L. (Cancer Lett. 2002) 3 23
  3. The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. (PMID: 1577483) Feo S. … Fried M. (Genomics 1992) 2 3
  4. cDNA encoding the human homologue of rat ribosomal protein L35a. (PMID: 2388839) Herzog H. … Schweiger M. (Nucleic Acids Res. 1990) 3 23
  5. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3

Products for RPL35A Gene

Sources for RPL35A Gene

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