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Aliases for RPL3 Gene

Aliases for RPL3 Gene

  • Ribosomal Protein L3 2 3
  • HIV-1 TAR RNA-Binding Protein B 3 4
  • TARBP-B 3 4
  • 60S Ribosomal Protein L3 3
  • Hypothetical Protein 3
  • ASC-1 3
  • L3 3

External Ids for RPL3 Gene

Previous GeneCards Identifiers for RPL3 Gene

  • GC22M036323
  • GC22M037951
  • GC22M038033
  • GC22M038046
  • GC22M039710
  • GC22M039717
  • GC22M039719
  • GC22M039721
  • GC22M039723
  • GC22M039728
  • GC22M039821
  • GC22M040108

Summaries for RPL3 Gene

Entrez Gene Summary for RPL3 Gene

  • Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL3 Gene

RPL3 (Ribosomal Protein L3) is a Protein Coding gene. Diseases associated with RPL3 include hiv-1. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include RNA binding and structural constituent of ribosome. An important paralog of this gene is RPL3L.

UniProtKB/Swiss-Prot for RPL3 Gene

  • The L3 protein is a component of the large subunit of cytoplasmic ribosomes

Gene Wiki entry for RPL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL3 Gene

Genomics for RPL3 Gene

Regulatory Elements for RPL3 Gene

Genomic Location for RPL3 Gene

Start:
39,312,882 bp from pter
End:
39,320,389 bp from pter
Size:
7,508 bases
Orientation:
Minus strand

Genomic View for RPL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL3 Gene

Proteins for RPL3 Gene

  • Protein details for RPL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P39023-RL3_HUMAN
    Recommended name:
    60S ribosomal protein L3
    Protein Accession:
    P39023
    Secondary Accessions:
    • B2RDV9
    • Q15548
    • Q5I0G0

    Protein attributes for RPL3 Gene

    Size:
    403 amino acids
    Molecular mass:
    46109 Da
    Quaternary structure:
    • Interacts with METTL18.

    Three dimensional structures from OCA and Proteopedia for RPL3 Gene

neXtProt entry for RPL3 Gene

Proteomics data for RPL3 Gene at MOPED

Post-translational modifications for RPL3 Gene

  • Ubiquitination at Lys39, Lys250, Lys286, Lys294, Lys300, Lys366, and Lys373
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL3 Gene

No data available for DME Specific Peptides for RPL3 Gene

Domains for RPL3 Gene

Gene Families for RPL3 Gene

HGNC:
  • RPL :L ribosomal proteins

Protein Domains for RPL3 Gene

Graphical View of Domain Structure for InterPro Entry

P39023

UniProtKB/Swiss-Prot:

RL3_HUMAN :
  • P39023
Family:
  • Belongs to the ribosomal protein L3P family.
genes like me logo Genes that share domains with RPL3: view

Function for RPL3 Gene

Molecular function for RPL3 Gene

GENATLAS Biochemistry: 60S ribosomal protein L3
UniProtKB/Swiss-Prot Function: The L3 protein is a component of the large subunit of cytoplasmic ribosomes

Gene Ontology (GO) - Molecular Function for RPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 2891103
GO:0003735 structural constituent of ribosome NAS 12962325
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RPL3: view
genes like me logo Genes that share phenotypes with RPL3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPL3 Gene

Localization for RPL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPL3 Gene

Nucleus, nucleolus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL3 Gene COMPARTMENTS Subcellular localization image for RPL3 gene
Compartment Confidence
cytosol 5
nucleus 5
chloroplast 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with RPL3: view

Pathways for RPL3 Gene

genes like me logo Genes that share pathways with RPL3: view

Pathways by source for RPL3 Gene

1 KEGG pathway for RPL3 Gene
1 GeneGo (Thomson Reuters) pathway for RPL3 Gene

Gene Ontology (GO) - Biological Process for RPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
GO:0006415 translational termination TAS --
genes like me logo Genes that share ontologies with RPL3: view

Compounds for RPL3 Gene

(4) Drugbank Compounds for RPL3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
target
ANISOMYCIN
target
Homoharringtonine
  • Cephalotaxus alkaloid
26833-87-4 target antagonist
PUROMYCIN
target
genes like me logo Genes that share compounds with RPL3: view

