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MRPS35 Gene(Protein Coding)

Mitochondrial Ribosomal Protein S35

GCID:
GC12P027710
GIFtS:
49
Genes Participants
UDN Logo

Aliases for MRPS35 Gene

Aliases for MRPS35 Gene

  • Mitochondrial Ribosomal Protein S35 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein MS35 3 4
  • 28S Ribosomal Protein S28, Mitochondrial 3 4
  • MRP-S28 3 4
  • MRP-S35 3 4
  • MRPS28 3 4
  • S28mt 3 4
  • S35mt 3 4
  • 28S Ribosomal Protein S35, Mitochondrial 3
  • Mitochondrial Ribosomal Protein S28 3
  • HDCMD11P 3
  • MDS023 3

External Ids for MRPS35 Gene

Previous GeneCards Identifiers for MRPS35 Gene

  • GC12P028236
  • GC12P027887
  • GC12P027763
  • GC12P027754
  • GC12P027863
  • GC12P027632

Summaries for MRPS35 Gene

Entrez Gene Summary for MRPS35 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010]

GeneCards Summary for MRPS35 Gene

MRPS35 (Mitochondrial Ribosomal Protein S35) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPS35 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS35 Gene

Genomics for MRPS35 Gene

Products:

  1. Regulatory Element

Regulatory Elements for MRPS35 Gene

Enhancers for MRPS35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G027865 0.4 ENCODE 4.2 +154.9 154914 0.8 CEBPB MANSC4 MRPS35 PIR49082 ENSG00000274075
GH12G027709 1.2 ENCODE 0.7 +0.3 267 3.0 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 ENSG00000256377 MANSC4 KLHL42 HMGB1P49 MRPS35 ENSG00000252585
GH12G027746 1.4 Ensembl ENCODE dbSUPER 0.3 +37.0 37006 2.6 ELF3 FOXA2 RAD21 YY1 RARA ETV6 FOS IKZF2 THAP11 SP5 KLHL42 ENSG00000256377 MANSC4 ENSG00000252585 MRPS35
GH12G027751 1.1 ENCODE dbSUPER 0.3 +41.4 41387 1.8 CBX3 BACH1 MAX RBBP5 YY1 ZNF316 NFE2 MAFK TCF7L2 NFE2L2 KLHL42 PTHLH ENSG00000256377 MANSC4 ENSG00000252585 MRPS35
GH12G027733 0.6 ENCODE 0.3 +22.5 22480 0.1 CTCF ZNF654 TRIM22 REST RAD21 ZNF664 SMC3 ZNF143 ENSG00000257042 ENSG00000252585 MRPS35
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPS35 on UCSC Golden Path with GeneCards custom track

Promoters for MRPS35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000050201 128 2200 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC

Transcription factor binding sites by QIAGEN in the MRPS35 gene promoter:

Genomic Location for MRPS35 Gene

Chromosome:
12
Start:
27,710,773 bp from pter
End:
27,756,304 bp from pter
Size:
45,532 bases
Orientation:
Plus strand

Genomic View for MRPS35 Gene

Genes around MRPS35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS35 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MRPS35 Gene

Proteins for MRPS35 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MRPS35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82673-RT35_HUMAN
    Recommended name:
    28S ribosomal protein S35, mitochondrial
    Protein Accession:
    P82673
    Secondary Accessions:
    • Q32LZ1
    • Q6P4C6
    • Q7L1M6
    • Q8NBP4
    • Q96AI0
    • Q9H044
    • Q9HC14
    • Q9P1R5

    Protein attributes for MRPS35 Gene

    Size:
    323 amino acids
    Molecular mass:
    36844 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
    SequenceCaution:
    • Sequence=AAG14958.1; Type=Frameshift; Positions=97; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS35 Gene

    Alternative splice isoforms for MRPS35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPS35 Gene

Protein Expression for MRPS35 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MRPS35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS35 Gene

Domains & Families for MRPS35 Gene

Gene Families for MRPS35 Gene

HGNC:

Protein Domains for MRPS35 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPS35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P82673

UniProtKB/Swiss-Prot:

RT35_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mS35 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mS35 family.
genes like me logo Genes that share domains with MRPS35: view

Function for MRPS35 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Gene Ontology (GO) - Molecular Function for MRPS35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0003735 structural constituent of ribosome IBA --
genes like me logo Genes that share ontologies with MRPS35: view
genes like me logo Genes that share phenotypes with MRPS35: view

Animal Models for MRPS35 Gene

MGI Knock Outs for MRPS35:

Animal Model Products

CRISPR Products

miRNA for MRPS35 Gene

miRTarBase miRNAs that target MRPS35

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRPS35 Gene

Localization for MRPS35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS35 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS35 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRPS35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IBA,NAS 11279123
GO:0005840 ribosome IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MRPS35: view

