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Aliases for RPL5 Gene

Aliases for RPL5 Gene

  • Ribosomal Protein L5 2 3
  • DBA6 3 6
  • Protein Phosphatase 1, Regulatory Subunit 135 3
  • 60S Ribosomal Protein L5 3
  • Regulatory Subunit 135 2
  • Protein Phosphatase 1 2
  • PPP1R135 3
  • MSTP030 3
  • L5 3

External Ids for RPL5 Gene

Summaries for RPL5 Gene

Entrez Gene Summary for RPL5 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18P family of ribosomal proteins. It is located in the cytoplasm. The protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The protein interacts specifically with the beta subunit of casein kinase II. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL5 Gene

RPL5 (Ribosomal Protein L5) is a Protein Coding gene. Diseases associated with RPL5 include diamond-blackfan anemia 6 and rpl5-related diamond-blackfan anemia. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and 5S rRNA binding.

UniProtKB/Swiss-Prot for RPL5 Gene

  • Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA.

Gene Wiki entry for RPL5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL5 Gene

Genomics for RPL5 Gene

Genomic Location for RPL5 Gene

92,832,025 bp from pter
92,841,924 bp from pter
9,900 bases
Plus strand

Genomic View for RPL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL5 Gene

Regulatory Elements for RPL5 Gene

Proteins for RPL5 Gene

  • Protein details for RPL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L5
    Protein Accession:
    Secondary Accessions:
    • Q32LZ3
    • Q53HH6
    • Q9H3F4

    Protein attributes for RPL5 Gene

    297 amino acids
    Molecular mass:
    34363 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL5 Gene

neXtProt entry for RPL5 Gene

Proteomics data for RPL5 Gene at MOPED

Post-translational modifications for RPL5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys5, Lys27, Lys164, Lys197, and Lys221

Other Protein References for RPL5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RPL5 Gene

Domains for RPL5 Gene

Gene Families for RPL5 Gene

  • RPL :L ribosomal proteins


  • Belongs to the ribosomal protein L18P family.:
    • P46777
genes like me logo Genes that share domains with RPL5: view

Function for RPL5 Gene

Molecular function for RPL5 Gene

GENATLAS Biochemistry: 60S ribosomal protein L5
UniProtKB/Swiss-Prot Function: Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA.

Gene Ontology (GO) - Molecular Function for RPL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 7772601
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0005515 protein binding IPI 12054647
GO:0008097 5S rRNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL5: view
genes like me logo Genes that share phenotypes with RPL5: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL5 Gene

Localization for RPL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL5 Gene

Cytoplasm. Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for RPL5 Gene COMPARTMENTS Subcellular localization image for RPL5 gene
Compartment Confidence
cytosol 5
nucleus 5
chloroplast 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 9687515
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RPL5: view

Pathways for RPL5 Gene

genes like me logo Genes that share pathways with RPL5: view

Pathways by source for RPL5 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RPL5 Gene
2 BioSystems pathways for RPL5 Gene

Gene Ontology (GO) - Biological Process for RPL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing IMP 18697920
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
genes like me logo Genes that share ontologies with RPL5: view

Compounds for RPL5 Gene

(3) Novoseek inferred chemical compound relationships for RPL5 Gene

Compound -log(P) Hits PubMed IDs
5s-rrna 87.5 3
rrna 47.7 5
zinc 12.4 1
genes like me logo Genes that share compounds with RPL5: view

Transcripts for RPL5 Gene

Unigene Clusters for RPL5 Gene

Ribosomal protein L5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL5 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - -
SP5: -
SP6: - -
SP9: -

Relevant External Links for RPL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL5 Gene

mRNA expression in normal human tissues for RPL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL5 Gene

