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Aliases for EXOC4 Gene

Aliases for EXOC4 Gene

  • Exocyst Complex Component 4 2 3
  • SEC8 3 4 6
  • Exocyst Complex Component Sec8 3 4
  • KIAA1699 4 6
  • SEC8L1 3 4
  • SEC8-Like 1 (S. Cerevisiae) 2
  • SEC8-Like 1 3
  • Sec8p 3

External Ids for EXOC4 Gene

Previous HGNC Symbols for EXOC4 Gene

  • SEC8L1

Previous GeneCards Identifiers for EXOC4 Gene

  • GC07P132396
  • GC07P132588
  • GC07P132937
  • GC07P127253

Summaries for EXOC4 Gene

Entrez Gene Summary for EXOC4 Gene

  • The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for EXOC4 Gene

EXOC4 (Exocyst Complex Component 4) is a Protein Coding gene. Among its related pathways are Actin Nucleation by ARP-WASP Complex and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include protein N-terminus binding and PDZ domain binding.

UniProtKB/Swiss-Prot for EXOC4 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Wiki entry for EXOC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC4 Gene

Genomics for EXOC4 Gene

Regulatory Elements for EXOC4 Gene

Genomic Location for EXOC4 Gene

133,253,067 bp from pter
134,066,589 bp from pter
813,523 bases
Plus strand

Genomic View for EXOC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EXOC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC4 Gene

Proteins for EXOC4 Gene

  • Protein details for EXOC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Exocyst complex component 4
    Protein Accession:
    Secondary Accessions:
    • E9PED2
    • Q541U8
    • Q9C0G4
    • Q9H9K0
    • Q9P102

    Protein attributes for EXOC4 Gene

    974 amino acids
    Molecular mass:
    110498 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with BIRC6/bruce. Interacts with MYRIP (By similarity).

    Alternative splice isoforms for EXOC4 Gene


neXtProt entry for EXOC4 Gene

Proteomics data for EXOC4 Gene at MOPED

Post-translational modifications for EXOC4 Gene

  • Ubiquitination at Lys9, Lys223, Lys240, and Lys486
  • Modification sites at PhosphoSitePlus

Other Protein References for EXOC4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for EXOC4 Gene

Domains for EXOC4 Gene

Gene Families for EXOC4 Gene

Protein Domains for EXOC4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SEC8 family.
  • Belongs to the SEC8 family.
genes like me logo Genes that share domains with EXOC4: view

Function for EXOC4 Gene

Molecular function for EXOC4 Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Ontology (GO) - Molecular Function for EXOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18329369
GO:0017160 Ral GTPase binding IPI 24056301
GO:0030165 PDZ domain binding IEA --
GO:0047485 protein N-terminus binding IPI 18480549
genes like me logo Genes that share ontologies with EXOC4: view

Phenotypes for EXOC4 Gene

genes like me logo Genes that share phenotypes with EXOC4: view

Animal Model Products

CRISPR Products

miRNA for EXOC4 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EXOC4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOC4 Gene

Localization for EXOC4 Gene

Subcellular locations from

Jensen Localization Image for EXOC4 Gene COMPARTMENTS Subcellular localization image for EXOC4 gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for EXOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with EXOC4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EXOC4 Gene

Pathways for EXOC4 Gene

genes like me logo Genes that share pathways with EXOC4: view

Gene Ontology (GO) - Biological Process for EXOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006904 vesicle docking involved in exocytosis IEA --
GO:0006996 organelle organization TAS --
GO:0015031 protein transport IEA --
GO:0044267 cellular protein metabolic process TAS --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with EXOC4: view

Transcripts for EXOC4 Gene

Unigene Clusters for EXOC4 Gene

Exocyst complex component 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EXOC4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC4 Gene

No ASD Table

Relevant External Links for EXOC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EXOC4 Gene

mRNA expression in normal human tissues for EXOC4 Gene

Protein differential expression in normal tissues for EXOC4 Gene

This gene is overexpressed in Bone (20.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EXOC4 Gene

SOURCE GeneReport for Unigene cluster for EXOC4 Gene Hs.321273

genes like me logo Genes that share expressions with EXOC4: view

Expression partners for EXOC4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EXOC4 Gene

