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Aliases for RPL8 Gene

Aliases for RPL8 Gene

  • Ribosomal Protein L8 2 3 5
  • 60S Ribosomal Protein L8 3
  • L8 3

External Ids for RPL8 Gene

Previous GeneCards Identifiers for RPL8 Gene

  • GC08M143622
  • GC08M146052
  • GC08M145619
  • GC08M146019
  • GC08M145985
  • GC08M141130
  • GC08M146015

Summaries for RPL8 Gene

Entrez Gene Summary for RPL8 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL8 Gene

RPL8 (Ribosomal Protein L8) is a Protein Coding gene. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL8 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL8 Gene

Genomics for RPL8 Gene

Regulatory Elements for RPL8 Gene

Enhancers for RPL8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F144835 0.2 ENCODE 38.9 -43.9 -43910 1.5 BHLHE40 FOS RPL8 ZNF517 MIR6850 ZNF34 GPAA1 PIR32044 ZNF7
GH08F144825 1.1 ENCODE 38.6 -36.0 -35992 6.5 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 RPL8 ZNF517 MIR6850 TSSK5P LOC105375803 ZNF16 ZNF252P COMMD5 ZNF7 PIR32044
GH08F144848 0.6 ENCODE 37.4 -56.3 -56349 1.7 ELF3 MLX ARID4B DMAP1 ZSCAN9 RARA SLC30A9 CREM MIXL1 THAP11 RPL8 ZNF7 ZNF517 MIR6850 SLC39A4 COMMD5 PIR55168
GH08F144785 0.5 ENCODE 36.4 +2.9 2857 9.0 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 RPL8 C8orf82 ZNF34 VPS28 ZNF517 PARP10 COMMD5 C8orf33 ZNF251 ARHGAP39
GH08F144770 1.5 FANTOM5 Ensembl ENCODE 35.8 +22.0 21987 1.2 KLF1 LEF1 ESRRA HINFP ZNF175 PTRF PYGO2 ZNF644 NCOR1 NR2F6 RPL8 LRRC14 COMMD5 ZNF517 ZNF250 ADCK5 VPS28 LOC105375803 ZNF251 ZNF34
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RPL8 on UCSC Golden Path with GeneCards custom track

Promoters for RPL8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001906810 -113 2601 HDGF CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143 KLF13

Transcription factor binding sites by QIAGEN in the RPL8 gene promoter:

Genomic Location for RPL8 Gene

144,789,765 bp from pter
144,792,587 bp from pter
2,823 bases
Minus strand

Genomic View for RPL8 Gene

Genes around RPL8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL8 Gene

Proteins for RPL8 Gene

  • Protein details for RPL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L8
    Protein Accession:
    Secondary Accessions:
    • A8K094
    • D3DWN2
    • P25120
    • Q567Q7
    • Q969V7
    • Q9BWQ9

    Protein attributes for RPL8 Gene

    257 amino acids
    Molecular mass:
    28025 Da
    Quaternary structure:
    • Interacts with CRY1.
    • Interacts with CRY1.
    • This protein can be partially incorporated into E.coli polysomes in vivo, indicating it can replace the endogenous protein.

    Three dimensional structures from OCA and Proteopedia for RPL8 Gene

neXtProt entry for RPL8 Gene

Post-translational modifications for RPL8 Gene

  • Hydroxylated on His-216 by NO66. The modification is impaired by hypoxia.
  • Ubiquitination at Lys 10, Lys 60, and Lys 181
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL8 Gene

Domains & Families for RPL8 Gene

Gene Families for RPL8 Gene

Suggested Antigen Peptide Sequences for RPL8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L2P family.
  • Belongs to the ribosomal protein L2P family.
genes like me logo Genes that share domains with RPL8: view

Function for RPL8 Gene

Molecular function for RPL8 Gene

GENATLAS Biochemistry:
60S ribosomal protein L8

Gene Ontology (GO) - Molecular Function for RPL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 7506540
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0019843 rRNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:1990932 5.8S rRNA binding IEA --
genes like me logo Genes that share ontologies with RPL8: view
genes like me logo Genes that share phenotypes with RPL8: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL8 Gene

Localization for RPL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL8 Gene

Subcellular locations from

Jensen Localization Image for RPL8 Gene COMPARTMENTS Subcellular localization image for RPL8 gene
Compartment Confidence
cytosol 5
nucleus 5
chloroplast 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPL8: view

