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Aliases for RPL5 Gene

Aliases for RPL5 Gene

  • Ribosomal Protein L5 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 135 3
  • Regulatory Subunit 135 2
  • Protein Phosphatase 1 2
  • PPP1R135 3
  • MSTP030 3
  • DBA6 3
  • L5 3

External Ids for RPL5 Gene

Previous GeneCards Identifiers for RPL5 Gene

  • GC01P093703
  • GC01P092503
  • GC01P092635
  • GC01P093009
  • GC01P093297

Summaries for RPL5 Gene

Entrez Gene Summary for RPL5 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18P family of ribosomal proteins. It is located in the cytoplasm. The protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The protein interacts specifically with the beta subunit of casein kinase II. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL5 Gene

RPL5 (Ribosomal Protein L5) is a Protein Coding gene. Diseases associated with RPL5 include diamond-blackfan anemia 6 and diamond-blackfan anemia. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for RPL5 Gene

  • Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA.

Gene Wiki entry for RPL5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL5 Gene

Genomics for RPL5 Gene

Regulatory Elements for RPL5 Gene

Promoters for RPL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL5 Gene

Chromosome:
1
Start:
92,832,025 bp from pter
End:
92,841,924 bp from pter
Size:
9,900 bases
Orientation:
Plus strand

Genomic View for RPL5 Gene

Genes around RPL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL5 Gene

Proteins for RPL5 Gene

  • Protein details for RPL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46777-RL5_HUMAN
    Recommended name:
    60S ribosomal protein L5
    Protein Accession:
    P46777
    Secondary Accessions:
    • Q32LZ3
    • Q53HH6
    • Q9H3F4

    Protein attributes for RPL5 Gene

    Size:
    297 amino acids
    Molecular mass:
    34363 Da
    Quaternary structure:
    • Interacts with isoform 1 of NVL in an ATP-dependent manner.

    Three dimensional structures from OCA and Proteopedia for RPL5 Gene

neXtProt entry for RPL5 Gene

Proteomics data for RPL5 Gene at MOPED

Post-translational modifications for RPL5 Gene

  • Ubiquitination at Lys 5, Lys 27, Lys 164, Lys 197, and Lys 221
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RPL5 (RPL5)

No data available for DME Specific Peptides for RPL5 Gene

Domains & Families for RPL5 Gene

Graphical View of Domain Structure for InterPro Entry

P46777

UniProtKB/Swiss-Prot:

RL5_HUMAN :
  • Belongs to the ribosomal protein L18P family.
Family:
  • Belongs to the ribosomal protein L18P family.
genes like me logo Genes that share domains with RPL5: view

Function for RPL5 Gene

Molecular function for RPL5 Gene

GENATLAS Biochemistry:
60S ribosomal protein L5
UniProtKB/Swiss-Prot Function:
Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA.

Gene Ontology (GO) - Molecular Function for RPL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 9465063
genes like me logo Genes that share ontologies with RPL5: view
genes like me logo Genes that share phenotypes with RPL5: view

Human Phenotype Ontology for RPL5 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL5 Gene

Localization for RPL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL5 Gene

Cytoplasm. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL5 Gene COMPARTMENTS Subcellular localization image for RPL5 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for RPL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA 15469983
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL5: view

Pathways & Interactions for RPL5 Gene

genes like me logo Genes that share pathways with RPL5: view

Pathways by source for RPL5 Gene

2 BioSystems pathways for RPL5 Gene
1 KEGG pathway for RPL5 Gene
1 GeneGo (Thomson Reuters) pathway for RPL5 Gene

SIGNOR curated interactions for RPL5 Gene

Activates:

Gene Ontology (GO) - Biological Process for RPL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing IMP,TAS --
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0016032 viral process TAS --
genes like me logo Genes that share ontologies with RPL5: view

Drugs & Compounds for RPL5 Gene

(1) Drugs for RPL5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for RPL5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RPL5: view

Transcripts for RPL5 Gene

Unigene Clusters for RPL5 Gene

Ribosomal protein L5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL5 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - -
SP5: -
SP6: - -
SP7:
SP8:
SP9: -

Relevant External Links for RPL5 Gene

GeneLoc Exon Structure for
RPL5
ECgene alternative splicing isoforms for
RPL5

Expression for RPL5 Gene

mRNA expression in normal human tissues for RPL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL5 Gene

This gene is overexpressed in Tlymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL5 Gene



SOURCE GeneReport for Unigene cluster for RPL5 Gene Hs.532359

genes like me logo Genes that share expression patterns with RPL5: view

Protein tissue co-expression partners for RPL5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL5 Gene

