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Aliases for RPL11 Gene

Aliases for RPL11 Gene

  • Ribosomal Protein L11 2 3
  • CLL-Associated Antigen KW-12 3 4
  • DBA7 3 6
  • Cell Growth-Inhibiting Protein 34 3
  • 60S Ribosomal Protein L11 3
  • GIG34 3
  • L11 3

External Ids for RPL11 Gene

Previous GeneCards Identifiers for RPL11 Gene

  • GC01P023575
  • GC01P023089
  • GC01P023487
  • GC01P023763
  • GC01P023890
  • GC01P024018
  • GC01P022268

Summaries for RPL11 Gene

Entrez Gene Summary for RPL11 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]

GeneCards Summary for RPL11 Gene

RPL11 (Ribosomal Protein L11) is a Protein Coding gene. Diseases associated with RPL11 include diamond-blackfan anemia 7 and rpl11-related diamond-blackfan anemia. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and rRNA binding.

UniProtKB/Swiss-Prot for RPL11 Gene

  • Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity).

Gene Wiki entry for RPL11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL11 Gene

Genomics for RPL11 Gene

Regulatory Elements for RPL11 Gene

Genomic Location for RPL11 Gene

Start:
23,691,779 bp from pter
End:
23,696,425 bp from pter
Size:
4,647 bases
Orientation:
Plus strand

Genomic View for RPL11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL11 Gene

Proteins for RPL11 Gene

  • Protein details for RPL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62913-RL11_HUMAN
    Recommended name:
    60S ribosomal protein L11
    Protein Accession:
    P62913
    Secondary Accessions:
    • P25121
    • P39026
    • Q8TDH2
    • Q9Y674

    Protein attributes for RPL11 Gene

    Size:
    178 amino acids
    Molecular mass:
    20252 Da
    Quaternary structure:
    • Interacts with PML and MDM2.

    Three dimensional structures from OCA and Proteopedia for RPL11 Gene

    Alternative splice isoforms for RPL11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPL11 Gene

Proteomics data for RPL11 Gene at MOPED

Post-translational modifications for RPL11 Gene

  • Ubiquitination at Lys8, Lys19, Lys38, Lys52, Lys78, Lys85, and Lys169
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RPL11 (RPL11)

No data available for DME Specific Peptides for RPL11 Gene

Domains for RPL11 Gene

Gene Families for RPL11 Gene

HGNC:
  • RPL :L ribosomal proteins

Protein Domains for RPL11 Gene

Graphical View of Domain Structure for InterPro Entry

P62913

UniProtKB/Swiss-Prot:

RL11_HUMAN :
  • P62913
Family:
  • Belongs to the ribosomal protein L5P family.
genes like me logo Genes that share domains with RPL11: view

Function for RPL11 Gene

Molecular function for RPL11 Gene

GENATLAS Biochemistry: 60S ribosomal protein L11
UniProtKB/Swiss-Prot Function: Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity).

Gene Ontology (GO) - Molecular Function for RPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 7748210
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 15195100
GO:0019843 rRNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with RPL11: view
genes like me logo Genes that share phenotypes with RPL11: view

miRNA for RPL11 Gene

miRTarBase miRNAs that target RPL11

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL11 Gene

Localization for RPL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL11 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL11 Gene COMPARTMENTS Subcellular localization image for RPL11 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA 15195100
GO:0005737 cytoplasm IDA 16791210
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL11: view

Pathways for RPL11 Gene

genes like me logo Genes that share pathways with RPL11: view

Pathways by source for RPL11 Gene

Gene Ontology (GO) - Biological Process for RPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing IMP 18697920
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
genes like me logo Genes that share ontologies with RPL11: view

Compounds for RPL11 Gene

(3) Drugbank Compounds for RPL11 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
target
ANISOMYCIN
target
PUROMYCIN
target

(2) Novoseek inferred chemical compound relationships for RPL11 Gene

Compound -log(P) Hits PubMed IDs
thiostrepton 89.7 4
rrna 47.4 1
genes like me logo Genes that share compounds with RPL11: view

Transcripts for RPL11 Gene

Unigene Clusters for RPL11 Gene

Ribosomal protein L11:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL11 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: -
SP7: - - -
SP8: - - -
SP9:

Relevant External Links for RPL11 Gene

GeneLoc Exon Structure for
RPL11
ECgene alternative splicing isoforms for
RPL11

Expression for RPL11 Gene

mRNA expression in normal human tissues for RPL11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL11 Gene

SOURCE GeneReport for Unigene cluster for RPL11 Gene Hs.719951

genes like me logo Genes that share expressions with RPL11: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL11 Gene