Pathways & Interactions for RPL8 Gene

genes like me logo Genes that share pathways with RPL8: view

Pathways by source for RPL8 Gene

1 KEGG pathway for RPL8 Gene
1 GeneGo (Thomson Reuters) pathway for RPL8 Gene

Gene Ontology (GO) - Biological Process for RPL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
genes like me logo Genes that share ontologies with RPL8: view

No data available for SIGNOR curated interactions for RPL8 Gene

Drugs & Compounds for RPL8 Gene

(3) Drugs for RPL8 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
Anisomycin Experimental Pharma Target JNK agonist, potent and specific 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL8: view

Transcripts for RPL8 Gene

Unigene Clusters for RPL8 Gene

Ribosomal protein L8:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - -
SP10: - - -
SP11: - - - - - - - - - - - - -
SP12: - -

Relevant External Links for RPL8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RPL8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL8 Gene

Protein tissue co-expression partners for RPL8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL8 Gene:


SOURCE GeneReport for Unigene cluster for RPL8 Gene:

genes like me logo Genes that share expression patterns with RPL8: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL8 Gene

Orthologs for RPL8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL8 35 34
  • 99.22 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 99 (a)
-- 35
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia RPL8 35
  • 99 (a)
(Bos Taurus)
Mammalia -- 35
  • 96 (a)
RPL8 35 34
  • 89.88 (n)
(Canis familiaris)
Mammalia RPL8 35 34
  • 90.66 (n)
(Mus musculus)
Mammalia Rpl8 16 35 34
  • 87.68 (n)
(Gallus gallus)
Aves RPL8 34 35
  • 81.97 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 99 (a)
-- 35
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl8 34
  • 79.64 (n)
MGC75725 34
African clawed frog
(Xenopus laevis)
Amphibia rpl8-prov 34
(Danio rerio)
Actinopterygii rpl8 35 34
  • 80.16 (n)
zgc73105 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8639 34
fruit fly
(Drosophila melanogaster)
Insecta RpL8 34 35 36
  • 74.13 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta RL8_ANOGA 34
  • 71.35 (n)
(Caenorhabditis elegans)
Secernentea rpl-2 34 35 36
  • 67.19 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL2B 35 37
  • 72 (a)
RPL2A 35 34
  • 63.52 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL127C 34
  • 65.22 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16027g 34
  • 63.52 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G51190 34
  • 64.52 (n)
(Glycine max)
eudicotyledons Gma.10752 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.710 34
(Hordeum vulgare)
Liliopsida Hv.12793 34
(Oryza sativa)
Liliopsida Os.11297 34
(Triticum aestivum)
Liliopsida Ta.28331 34
(Zea mays)
Liliopsida Zm.13965 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4346 35
  • 78 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00413 34
  • 65.49 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl801 34
  • 64.69 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15561 34
Species where no ortholog for RPL8 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL8 Gene

Gene Tree for RPL8 (if available)
Gene Tree for RPL8 (if available)

Paralogs for RPL8 Gene

genes like me logo Genes that share paralogs with RPL8: view

No data available for Paralogs for RPL8 Gene

Variants for RPL8 Gene

Sequence variations from dbSNP and Humsavar for RPL8 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1060317 -- 144,790,410(-) GTACC(A/C)CAAAT reference, missense
rs1060859 -- 144,790,364(-) GGTGT(A/G)GCCAT reference, synonymous-codon
rs1061382 -- 144,789,812(-) AGAAA(A/G)AGAAC downstream-variant-500B, reference, missense
rs1064542 -- 144,792,033(-) CCGTG(A/G)ATTTC upstream-variant-2KB, reference, missense
rs1065750 -- 144,791,374(-) TATGC(C/T)ACCGT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RPL8 Gene

Variant ID Type Subtype PubMed ID
nsv522459 CNV loss 19592680
nsv612969 CNV loss 21841781

Variation tolerance for RPL8 Gene

Residual Variation Intolerance Score: 27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL8 Gene

Disorders for RPL8 Gene

Relevant External Links for RPL8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL8 Gene

Publications for RPL8 Gene

  1. Characterization by cDNA cloning of the mRNA of human ribosomal protein L8. (PMID: 7506540) Hanes J. … Scheit K.H. (Biochem. Biophys. Res. Commun. 1993) 2 3 4 22 64
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 64
  3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova T.I. … Karpova G.G. (J. Protein Chem. 2003) 3 4 64

Products for RPL8 Gene

Sources for RPL8 Gene

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