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Aliases for RPL8 Gene

Aliases for RPL8 Gene

  • Ribosomal Protein L8 2 3 5
  • L8 3

External Ids for RPL8 Gene

Previous GeneCards Identifiers for RPL8 Gene

  • GC08M143622
  • GC08M146052
  • GC08M145619
  • GC08M146019
  • GC08M145985
  • GC08M141130
  • GC08M146015

Summaries for RPL8 Gene

Entrez Gene Summary for RPL8 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL8 Gene

RPL8 (Ribosomal Protein L8) is a Protein Coding gene. Diseases associated with RPL8 include Giant Axonal Neuropathy. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL8 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL8 Gene

Genomics for RPL8 Gene

Regulatory Elements for RPL8 Gene

Enhancers for RPL8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPL8 on UCSC Golden Path with GeneCards custom track

Promoters for RPL8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL8 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the RPL8 gene promoter:

Genomic Location for RPL8 Gene

Chromosome:
8
Start:
144,789,765 bp from pter
End:
144,792,587 bp from pter
Size:
2,823 bases
Orientation:
Minus strand

Genomic View for RPL8 Gene

Genes around RPL8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL8 Gene

Proteins for RPL8 Gene

  • Protein details for RPL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62917-RL8_HUMAN
    Recommended name:
    60S ribosomal protein L8
    Protein Accession:
    P62917
    Secondary Accessions:
    • A8K094
    • D3DWN2
    • P25120
    • Q567Q7
    • Q969V7
    • Q9BWQ9

    Protein attributes for RPL8 Gene

    Size:
    257 amino acids
    Molecular mass:
    28025 Da
    Quaternary structure:
    • Interacts with CRY1.
    Miscellaneous:
    • This protein can be partially incorporated into E.coli polysomes in vivo, indicating it can replace the endogenous protein.

    Three dimensional structures from OCA and Proteopedia for RPL8 Gene

neXtProt entry for RPL8 Gene

Proteomics data for RPL8 Gene at MOPED

Post-translational modifications for RPL8 Gene

  • Hydroxylated on His-216 by NO66. The modification is impaired by hypoxia.
  • Ubiquitination at Lys 10, Lys 60, and Lys 181
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RPL8 Gene

Domains & Families for RPL8 Gene

Gene Families for RPL8 Gene

Suggested Antigen Peptide Sequences for RPL8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62917

UniProtKB/Swiss-Prot:

RL8_HUMAN :
  • Belongs to the ribosomal protein L2P family.
Family:
  • Belongs to the ribosomal protein L2P family.
genes like me logo Genes that share domains with RPL8: view

Function for RPL8 Gene

Molecular function for RPL8 Gene

GENATLAS Biochemistry:
60S ribosomal protein L8

Gene Ontology (GO) - Molecular Function for RPL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with RPL8: view
genes like me logo Genes that share phenotypes with RPL8: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL8 Gene

Localization for RPL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL8 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL8 Gene COMPARTMENTS Subcellular localization image for RPL8 gene
Compartment Confidence
cytosol 5
nucleus 5
chloroplast 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL8: view

Pathways & Interactions for RPL8 Gene

genes like me logo Genes that share pathways with RPL8: view

Pathways by source for RPL8 Gene

Gene Ontology (GO) - Biological Process for RPL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002181 cytoplasmic translation IBA --
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL8: view

No data available for SIGNOR curated interactions for RPL8 Gene

Drugs & Compounds for RPL8 Gene

(3) Drugs for RPL8 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
anisomycin Experimental Pharma Target JNK, SAPK and p38 activator 0
puromycin Experimental Pharma Target 0
genes like me logo Genes that share compounds with RPL8: view

Transcripts for RPL8 Gene

Unigene Clusters for RPL8 Gene

Ribosomal protein L8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: - - -
SP10: - - -
SP11: - - - - - - - - - - - - -
SP12: - -

Relevant External Links for RPL8 Gene

GeneLoc Exon Structure for
RPL8
ECgene alternative splicing isoforms for
RPL8

Expression for RPL8 Gene

mRNA expression in normal human tissues for RPL8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL8 Gene



SOURCE GeneReport for Unigene cluster for RPL8 Gene Hs.178551

genes like me logo Genes that share expression patterns with RPL8: view

Protein tissue co-expression partners for RPL8 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL8 Gene

