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Aliases for EXOC4 Gene

Aliases for EXOC4 Gene

  • Exocyst Complex Component 4 2 3 5
  • Exocyst Complex Component Sec8 3 4
  • SEC8L1 3 4
  • SEC8 3 4
  • SEC8-Like 1 (S. Cerevisiae) 2
  • SEC8-Like 1 3
  • KIAA1699 4
  • Sec8p 3

External Ids for EXOC4 Gene

Previous HGNC Symbols for EXOC4 Gene

  • SEC8L1

Previous GeneCards Identifiers for EXOC4 Gene

  • GC07P132396
  • GC07P132588
  • GC07P132937
  • GC07P127253

Summaries for EXOC4 Gene

Entrez Gene Summary for EXOC4 Gene

  • The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for EXOC4 Gene

EXOC4 (Exocyst Complex Component 4) is a Protein Coding gene. Among its related pathways are Translocation of GLUT4 to the plasma membrane and Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include PDZ domain binding and Ral GTPase binding.

UniProtKB/Swiss-Prot for EXOC4 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Wiki entry for EXOC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC4 Gene

Genomics for EXOC4 Gene

Regulatory Elements for EXOC4 Gene

Enhancers for EXOC4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EXOC4 on UCSC Golden Path with GeneCards custom track

Promoters for EXOC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EXOC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for EXOC4 Gene

133,253,067 bp from pter
134,066,589 bp from pter
813,523 bases
Plus strand

Genomic View for EXOC4 Gene

Genes around EXOC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC4 Gene

Proteins for EXOC4 Gene

  • Protein details for EXOC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Exocyst complex component 4
    Protein Accession:
    Secondary Accessions:
    • E9PED2
    • Q541U8
    • Q9C0G4
    • Q9H9K0
    • Q9P102

    Protein attributes for EXOC4 Gene

    974 amino acids
    Molecular mass:
    110498 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with BIRC6/bruce. Interacts with MYRIP (By similarity).

    Alternative splice isoforms for EXOC4 Gene


neXtProt entry for EXOC4 Gene

Proteomics data for EXOC4 Gene at MOPED

Post-translational modifications for EXOC4 Gene

  • Ubiquitination at Lys 9, Lys 223, Lys 240, and Lys 486
  • Modification sites at PhosphoSitePlus

Other Protein References for EXOC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EXOC4 Gene

Domains & Families for EXOC4 Gene

Gene Families for EXOC4 Gene

Protein Domains for EXOC4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SEC8 family.
  • Belongs to the SEC8 family.
genes like me logo Genes that share domains with EXOC4: view

Function for EXOC4 Gene

Molecular function for EXOC4 Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Ontology (GO) - Molecular Function for EXOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017160 Ral GTPase binding IPI 24056301
genes like me logo Genes that share ontologies with EXOC4: view
genes like me logo Genes that share phenotypes with EXOC4: view

Animal Model Products

CRISPR Products

miRNA for EXOC4 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOC4 Gene

Localization for EXOC4 Gene

Subcellular locations from

Jensen Localization Image for EXOC4 Gene COMPARTMENTS Subcellular localization image for EXOC4 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
golgi apparatus 2
cytoskeleton 1
endosome 1

Gene Ontology (GO) - Cellular Components for EXOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IEA --
GO:0032584 growth cone membrane IEA --
genes like me logo Genes that share ontologies with EXOC4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EXOC4 Gene

Pathways & Interactions for EXOC4 Gene

genes like me logo Genes that share pathways with EXOC4: view

Gene Ontology (GO) - Biological Process for EXOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with EXOC4: view

No data available for SIGNOR curated interactions for EXOC4 Gene

Drugs & Compounds for EXOC4 Gene

No Compound Related Data Available

Transcripts for EXOC4 Gene

Unigene Clusters for EXOC4 Gene

Exocyst complex component 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC4 Gene

No ASD Table

Relevant External Links for EXOC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EXOC4 Gene

mRNA expression in normal human tissues for EXOC4 Gene

Protein differential expression in normal tissues from HIPED for EXOC4 Gene

This gene is overexpressed in Bone (20.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EXOC4 Gene

SOURCE GeneReport for Unigene cluster for EXOC4 Gene Hs.321273

genes like me logo Genes that share expression patterns with EXOC4: view

Protein tissue co-expression partners for EXOC4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EXOC4 Gene

