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Aliases for RPL4 Gene

Aliases for RPL4 Gene

  • Ribosomal Protein L4 2 3 5
  • Large Ribosomal Subunit Protein UL4 3 4
  • 60S Ribosomal Protein L4 2 3
  • 60S Ribosomal Protein L1 3 4
  • RPL1 4
  • L4 3

External Ids for RPL4 Gene

Previous GeneCards Identifiers for RPL4 Gene

  • GC15M062584
  • GC15M059890
  • GC15M064370
  • GC15M064507
  • GC15M064578
  • GC15M066790
  • GC15M043627

Summaries for RPL4 Gene

Entrez Gene Summary for RPL4 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L4E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL4 Gene

RPL4 (Ribosomal Protein L4) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and rRNA processing in the nucleus and cytosol. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL4 Gene

Genomics for RPL4 Gene

Regulatory Elements for RPL4 Gene

Enhancers for RPL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G066408 1.7 FANTOM5 Ensembl dbSUPER 10.2 +115.6 115632 1.0 PKNOX1 AGO1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF263 SP3 SNAPC5 SNORD16 SNORD18A SNORD18B SNORD18C ZWILCH RPL4 DIS3L MAP2K1 LOC105370868
GH15G066768 1.7 Ensembl ENCODE dbSUPER 9.9 -247.4 -247438 6.2 DMAP1 FEZF1 YY1 ZNF416 ZNF143 ZNF263 SP3 SSRP1 ZNF610 GLIS1 ENSG00000260773 SNORD16 LOC646358 RPL35AP32 IQCH-AS1 RPL4 ZWILCH SNORD18A GC15M066763 ENSG00000274995
GH15G066410 1.4 Ensembl ENCODE dbSUPER 10.4 +113.1 113142 1.6 WRNIP1 SIN3A ZNF48 ZNF2 ZNF335 GLIS2 ZNF391 EGR2 ZNF263 YY2 TIPIN SNAPC5 ENSG00000260773 MAP2K1 LOC646358 SLC24A1 SNORD18C ZWILCH SNORD16 SNORD18A
GH15G066734 1.4 Ensembl ENCODE dbSUPER 10.1 -210.9 -210877 1.1 ATF1 CBX3 PKNOX1 ARNT NFIB ZSCAN4 EGR1 SCRT2 FOS CREM RPL4 ZWILCH SNORD16 SNORD18A ENSG00000274995 PIR60751
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL4 on UCSC Golden Path with GeneCards custom track

Promoters for RPL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000078185 -45 3001 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D

Genomic Location for RPL4 Gene

66,498,015 bp from pter
66,524,532 bp from pter
26,518 bases
Minus strand

Genomic View for RPL4 Gene

Genes around RPL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL4 Gene

Proteins for RPL4 Gene

  • Protein details for RPL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L4
    Protein Accession:
    Secondary Accessions:
    • A8K502
    • P39029
    • Q4VBR0
    • Q969Z9

    Protein attributes for RPL4 Gene

    427 amino acids
    Molecular mass:
    47697 Da
    Quaternary structure:
    • May bind IPO9 with low affinity. Interacts with RBM3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for RPL4 Gene

neXtProt entry for RPL4 Gene

Post-translational modifications for RPL4 Gene

  • Citrullinated by PADI4.
  • Ubiquitination at Lys20, isoforms=29, Lys46, Lys106, isoforms=140, isoforms=157, isoforms=165, Lys175, isoforms=219, isoforms=234, Lys239, isoforms=259, Lys274, isoforms=283, Lys327, Lys333, and isoforms=353
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL4 Gene

No data available for DME Specific Peptides for RPL4 Gene

Domains & Families for RPL4 Gene

Gene Families for RPL4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the universal ribosomal protein uL4 family.
  • Belongs to the universal ribosomal protein uL4 family.
genes like me logo Genes that share domains with RPL4: view

Function for RPL4 Gene

Molecular function for RPL4 Gene

GENATLAS Biochemistry:
60S ribosomal protein L4

Gene Ontology (GO) - Molecular Function for RPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,IDA 22658674
GO:0003735 structural constituent of ribosome IEA,NAS 12962325
GO:0005515 protein binding IPI 22720776
genes like me logo Genes that share ontologies with RPL4: view
genes like me logo Genes that share phenotypes with RPL4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPL4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL4 Gene

Localization for RPL4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL4 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005730 nucleolus IDA 16791210
GO:0005737 cytoplasm IDA 16791210
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPL4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL4 Gene

Pathways & Interactions for RPL4 Gene

genes like me logo Genes that share pathways with RPL4: view

Pathways by source for RPL4 Gene

1 KEGG pathway for RPL4 Gene
1 GeneGo (Thomson Reuters) pathway for RPL4 Gene

Gene Ontology (GO) - Biological Process for RPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL4: view