Pathways & Interactions for MRPS35 Gene

genes like me logo Genes that share pathways with MRPS35: view

Gene Ontology (GO) - Biological Process for MRPS35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042769 DNA damage response, detection of DNA damage NAS 15300802
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS35: view

No data available for SIGNOR curated interactions for MRPS35 Gene

Drugs & Compounds for MRPS35 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MRPS35 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for MRPS35 Gene

(3) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(301) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRPS35 Gene

Mitochondrial ribosomal protein S35:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS35 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3: - - - - - -

Relevant External Links for MRPS35 Gene

GeneLoc Exon Structure for
MRPS35
ECgene alternative splicing isoforms for
MRPS35

Expression for MRPS35 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS35 Gene

mRNA expression in normal human tissues for MRPS35 Gene
mRNA expression by BioGPS for MRPS35 GenemRNA expression by GTEx for MRPS35 Gene

Protein differential expression in normal tissues from HIPED for MRPS35 Gene

This gene is overexpressed in Pancreas (10.4) and Adrenal (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS35 Gene



Protein tissue co-expression partners for MRPS35 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS35 Gene:

MRPS35

SOURCE GeneReport for Unigene cluster for MRPS35 Gene:

Hs.714076

Evidence on tissue expression from TISSUES for MRPS35 Gene

  • Nervous system(4)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with MRPS35: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS35 Gene

Orthologs for MRPS35 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MRPS35 34 35
  • 98.04 (n)
dog
(Canis familiaris)
 Mammalia MRPS35 34 35
  • 87.06 (n)
cow
(Bos Taurus)
 Mammalia MRPS35 34 35
  • 86.85 (n)
rat
(Rattus norvegicus)
 Mammalia Mrps35 34
  • 77.12 (n)
mouse
(Mus musculus)
 Mammalia Mrps35 34 16 35
  • 76.59 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia MRPS35 35
  • 69 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia MRPS35 35
  • 60 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MRPS35 34 35
  • 69.05 (n)
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 70 (a)
 OneToMany
-- 35
  • 60 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia mrps35 34
  • 63.21 (n)
Str.11071 34
African clawed frog
(Xenopus laevis)
 Amphibia Xl.6303 34
zebrafish
(Danio rerio)
 Actinopterygii mrps35 34 35
  • 61.65 (n)
Dr.10387 34
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.5353 34
fruit fly
(Drosophila melanogaster)
 Insecta mRpS35 34 35
  • 52.95 (n)
mRpS28 36
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP006802 34
  • 51.23 (n)
worm
(Caenorhabditis elegans)
 Secernentea mrps-35 34 35
  • 51.19 (n)
Y39B6A.39 36
  • 39 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 40 (a)
 OneToOne
Species where no ortholog for MRPS35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS35 Gene

ENSEMBL:
Gene Tree for MRPS35 (if available)
TreeFam:
Gene Tree for MRPS35 (if available)

Paralogs for MRPS35 Gene

Pseudogenes.org Pseudogenes for MRPS35 Gene

genes like me logo Genes that share paralogs with MRPS35: view

No data available for Paralogs for MRPS35 Gene

Variants for MRPS35 Gene

Sequence variations from dbSNP and Humsavar for MRPS35 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000010454 -- 27,741,512(+) TTCAT(A/G)GTTTC intron-variant
rs1000022731 -- 27,750,347(+) AATCT(A/G)TCCCA intron-variant
rs1000210355 -- 27,746,380(+) GAATG(C/T)TCAAC intron-variant
rs1000218549 -- 27,722,725(+) AAGAT(A/G)CTTCT intron-variant
rs1000233666 -- 27,710,227(+) TAATT(C/T)TAAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRPS35 Gene

Variant ID Type Subtype PubMed ID
esv2674076 CNV deletion 23128226
esv2745664 CNV deletion 23290073
esv2745671 CNV deletion 23290073
esv2761729 CNV gain 21179565
esv3306307 CNV mobile element insertion 20981092
esv3308470 CNV mobile element insertion 20981092
esv3356317 CNV insertion 20981092
esv3396389 CNV insertion 20981092
esv3548934 CNV deletion 23714750
esv3628947 CNV loss 21293372
nsv1129364 OTHER inversion 24896259
nsv469178 CNV gain 19166990
nsv557823 CNV gain 21841781

Variation tolerance for MRPS35 Gene

Residual Variation Intolerance Score: 58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.95; 68.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS35 Gene

Disorders for MRPS35 Gene

Relevant External Links for MRPS35

Genetic Association Database (GAD)
MRPS35
Human Genome Epidemiology (HuGE) Navigator
MRPS35
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS35

No disorders were found for MRPS35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS35 Gene

Publications for MRPS35 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 64
  5. Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach. (PMID: 11344316) Koc E.C. … Spremulli L.L. (Protein Sci. 2001) 3 4 64

Products for MRPS35 Gene

Sources for MRPS35 Gene

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