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Aliases for RPL28 Gene

Aliases for RPL28 Gene

  • Ribosomal Protein L28 2 3 5
  • Large Ribosomal Subunit Protein EL28 3 4
  • 60S Ribosomal Protein L28 2 3
  • L28 3

External Ids for RPL28 Gene

Previous GeneCards Identifiers for RPL28 Gene

  • GC19P056761
  • GC19P056320
  • GC19P060571
  • GC19P060589
  • GC19P055897
  • GC19P052219

Summaries for RPL28 Gene

Entrez Gene Summary for RPL28 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

GeneCards Summary for RPL28 Gene

RPL28 (Ribosomal Protein L28) is a Protein Coding gene. Diseases associated with RPL28 include Albinism-Deafness Syndrome. Among its related pathways are Viral mRNA Translation and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL28 Gene

  • Component of the large ribosomal subunit.

Gene Wiki entry for RPL28 Gene

Additional gene information for RPL28 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL28 Gene

Genomics for RPL28 Gene

Regulatory Elements for RPL28 Gene

Enhancers for RPL28 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H055382 1.4 ENCODE dbSUPER 32.8 +1.8 1763 8 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 PAF1 SP3 RPL28 ZNF628 ENSG00000267689 RFPL4AP1 RPL13P13 LENG8-AS1 ZNF581 U2AF2 COX6B2 ENSG00000269275
GH19H055405 1.4 FANTOM5 ENCODE 22.5 +22.3 22325 3 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 ZNF416 U2AF2 LENG8 ZNF628 LENG8-AS1 RPL28 ENSG00000267523 EDDM13 ZNF581 ENSG00000235681 ENSG00000267838
GH19H055337 1.8 FANTOM5 ENCODE dbSUPER 11.5 -45.3 -45274 4 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 LENG8-AS1 U2AF2 LENG8 ENSG00000235681 ZNF628 FAM71E2 SSC5D KMT5C PPP6R1 LOC729999
GH19H055246 1.7 Ensembl ENCODE dbSUPER 11.2 -131.2 -131243 14 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D ZNF610 LENG8 LENG8-AS1 U2AF2 ZNF628 ENSG00000235681 ZNF581 BRSK1 HSPBP1 FIZ1 TMEM86B
GH19H055111 1.8 FANTOM5 ENCODE dbSUPER 9.5 -269.7 -269719 8 HDGF ARNT ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 YY1 ZNF766 EPS8L1 RDH13 U2AF2 LENG8-AS1 LENG8 ENSG00000235681 CNOT3 ENSG00000267523 ZNF580 KMT5C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL28 on UCSC Golden Path with GeneCards custom track

Promoters for RPL28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111647 999 1801 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF207 SP3 SP5 NFYC
ENSR00000289207 -1201 1001 TBP RB1 SREBF2 SIN3A ZBTB40 BRCA1 RAD21 ZNF143 RUNX3 SMARCA5

Genomic Location for RPL28 Gene

Chromosome:
19
Start:
55,385,101 bp from pter
End:
55,403,250 bp from pter
Size:
18,150 bases
Orientation:
Plus strand

Genomic View for RPL28 Gene

Genes around RPL28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL28 Gene

Proteins for RPL28 Gene

  • Protein details for RPL28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46779-RL28_HUMAN
    Recommended name:
    60S ribosomal protein L28
    Protein Accession:
    P46779
    Secondary Accessions:
    • B2R4A6
    • B4DEP9
    • C9JB50
    • E9PB24
    • G5E9L2
    • Q6IAY0
    • Q96FX1
    • Q9BWQ0

    Protein attributes for RPL28 Gene

    Size:
    137 amino acids
    Molecular mass:
    15748 Da
    Quaternary structure:
    • Component of the large ribosomal subunit.

    Three dimensional structures from OCA and Proteopedia for RPL28 Gene

    Alternative splice isoforms for RPL28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPL28 Gene

Post-translational modifications for RPL28 Gene

  • Ubiquitination at Lys19, Lys22, isoforms=2, 3, 4, 533, Lys47, Lys58, Lys65, Lys72, and Lys101
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL28 Gene

Domains & Families for RPL28 Gene

Gene Families for RPL28 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for RPL28 Gene

Suggested Antigen Peptide Sequences for RPL28 Gene

Graphical View of Domain Structure for InterPro Entry

P46779

UniProtKB/Swiss-Prot:

RL28_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eL28 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eL28 family.
genes like me logo Genes that share domains with RPL28: view

Function for RPL28 Gene

Molecular function for RPL28 Gene

GENATLAS Biochemistry:
60S ribosomal protein L28,15kDa
UniProtKB/Swiss-Prot Function:
Component of the large ribosomal subunit.

