Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPL17 Gene

Aliases for RPL17 Gene

  • Ribosomal Protein L17 2 3
  • 60S Ribosomal Protein L23 3 4
  • PD-1 3 4
  • Gene Encoding Putative NFkB Activating Protein 3
  • 60S Ribosomal Protein L17 3
  • RPL23 3
  • L17 3

External Ids for RPL17 Gene

Summaries for RPL17 Gene

Entrez Gene Summary for RPL17 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui; however, its official symbol is RPL17. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream C18orf32 (chromosome 18 open reading frame 32) gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for RPL17 Gene

RPL17 (Ribosomal Protein L17) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPL17-C18orf32.

Gene Wiki entry for RPL17 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL17 Gene

Genomics for RPL17 Gene

Genomic Location for RPL17 Gene

Start:
49,488,453 bp from pter
End:
49,492,565 bp from pter
Size:
4,113 bases
Orientation:
Minus strand

Genomic View for RPL17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL17 Gene

Regulatory Elements for RPL17 Gene

Proteins for RPL17 Gene

  • Protein details for RPL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18621-RL17_HUMAN
    Recommended name:
    60S ribosomal protein L17
    Protein Accession:
    P18621
    Secondary Accessions:
    • B2R4H3
    • B4E3C2
    • B5ME31
    • J3QL51
    • Q3KQW2
    • Q6NZ54
    • Q7M4M5

    Protein attributes for RPL17 Gene

    Size:
    184 amino acids
    Molecular mass:
    21397 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL17 Gene

    Alternative splice isoforms for RPL17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPL17 Gene

Proteomics data for RPL17 Gene at MOPED

Post-translational modifications for RPL17 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys13, Lys49, Lys55, Lys74, Lys86, Lys96, and Lys105

No data available for DME Specific Peptides for RPL17 Gene

Domains for RPL17 Gene

Gene Families for RPL17 Gene

HGNC:
  • RPL :L ribosomal proteins

Protein Domains for RPL17 Gene

UniProtKB/Swiss-Prot:

RL17_HUMAN
Family:
  • Belongs to the ribosomal protein L22P family.:
    • P18621
genes like me logo Genes that share domains with RPL17: view

Function for RPL17 Gene

Molecular function for RPL17 Gene

GENATLAS Biochemistry: 60S ribosomal protein L17

Gene Ontology (GO) - Molecular Function for RPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL17: view

Phenotypes for RPL17 Gene

genes like me logo Genes that share phenotypes with RPL17: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL17 Gene

Localization for RPL17 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL17 Gene COMPARTMENTS Subcellular localization image for RPL17 gene
Compartment Confidence
cytosol 5
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
GO:0015934 large ribosomal subunit --
GO:0022625 cytosolic large ribosomal subunit IDA 12962325
genes like me logo Genes that share ontologies with RPL17: view

Pathways for RPL17 Gene

genes like me logo Genes that share pathways with RPL17: view

Pathways by source for RPL17 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RPL17 Gene
2 BioSystems pathways for RPL17 Gene

Gene Ontology (GO) - Biological Process for RPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL17: view

Transcripts for RPL17 Gene

Unigene Clusters for RPL17 Gene

Ribosomal protein L17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL17 Gene

No ASD Table

Relevant External Links for RPL17 Gene

GeneLoc Exon Structure for
RPL17
ECgene alternative splicing isoforms for
RPL17

Expression for RPL17 Gene

mRNA expression in normal human tissues for RPL17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL17 Gene

SOURCE GeneReport for Unigene cluster for RPL17 Gene Hs.293653

mRNA Expression by UniProt/SwissProt for RPL17 Gene

P18621-RL17_HUMAN
Tissue specificity: Expressed in pancreas, lung, colon, cystic duct, gall bladder, kidney and liver. Expressed at high levels in the well differentiated pancreatic tumor cell lines HPAF, COLO 357 and Capan-1, the moderately differentiated pancreatic tumor cell lines T3M-4, AsPc-1 and BxPc-3, the poorly differentiated pancreatic tumor cell line MIA PaCa-2, and the pancreatic tumor cell lines of undefined differentiation status such as SW979. Expressed at lower levels in the poorly differentiated pancreatic tumor cell lines HCG-25 and PANC-1.
genes like me logo Genes that share expressions with RPL17: view

Orthologs for RPL17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL17 36
  • 99.46 (n)
  • 100 (a)
RPL17 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPL17 36
  • 92.03 (n)
  • 99.46 (a)
RPL17 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 92 (a)
OneToMany
-- 37
  • 99 (a)
OneToMany
-- 37
  • 100 (a)
OneToMany
RPL17 36
  • 91.67 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Gm5277 37
  • 76 (a)
OneToMany
Rpl17 36
  • 90.22 (n)
  • 99.46 (a)
Rpl17 16
oppossum
(Monodelphis domestica)
Mammalia RPL17 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rpl17 36
  • 90.04 (n)
  • 99.46 (a)
chicken
(Gallus gallus)
Aves RPL17 37
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL17 37
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8095 36
zebrafish
(Danio rerio)
Actinopterygii rpl17 37
  • 95 (a)
OneToMany
wufa91a06 36
fruit fly
(Drosophila melanogaster)
Insecta RpL17 37
  • 69 (a)
OneToMany
CG3203 38
  • 71 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-17 37
  • 64 (a)
OneToMany
Y48G8AL.8a 38
  • 64 (a)
Y48G8AL.8b 38
  • 53 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL137W 36
  • 55.83 (n)
  • 58.9 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL17A 36
  • 56.24 (n)
  • 57.67 (a)
RPL17A 37
  • 54 (a)
ManyToMany
RPL17B 37
  • 54 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A06336g 36
  • 57.06 (n)
  • 57.06 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1291 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G67430 36
  • 62.63 (n)
  • 67.88 (a)
rice
(Oryza sativa)
Liliopsida Os.9941 36
Os09g0258600 36
  • 63.23 (n)
  • 67.88 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03703 36
  • 58.74 (n)
  • 64.02 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl1702 36
  • 59.6 (n)
  • 59.39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4564 37
  • 77 (a)
OneToMany
Species with no ortholog for RPL17:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RPL17 Gene

ENSEMBL:
Gene Tree for RPL17 (if available)
TreeFam:
Gene Tree for RPL17 (if available)

Paralogs for RPL17 Gene

Paralogs for RPL17 Gene

Selected SIMAP similar genes for RPL17 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RPL17: view

Variants for RPL17 Gene

Structural Variations from Database of Genomic Variants (DGV) for RPL17 Gene

Variant ID Type Subtype PubMed ID
nsv2294 CNV Loss 18451855

Relevant External Links for RPL17 Gene

HapMap Linkage Disequilibrium report
RPL17

No data available for Sequence variations from dbSNP and Humsavar for RPL17 Gene

Disorders for RPL17 Gene

No disorders were found for RPL17 Gene.

No data available for UniProtKB/Swiss-Prot for RPL17 Gene

Publications for RPL17 Gene

  1. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova T.I. … Karpova G.G. (J. Protein Chem. 2003) 3 4 23
  2. A human gene related to the ribosomal protein L23 gene of Halobacterium marismortui. (PMID: 2402465) Mager D.L. … Freeman J.D. (Nucleic Acids Res. 1990) 2 3 4
  3. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4
  4. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M. … Kenmochi N. (Genome Res. 2002) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RPL17 Gene

Sources for RPL17 Gene

Back to Top

Content