Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPL28 Gene

Aliases for RPL28 Gene

  • Ribosomal Protein L28 2 3
  • 60S Ribosomal Protein L28 2 3
  • L28 3

External Ids for RPL28 Gene

Previous GeneCards Identifiers for RPL28 Gene

  • GC19P056761
  • GC19P056320
  • GC19P060571
  • GC19P060589
  • GC19P055897
  • GC19P052219

Summaries for RPL28 Gene

Entrez Gene Summary for RPL28 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

GeneCards Summary for RPL28 Gene

RPL28 (Ribosomal Protein L28) is a Protein Coding gene. Diseases associated with RPL28 include albinism-deafness syndrome and esophagus squamous cell carcinoma. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL28 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL28 Gene

Genomics for RPL28 Gene

Regulatory Elements for RPL28 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPL28 Gene

55,385,345 bp from pter
55,403,250 bp from pter
17,906 bases
Plus strand

Genomic View for RPL28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL28 Gene

Proteins for RPL28 Gene

  • Protein details for RPL28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L28
    Protein Accession:
    Secondary Accessions:
    • B2R4A6
    • B4DEP9
    • C9JB50
    • E9PB24
    • G5E9L2
    • Q6IAY0
    • Q96FX1
    • Q9BWQ0

    Protein attributes for RPL28 Gene

    137 amino acids
    Molecular mass:
    15748 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL28 Gene

    Alternative splice isoforms for RPL28 Gene


neXtProt entry for RPL28 Gene

Proteomics data for RPL28 Gene at MOPED

Post-translational modifications for RPL28 Gene

  • Ubiquitination at Lys19, Lys22, Lys33, Lys47, Lys58, Lys65, Lys72, and Lys101
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RPL28 Gene

Domains for RPL28 Gene

Gene Families for RPL28 Gene

Protein Domains for RPL28 Gene

Suggested Antigen Peptide Sequences for RPL28 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L28e family.
  • Belongs to the ribosomal protein L28e family.
genes like me logo Genes that share domains with RPL28: view

Function for RPL28 Gene

Molecular function for RPL28 Gene

GENATLAS Biochemistry:
60S ribosomal protein L28,15kDa

Gene Ontology (GO) - Molecular Function for RPL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 7772601
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 20434207
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL28: view

Phenotypes for RPL28 Gene

GenomeRNAi human phenotypes for RPL28:
genes like me logo Genes that share phenotypes with RPL28: view

miRNA for RPL28 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL28

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL28 Gene

Localization for RPL28 Gene

Subcellular locations from

Jensen Localization Image for RPL28 Gene COMPARTMENTS Subcellular localization image for RPL28 gene
Compartment Confidence
cytosol 5
mitochondrion 3
peroxisome 2
chloroplast 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RPL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
GO:0016020 membrane IDA 19946888
GO:0022625 cytosolic large ribosomal subunit IDA 12962325
genes like me logo Genes that share ontologies with RPL28: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL28 Gene

Pathways for RPL28 Gene

genes like me logo Genes that share pathways with RPL28: view

Pathways by source for RPL28 Gene

1 KEGG pathway for RPL28 Gene

Gene Ontology (GO) - Biological Process for RPL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL28: view

Transcripts for RPL28 Gene

Unigene Clusters for RPL28 Gene

Ribosomal protein L28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL28 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - -
SP2: - - - - - -
SP3: - - -
SP5: - - -

Relevant External Links for RPL28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL28 Gene

mRNA expression in normal human tissues for RPL28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RPL28 Gene

This gene is overexpressed in Nasal epithelium (14.8) and Tlymphocyte (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for RPL28 Gene

SOURCE GeneReport for Unigene cluster for RPL28 Gene Hs.652114

genes like me logo Genes that share expressions with RPL28: view

Expression partners for RPL28 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL28 Gene

Orthologs for RPL28 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL28 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPL28 35
  • 90.27 (n)
  • 97.81 (a)
RPL28 36
  • 81 (a)
(Canis familiaris)
Mammalia RPL28 35
  • 90.02 (n)
  • 98.54 (a)
RPL28 36
  • 81 (a)
(Mus musculus)
Mammalia Rpl28 35
  • 89.29 (n)
  • 98.54 (a)
Rpl28 16
Rpl28 36
  • 81 (a)
Rpl28-ps4 36
  • 66 (a)
(Rattus norvegicus)
Mammalia Rpl28 35
  • 89.05 (n)
  • 98.54 (a)
(Monodelphis domestica)
Mammalia RPL28 36
  • 76 (a)
(Pan troglodytes)
Mammalia RPL28 36
  • 99 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
-- 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl28 35
  • 70.07 (n)
  • 79.56 (a)
Str.5096 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.17523 35
(Danio rerio)
Actinopterygii rpl28 35
  • 76.96 (n)
  • 80.15 (a)
zgc66289 35
rpl28 36
  • 67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8348 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005427 35
  • 56.35 (n)
  • 48.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL28 35
  • 56.49 (n)
  • 46.56 (a)
RpL28 36
  • 33 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06210 35
  • 51.79 (n)
  • 44.63 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl44 35
  • 43.44 (n)
  • 39.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4607 36
  • 53 (a)
Species with no ortholog for RPL28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPL28 Gene

Gene Tree for RPL28 (if available)
Gene Tree for RPL28 (if available)

Paralogs for RPL28 Gene

genes like me logo Genes that share paralogs with RPL28: view

No data available for Paralogs for RPL28 Gene

Variants for RPL28 Gene

Sequence variations from dbSNP and Humsavar for RPL28 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs531956633 -- 55,396,472(+) AGGAA(A/C)GTTCT intron-variant
rs531818902 -- 55,397,957(+) TTGGG(A/C)GGCCG intron-variant
rs531353413 -- 55,391,967(+) TGTGA(A/G)TATCA utr-variant-3-prime, intron-variant
rs531342632 -- 55,399,724(+) AAGGG(A/G)TTGAG intron-variant
rs530937697 -- 55,393,161(+) TGCTG(C/T)CCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPL28 Gene

Variant ID Type Subtype PubMed ID
dgv4016n71 CNV Loss 21882294
nsv912457 CNV Loss 21882294
nsv912460 CNV Loss 21882294
nsv912461 CNV Loss 21882294
nsv470162 CNV Loss 18288195
dgv4017n71 CNV Loss 21882294
nsv912463 CNV Loss 21882294
nsv516199 CNV Loss 19592680
dgv4020n71 CNV Loss 21882294
nsv912473 CNV Loss 21882294

Relevant External Links for RPL28 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL28 Gene

Disorders for RPL28 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RPL28 Gene in MalaCards »

(2) Diseases for RPL28 Gene

(1) University of Copenhagen DISEASES for RPL28 Gene

Relevant External Links for RPL28

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RPL28: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for RPL28 Gene

Publications for RPL28 Gene

  1. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio J.-M. … Iovanna J.L. (Biochim. Biophys. Acta 1995) 2 3 4
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova T.I. … Karpova G.G. (J. Protein Chem. 2003) 3 4

Products for RPL28 Gene

Sources for RPL28 Gene

Back to Top