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Aliases for RPL29 Gene

Aliases for RPL29 Gene

  • Ribosomal Protein L29 2 3 5
  • Cell Surface Heparin-Binding Protein HIP 2 3 4
  • Heparin/Heparan Sulfate-Interacting Protein 2 3
  • Heparin/Heparan Sulfate-Binding Protein 2 3
  • HP/HS-Interacting Protein 2 3
  • Ribosomal Protein L29 Pseudogene 10 2
  • Ribosomal Protein YL43 Homologue 3
  • 60S Ribosomal Protein L29 2
  • RPL29_3_370 3
  • HUMRPL29 3
  • RPL29P10 3
  • HIP 3
  • L29 3

External Ids for RPL29 Gene

Previous HGNC Symbols for RPL29 Gene

  • RPL29P10

Previous GeneCards Identifiers for RPL29 Gene

  • GC03M051120
  • GC03M051280
  • GC03M051879
  • GC03M051986
  • GC03M052002
  • GC03M052028

Summaries for RPL29 Gene

Entrez Gene Summary for RPL29 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29E family of ribosomal proteins. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin. Although this gene was previously reported to map to 3q29-qter, it is believed that it is located at 3p21.3-p21.2. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL29 Gene

RPL29 (Ribosomal Protein L29) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL29 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL29 Gene

Genomics for RPL29 Gene

Regulatory Elements for RPL29 Gene

Enhancers for RPL29 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPL29 on UCSC Golden Path with GeneCards custom track

Promoters for RPL29 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL29 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL29 Gene

51,993,600 bp from pter
51,995,942 bp from pter
2,343 bases
Minus strand

Genomic View for RPL29 Gene

Genes around RPL29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL29 Gene

Proteins for RPL29 Gene

  • Protein details for RPL29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L29
    Protein Accession:
    Secondary Accessions:
    • A8K0H3
    • B2R4M8
    • Q6IPY3

    Protein attributes for RPL29 Gene

    159 amino acids
    Molecular mass:
    17752 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL29 Gene

neXtProt entry for RPL29 Gene

Proteomics data for RPL29 Gene at MOPED

Post-translational modifications for RPL29 Gene

  • Ubiquitination at Lys 38, Lys 56, Lys 63, and Lys 73
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL29 Gene

Domains & Families for RPL29 Gene

Gene Families for RPL29 Gene

Protein Domains for RPL29 Gene


Suggested Antigen Peptide Sequences for RPL29 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L29e family.
  • Belongs to the ribosomal protein L29e family.
genes like me logo Genes that share domains with RPL29: view

Function for RPL29 Gene

Molecular function for RPL29 Gene

GENATLAS Biochemistry:
60S ribosomal protein L29,identical to a cell surface heparin/heparan (HP/HS) binding protein

Gene Ontology (GO) - Molecular Function for RPL29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with RPL29: view

Phenotypes for RPL29 Gene

genes like me logo Genes that share phenotypes with RPL29: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL29 Gene

Localization for RPL29 Gene

Subcellular locations from

Jensen Localization Image for RPL29 Gene COMPARTMENTS Subcellular localization image for RPL29 gene
Compartment Confidence
cytosol 5
nucleus 3

Gene Ontology (GO) - Cellular Components for RPL29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL29: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL29 Gene

Pathways & Interactions for RPL29 Gene

genes like me logo Genes that share pathways with RPL29: view

Pathways by source for RPL29 Gene

1 KEGG pathway for RPL29 Gene
1 GeneGo (Thomson Reuters) pathway for RPL29 Gene

Gene Ontology (GO) - Biological Process for RPL29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL29: view

No data available for SIGNOR curated interactions for RPL29 Gene

Drugs & Compounds for RPL29 Gene

(2) Drugs for RPL29 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 761,246

(5) Additional Compounds for RPL29 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPL29: view

Transcripts for RPL29 Gene

Unigene Clusters for RPL29 Gene

Ribosomal protein L29:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL29 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4
SP2: - -

Relevant External Links for RPL29 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL29 Gene

mRNA expression in normal human tissues for RPL29 Gene

Protein differential expression in normal tissues from HIPED for RPL29 Gene

This gene is overexpressed in Stomach (9.9) and Tlymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RPL29 Gene