Orthologs for EXOC4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EXOC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EXOC4 35
  • 91.1 (n)
  • 96.41 (a)
EXOC4 36
  • 96 (a)
(Canis familiaris)
Mammalia EXOC4 35
  • 91.92 (n)
  • 97.02 (a)
EXOC4 36
  • 97 (a)
(Mus musculus)
Mammalia Exoc4 35
  • 89.19 (n)
  • 95.89 (a)
Exoc4 16
Exoc4 36
  • 96 (a)
(Pan troglodytes)
Mammalia EXOC4 35
  • 99.62 (n)
  • 99.9 (a)
EXOC4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Exoc4 35
  • 89.36 (n)
  • 95.38 (a)
(Monodelphis domestica)
Mammalia EXOC4 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
-- 36
  • 85 (a)
(Gallus gallus)
Aves EXOC4 35
  • 80.63 (n)
  • 89.94 (a)
EXOC4 36
  • 90 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 88 (a)
-- 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc4 35
  • 76.59 (n)
  • 87.34 (a)
(Danio rerio)
Actinopterygii exoc4 35
  • 72.83 (n)
  • 80.89 (a)
exoc4 36
  • 80 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001694 35
  • 49.17 (n)
  • 39.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta sec8 35
  • 49.52 (n)
  • 38.13 (a)
sec8 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea sec-8 35
  • 44.71 (n)
  • 35.27 (a)
sec-8 36
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC8 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for EXOC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC4 Gene

Gene Tree for EXOC4 (if available)
Gene Tree for EXOC4 (if available)

Paralogs for EXOC4 Gene

No data available for Paralogs for EXOC4 Gene

Variants for EXOC4 Gene

Sequence variations from dbSNP and Humsavar for EXOC4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs166427 -- 133,404,276(+) ttttt(G/T)gtatt intron-variant
rs169057 -- 133,343,802(-) tGCCC(A/C)AGAGA intron-variant
rs169058 -- 133,419,999(-) accct(A/T)aaact intron-variant
rs183810 -- 133,363,510(+) TGTCC(C/T)TTGGT intron-variant
rs187824 -- 133,478,299(-) CACAA(C/T)TTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOC4 Gene

Variant ID Type Subtype PubMed ID
nsv521054 CNV Loss 19592680
nsv889220 CNV Gain 21882294
esv2662196 CNV Deletion 23128226
esv2657515 CNV Deletion 23128226
nsv428186 CNV Gain 18775914
dgv2139e1 CNV Complex 17122850
esv271075 CNV Insertion 20981092
esv1677306 CNV Insertion 17803354
esv2473150 CNV Insertion 19546169
nsv831144 CNV Loss 17160897
esv2663337 CNV Deletion 23128226
nsv366574 CNV Loss 16902084
esv1010219 CNV Insertion 20482838
esv2121190 CNV Deletion 18987734
esv2735175 CNV Deletion 23290073
esv2735174 CNV Deletion 23290073
nsv470393 CNV Gain 18288195
nsv889219 CNV Loss 21882294
nsv525065 CNV Loss 19592680
esv2567326 CNV Deletion 19546169
nsv831143 CNV Gain 17160897
esv2669987 CNV Deletion 23128226
nsv889218 CNV Loss 21882294
nsv528972 CNV Loss 19592680
esv9349 CNV Loss 19470904
esv1081495 CNV Deletion 17803354
esv2735172 CNV Deletion 23290073
dgv237n6 CNV Loss 16902084
esv999690 CNV Deletion 20482838
esv1009705 CNV Deletion 20482838
esv5070 CNV Deletion 18987735
esv2244756 CNV Deletion 18987734
esv2491664 CNV Deletion 19546169
nsv464725 CNV Loss 19166990
esv2676200 CNV Deletion 23128226
nsv5956 CNV Insertion 18451855
esv2663117 CNV Deletion 23128226
nsv5955 CNV Loss 18451855
nsv889217 CNV Gain 21882294
nsv889216 CNV Gain 21882294
nsv889215 CNV Loss 21882294

Relevant External Links for EXOC4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC4 Gene

Disorders for EXOC4 Gene

Relevant External Links for EXOC4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for EXOC4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for EXOC4 Gene

Publications for EXOC4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. (PMID: 12687004) Inoue M. … Saltiel A.R. (Nature 2003) 2 3
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Screening for replication of genome-wide SNP associations in sporadic ALS. (PMID: 18987618) Cronin S. … Hardiman O. (Eur. J. Hum. Genet. 2009) 3 48

Products for EXOC4 Gene

  • Addgene plasmids for EXOC4

Sources for EXOC4 Gene

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