Transcripts for RPL3 Gene

Unigene Clusters for RPL3 Gene

Ribosomal protein L3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^
SP1: - - - - - -
SP2: -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6: - - - - - - - - - - - - - -
SP7: - - -
SP8: - - - - -
SP9: - - -
SP10: - - -
SP11: -
SP12:

ExUns: 12a · 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for RPL3 Gene

GeneLoc Exon Structure for
RPL3
ECgene alternative splicing isoforms for
RPL3

Expression for RPL3 Gene

mRNA expression in normal human tissues for RPL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL3 Gene

SOURCE GeneReport for Unigene cluster for RPL3 Gene Hs.119598

genes like me logo Genes that share expressions with RPL3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL3 Gene

Orthologs for RPL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPL3 35
  • 99.65 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RPL3 35
  • 90.49 (n)
  • 98.01 (a)
RPL3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL3 35
  • 91.56 (n)
  • 98.76 (a)
RPL3 36
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rpl3 35
  • 89.16 (n)
  • 98.51 (a)
Rpl3 16
Rpl3 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPL3 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL3 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl3 35
  • 89.74 (n)
  • 98.76 (a)
chicken
(Gallus gallus)
Aves RPL3 35
  • 84.62 (n)
  • 95.78 (a)
RPL3 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL3 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rpl3-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl3 35
  • 81.22 (n)
  • 92.8 (a)
Str.6702 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8466 35
zebrafish
(Danio rerio)
Actinopterygii rpl3 35
  • 80.31 (n)
  • 89.58 (a)
rpl3 36
  • 90 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003556 35
  • 67.87 (n)
  • 70.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL3 35
  • 72.04 (n)
  • 74.69 (a)
RpL3 36
  • 72 (a)
OneToMany
RpL3 37
  • 74 (a)
worm
(Caenorhabditis elegans)
Secernentea rpl-3 35
  • 69.17 (n)
  • 71.93 (a)
rpl-3 36
  • 71 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR206W 35
  • 66.67 (n)
  • 69.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL3 35
  • 62.86 (n)
  • 68.57 (a)
RPL3 36
  • 67 (a)
OneToMany
RPL3 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F16511g 35
  • 63.04 (n)
  • 68.13 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7639 35
thale cress
(Arabidopsis thaliana)
eudicotyledons RPL3B 35
  • 65.36 (n)
  • 67.97 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.977 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06843 35
  • 68.55 (n)
  • 66.92 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rpl302 35
  • 64.59 (n)
  • 70.47 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3689 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 74 (a)
OneToMany
Species with no ortholog for RPL3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL3 Gene

ENSEMBL:
Gene Tree for RPL3 (if available)
TreeFam:
Gene Tree for RPL3 (if available)

Paralogs for RPL3 Gene

Paralogs for RPL3 Gene

Selected SIMAP similar genes for RPL3 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with RPL3: view

Variants for RPL3 Gene

Sequence variations from dbSNP and Humsavar for RPL3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs137629 -- 39,321,228(-) atgct(C/G)aattt upstream-variant-2KB
rs137630 -- 39,321,640(+) gaggc(C/T)gaggg upstream-variant-2KB
rs2014840 -- 39,312,983(+) GTGGT(A/C)CCTGT reference, missense
rs2014842 -- 39,313,004(+) GCAGT(A/G)GTCAG intron-variant
rs5757614 -- 39,321,549(+) gacca(G/T)cctgg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPL3 Gene

Variant ID Type Subtype PubMed ID
nsv834198 CNV Loss 17160897

Relevant External Links for RPL3 Gene

HapMap Linkage Disequilibrium report
RPL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPL3 Gene

Disorders for RPL3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RPL3 Gene including...

Search for RPL3 Gene in MalaCards »
genes like me logo Genes that share disorders with RPL3: view

No data available for UniProtKB/Swiss-Prot for RPL3 Gene

Publications for RPL3 Gene

  1. Molecular cloning and characterization of a TAR-binding nuclear factor from T cells. (PMID: 7576925) Reddy T.R. … Wong-Staal F. (AIDS Res. Hum. Retroviruses 1995) 3 4 23
  2. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  4. Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells. (PMID: 2891103) Ou J.-H. … Rutter W. (Nucleic Acids Res. 1987) 2 3
  5. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova T.I. … Karpova G.G. (J. Protein Chem. 2003) 3 4

Products for RPL3 Gene

Sources for RPL3 Gene

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