SOURCE GeneReport for Unigene cluster for RPL29 Gene Hs.425125

genes like me logo Genes that share expression patterns with RPL29: view

Protein tissue co-expression partners for RPL29 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL29 Gene

Orthologs for RPL29 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL29 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPL29 35
  • 91.34 (n)
  • 93.7 (a)
RPL29 36
  • 84 (a)
(Canis familiaris)
Mammalia RPL29 35
  • 92.78 (n)
  • 97.5 (a)
-- 36
  • 46 (a)
-- 36
  • 45 (a)
-- 36
  • 64 (a)
-- 36
  • 78 (a)
(Pan troglodytes)
Mammalia RPL29 35
  • 99.57 (n)
  • 99.35 (a)
RPL29 36
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 48 (a)
-- 36
  • 59 (a)
(Mus musculus)
Mammalia Gm4889 36
  • 81 (a)
(Gallus gallus)
Aves RPL29 35
  • 87.3 (n)
  • 98.41 (a)
RPL29 36
  • 89 (a)
(Anolis carolinensis)
Reptilia RPL29 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl29 35
  • 84.66 (n)
  • 96.83 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8224 35
(Danio rerio)
Actinopterygii RPL29 36
  • 86 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL29 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea rpl-29 36
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL29 36
  • 66 (a)
(Oryza sativa)
Liliopsida Os.1082 35
(Triticum aestivum)
Liliopsida Ta.12895 35
(Zea mays)
Liliopsida Zm.6182 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4934 36
  • 71 (a)
Species with no ortholog for RPL29:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL29 Gene

Gene Tree for RPL29 (if available)
Gene Tree for RPL29 (if available)

Paralogs for RPL29 Gene

genes like me logo Genes that share paralogs with RPL29: view

No data available for Paralogs for RPL29 Gene

Variants for RPL29 Gene

Sequence variations from dbSNP and Humsavar for RPL29 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1062406 -- 51,993,754(-) CTTCA(A/G)AGTAG reference, missense
rs1062408 -- 51,993,744(-) GATAT(C/T)TCTGC utr-variant-3-prime
rs1062409 -- 51,993,742(-) TATCT(C/T)TGCCA utr-variant-3-prime
rs1065689 -- 51,993,956(-) AGCCG(C/T)AAGCT reference, synonymous-codon
rs1065748 -- 51,993,923(-) CACCC(C/T)AAGCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RPL29 Gene

Variant ID Type Subtype PubMed ID
nsv520211 CNV Gain 19592680
nsv508922 CNV Insertion 20534489
nsv876780 CNV Loss 21882294
nsv519445 CNV Gain+Loss 19592680

Variation tolerance for RPL29 Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.41; 81.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RPL29 Gene

Disorders for RPL29 Gene

Relevant External Links for RPL29

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL29 Gene

Publications for RPL29 Gene

  1. A novel cDNA encoding a human homologue of ribosomal protein L29. (PMID: 8597591) Law P.T. … Waye M.M.Y. (Biochim. Biophys. Acta 1996) 2 3 4 23 67
  2. Repression of HIP/RPL29 expression induces differentiation in colon cancer cells. (PMID: 16475173) Liu J.J. … Hooi S.C. (J. Cell. Physiol. 2006) 3 23
  3. Analysis of eluted peptides from type 1 diabetes-susceptible HLA class II molecules identified novel islet protein, heparin/heparan sulfate-interacting protein. (PMID: 15721314) Nakanishi K. … Matsushita H. (Biochem. Biophys. Res. Commun. 2005) 3 23
  4. Heparin/heparan sulfate interacting protein expression and functions in human breast cancer cells and normal breast epithelia. (PMID: 9371517) Jacobs A.L. … Carson D.D. (Cancer Res. 1997) 3 23
  5. Mapping of the human ribosomal large subunit protein gene RPL29 to human chromosome 3q29-qter. (PMID: 9403071) Garcia-Barcelo M. … Waye M.M. (Genomics 1997) 3 23

Products for RPL29 Gene

Sources for RPL29 Gene