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Aliases for MRPS35 Gene

Aliases for MRPS35 Gene

  • Mitochondrial Ribosomal Protein S35 2 3 5
  • 28S Ribosomal Protein S28, Mitochondrial 3 4
  • MRP-S28 3 4
  • MRP-S35 3 4
  • MRPS28 3 4
  • S28mt 3 4
  • S35mt 3 4
  • Mitochondrial Ribosomal Protein S28 3
  • HDCMD11P 3
  • MDS023 3

External Ids for MRPS35 Gene

Previous GeneCards Identifiers for MRPS35 Gene

  • GC12P028236
  • GC12P027887
  • GC12P027763
  • GC12P027754
  • GC12P027863
  • GC12P027632

Summaries for MRPS35 Gene

Entrez Gene Summary for MRPS35 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010]

GeneCards Summary for MRPS35 Gene

MRPS35 (Mitochondrial Ribosomal Protein S35) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPS35 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS35 Gene

Genomics for MRPS35 Gene

Regulatory Elements for MRPS35 Gene

Enhancers for MRPS35 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPS35 on UCSC Golden Path with GeneCards custom track

Promoters for MRPS35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPS35 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPS35 Gene

Chromosome:
12
Start:
27,710,773 bp from pter
End:
27,756,304 bp from pter
Size:
45,532 bases
Orientation:
Plus strand

Genomic View for MRPS35 Gene

Genes around MRPS35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS35 Gene

Proteins for MRPS35 Gene

  • Protein details for MRPS35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82673-RT35_HUMAN
    Recommended name:
    28S ribosomal protein S35, mitochondrial
    Protein Accession:
    P82673
    Secondary Accessions:
    • Q32LZ1
    • Q6P4C6
    • Q7L1M6
    • Q8NBP4
    • Q96AI0
    • Q9H044
    • Q9HC14
    • Q9P1R5

    Protein attributes for MRPS35 Gene

    Size:
    323 amino acids
    Molecular mass:
    36844 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
    SequenceCaution:
    • Sequence=AAG14958.1; Type=Frameshift; Positions=97; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS35 Gene

    Alternative splice isoforms for MRPS35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPS35 Gene

Proteomics data for MRPS35 Gene at MOPED

Post-translational modifications for MRPS35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS35 Gene

Antibody Products

No data available for DME Specific Peptides for MRPS35 Gene

Domains & Families for MRPS35 Gene

Gene Families for MRPS35 Gene

Protein Domains for MRPS35 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPS35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPS35: view

No data available for UniProtKB/Swiss-Prot for MRPS35 Gene

Function for MRPS35 Gene

genes like me logo Genes that share phenotypes with MRPS35: view

Animal Models for MRPS35 Gene

MGI Knock Outs for MRPS35:

Animal Model Products

miRNA for MRPS35 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRPS35 Gene

Localization for MRPS35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS35 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS35 Gene COMPARTMENTS Subcellular localization image for MRPS35 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for MRPS35 Gene

Pathways & Interactions for MRPS35 Gene

genes like me logo Genes that share pathways with MRPS35: view

Gene Ontology (GO) - Biological Process for MRPS35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPS35: view

No data available for SIGNOR curated interactions for MRPS35 Gene

Drugs & Compounds for MRPS35 Gene

No Compound Related Data Available

Transcripts for MRPS35 Gene

Unigene Clusters for MRPS35 Gene

Mitochondrial ribosomal protein S35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS35 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3: - - - - - -

Relevant External Links for MRPS35 Gene

GeneLoc Exon Structure for
MRPS35
ECgene alternative splicing isoforms for
MRPS35

Expression for MRPS35 Gene

mRNA expression in normal human tissues for MRPS35 Gene

Protein differential expression in normal tissues from HIPED for MRPS35 Gene

This gene is overexpressed in Pancreas (10.4) and Adrenal (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS35 Gene



SOURCE GeneReport for Unigene cluster for MRPS35 Gene Hs.714076

genes like me logo Genes that share expression patterns with MRPS35: view

Protein tissue co-expression partners for MRPS35 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS35 Gene

Orthologs for MRPS35 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS35 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPS35 35
  • 86.85 (n)
  • 84.16 (a)
MRPS35 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS35 35
  • 87.06 (n)
  • 85.09 (a)
MRPS35 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrps35 35
  • 76.59 (n)
  • 76.8 (a)
Mrps35 16
Mrps35 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPS35 35
  • 98.04 (n)
  • 97.5 (a)
MRPS35 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps35 35
  • 77.12 (n)
  • 78.37 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPS35 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS35 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS35 35
  • 69.05 (n)
  • 67.86 (a)
MRPS35 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps35 35
  • 63.21 (n)
  • 65.93 (a)
Str.11071 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6303 35
zebrafish
(Danio rerio)
Actinopterygii Dr.10387 35
mrps35 35
  • 61.65 (n)
  • 63.55 (a)
mrps35 36
  • 58 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5353 35
fruit fly
(Drosophila melanogaster)
Insecta mRpS28 37
  • 47 (a)
mRpS35 35
  • 52.95 (n)
  • 50.38 (a)
mRpS35 36
  • 41 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006802 35
  • 51.23 (n)
  • 52.96 (a)
worm
(Caenorhabditis elegans)
Secernentea Y39B6A.39 37
  • 39 (a)
mrps-35 35
  • 51.19 (n)
  • 41.95 (a)
mrps-35 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for MRPS35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS35 Gene

ENSEMBL:
Gene Tree for MRPS35 (if available)
TreeFam:
Gene Tree for MRPS35 (if available)

Paralogs for MRPS35 Gene

Pseudogenes.org Pseudogenes for MRPS35 Gene

genes like me logo Genes that share paralogs with MRPS35: view

No data available for Paralogs for MRPS35 Gene

Variants for MRPS35 Gene

Sequence variations from dbSNP and Humsavar for MRPS35 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs35475802 - 27,710,859(+) CCGCG(A/C)TCCCA reference, missense
rs7302334 -- 27,716,841(+) aaaaa(A/T)ttagc intron-variant
rs7302395 -- 27,746,724(+) ACTCA(C/G)GTTCT intron-variant
rs12822020 -- 27,750,761(+) GATAG(C/T)GCCAC intron-variant
rs12827496 -- 27,730,240(+) ATCAC(A/G)TTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS35 Gene

Variant ID Type Subtype PubMed ID
esv2745664 CNV Deletion 23290073
nsv469178 CNV Gain 19166990
esv270584 CNV Insertion 20981092
esv272743 CNV Insertion 20981092
esv2674076 CNV Deletion 23128226
esv2745671 CNV Deletion 23290073

Variation tolerance for MRPS35 Gene

Residual Variation Intolerance Score: 58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.95; 68.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS35 Gene

HapMap Linkage Disequilibrium report
MRPS35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS35 Gene

Disorders for MRPS35 Gene

Relevant External Links for MRPS35

Genetic Association Database (GAD)
MRPS35
Human Genome Epidemiology (HuGE) Navigator
MRPS35
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS35

No disorders were found for MRPS35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS35 Gene

Publications for MRPS35 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3
  3. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for MRPS35 Gene

Sources for MRPS35 Gene

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