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Aliases for CCDC90B Gene

Aliases for CCDC90B Gene

  • Coiled-Coil Domain Containing 90B 2 3 5
  • Coiled-Coil Domain-Containing Protein 90B, Mitochondrial 3
  • MDS011 3
  • MDS025 3

External Ids for CCDC90B Gene

Previous GeneCards Identifiers for CCDC90B Gene

  • GC11M082651
  • GC11M082972
  • GC11M079269

Summaries for CCDC90B Gene

GeneCards Summary for CCDC90B Gene

CCDC90B (Coiled-Coil Domain Containing 90B) is a Protein Coding gene. An important paralog of this gene is MCUR1.

Gene Wiki entry for CCDC90B Gene

Additional gene information for CCDC90B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC90B Gene

Genomics for CCDC90B Gene

Regulatory Elements for CCDC90B Gene

Enhancers for CCDC90B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H083284 1.2 ENCODE 50.1 +0.7 661 3.4 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 CCDC90B PCF11 ENSG00000255234 ENSG00000254676 GC11M083251
GH11H083256 0.9 ENCODE 60.9 +28.7 28748 2.6 FOXA2 RARA YY1 MIXL1 CEBPB PPARG NR2F2 KAT8 NFIL3 SSRP1 CCDC90B ENSG00000255234 RAB30 RAB30-AS1 GC11M083251
GH11H083282 0.4 Ensembl 50.1 +3.8 3807 0.4 HNF4A CCDC90B ENSG00000255234 GC11M083251
GH11H083272 0.4 ENCODE 49.8 +13.4 13432 1.4 JUND FOS CCDC90B ENSG00000255234 GC11M083251
GH11H082867 1.2 Ensembl ENCODE dbSUPER 10.3 +418.8 418848 0.9 CTCF ZNF654 ZNF362 RB1 HLF TRIM22 ZNF384 REST RAD21 CC2D1A DDIAS PRCP FAM181B CCDC90B ENSG00000255234 RAB30 ENSG00000254441
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC90B on UCSC Golden Path with GeneCards custom track

Promoters for CCDC90B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for CCDC90B Gene

Genomic Locations for CCDC90B Gene
27,315 bases
Minus strand

Genomic View for CCDC90B Gene

Genes around CCDC90B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC90B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC90B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC90B Gene

Proteins for CCDC90B Gene

  • Protein details for CCDC90B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 90B, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A8K8I4
    • B3KP87
    • B4E3L2
    • Q3B781
    • Q9GZU6

    Protein attributes for CCDC90B Gene

    254 amino acids
    Molecular mass:
    29506 Da
    Quaternary structure:
    • Interacts with MCU (PubMed:27184846).

    Alternative splice isoforms for CCDC90B Gene


neXtProt entry for CCDC90B Gene

Post-translational modifications for CCDC90B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC90B Gene

Domains & Families for CCDC90B Gene

Gene Families for CCDC90B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CCDC90B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCDC90 family.
  • Belongs to the CCDC90 family.
genes like me logo Genes that share domains with CCDC90B: view

Function for CCDC90B Gene

Gene Ontology (GO) - Molecular Function for CCDC90B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27184846
genes like me logo Genes that share ontologies with CCDC90B: view

Phenotypes for CCDC90B Gene

genes like me logo Genes that share phenotypes with CCDC90B: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC90B Gene

Localization for CCDC90B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC90B Gene

Mitochondrion membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC90B gene
Compartment Confidence
mitochondrion 5
plasma membrane 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCDC90B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with CCDC90B: view

Pathways & Interactions for CCDC90B Gene

SuperPathways for CCDC90B Gene

No Data Available

Interacting Proteins for CCDC90B Gene

Gene Ontology (GO) - Biological Process for CCDC90B Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC90B Gene

Drugs & Compounds for CCDC90B Gene

No Compound Related Data Available

Transcripts for CCDC90B Gene

Unigene Clusters for CCDC90B Gene

Coiled-coil domain containing 90B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC90B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - - - - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - -
SP9: - -
SP10: - - - - -
SP11: - - -

Relevant External Links for CCDC90B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC90B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC90B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCDC90B Gene

This gene is overexpressed in Bone (8.0) and Placenta (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC90B Gene

Protein tissue co-expression partners for CCDC90B Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC90B Gene:


SOURCE GeneReport for Unigene cluster for CCDC90B Gene:


Evidence on tissue expression from TISSUES for CCDC90B Gene

  • Liver(4.4)
  • Nervous system(3.7)
  • Spleen(2)
genes like me logo Genes that share expression patterns with CCDC90B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC90B Gene

Orthologs for CCDC90B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC90B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC90B 33 34
  • 99.74 (n)
(Bos Taurus)
Mammalia CCDC90B 33 34
  • 90.64 (n)
(Canis familiaris)
Mammalia CCDC90B 33 34
  • 88.06 (n)
(Mus musculus)
Mammalia Ccdc90b 33 16 34
  • 85.96 (n)
(Rattus norvegicus)
Mammalia Ccdc90b 33
  • 85.43 (n)
(Ornithorhynchus anatinus)
Mammalia CCDC90B 34
  • 81 (a)
(Monodelphis domestica)
Mammalia CCDC90B 34
  • 67 (a)
(Gallus gallus)
Aves CCDC90B 33 34
  • 78.03 (n)
(Anolis carolinensis)
Reptilia CCDC90B 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc90b 33
  • 65.48 (n)
(Danio rerio)
Actinopterygii ccdc90b 33 34
  • 63.56 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.494 33
Species where no ortholog for CCDC90B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC90B Gene

Gene Tree for CCDC90B (if available)
Gene Tree for CCDC90B (if available)

Paralogs for CCDC90B Gene

Paralogs for CCDC90B Gene Pseudogenes for CCDC90B Gene

genes like me logo Genes that share paralogs with CCDC90B: view

Variants for CCDC90B Gene

Sequence variations from dbSNP and Humsavar for CCDC90B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000036127 -- 83,267,472(+) ATGCC(C/T)AAGCT intron-variant
rs1000118027 -- 83,272,858(+) AGAGA(C/T)GAAGT intron-variant
rs1000144707 -- 83,273,451(+) TTCAA(A/G)GTCAT intron-variant
rs1000229576 -- 83,273,361(+) CTACT(C/G)TGCCT intron-variant
rs1000392429 -- 83,266,996(+) AAACT(C/T)CAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC90B Gene

Variant ID Type Subtype PubMed ID
nsv555606 CNV loss 21841781
nsv468764 CNV loss 19166990
nsv1138058 CNV deletion 24896259
esv33531 CNV loss 17666407

Variation tolerance for CCDC90B Gene

Residual Variation Intolerance Score: 87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC90B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC90B Gene

Disorders for CCDC90B Gene

Relevant External Links for CCDC90B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC90B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC90B Gene

Publications for CCDC90B Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 60
  2. MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics. (PMID: 27184846) Tomar D … Madesh M (Cell reports 2016) 3 4 60
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PMID: 11256614) Simpson JC … Wiemann S (EMBO reports 2000) 3 4 60

Products for CCDC90B Gene

Sources for CCDC90B Gene

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