Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPS35 Gene

Aliases for MRPS35 Gene

  • Mitochondrial Ribosomal Protein S35 2 3
  • 28S Ribosomal Protein S28, Mitochondrial 3 4
  • MRP-S28 3 4
  • MRP-S35 3 4
  • MRPS28 3 4
  • S28mt 3 4
  • S35mt 3 4
  • Mitochondrial Ribosomal Protein S28 3
  • HDCMD11P 3
  • MDS023 3

External Ids for MRPS35 Gene

Previous GeneCards Identifiers for MRPS35 Gene

  • GC12P028236
  • GC12P027887
  • GC12P027763
  • GC12P027754
  • GC12P027863
  • GC12P027632

Summaries for MRPS35 Gene

Entrez Gene Summary for MRPS35 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010]

GeneCards Summary for MRPS35 Gene

MRPS35 (Mitochondrial Ribosomal Protein S35) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPS35 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS35 Gene

Genomics for MRPS35 Gene

Regulatory Elements for MRPS35 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPS35 Gene

27,710,773 bp from pter
27,756,304 bp from pter
45,532 bases
Plus strand

Genomic View for MRPS35 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS35 Gene

Proteins for MRPS35 Gene

  • Protein details for MRPS35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S35, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q32LZ1
    • Q6P4C6
    • Q7L1M6
    • Q8NBP4
    • Q96AI0
    • Q9H044
    • Q9HC14
    • Q9P1R5

    Protein attributes for MRPS35 Gene

    323 amino acids
    Molecular mass:
    36844 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
    • Sequence=AAG14958.1; Type=Frameshift; Positions=97; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS35 Gene

    Alternative splice isoforms for MRPS35 Gene


neXtProt entry for MRPS35 Gene

Proteomics data for MRPS35 Gene at MOPED

Post-translational modifications for MRPS35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS35 Gene

Antibody Products

No data available for DME Specific Peptides for MRPS35 Gene

Domains & Families for MRPS35 Gene

Gene Families for MRPS35 Gene

Protein Domains for MRPS35 Gene


Suggested Antigen Peptide Sequences for MRPS35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPS35: view

No data available for UniProtKB/Swiss-Prot for MRPS35 Gene

Function for MRPS35 Gene

Gene Ontology (GO) - Molecular Function for MRPS35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MRPS35: view

Phenotypes for MRPS35 Gene

genes like me logo Genes that share phenotypes with MRPS35: view

Animal Model Products

miRNA for MRPS35 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS35

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS35 Gene

Localization for MRPS35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS35 Gene


Subcellular locations from

Jensen Localization Image for MRPS35 Gene COMPARTMENTS Subcellular localization image for MRPS35 gene
Compartment Confidence
mitochondrion 4
cytosol 2

Gene Ontology (GO) - Cellular Components for MRPS35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit NAS 11279123
genes like me logo Genes that share ontologies with MRPS35: view

Pathways & Interactions for MRPS35 Gene

genes like me logo Genes that share pathways with MRPS35: view

Gene Ontology (GO) - Biological Process for MRPS35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0042769 DNA damage response, detection of DNA damage NAS 15300802
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPS35: view

No data available for SIGNOR curated interactions for MRPS35 Gene

Drugs & Compounds for MRPS35 Gene

No Compound Related Data Available

Transcripts for MRPS35 Gene

Unigene Clusters for MRPS35 Gene

Mitochondrial ribosomal protein S35:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS35

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS35 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP2: -
SP3: - - - - - -

Relevant External Links for MRPS35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS35 Gene

mRNA expression in normal human tissues for MRPS35 Gene

Protein differential expression in normal tissues from HIPED for MRPS35 Gene

This gene is overexpressed in Pancreas (10.4) and Adrenal (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS35 Gene

SOURCE GeneReport for Unigene cluster for MRPS35 Gene Hs.714076

genes like me logo Genes that share expression patterns with MRPS35: view

Protein tissue co-expression partners for MRPS35 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS35 Gene

Orthologs for MRPS35 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS35 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS35 35
  • 86.85 (n)
  • 84.16 (a)
MRPS35 36
  • 83 (a)
(Canis familiaris)
Mammalia MRPS35 35
  • 87.06 (n)
  • 85.09 (a)
MRPS35 36
  • 84 (a)
(Mus musculus)
Mammalia Mrps35 35
  • 76.59 (n)
  • 76.8 (a)
Mrps35 16
Mrps35 36
  • 76 (a)
(Pan troglodytes)
Mammalia MRPS35 35
  • 98.04 (n)
  • 97.5 (a)
MRPS35 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Mrps35 35
  • 77.12 (n)
  • 78.37 (a)
(Monodelphis domestica)
Mammalia MRPS35 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS35 36
  • 69 (a)
(Gallus gallus)
Aves MRPS35 35
  • 69.05 (n)
  • 67.86 (a)
MRPS35 36
  • 65 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
-- 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps35 35
  • 63.21 (n)
  • 65.93 (a)
Str.11071 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6303 35
(Danio rerio)
Actinopterygii Dr.10387 35
mrps35 35
  • 61.65 (n)
  • 63.55 (a)
mrps35 36
  • 58 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5353 35
fruit fly
(Drosophila melanogaster)
Insecta mRpS28 37
  • 47 (a)
mRpS35 35
  • 52.95 (n)
  • 50.38 (a)
mRpS35 36
  • 41 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006802 35
  • 51.23 (n)
  • 52.96 (a)
(Caenorhabditis elegans)
Secernentea Y39B6A.39 37
  • 39 (a)
mrps-35 35
  • 51.19 (n)
  • 41.95 (a)
mrps-35 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
Species with no ortholog for MRPS35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS35 Gene

Gene Tree for MRPS35 (if available)
Gene Tree for MRPS35 (if available)

Paralogs for MRPS35 Gene Pseudogenes for MRPS35 Gene

genes like me logo Genes that share paralogs with MRPS35: view

No data available for Paralogs for MRPS35 Gene

Variants for MRPS35 Gene

Sequence variations from dbSNP and Humsavar for MRPS35 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs720878 -- 27,753,353(-) ACACC(A/G)AGTCA intron-variant
rs1035684 -- 27,721,913(+) gagat(A/C)atgtc intron-variant
rs1127787 -- 27,714,794(+) CACCC(A/G)GAAAT missense, reference
rs1863222 -- 27,729,305(+) GGACA(A/G)TGGTG intron-variant
rs2346760 -- 27,719,121(+) CACGT(C/G)CTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS35 Gene

Variant ID Type Subtype PubMed ID
esv2745664 CNV Deletion 23290073
nsv469178 CNV Gain 19166990
esv270584 CNV Insertion 20981092
esv272743 CNV Insertion 20981092
esv2674076 CNV Deletion 23128226
esv2745671 CNV Deletion 23290073

Variation tolerance for MRPS35 Gene

Residual Variation Intolerance Score: 58.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.95; 68.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS35 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS35 Gene

Disorders for MRPS35 Gene

Relevant External Links for MRPS35

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MRPS35: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS35 Gene

Publications for MRPS35 Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for MRPS35 Gene

Sources for MRPS35 Gene

Back to Top