SOURCE GeneReport for Unigene cluster for RPL5 Gene Hs.532359

genes like me logo Genes that share expressions with RPL5: view

Orthologs for RPL5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL5 36
  • 99.78 (n)
  • 100 (a)
RPL5 37
  • 100 (a)
(Bos Taurus)
Mammalia RPL5 36
  • 91.36 (n)
  • 98.65 (a)
RPL5 37
  • 98 (a)
(Canis familiaris)
Mammalia RPL5 36
  • 92.26 (n)
  • 99.66 (a)
RPL5 37
  • 99 (a)
(Mus musculus)
Mammalia Rpl5 36
  • 92.03 (n)
  • 98.32 (a)
Rpl5 16
Rpl5 37
  • 98 (a)
(Monodelphis domestica)
Mammalia RPL5 37
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 85 (a)
-- 37
  • 98 (a)
(Rattus norvegicus)
Mammalia Rpl5 36
  • 90.24 (n)
  • 98.65 (a)
(Gallus gallus)
Aves RPL5 36
  • 83.16 (n)
  • 95.29 (a)
RPL5 37
  • 95 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 96 (a)
-- 37
  • 91 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52733 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75757 36
rpl5 36
  • 81.18 (n)
  • 92.52 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8270 36
(Danio rerio)
Actinopterygii mgcb01f08 36
rpl5a 37
  • 85 (a)
rpl5b 36
  • 76.86 (n)
  • 88.32 (a)
rpl5b 37
  • 87 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta RL5_ANOGA 36
  • 64.27 (n)
  • 72.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL5 36
  • 63.54 (n)
  • 69.1 (a)
RpL5 37
  • 67 (a)
yip6 38
  • 62 (a)
(Caenorhabditis elegans)
Secernentea rpl-5 36
  • 57.96 (n)
  • 58.76 (a)
rpl-5 37
  • 59 (a)
rpl-5 38
  • 64 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR104C 36
  • 54.87 (n)
  • 52.58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL5 36
  • 56.21 (n)
  • 50.52 (a)
RPL5 37
  • 49 (a)
RPL5 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D06941g 36
  • 55.44 (n)
  • 52.23 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.22 36
thale cress
(Arabidopsis thaliana)
eudicotyledons RPL5B 36
  • 60.52 (n)
  • 57.45 (a)
(Hordeum vulgare)
Liliopsida Hv.10282 36
(Oryza sativa)
Liliopsida Os.9738 36
Os01g0896800 36
  • 60.02 (n)
  • 57.65 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04331 36
  • 57.2 (n)
  • 58 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl502 36
  • 56.13 (n)
  • 53.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7866 37
  • 75 (a)
Species with no ortholog for RPL5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL5 Gene

Gene Tree for RPL5 (if available)
Gene Tree for RPL5 (if available)

Paralogs for RPL5 Gene

genes like me logo Genes that share paralogs with RPL5: view

No data available for Paralogs for RPL5 Gene

Variants for RPL5 Gene

Sequence variations from dbSNP and Humsavar for RPL5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs11540837 -- 92,832,062(+) CGCCG(A/G)CTGGG utr-variant-5-prime
rs28365860 -- 92,831,846(+) CTCCC(-/C)TGCTC upstream-variant-2KB
rs34168045 -- 92,830,596(+) CCAAA(A/G)TGCTG upstream-variant-2KB
rs34244251 -- 92,831,623(+) CTGGG(A/G)GTGAG upstream-variant-2KB
rs35031391 -- 92,830,689(+) CGCCA(A/G)GCTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL5 Gene

Variant ID Type Subtype PubMed ID
esv2714684 CNV Deletion 23290073
nsv508393 CNV Loss 20534489

Relevant External Links for RPL5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

Disorders for RPL5 Gene

(1) OMIM Diseases for RPL5 Gene (603634)


  • Diamond-Blackfan anemia 6 (DBA6) [MIM:612561]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:19061985, ECO:0000269 PubMed:19191325}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for RPL5 Gene

Relevant External Links for RPL5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RPL5: view

Publications for RPL5 Gene

  1. Interaction of the beta subunit of casein kinase II with the ribosomal protein L5. (PMID: 8806611) Kim J.-M. … Bae Y.-S. (Biochem. Biophys. Res. Commun. 1996) 3 4 23
  2. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio J.-M. … Iovanna J.L. (Biochim. Biophys. Acta 1995) 2 3 4
  3. U21, a novel small nucleolar RNA with a 13 nt. complementarity to 28S rRNA, is encoded in an intron of ribosomal protein L5 gene in chicken and mammals. (PMID: 7937132) Qu L.H. … Bachellerie J.-P. (Nucleic Acids Res. 1994) 2 3 4
  4. Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. (PMID: 19061985) Gazda H.T. … Beggs A.H. (Am. J. Hum. Genet. 2008) 3 4 23
  5. Identification of mutations in the ribosomal protein L5 (RPL5) and ribosomal protein L11 (RPL11) genes in Czech patients with Diamond- Blackfan anemia. (PMID: 19191325) Cmejla R. … Pospisilova D. (Hum. Mutat. 2009) 3 4 23

Products for RPL5 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RPL5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RPL5
    • Block miRNA regulation of RPL5 using miScript Target Protectors

    Sources for RPL5 Gene

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