Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPL24 Gene

Aliases for RPL24 Gene

  • Ribosomal Protein L24 2 3 5
  • Large Ribosomal Subunit Protein EL24 3 4
  • 60S Ribosomal Protein L30 3 4
  • Epididymis Secretory Protein Li 310 3
  • 60S Ribosomal Protein L24 3
  • Ribosomal Protein L30 3
  • HEL-S-310 3
  • L24 3

External Ids for RPL24 Gene

Previous GeneCards Identifiers for RPL24 Gene

  • GC03M098065
  • GC03M100829
  • GC03M102677
  • GC03M102720
  • GC03M102882
  • GC03M101399
  • GC03M098769

Summaries for RPL24 Gene

Entrez Gene Summary for RPL24 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24E family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as ribosomal protein L30 because the encoded protein shares amino acid identity with the L30 ribosomal proteins from S. cerevisiae; however, its official name is ribosomal protein L24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL24 Gene

RPL24 (Ribosomal Protein L24) is a Protein Coding gene. Diseases associated with RPL24 include Cauda Equina Neoplasm and Bone Resorption Disease. Among its related pathways are Viral mRNA Translation and rRNA processing in the nucleus and cytosol. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL24 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL24 Gene

Genomics for RPL24 Gene

Regulatory Elements for RPL24 Gene

Enhancers for RPL24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G101643 1.5 Ensembl ENCODE dbSUPER 10.6 +42.6 42631 1.8 PKNOX1 ATF1 ZNF766 ELK1 GATA2 FOS KLF13 CAVIN1 ZNF592 MEF2D NXPE3 ZBTB11-AS1 RPL24 PDCL3P4 GC03P101648 PIR36650
GH03G101845 1.7 Ensembl ENCODE dbSUPER 9.2 -168.3 -168320 19.2 MLX CREB3L1 AGO1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 SSRP1 PCNP RPS18P5 RPL24 ZBTB11-AS1 PDCL3P4 SENP7 GC03P101863 GC03P101828
GH03G101778 1.3 ENCODE dbSUPER 10.9 -93.2 -93244 3.4 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF48 ZBTB7B ZNF121 GLIS2 GATA2 NXPE3 CEP97 RPL24 SENP7 ENSG00000249474
GH03G102223 1.3 FANTOM5 Ensembl dbSUPER 10.2 -536.6 -536615 0.4 PKNOX1 BACH1 BMI1 ZNF316 EED ETV6 RELB MAFK IKZF2 CREM NFKBIZ ENSG00000249474 RPL24 ZPLD1 PIR36108 GC03P102210 GC03P102209 GC03M102416
GH03G101809 1.2 Ensembl ENCODE dbSUPER 10.8 -123.2 -123178 1.9 CTCF PKNOX1 ZNF654 ZNF362 TRIM22 ELF4 ZNF384 REST RAD21 ZNF121 NXPE3 RPL24 ENSG00000249474
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL24 on UCSC Golden Path with GeneCards custom track

Promoters for RPL24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000155784 382 2401 PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207

Genomic Location for RPL24 Gene

Chromosome:
3
Start:
101,681,090 bp from pter
End:
101,686,782 bp from pter
Size:
5,693 bases
Orientation:
Minus strand

Genomic View for RPL24 Gene

Genes around RPL24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL24 Gene

Proteins for RPL24 Gene

  • Protein details for RPL24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P83731-RL24_HUMAN
    Recommended name:
    60S ribosomal protein L24
    Protein Accession:
    P83731
    Secondary Accessions:
    • B2R4Y3
    • P38663
    • Q6IBS3

    Protein attributes for RPL24 Gene

    Size:
    157 amino acids
    Molecular mass:
    17779 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL24 Gene

neXtProt entry for RPL24 Gene

Post-translational modifications for RPL24 Gene

  • Ubiquitination at isoforms=2, isoforms=12, isoforms=35, isoforms=43, isoforms=131, and Lys147
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL24 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL24 Gene

Domains & Families for RPL24 Gene

Gene Families for RPL24 Gene

Protein Domains for RPL24 Gene

Suggested Antigen Peptide Sequences for RPL24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P83731

UniProtKB/Swiss-Prot:

RL24_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eL24 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eL24 family.
genes like me logo Genes that share domains with RPL24: view

Function for RPL24 Gene

Molecular function for RPL24 Gene

GENATLAS Biochemistry:
60S ribosomal protein L24

Gene Ontology (GO) - Molecular Function for RPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,TAS 22658674
GO:0003735 structural constituent of ribosome NAS,TAS 12962325
GO:0005515 protein binding IPI 24965446
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with RPL24: view
genes like me logo Genes that share phenotypes with RPL24: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL24 Gene

Localization for RPL24 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL24 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 25468996
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0016020 membrane IDA 19946888
GO:0022625 cytosolic large ribosomal subunit IDA,TAS 12962325
genes like me logo Genes that share ontologies with RPL24: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL24 Gene

