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Aliases for RPL11 Gene

Aliases for RPL11 Gene

  • Ribosomal Protein L11 2 3 5
  • CLL-Associated Antigen KW-12 3 4
  • Cell Growth-Inhibiting Protein 34 3
  • GIG34 3
  • DBA7 3
  • L11 3

External Ids for RPL11 Gene

Previous GeneCards Identifiers for RPL11 Gene

  • GC01P023575
  • GC01P023089
  • GC01P023487
  • GC01P023763
  • GC01P023890
  • GC01P024018
  • GC01P022268

Summaries for RPL11 Gene

Entrez Gene Summary for RPL11 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]

GeneCards Summary for RPL11 Gene

RPL11 (Ribosomal Protein L11) is a Protein Coding gene. Diseases associated with RPL11 include diamond-blackfan anemia 7 and diamond-blackfan anemia. Among its related pathways are Viral mRNA Translation and Translational Control. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL11 Gene

  • Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity).

Gene Wiki entry for RPL11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL11 Gene

Genomics for RPL11 Gene

Regulatory Elements for RPL11 Gene

Enhancers for RPL11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPL11 on UCSC Golden Path with GeneCards custom track

Promoters for RPL11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL11 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL11 Gene

23,691,779 bp from pter
23,696,425 bp from pter
4,647 bases
Plus strand

Genomic View for RPL11 Gene

Genes around RPL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL11 Gene

Proteins for RPL11 Gene

  • Protein details for RPL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L11
    Protein Accession:
    Secondary Accessions:
    • P25121
    • P39026
    • Q8TDH2
    • Q9Y674

    Protein attributes for RPL11 Gene

    178 amino acids
    Molecular mass:
    20252 Da
    Quaternary structure:
    • Interacts with PML and MDM2.

    Three dimensional structures from OCA and Proteopedia for RPL11 Gene

    Alternative splice isoforms for RPL11 Gene


neXtProt entry for RPL11 Gene

Proteomics data for RPL11 Gene at MOPED

Post-translational modifications for RPL11 Gene

  • Ubiquitination at Lys 8, Lys 19, Lys 38, Lys 78, Lys 85, and Lys 169
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL11 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RPL11 (RPL11)

No data available for DME Specific Peptides for RPL11 Gene

Domains & Families for RPL11 Gene

Gene Families for RPL11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L5P family.
  • Belongs to the ribosomal protein L5P family.
genes like me logo Genes that share domains with RPL11: view

Function for RPL11 Gene

Molecular function for RPL11 Gene

GENATLAS Biochemistry:
60S ribosomal protein L11
UniProtKB/Swiss-Prot Function:
Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity).

Gene Ontology (GO) - Molecular Function for RPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 15195100
genes like me logo Genes that share ontologies with RPL11: view
genes like me logo Genes that share phenotypes with RPL11: view

Human Phenotype Ontology for RPL11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for RPL11 Gene

miRTarBase miRNAs that target RPL11

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL11 Gene

Localization for RPL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL11 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for RPL11 Gene COMPARTMENTS Subcellular localization image for RPL11 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA,IDA 15195100
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL11: view

Pathways & Interactions for RPL11 Gene

genes like me logo Genes that share pathways with RPL11: view

Pathways by source for RPL11 Gene

1 KEGG pathway for RPL11 Gene
1 GeneGo (Thomson Reuters) pathway for RPL11 Gene

SIGNOR curated interactions for RPL11 Gene


Gene Ontology (GO) - Biological Process for RPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing IMP,TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL11: view

Drugs & Compounds for RPL11 Gene

(3) Drugs for RPL11 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
anisomycin Experimental Pharma Target JNK, SAPK and p38 activator 0
puromycin Experimental Pharma Target 0

(2) Additional Compounds for RPL11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPL11: view

Transcripts for RPL11 Gene

Unigene Clusters for RPL11 Gene

Ribosomal protein L11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL11 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: -
SP7: - - -
SP8: - - -

Relevant External Links for RPL11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL11 Gene

mRNA expression in normal human tissues for RPL11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL11 Gene

This gene is overexpressed in Tlymphocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL11 Gene

SOURCE GeneReport for Unigene cluster for RPL11 Gene Hs.719951

genes like me logo Genes that share expression patterns with RPL11: view

Protein tissue co-expression partners for RPL11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL11 Gene