Phenotypes From GWAS Catalog for RPL28 Gene

Gene Ontology (GO) - Molecular Function for RPL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,TAS 22658674
GO:0003735 structural constituent of ribosome NAS,IEA 12962325
GO:0005515 protein binding IPI 20434207
genes like me logo Genes that share ontologies with RPL28: view
genes like me logo Genes that share phenotypes with RPL28: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL28 Gene

Localization for RPL28 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL28 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 3
peroxisome 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RPL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0016020 membrane IDA 19946888
GO:0022625 cytosolic large ribosomal subunit IDA,TAS 12962325
genes like me logo Genes that share ontologies with RPL28: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL28 Gene

Pathways & Interactions for RPL28 Gene

genes like me logo Genes that share pathways with RPL28: view

Pathways by source for RPL28 Gene

Gene Ontology (GO) - Biological Process for RPL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL28: view

No data available for SIGNOR curated interactions for RPL28 Gene

Drugs & Compounds for RPL28 Gene

No Compound Related Data Available

Transcripts for RPL28 Gene

Unigene Clusters for RPL28 Gene

Ribosomal protein L28:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL28 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - -
SP2: - - - - - -
SP3: - - -
SP4:
SP5: - - -
SP6:
SP7:

Relevant External Links for RPL28 Gene

GeneLoc Exon Structure for
RPL28
ECgene alternative splicing isoforms for
RPL28

Expression for RPL28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL28 Gene

This gene is overexpressed in Nasal epithelium (14.8) and Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RPL28 Gene



Protein tissue co-expression partners for RPL28 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL28 Gene:

RPL28

SOURCE GeneReport for Unigene cluster for RPL28 Gene:

Hs.652114

Evidence on tissue expression from TISSUES for RPL28 Gene

  • Nervous system(5)
  • Intestine(4.9)
  • Kidney(4.5)
  • Pancreas(4.4)
  • Skin(4.4)
  • Lung(4.3)
  • Eye(3.9)
  • Blood(3.8)
  • Liver(3.6)
  • Muscle(3.3)
  • Stomach(3)
  • Heart(2.7)
  • Lymph node(2.7)
  • Spleen(2.7)
  • Bone marrow(2.6)
  • Adrenal gland(2.4)
  • Gall bladder(2.4)
  • Thyroid gland(2.4)
  • Bone(2.2)
genes like me logo Genes that share expression patterns with RPL28: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL28 Gene

Orthologs for RPL28 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RPL28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL28 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPL28 33 34
  • 90.27 (n)
dog
(Canis familiaris)
Mammalia RPL28 33 34
  • 90.02 (n)
mouse
(Mus musculus)
Mammalia Rpl28 33 16 34
  • 89.29 (n)
Rpl28-ps4 34
  • 66 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rpl28 33
  • 89.05 (n)
oppossum
(Monodelphis domestica)
Mammalia RPL28 34
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 72 (a)
OneToMany
-- 34
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl28 33
  • 70.07 (n)
Str.5096 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.17523 33
zebrafish
(Danio rerio)
Actinopterygii rpl28 33 34
  • 76.96 (n)
zgc66289 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8348 33
fruit fly
(Drosophila melanogaster)
Insecta RpL28 33 34
  • 56.49 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005427 33
  • 56.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4607 34
  • 53 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU06210 33
  • 51.79 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl44 33
  • 43.44 (n)
Species where no ortholog for RPL28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RPL28 Gene

ENSEMBL:
Gene Tree for RPL28 (if available)
TreeFam:
Gene Tree for RPL28 (if available)

Paralogs for RPL28 Gene

genes like me logo Genes that share paralogs with RPL28: view

No data available for Paralogs for RPL28 Gene

Variants for RPL28 Gene

Sequence variations from dbSNP and Humsavar for RPL28 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000121465 -- 55,386,972(+) GTTTT(C/T)AGATG intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000302654 -- 55,386,249(+) CAAGT(G/T)CCCAG intron-variant, upstream-variant-2KB
rs1000355646 -- 55,386,454(+) CCCGG(A/T)TGCGT intron-variant, upstream-variant-2KB
rs1000594492 -- 55,385,528(+) TCCAA(A/C)GGTGC upstream-variant-2KB
rs1000939876 -- 55,389,601(+) GCTGG(A/G)AGCCC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPL28 Gene

Variant ID Type Subtype PubMed ID
nsv470162 CNV loss 18288195
nsv516199 CNV loss 19592680
nsv953624 CNV deletion 24416366

Variation tolerance for RPL28 Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.70; 91.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL28 Gene

Disorders for RPL28 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL28 Gene - From: GeneCards

Disorder Aliases PubMed IDs
albinism-deafness syndrome
  • albinism deafness syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RPL28 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPL28

Genetic Association Database (GAD)
RPL28
Human Genome Epidemiology (HuGE) Navigator
RPL28
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL28
genes like me logo Genes that share disorders with RPL28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL28 Gene

Publications for RPL28 Gene

  1. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio JM … Iovanna JL (Biochimica et biophysica acta 1995) 2 3 4 60
  2. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova TI … Karpova GG (Journal of protein chemistry 2003) 3 4 60

Products for RPL28 Gene

Sources for RPL28 Gene

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