Orthologs for RPL5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPL5 35
  • 91.36 (n)
  • 98.65 (a)
RPL5 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPL5 35
  • 92.26 (n)
  • 99.66 (a)
RPL5 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rpl5 35
  • 92.03 (n)
  • 98.32 (a)
Rpl5 16
Rpl5 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPL5 35
  • 99.78 (n)
  • 100 (a)
RPL5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl5 35
  • 90.24 (n)
  • 98.65 (a)
oppossum
(Monodelphis domestica)
Mammalia RPL5 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
chicken
(Gallus gallus)
Aves RPL5 35
  • 83.16 (n)
  • 95.29 (a)
RPL5 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 96 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75757 35
rpl5 35
  • 81.18 (n)
  • 92.52 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52733 35
zebrafish
(Danio rerio)
Actinopterygii mgcb01f08 35
rpl5b 35
  • 76.86 (n)
  • 88.32 (a)
rpl5a 36
  • 85 (a)
OneToMany
rpl5b 36
  • 87 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8270 35
fruit fly
(Drosophila melanogaster)
Insecta yip6 37
  • 62 (a)
RpL5 35
  • 63.54 (n)
  • 69.1 (a)
RpL5 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta RL5_ANOGA 35
  • 64.27 (n)
  • 72.4 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-5 37
  • 64 (a)
rpl-5 35
  • 57.96 (n)
  • 58.76 (a)
rpl-5 36
  • 59 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR104C 35
  • 54.87 (n)
  • 52.58 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D06941g 35
  • 55.44 (n)
  • 52.23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL5 35
  • 56.21 (n)
  • 50.52 (a)
RPL5 36
  • 49 (a)
OneToOne
RPL5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons RPL5B 35
  • 60.52 (n)
  • 57.45 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.22 35
barley
(Hordeum vulgare)
Liliopsida Hv.10282 35
rice
(Oryza sativa)
Liliopsida Os.9738 35
Os01g0896800 35
  • 60.02 (n)
  • 57.65 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04331 35
  • 57.2 (n)
  • 58 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl502 35
  • 56.13 (n)
  • 53.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7866 36
  • 75 (a)
OneToOne
Species with no ortholog for RPL5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL5 Gene

ENSEMBL:
Gene Tree for RPL5 (if available)
TreeFam:
Gene Tree for RPL5 (if available)

Paralogs for RPL5 Gene

genes like me logo Genes that share paralogs with RPL5: view

No data available for Paralogs for RPL5 Gene

Variants for RPL5 Gene

Sequence variations from dbSNP and Humsavar for RPL5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_052009 -
VAR_055450 Diamond-Blackfan anemia 6 (DBA6)
VAR_055451 Diamond-Blackfan anemia 6 (DBA6)
rs34168045 -- 92,830,596(+) CCAAA(A/G)TGCTG upstream-variant-2KB
rs34244251 -- 92,831,623(+) CTGGG(A/G)GTGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL5 Gene

Variant ID Type Subtype PubMed ID
esv2714684 CNV Deletion 23290073
nsv508393 CNV Loss 20534489

Variation tolerance for RPL5 Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL5 Gene

HapMap Linkage Disequilibrium report
RPL5
Human Gene Mutation Database (HGMD)
RPL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL5 Gene

Disorders for RPL5 Gene

MalaCards: The human disease database

(7) MalaCards diseases for RPL5 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia 6
  • diamond-blackfan anemia 1
diamond-blackfan anemia
  • blackfan - diamond syndrome
rpl5-related diamond-blackfan anemia
  • diamond-blackfan anemia 6
macrocytic anemia
  • anemia macrocytic
pierre robin syndrome
  • pierre robin sequence
- elite association - COSMIC cancer census association via MalaCards
Search RPL5 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RL5_HUMAN
  • Diamond-Blackfan anemia 6 (DBA6) [MIM:612561]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:19061985, ECO:0000269 PubMed:19191325}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RPL5

Genetic Association Database (GAD)
RPL5
Human Genome Epidemiology (HuGE) Navigator
RPL5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL5
genes like me logo Genes that share disorders with RPL5: view

No data available for Genatlas for RPL5 Gene

Publications for RPL5 Gene

  1. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio J.-M. … Iovanna J.L. (Biochim. Biophys. Acta 1995) 2 3 4 67
  2. Identification of mutations in the ribosomal protein L5 (RPL5) and ribosomal protein L11 (RPL11) genes in Czech patients with Diamond- Blackfan anemia. (PMID: 19191325) Cmejla R. … Pospisilova D. (Hum. Mutat. 2009) 3 23
  3. Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2. (PMID: 18426907) Dai M.S. … Lu H. (Mol. Cell. Biol. 2008) 3 23
  4. Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway. (PMID: 18560357) Horn H.F. … Vousden K.H. (Oncogene 2008) 3 23
  5. Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. (PMID: 19061985) Gazda H.T. … Beggs A.H. (Am. J. Hum. Genet. 2008) 3 23

Products for RPL5 Gene

Sources for RPL5 Gene

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