Orthologs for RPL11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPL11 35
  • 93.26 (n)
  • 100 (a)
RPL11 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
RPL11 35
  • 94.94 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Gm10036 36
  • 99 (a)
OneToMany
Gm10288 36
  • 99 (a)
OneToMany
Gm5093 36
  • 97 (a)
OneToMany
Gm7589 36
  • 96 (a)
OneToMany
Rpl11 35
  • 91.57 (n)
  • 100 (a)
Rpl11 16
Rpl11 36
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RPL11 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl11 35
  • 91.02 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RPL11 35
  • 79.21 (n)
  • 89.89 (a)
lizard
(Anolis carolinensis)
Reptilia RPL11 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl11 35
  • 80.19 (n)
  • 96 (a)
zebrafish
(Danio rerio)
Actinopterygii rpl11 35
  • 82.77 (n)
  • 95.51 (a)
rpl11 36
  • 96 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011173 35
  • 69.68 (n)
  • 80.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL11 35
  • 72.35 (n)
  • 84.71 (a)
RpL11 36
  • 78 (a)
OneToOne
RpL11 37
  • 82 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-11.1 36
  • 70 (a)
OneToMany
rpl-11.2 35
  • 70.41 (n)
  • 82.25 (a)
rpl-11.2 36
  • 71 (a)
OneToMany
rpl-11.2 37
  • 82 (a)
rpl-11.1 37
  • 81 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL325W 35
  • 68.86 (n)
  • 73.05 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL11A 35
  • 65.87 (n)
  • 72.46 (a)
RPL11A 36
  • 70 (a)
OneToMany
RPL11B 36
  • 70 (a)
OneToMany
RPL11B 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08261g 35
  • 67.66 (n)
  • 73.65 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G58700 35
  • 66.27 (n)
  • 72.29 (a)
rice
(Oryza sativa)
Liliopsida Os02g0235600 35
  • 65.9 (n)
  • 70.69 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02509 35
  • 65.51 (n)
  • 70.52 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl1101 35
  • 68.66 (n)
  • 74.25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.110 36
  • 74 (a)
OneToOne
Species with no ortholog for RPL11:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL11 Gene

ENSEMBL:
Gene Tree for RPL11 (if available)
TreeFam:
Gene Tree for RPL11 (if available)

Paralogs for RPL11 Gene

genes like me logo Genes that share paralogs with RPL11: view

No data available for Paralogs for RPL11 Gene

Variants for RPL11 Gene

Sequence variations from dbSNP and Humsavar for RPL11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8880 -- 23,694,734(+) CACAT(C/T)GATCT reference, synonymous-codon
rs1059635 -- 23,693,861(+) TGTCC(A/C)CTGCA reference, missense
rs1059937 -- 23,694,692(+) AACTT(C/T)TCAGA reference, synonymous-codon
rs1804294 -- 23,692,677(+) ATCTG(C/T)GTTGG synonymous-codon, reference
rs1804295 -- 23,692,721(+) GGTGT(C/T)GGAGC missense, reference

Relevant External Links for RPL11 Gene

HapMap Linkage Disequilibrium report
RPL11
Human Gene Mutation Database (HGMD)
RPL11
Locus Specific Mutation Databases (LSDB)
RPL11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RPL11 Gene

Disorders for RPL11 Gene

(1) OMIM Diseases for RPL11 Gene (604175)

UniProtKB/Swiss-Prot

RL11_HUMAN
  • Diamond-Blackfan anemia 7 (DBA7) [MIM:612562]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:19061985, ECO:0000269 PubMed:19191325}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for RPL11 Gene

Relevant External Links for RPL11

GeneTests
RPL11
GeneReviews
RPL11
Genetic Association Database (GAD)
RPL11
Human Genome Epidemiology (HuGE) Navigator
RPL11
genes like me logo Genes that share disorders with RPL11: view

Publications for RPL11 Gene

  1. Cloning and determination of the primary structure of DNA complementary to the mRNA of human ribosomal protein L11. (PMID: 7748210) Mishin V.P. … Mertvetsov N.P. (Bioorg. Khim. 1995) 3 4 23
  2. Structural and functional analysis of the human ribosomal protein L11 gene. (PMID: 12815950) Voronina E.N. … Filipenko M.L. (Mol. Biol. (Mosk.) 2003) 3 4 23
  3. Identification of mutations in the ribosomal protein L5 (RPL5) and ribosomal protein L11 (RPL11) genes in Czech patients with Diamond- Blackfan anemia. (PMID: 19191325) Cmejla R. … Pospisilova D. (Hum. Mutat. 2009) 3 4 23
  4. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4
  5. Assignment of the L11 ribosomal protein gene (RPL11) to human chromosome 1p36.1-->p35 by in situ hybridization. (PMID: 10343117) Graphodatsky A.S. … Prydz H. (Cytogenet. Cell Genet. 1999) 2 3

Products for RPL11 Gene

  • Addgene plasmids for RPL11

Sources for RPL11 Gene

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