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Aliases for RPL24 Gene

Aliases for RPL24 Gene

  • Ribosomal Protein L24 2 3 5
  • 60S Ribosomal Protein L30 3 4
  • Epididymis Secretory Protein Li 310 3
  • Ribosomal Protein L30 3
  • HEL-S-310 3
  • L24 3

External Ids for RPL24 Gene

Previous GeneCards Identifiers for RPL24 Gene

  • GC03M098065
  • GC03M100829
  • GC03M102677
  • GC03M102720
  • GC03M102882
  • GC03M101399
  • GC03M098769

Summaries for RPL24 Gene

Entrez Gene Summary for RPL24 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24E family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as ribosomal protein L30 because the encoded protein shares amino acid identity with the L30 ribosomal proteins from S. cerevisiae; however, its official name is ribosomal protein L24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL24 Gene

RPL24 (Ribosomal Protein L24) is a Protein Coding gene. Diseases associated with RPL24 include bone resorption disease and bone remodeling disease. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL24 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL24 Gene

Genomics for RPL24 Gene

Regulatory Elements for RPL24 Gene

Promoters for RPL24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL24 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL24 Gene

Chromosome:
3
Start:
101,681,090 bp from pter
End:
101,686,782 bp from pter
Size:
5,693 bases
Orientation:
Minus strand

Genomic View for RPL24 Gene

Genes around RPL24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL24 Gene

Proteins for RPL24 Gene

  • Protein details for RPL24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P83731-RL24_HUMAN
    Recommended name:
    60S ribosomal protein L24
    Protein Accession:
    P83731
    Secondary Accessions:
    • B2R4Y3
    • P38663
    • Q6IBS3

    Protein attributes for RPL24 Gene

    Size:
    157 amino acids
    Molecular mass:
    17779 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL24 Gene

neXtProt entry for RPL24 Gene

Proteomics data for RPL24 Gene at MOPED

Post-translational modifications for RPL24 Gene

  • Ubiquitination at Lys 2, Lys 12, Lys 35, Lys 43, Lys 131, and Lys 147
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL24 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RPL24 Gene

Domains & Families for RPL24 Gene

Gene Families for RPL24 Gene

Protein Domains for RPL24 Gene

Suggested Antigen Peptide Sequences for RPL24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P83731

UniProtKB/Swiss-Prot:

RL24_HUMAN :
  • Belongs to the ribosomal protein L24e family.
Family:
  • Belongs to the ribosomal protein L24e family.
genes like me logo Genes that share domains with RPL24: view

Function for RPL24 Gene

Molecular function for RPL24 Gene

GENATLAS Biochemistry:
60S ribosomal protein L24

Gene Ontology (GO) - Molecular Function for RPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24965446
genes like me logo Genes that share ontologies with RPL24: view
genes like me logo Genes that share phenotypes with RPL24: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RPL24

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL24 Gene

Localization for RPL24 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL24 Gene COMPARTMENTS Subcellular localization image for RPL24 gene
Compartment Confidence
cytosol 5
extracellular 5
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL24: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL24 Gene

Pathways & Interactions for RPL24 Gene

genes like me logo Genes that share pathways with RPL24: view

Pathways by source for RPL24 Gene

1 BioSystems pathway for RPL24 Gene
1 KEGG pathway for RPL24 Gene
1 GeneGo (Thomson Reuters) pathway for RPL24 Gene

Gene Ontology (GO) - Biological Process for RPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL24: view

No data available for SIGNOR curated interactions for RPL24 Gene

Drugs & Compounds for RPL24 Gene

No Compound Related Data Available

Transcripts for RPL24 Gene

Unigene Clusters for RPL24 Gene

Ribosomal protein L24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL24 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3: - -
SP4:

Relevant External Links for RPL24 Gene

GeneLoc Exon Structure for
RPL24
ECgene alternative splicing isoforms for
RPL24

Expression for RPL24 Gene

mRNA expression in normal human tissues for RPL24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL24 Gene

This gene is overexpressed in Tlymphocyte (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RPL24 Gene



SOURCE GeneReport for Unigene cluster for RPL24 Gene Hs.477028

genes like me logo Genes that share expression patterns with RPL24: view

Protein tissue co-expression partners for RPL24 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL24 Gene

Orthologs for RPL24 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
OneToMany
RPL24 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RPL24 35
  • 94.48 (n)
  • 100 (a)
RPL24 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL24 36
  • 99 (a)
OneToOne
RPL24 35
  • 94.27 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia RPL24 36
  • 100 (a)
OneToOne
Rpl24 35
  • 91.51 (n)
  • 100 (a)
Rpl24 16
oppossum
(Monodelphis domestica)
Mammalia RPL24 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL24 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl24 35
  • 90.66 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RPL24 35
  • 80.04 (n)
  • 97.45 (a)
RPL24 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL24 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24759 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl24 35
  • 76.56 (n)
  • 86.45 (a)
Str.1374 35
zebrafish
(Danio rerio)
Actinopterygii rpl24 36
  • 89 (a)
OneToOne
-- 35
rpl24 35
  • 74.31 (n)
  • 89.17 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010216 35
  • 59.48 (n)
  • 64.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9282 37
  • 70 (a)
RpL24 35
  • 57.63 (n)
  • 60.65 (a)
RpL24 36
  • 66 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpl-24.1 37
  • 51 (a)
rpl-24.1 35
  • 52.78 (n)
  • 48.72 (a)
rpl-24.1 36
  • 52 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR477C 35
  • 55.45 (n)
  • 57.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL24A 35
  • 56.36 (n)
  • 57.27 (a)
RPL24A 36
  • 50 (a)
OneToMany
RPL24B 36
  • 50 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E10869g 35
  • 56.39 (n)
  • 58.88 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons STV1 35
  • 57.8 (n)
  • 53.21 (a)
rice
(Oryza sativa)
Liliopsida Os05g0486700 35
  • 55.76 (n)
  • 50.91 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03150 35
  • 56.06 (n)
  • 57.27 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl2402 35
  • 56.97 (n)
  • 63.64 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4973 36
  • 64 (a)
OneToOne
Species with no ortholog for RPL24:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL24 Gene

ENSEMBL:
Gene Tree for RPL24 (if available)
TreeFam:
Gene Tree for RPL24 (if available)

Paralogs for RPL24 Gene

(1) SIMAP similar genes for RPL24 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RPL24: view

No data available for Paralogs for RPL24 Gene

Variants for RPL24 Gene

Sequence variations from dbSNP and Humsavar for RPL24 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1804331 -- 101,681,160(-) TTCAG(A/C/T)TCCCC reference, missense
rs3094295 -- 101,683,151(-) GAATA(A/G)CCATT intron-variant
rs7650435 -- 101,684,247(+) gcaac(C/G)cccca intron-variant
rs11558559 -- 101,681,144(+) CGTTT(C/T)CCACC reference, synonymous-codon
rs11720515 -- 101,684,847(+) CGCTG(G/T)GTAGC intron-variant

Variation tolerance for RPL24 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL24 Gene

HapMap Linkage Disequilibrium report
RPL24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RPL24 Gene

Disorders for RPL24 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RPL24 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bone resorption disease
bone remodeling disease
cauda equina neoplasm
  • tumor of the cauda equina
idiopathic juvenile osteoporosis
  • idiopathic osteoporosis
- elite association - COSMIC cancer census association via MalaCards
Search RPL24 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPL24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL24
genes like me logo Genes that share disorders with RPL24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL24 Gene

Publications for RPL24 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N. … Wilson S.A. (Nucleic Acids Res. 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for RPL24 Gene

Sources for RPL24 Gene

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