Orthologs for RPL8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPL8 35
  • 89.88 (n)
  • 100 (a)
-- 36
  • 96 (a)
OneToMany
RPL8 36
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPL8 35
  • 90.66 (n)
  • 100 (a)
RPL8 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl8 35
  • 87.68 (n)
  • 100 (a)
Rpl8 16
Rpl8 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPL8 35
  • 99.22 (n)
  • 100 (a)
RPL8 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RPL8 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL8 35
  • 81.97 (n)
  • 98.05 (a)
RPL8 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 99 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75725 35
rpl8 35
  • 79.64 (n)
  • 97.67 (a)
African clawed frog
(Xenopus laevis)
Amphibia rpl8-prov 35
zebrafish
(Danio rerio)
Actinopterygii rpl8 35
  • 80.16 (n)
  • 96.89 (a)
zgc73105 35
rpl8 36
  • 97 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8639 35
fruit fly
(Drosophila melanogaster)
Insecta RpL8 37
  • 80 (a)
RpL8 35
  • 74.13 (n)
  • 80.8 (a)
RpL8 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta RL8_ANOGA 35
  • 71.35 (n)
  • 79.3 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-2 37
  • 73 (a)
rpl-2 35
  • 67.19 (n)
  • 73.54 (a)
rpl-2 36
  • 73 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL127C 35
  • 65.22 (n)
  • 69.69 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16027g 35
  • 63.52 (n)
  • 72.05 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL2A 35
  • 63.52 (n)
  • 71.65 (a)
RPL2A 36
  • 72 (a)
OneToMany
RPL2B 36
  • 72 (a)
OneToMany
RPL2B 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G51190 35
  • 64.52 (n)
  • 70.68 (a)
soybean
(Glycine max)
eudicotyledons Gma.10752 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.710 35
barley
(Hordeum vulgare)
Liliopsida Hv.12793 35
rice
(Oryza sativa)
Liliopsida Os.11297 35
wheat
(Triticum aestivum)
Liliopsida Ta.28331 35
corn
(Zea mays)
Liliopsida Zm.13965 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15561 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00413 35
  • 65.49 (n)
  • 66.54 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl801 35
  • 64.69 (n)
  • 67.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4346 36
  • 78 (a)
OneToOne
Species with no ortholog for RPL8:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPL8 Gene

ENSEMBL:
Gene Tree for RPL8 (if available)
TreeFam:
Gene Tree for RPL8 (if available)

Paralogs for RPL8 Gene

genes like me logo Genes that share paralogs with RPL8: view

No data available for Paralogs for RPL8 Gene

Variants for RPL8 Gene

Sequence variations from dbSNP and Humsavar for RPL8 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_019658 -
rs2280933 -- 144,789,533(+) CCCAC(A/C)TAAGT downstream-variant-500B
rs2958513 -- 144,790,080(+) TGCCG(C/G)TAGAC intron-variant
rs2958517 -- 144,793,993(+) TTCAC(A/G)GGAGA upstream-variant-2KB
rs2958518 -- 144,794,228(+) TTATT(C/G)TTAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL8 Gene

Variant ID Type Subtype PubMed ID
nsv891807 CNV Loss 21882294
nsv891897 CNV Loss 21882294
nsv522459 CNV Loss 19592680
nsv891925 CNV Loss 21882294
dgv7985n71 CNV Loss 21882294
nsv891929 CNV Loss 21882294

Variation tolerance for RPL8 Gene

Residual Variation Intolerance Score: 27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RPL8 Gene

Disorders for RPL8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPL8 Gene - From: GeneCards

Disorder Aliases PubMed IDs
giant axonal neuropathy
  • gan
- elite association - COSMIC cancer census association via MalaCards
Search RPL8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPL8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL8
genes like me logo Genes that share disorders with RPL8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPL8 Gene

Publications for RPL8 Gene

  1. Characterization by cDNA cloning of the mRNA of human ribosomal protein L8. (PMID: 7506540) Hanes J. … Scheit K.H. (Biochem. Biophys. Res. Commun. 1993) 2 3 4 23 67
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3
  3. The Dual Estrogen Receptor I+ Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. (PMID: 26487511) Han S.J. … O'Malley B.W. (Mol. Pharmacol. 2016) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for RPL8 Gene

Sources for RPL8 Gene

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