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Aliases for RPL8 Gene

Aliases for RPL8 Gene

  • Ribosomal Protein L8 2 3
  • L8 3

External Ids for RPL8 Gene

Previous GeneCards Identifiers for RPL8 Gene

  • GC08M143622
  • GC08M146052
  • GC08M145619
  • GC08M146019
  • GC08M145985
  • GC08M141130
  • GC08M146015

Summaries for RPL8 Gene

Entrez Gene Summary for RPL8 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL8 Gene

RPL8 (Ribosomal Protein L8) is a Protein Coding gene. Among its related pathways are Infectious disease and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL8 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL8 Gene

Genomics for RPL8 Gene

Regulatory Elements for RPL8 Gene

Transcription factor binding sites by QIAGEN in the RPL8 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RPL8 Gene

144,789,765 bp from pter
144,792,587 bp from pter
2,823 bases
Minus strand

Genomic View for RPL8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL8 Gene

Proteins for RPL8 Gene

  • Protein details for RPL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L8
    Protein Accession:
    Secondary Accessions:
    • A8K094
    • D3DWN2
    • P25120
    • Q567Q7
    • Q969V7
    • Q9BWQ9

    Protein attributes for RPL8 Gene

    257 amino acids
    Molecular mass:
    28025 Da
    Quaternary structure:
    • Interacts with CRY1.
    • This protein can be partially incorporated into E.coli polysomes in vivo, indicating it can replace the endogenous protein

    Three dimensional structures from OCA and Proteopedia for RPL8 Gene

neXtProt entry for RPL8 Gene

Proteomics data for RPL8 Gene at MOPED

Post-translational modifications for RPL8 Gene

  • Hydroxylated on His-216 by NO66. The modification is impaired by hypoxia.
  • Ubiquitination at Lys 10, Lys 60, and Lys 181
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RPL8 Gene

Domains & Families for RPL8 Gene

Gene Families for RPL8 Gene

Suggested Antigen Peptide Sequences for RPL8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L2P family.
  • Belongs to the ribosomal protein L2P family.
genes like me logo Genes that share domains with RPL8: view

Function for RPL8 Gene

Molecular function for RPL8 Gene

GENATLAS Biochemistry:
60S ribosomal protein L8

Gene Ontology (GO) - Molecular Function for RPL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 7506540
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding --
GO:0019843 rRNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL8: view
genes like me logo Genes that share phenotypes with RPL8: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL8 Gene

Localization for RPL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL8 Gene


Subcellular locations from

Jensen Localization Image for RPL8 Gene COMPARTMENTS Subcellular localization image for RPL8 gene
Compartment Confidence
cytosol 5
nucleus 4
chloroplast 1

Gene Ontology (GO) - Cellular Components for RPL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with RPL8: view

Pathways & Interactions for RPL8 Gene

genes like me logo Genes that share pathways with RPL8: view

Pathways by source for RPL8 Gene

1 KEGG pathway for RPL8 Gene
1 GeneGo (Thomson Reuters) pathway for RPL8 Gene

Gene Ontology (GO) - Biological Process for RPL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0002181 cytoplasmic translation IBA --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
genes like me logo Genes that share ontologies with RPL8: view

No data available for SIGNOR curated interactions for RPL8 Gene

Drugs & Compounds for RPL8 Gene

(3) Drugs for RPL8 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
anisomycin Experimental Pharma Target JNK, SAPK and p38 activator 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL8: view

Transcripts for RPL8 Gene

Unigene Clusters for RPL8 Gene

Ribosomal protein L8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RPL8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - -
SP10: - - -
SP11: - - - - - - - - - - - - -
SP12: - -

Relevant External Links for RPL8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL8 Gene

mRNA expression in normal human tissues for RPL8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL8 Gene

SOURCE GeneReport for Unigene cluster for RPL8 Gene Hs.178551

genes like me logo Genes that share expression patterns with RPL8: view

Protein tissue co-expression partners for RPL8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL8 Gene

