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Aliases for RPL32 Gene

Aliases for RPL32 Gene

  • Ribosomal Protein L32 2 3 5
  • PP9932 3
  • L32 3

External Ids for RPL32 Gene

Previous GeneCards Identifiers for RPL32 Gene

  • GC03M012806
  • GC03M012869
  • GC03M012852
  • GC03M012853
  • GC03M012810
  • GC03M012876
  • GC03M012877

Summaries for RPL32 Gene

Entrez Gene Summary for RPL32 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L32E family of ribosomal proteins. It is located in the cytoplasm. Although some studies have mapped this gene to 3q13.3-q21, it is believed to map to 3p25-p24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL32 Gene

RPL32 (Ribosomal Protein L32) is a Protein Coding gene. Diseases associated with RPL32 include malignant melanoma, somatic. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL32 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL32 Gene

Genomics for RPL32 Gene

Regulatory Elements for RPL32 Gene

Promoters for RPL32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL32 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the RPL32 gene promoter:

Genomic Location for RPL32 Gene

Chromosome:
3
Start:
12,834,485 bp from pter
End:
12,841,588 bp from pter
Size:
7,104 bases
Orientation:
Minus strand

Genomic View for RPL32 Gene

Genes around RPL32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL32 Gene

Proteins for RPL32 Gene

  • Protein details for RPL32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62910-RL32_HUMAN
    Recommended name:
    60S ribosomal protein L32
    Protein Accession:
    P62910
    Secondary Accessions:
    • B2R4Q3
    • P02433

    Protein attributes for RPL32 Gene

    Size:
    135 amino acids
    Molecular mass:
    15860 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL32 Gene

neXtProt entry for RPL32 Gene

Proteomics data for RPL32 Gene at MOPED

Post-translational modifications for RPL32 Gene

  • Ubiquitination at Lys 50
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RPL32 Gene

Domains & Families for RPL32 Gene

Gene Families for RPL32 Gene

Protein Domains for RPL32 Gene

Suggested Antigen Peptide Sequences for RPL32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62910

UniProtKB/Swiss-Prot:

RL32_HUMAN :
  • Belongs to the ribosomal protein L32e family.
Family:
  • Belongs to the ribosomal protein L32e family.
genes like me logo Genes that share domains with RPL32: view

Function for RPL32 Gene

Molecular function for RPL32 Gene

GENATLAS Biochemistry:
60S ribosomal protein L32,15kDa

Gene Ontology (GO) - Molecular Function for RPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
genes like me logo Genes that share ontologies with RPL32: view
genes like me logo Genes that share phenotypes with RPL32: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL32 Gene

Localization for RPL32 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL32 Gene COMPARTMENTS Subcellular localization image for RPL32 gene
Compartment Confidence
cytosol 5
chloroplast 3
cytoskeleton 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for RPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005840 ribosome IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL32: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL32 Gene

Pathways & Interactions for RPL32 Gene

genes like me logo Genes that share pathways with RPL32: view

Pathways by source for RPL32 Gene

1 BioSystems pathway for RPL32 Gene
1 KEGG pathway for RPL32 Gene
1 GeneGo (Thomson Reuters) pathway for RPL32 Gene

Gene Ontology (GO) - Biological Process for RPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with RPL32: view

No data available for SIGNOR curated interactions for RPL32 Gene

Drugs & Compounds for RPL32 Gene

(1) Additional Compounds for RPL32 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPL32: view

Transcripts for RPL32 Gene

Unigene Clusters for RPL32 Gene

Ribosomal protein L32:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL32 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for RPL32 Gene

GeneLoc Exon Structure for
RPL32
ECgene alternative splicing isoforms for
RPL32

Expression for RPL32 Gene

mRNA expression in normal human tissues for RPL32 Gene

Protein differential expression in normal tissues from HIPED for RPL32 Gene

This gene is overexpressed in Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL32 Gene