Orthologs for RPL11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPL11 35
  • 93.26 (n)
  • 100 (a)
RPL11 36
  • 100 (a)
(Canis familiaris)
Mammalia RPL11 35
  • 94.94 (n)
  • 100 (a)
-- 36
  • 68 (a)
-- 36
  • 100 (a)
-- 36
  • 90 (a)
(Mus musculus)
Mammalia Rpl11 35
  • 91.57 (n)
  • 100 (a)
Rpl11 16
Gm10036 36
  • 99 (a)
Gm10288 36
  • 99 (a)
Gm5093 36
  • 97 (a)
Gm7589 36
  • 96 (a)
Rpl11 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rpl11 35
  • 91.02 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia RPL11 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia RPL11 36
  • 99 (a)
(Pan troglodytes)
Mammalia RPL11 36
  • 99 (a)
(Gallus gallus)
Aves RPL11 35
  • 79.21 (n)
  • 89.89 (a)
(Anolis carolinensis)
Reptilia RPL11 36
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl11 35
  • 80.19 (n)
  • 96 (a)
(Danio rerio)
Actinopterygii rpl11 35
  • 82.77 (n)
  • 95.51 (a)
rpl11 36
  • 96 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL11 37
  • 82 (a)
RpL11 35
  • 72.35 (n)
  • 84.71 (a)
RpL11 36
  • 78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011173 35
  • 69.68 (n)
  • 80.79 (a)
(Caenorhabditis elegans)
Secernentea rpl-11.1 37
  • 81 (a)
rpl-11.2 37
  • 82 (a)
rpl-11.2 35
  • 70.41 (n)
  • 82.25 (a)
rpl-11.1 36
  • 70 (a)
rpl-11.2 36
  • 71 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL325W 35
  • 68.86 (n)
  • 73.05 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08261g 35
  • 67.66 (n)
  • 73.65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL11A 35
  • 65.87 (n)
  • 72.46 (a)
RPL11A 36
  • 70 (a)
RPL11B 36
  • 70 (a)
RPL11B 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G58700 35
  • 66.27 (n)
  • 72.29 (a)
(Oryza sativa)
Liliopsida Os02g0235600 35
  • 65.9 (n)
  • 70.69 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02509 35
  • 65.51 (n)
  • 70.52 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl1101 35
  • 68.66 (n)
  • 74.25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.110 36
  • 74 (a)
Species with no ortholog for RPL11:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL11 Gene

Gene Tree for RPL11 (if available)
Gene Tree for RPL11 (if available)

Paralogs for RPL11 Gene

genes like me logo Genes that share paralogs with RPL11: view

No data available for Paralogs for RPL11 Gene

Variants for RPL11 Gene

Sequence variations from dbSNP and Humsavar for RPL11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_055448 Diamond-Blackfan anemia 7 (DBA7)
rs8880 -- 23,694,734(+) CACAT(C/T)GATCT reference, synonymous-codon
rs1059635 -- 23,693,861(+) TGTCC(A/C)CTGCA reference, missense
rs1059937 -- 23,694,692(+) AACTT(C/T)TCAGA reference, synonymous-codon
rs1804294 -- 23,692,677(+) ATCTG(C/T)GTTGG reference, synonymous-codon

Variation tolerance for RPL11 Gene

Residual Variation Intolerance Score: 35.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL11 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RPL11 Gene

Disorders for RPL11 Gene

MalaCards: The human disease database

(6) MalaCards diseases for RPL11 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia 7
  • dba7
diamond-blackfan anemia
  • blackfan - diamond syndrome
rpl11-related diamond-blackfan anemia
  • diamond-blackfan anemia 7
macrocytic anemia
  • anemia macrocytic
pierre robin syndrome
  • pierre robin sequence
- elite association - COSMIC cancer census association via MalaCards
Search RPL11 in MalaCards View complete list of genes associated with diseases


  • Diamond-Blackfan anemia 7 (DBA7) [MIM:612562]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:19061985, ECO:0000269 PubMed:19191325}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RPL11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPL11: view

No data available for Genatlas for RPL11 Gene

Publications for RPL11 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 67
  2. Ribosomal protein L11 associates with c-Myc at 5 S rRNA and tRNA genes and regulates their expression. (PMID: 20194507) Dai M.S. … Lu H. (J. Biol. Chem. 2010) 3 23
  3. Defects in 18 S or 28 S rRNA processing activate the p53 pathway. (PMID: 20056613) HAPlzel M. … Eick D. (J. Biol. Chem. 2010) 3 23
  4. Identification of mutations in the ribosomal protein L5 (RPL5) and ribosomal protein L11 (RPL11) genes in Czech patients with Diamond- Blackfan anemia. (PMID: 19191325) Cmejla R. … Pospisilova D. (Hum. Mutat. 2009) 3 23
  5. Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction. (PMID: 19287375) Fumagalli S. … Thomas G. (Nat. Cell Biol. 2009) 3 23

Products for RPL11 Gene

Sources for RPL11 Gene