Orthologs for RPL8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPL8 35
  • 89.88 (n)
  • 100 (a)
-- 36
  • 96 (a)
RPL8 36
  • 100 (a)
(Canis familiaris)
Mammalia RPL8 35
  • 90.66 (n)
  • 100 (a)
RPL8 36
  • 100 (a)
(Mus musculus)
Mammalia Rpl8 35
  • 87.68 (n)
  • 100 (a)
Rpl8 16
Rpl8 36
  • 100 (a)
(Pan troglodytes)
Mammalia RPL8 35
  • 99.22 (n)
  • 100 (a)
RPL8 36
  • 100 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
-- 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia RPL8 36
  • 99 (a)
(Gallus gallus)
Aves RPL8 35
  • 81.97 (n)
  • 98.05 (a)
RPL8 36
  • 98 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 99 (a)
-- 36
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75725 35
rpl8 35
  • 79.64 (n)
  • 97.67 (a)
African clawed frog
(Xenopus laevis)
Amphibia rpl8-prov 35
(Danio rerio)
Actinopterygii rpl8 35
  • 80.16 (n)
  • 96.89 (a)
zgc73105 35
rpl8 36
  • 97 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8639 35
fruit fly
(Drosophila melanogaster)
Insecta RpL8 37
  • 80 (a)
RpL8 35
  • 74.13 (n)
  • 80.8 (a)
RpL8 36
  • 79 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta RL8_ANOGA 35
  • 71.35 (n)
  • 79.3 (a)
(Caenorhabditis elegans)
Secernentea rpl-2 37
  • 73 (a)
rpl-2 35
  • 67.19 (n)
  • 73.54 (a)
rpl-2 36
  • 73 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL127C 35
  • 65.22 (n)
  • 69.69 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16027g 35
  • 63.52 (n)
  • 72.05 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL2A 35
  • 63.52 (n)
  • 71.65 (a)
RPL2A 36
  • 72 (a)
RPL2B 36
  • 72 (a)
RPL2B 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G51190 35
  • 64.52 (n)
  • 70.68 (a)
(Glycine max)
eudicotyledons Gma.10752 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.710 35
(Hordeum vulgare)
Liliopsida Hv.12793 35
(Oryza sativa)
Liliopsida Os.11297 35
(Triticum aestivum)
Liliopsida Ta.28331 35
(Zea mays)
Liliopsida Zm.13965 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15561 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00413 35
  • 65.49 (n)
  • 66.54 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl801 35
  • 64.69 (n)
  • 67.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4346 36
  • 78 (a)
Species with no ortholog for RPL8:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL8 Gene

Gene Tree for RPL8 (if available)
Gene Tree for RPL8 (if available)

Paralogs for RPL8 Gene

genes like me logo Genes that share paralogs with RPL8: view

No data available for Paralogs for RPL8 Gene

Variants for RPL8 Gene

Sequence variations from dbSNP and Humsavar for RPL8 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1060317 -- 144,790,410(-) GTACC(A/C)CAAAT reference, missense
rs1060859 -- 144,790,364(-) GGTGT(A/G)GCCAT synonymous-codon, reference
rs1061382 -- 144,789,812(-) AGAAA(A/G)AGAAC missense, reference
rs1065750 -- 144,791,374(-) TATGC(C/T)ACCGT reference, synonymous-codon
rs2280933 -- 144,789,533(+) CCCAC(A/C)TAAGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RPL8 Gene

Variant ID Type Subtype PubMed ID
nsv891807 CNV Loss 21882294
nsv891897 CNV Loss 21882294
nsv522459 CNV Loss 19592680
nsv891925 CNV Loss 21882294
dgv7985n71 CNV Loss 21882294
nsv891929 CNV Loss 21882294

Variation tolerance for RPL8 Gene

Residual Variation Intolerance Score: 26.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL8 Gene

Disorders for RPL8 Gene

Relevant External Links for RPL8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RPL8: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL8 Gene

Publications for RPL8 Gene

  1. Characterization by cDNA cloning of the mRNA of human ribosomal protein L8. (PMID: 7506540) Hanes J. … Scheit K.H. (Biochem. Biophys. Res. Commun. 1993) 2 23 67
  2. Shared MHC class II-dependent melanoma ribosomal protein L8 identified by phage display. (PMID: 17440064) Swoboda R.K. … Herlyn D. (Cancer Res. 2007) 23 67
  3. Identification of heat shock protein 90 and other proteins as tumour antigens by serological screening of an ovarian carcinoma expression library. (PMID: 12177805) Luo L.Y. … Diamandis E.P. (Br. J. Cancer 2002) 23 67
  4. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 67
  5. Approaches to determine the specific role of the delta isoform of protein kinase C. (PMID: 9507372) Garrone B. … Watters D. (J. Biochem. Biophys. Methods 1997) 23 67

Products for RPL8 Gene

Sources for RPL8 Gene

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