No data available for SIGNOR curated interactions for RPL4 Gene

Drugs & Compounds for RPL4 Gene

(2) Drugs for RPL4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RPL4: view

Transcripts for RPL4 Gene

Unigene Clusters for RPL4 Gene

Ribosomal protein L4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPL4

Alternative Splicing Database (ASD) splice patterns (SP) for RPL4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1: - - - - -
SP2: -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - -
SP8: - - - -
SP10: -

Relevant External Links for RPL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL4 Gene

Protein tissue co-expression partners for RPL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL4 Gene:


SOURCE GeneReport for Unigene cluster for RPL4 Gene:


Evidence on tissue expression from TISSUES for RPL4 Gene

  • Blood(5)
  • Liver(5)
  • Muscle(5)
  • Nervous system(5)
  • Eye(4.9)
  • Intestine(4.9)
  • Lung(4.9)
  • Skin(4.9)
  • Pancreas(4.8)
  • Kidney(4.7)
  • Stomach(4.6)
  • Bone(4.5)
  • Heart(4)
  • Spleen(3.6)
  • Thyroid gland(3.2)
  • Bone marrow(2.6)
  • Lymph node(2.6)
  • Adrenal gland(2.5)
  • Gall bladder(2.2)
genes like me logo Genes that share expression patterns with RPL4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL4 Gene

Orthologs for RPL4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 97 (a)
-- 35
  • 93 (a)
-- 35
  • 75 (a)
(Canis familiaris)
Mammalia RPL4 35 35
  • 96 (a)
-- 35
  • 95 (a)
(Bos Taurus)
Mammalia RPL4 34 35
  • 91.55 (n)
-- 35
  • 89 (a)
(Pan troglodytes)
Mammalia RPL4 34 35
  • 88.89 (n)
(Rattus norvegicus)
Mammalia Rpl4 34
  • 87.18 (n)
(Mus musculus)
Mammalia Rpl4 34 16 35
  • 85.52 (n)
(Monodelphis domestica)
Mammalia RPL4 35
  • 84 (a)
(Gallus gallus)
Aves RPL4 34 35
  • 80.73 (n)
(Anolis carolinensis)
Reptilia RPL4 35
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl4 34
  • 76.58 (n)
Str.8811 34
African clawed frog
(Xenopus laevis)
Amphibia MGC64318 34
(Danio rerio)
Actinopterygii rpl4 34 35
  • 76.15 (n)
wufa97a02 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.806 34
fruit fly
(Drosophila melanogaster)
Insecta RpL1 36
  • 62 (a)
RpL4 34 35
  • 61.88 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002306 34
  • 59.62 (n)
(Caenorhabditis elegans)
Secernentea rpl-4 36 34 35
  • 58.59 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR191C 34
  • 61.13 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL4A 34 35 37
  • 60.59 (n)
RPL4B 35
  • 57 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B07139g 34
  • 60.08 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09630 34
  • 57.48 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1107 34
(Oryza sativa)
Liliopsida Os07g0180900 34
  • 55.65 (n)
Os.8767 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4071 35
  • 67 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl401 34
  • 60.37 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03757 34
  • 56.5 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5831 34
Species where no ortholog for RPL4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL4 Gene

Gene Tree for RPL4 (if available)
Gene Tree for RPL4 (if available)

Paralogs for RPL4 Gene

No data available for Paralogs for RPL4 Gene

Variants for RPL4 Gene

Sequence variations from dbSNP and Humsavar for RPL4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000194503 -- 66,500,899(+) GAATG(C/T)TAATA intron-variant, downstream-variant-500B
rs1000289102 -- 66,505,351(+) AGCGG(A/C/G)TGAAC nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000408247 -- 66,503,846(+) TGTCT(A/C)CCCGG intron-variant, upstream-variant-2KB
rs1000482133 -- 66,505,594(+) AAAAC(A/G)TGTAC intron-variant, upstream-variant-2KB
rs1000707260 -- 66,501,605(+) CACAA(G/T)AACTT intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL4 Gene

Variant ID Type Subtype PubMed ID
nsv974591 CNV duplication 23825009

Variation tolerance for RPL4 Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL4 Gene

Disorders for RPL4 Gene

Relevant External Links for RPL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL4 Gene

Publications for RPL4 Gene

  1. Human ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein. (PMID: 8268230) Bagni C. … Amaldi F. (Biochim. Biophys. Acta 1993) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. (PMID: 11823430) Jaekel S. … Goerlich D. (EMBO J. 2002) 3 4 64
  4. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M. … Kenmochi N. (Genome Res. 2002) 3 4 64
  5. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 64

Products for RPL4 Gene

Sources for RPL4 Gene

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