Pathways & Interactions for RPL24 Gene

genes like me logo Genes that share pathways with RPL24: view

Pathways by source for RPL24 Gene

1 KEGG pathway for RPL24 Gene
1 GeneGo (Thomson Reuters) pathway for RPL24 Gene

Gene Ontology (GO) - Biological Process for RPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS,TAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL24: view

No data available for SIGNOR curated interactions for RPL24 Gene

Transcripts for RPL24 Gene

Unigene Clusters for RPL24 Gene

Ribosomal protein L24:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL24 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3: - -
SP4:

Relevant External Links for RPL24 Gene

GeneLoc Exon Structure for
RPL24
ECgene alternative splicing isoforms for
RPL24

Expression for RPL24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL24 Gene

This gene is overexpressed in Tlymphocyte (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RPL24 Gene



Protein tissue co-expression partners for RPL24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL24 Gene:

RPL24

SOURCE GeneReport for Unigene cluster for RPL24 Gene:

Hs.477028

Evidence on tissue expression from TISSUES for RPL24 Gene

  • Liver(4.6)
  • Intestine(4.5)
  • Nervous system(4.1)
  • Lung(3.9)
  • Bone(3.7)
  • Muscle(3.6)
  • Pancreas(3.6)
  • Blood(2.8)
  • Thyroid gland(2.8)
  • Eye(2.7)
  • Heart(2.7)
  • Skin(2.7)
  • Kidney(2.6)
  • Stomach(2.6)
  • Spleen(2.4)
  • Lymph node(2.2)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with RPL24: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL24 Gene

Orthologs for RPL24 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL24 34
  • 100 (n)
-- 35
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia RPL24 35
  • 100 (a)
OneToOne
Rpl24 34 16
  • 91.51 (n)
oppossum
(Monodelphis domestica)
Mammalia RPL24 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL24 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPL24 34 35
  • 94.48 (n)
dog
(Canis familiaris)
Mammalia RPL24 34 35
  • 94.27 (n)
rat
(Rattus norvegicus)
Mammalia Rpl24 34
  • 90.66 (n)
chicken
(Gallus gallus)
Aves RPL24 34 35
  • 80.04 (n)
lizard
(Anolis carolinensis)
Reptilia RPL24 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl24 34
  • 76.56 (n)
Str.1374 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24759 34
zebrafish
(Danio rerio)
Actinopterygii rpl24 34 35
  • 74.31 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta CG9282 36
  • 70 (a)
RpL24 34 35
  • 57.63 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010216 34
  • 59.48 (n)
worm
(Caenorhabditis elegans)
Secernentea rpl-24.1 36 34 35
  • 52.78 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E10869g 34
  • 56.39 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL24A 34 35
  • 56.36 (n)
RPL24B 35
  • 50 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR477C 34
  • 55.45 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons STV1 34
  • 57.8 (n)
rice
(Oryza sativa)
Liliopsida Os05g0486700 34
  • 55.76 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4973 35
  • 64 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl2402 34
  • 56.97 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03150 34
  • 56.06 (n)
Species where no ortholog for RPL24 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL24 Gene

ENSEMBL:
Gene Tree for RPL24 (if available)
TreeFam:
Gene Tree for RPL24 (if available)

Paralogs for RPL24 Gene

(1) SIMAP similar genes for RPL24 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RPL24: view

No data available for Paralogs for RPL24 Gene

Variants for RPL24 Gene

Sequence variations from dbSNP and Humsavar for RPL24 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000445823 -- 101,687,982(+) TTTTT(G/T)TTTTC intron-variant, upstream-variant-2KB
rs1000733750 -- 101,688,259(+) GAGCC(A/G)CCGCG intron-variant, upstream-variant-2KB
rs1000814459 -- 101,687,786(+) AATTC(C/T)TGAAT intron-variant, upstream-variant-2KB
rs1001099590 -- 101,688,178(+) CACCA(C/T)GTTGT intron-variant, upstream-variant-2KB
rs1001270862 -- 101,684,134(+) AATTA(C/T)AGGCG intron-variant

Variation tolerance for RPL24 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPL24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RPL24 Gene

Disorders for RPL24 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RPL24 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cauda equina neoplasm
  • tumor of the cauda equina
bone resorption disease
  • bone resorption
bone remodeling disease
- elite association - COSMIC cancer census association via MalaCards
Search RPL24 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPL24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL24
genes like me logo Genes that share disorders with RPL24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL24 Gene

Publications for RPL24 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M. … Kenmochi N. (Genome Res. 2002) 3 4 64
  5. Characterization of cDNA clones encoding the human homologue of Saccharomyces cerevisiae ribosomal protein L30. (PMID: 8428672) Johnson K.R. (Gene 1993) 3 4 64

Products for RPL24 Gene

Sources for RPL24 Gene

Content
Loading form....