SOURCE GeneReport for Unigene cluster for RPL32 Gene Hs.265174

genes like me logo Genes that share expression patterns with RPL32: view

Protein tissue co-expression partners for RPL32 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL32 Gene

Orthologs for RPL32 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL32 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPL32 35
  • 92.1 (n)
  • 99.26 (a)
RPL32 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL32 35
  • 94.07 (n)
  • 100 (a)
-- 36
  • 97 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm6251 35
  • 88.47 (n)
  • 95.49 (a)
Rpl32l 16
Gm21893 36
  • 45 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC450727 35
  • 100 (n)
  • 100 (a)
RPL32 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC680959 35
  • 87.16 (n)
  • 91.11 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia RPL32 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL32 35
  • 83.7 (n)
  • 94.81 (a)
RPL32 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL32 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl32 35
  • 79.75 (n)
  • 93.33 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26095 35
zebrafish
(Danio rerio)
Actinopterygii rpl32 35
  • 80 (n)
  • 91.85 (a)
rpl32 36
  • 92 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RpL32 37
  • 77 (a)
RpL32 35
  • 69.92 (n)
  • 76.69 (a)
RpL32 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002122 35
  • 69.42 (n)
  • 79.7 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-32 37
  • 60 (a)
rpl-32 35
  • 59.9 (n)
  • 59.37 (a)
rpl-32 36
  • 57 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL281C 35
  • 62.56 (n)
  • 63.85 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06843g 35
  • 60.7 (n)
  • 62.6 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL32 35
  • 59.69 (n)
  • 61.24 (a)
RPL32 36
  • 62 (a)
OneToOne
RPL32 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G18100 35
  • 64.62 (n)
  • 66.92 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8117 35
rice
(Oryza sativa)
Liliopsida Os.12339 35
Os08g0524600 35
  • 67.44 (n)
  • 68.46 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl3202 35
  • 59.56 (n)
  • 59.02 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToOne
Species with no ortholog for RPL32:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL32 Gene

ENSEMBL:
Gene Tree for RPL32 (if available)
TreeFam:
Gene Tree for RPL32 (if available)

Paralogs for RPL32 Gene

genes like me logo Genes that share paralogs with RPL32: view

No data available for Paralogs for RPL32 Gene

Variants for RPL32 Gene

Sequence variations from dbSNP and Humsavar for RPL32 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs6497 -- 12,836,205(-) GAGAT(A/C/G/T)GCTCA reference, synonymous-codon
rs748199 -- 12,835,406(-) TTGGA(A/G)ACGGG utr-variant-3-prime
rs1064728 -- 12,836,117(-) CCAGG(C/G/T)TGCGC reference, synonymous-codon, missense
rs2290312 -- 12,839,319(-) TTCAG(G/T)GATCA intron-variant
rs2290314 -- 12,836,078(-) TGCAC(A/G)TTTTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPL32 Gene

Variant ID Type Subtype PubMed ID
dgv810e201 CNV Deletion 23290073
dgv850e199 CNV Deletion 23128226
nsv7351 OTHER Inversion 18451855
esv2751977 CNV Gain 17911159
nsv460435 CNV Loss 19166990
nsv821995 CNV Gain 20364138

Variation tolerance for RPL32 Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL32 Gene

HapMap Linkage Disequilibrium report
RPL32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL32 Gene

Disorders for RPL32 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL32 Gene - From: DISEASES

Disorder Aliases PubMed IDs
malignant melanoma, somatic
  • familial melanoma
- elite association - COSMIC cancer census association via MalaCards
Search RPL32 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPL32

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL32
genes like me logo Genes that share disorders with RPL32: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL32 Gene

Publications for RPL32 Gene

  1. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Assignment of the L32 ribosomal protein gene (RPL32) to human chromosome 3q13.3-->q21 by in situ hybridization. (PMID: 9284913) Vorobieva N.V. … Graphodatsky A.S. (Cytogenet. Cell Genet. 1997) 2 3
  3. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for RPL32 Gene

Sources for RPL32 Gene

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