Orthologs for EXOC4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EXOC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EXOC4 35
  • 91.1 (n)
  • 96.41 (a)
EXOC4 36
  • 96 (a)
(Canis familiaris)
Mammalia EXOC4 35
  • 91.92 (n)
  • 97.02 (a)
EXOC4 36
  • 97 (a)
(Mus musculus)
Mammalia Exoc4 35
  • 89.19 (n)
  • 95.89 (a)
Exoc4 16
Exoc4 36
  • 96 (a)
(Pan troglodytes)
Mammalia EXOC4 35
  • 99.62 (n)
  • 99.9 (a)
EXOC4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Exoc4 35
  • 89.36 (n)
  • 95.38 (a)
(Monodelphis domestica)
Mammalia EXOC4 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
-- 36
  • 85 (a)
(Gallus gallus)
Aves EXOC4 35
  • 80.63 (n)
  • 89.94 (a)
EXOC4 36
  • 90 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 88 (a)
-- 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc4 35
  • 76.59 (n)
  • 87.34 (a)
(Danio rerio)
Actinopterygii exoc4 35
  • 72.83 (n)
  • 80.89 (a)
exoc4 36
  • 80 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001694 35
  • 49.17 (n)
  • 39.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta sec8 35
  • 49.52 (n)
  • 38.13 (a)
sec8 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea sec-8 35
  • 44.71 (n)
  • 35.27 (a)
sec-8 36
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC8 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for EXOC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC4 Gene

Gene Tree for EXOC4 (if available)
Gene Tree for EXOC4 (if available)

Paralogs for EXOC4 Gene

No data available for Paralogs for EXOC4 Gene

Variants for EXOC4 Gene

Sequence variations from dbSNP and Humsavar for EXOC4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_036292 A colorectal cancer sample
VAR_036293 A colorectal cancer sample
rs766294 -- 133,758,428(+) GCCAC(C/T)GTGCC intron-variant
rs809872 -- 133,338,580(+) gggcg(A/C)cagag intron-variant
rs880429 -- 133,782,097(+) GCAGT(A/G)TTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOC4 Gene

Variant ID Type Subtype PubMed ID
nsv889215 CNV Loss 21882294
nsv889216 CNV Gain 21882294
nsv889217 CNV Gain 21882294
nsv5955 CNV Loss 18451855
esv2663117 CNV Deletion 23128226
nsv5956 CNV Insertion 18451855
esv2676200 CNV Deletion 23128226
nsv464725 CNV Loss 19166990
esv2491664 CNV Deletion 19546169
esv2244756 CNV Deletion 18987734
esv5070 CNV Deletion 18987735
esv1009705 CNV Deletion 20482838
esv999690 CNV Deletion 20482838
dgv237n6 CNV Loss 16902084
esv2735172 CNV Deletion 23290073
esv1081495 CNV Deletion 17803354
esv9349 CNV Loss 19470904
nsv528972 CNV Loss 19592680
nsv889218 CNV Loss 21882294
esv2669987 CNV Deletion 23128226
nsv831143 CNV Gain 17160897
esv2567326 CNV Deletion 19546169
nsv525065 CNV Loss 19592680
nsv889219 CNV Loss 21882294
nsv470393 CNV Gain 18288195
esv2735174 CNV Deletion 23290073
esv2735175 CNV Deletion 23290073
esv2121190 CNV Deletion 18987734
esv1010219 CNV Insertion 20482838
nsv366574 CNV Loss 16902084
esv2663337 CNV Deletion 23128226
nsv831144 CNV Loss 17160897
esv2473150 CNV Insertion 19546169
esv1677306 CNV Insertion 17803354
esv271075 CNV Insertion 20981092
dgv2139e1 CNV Complex 17122850
nsv428186 CNV Gain 18775914
esv2657515 CNV Deletion 23128226
esv2662196 CNV Deletion 23128226
nsv889220 CNV Gain 21882294
nsv521054 CNV Loss 19592680

Variation tolerance for EXOC4 Gene

Residual Variation Intolerance Score: 16.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 46.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOC4 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC4 Gene

Disorders for EXOC4 Gene

Relevant External Links for EXOC4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EXOC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOC4 Gene

Publications for EXOC4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. (PMID: 12687004) Inoue M. … Saltiel A.R. (Nature 2003) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. A kinase-independent role for EGF receptor in autophagy initiation. (PMID: 25594178) Tan X. … Anderson R.A. (Cell 2015) 3
  5. Sec8 regulates cytokeratin8 phosphorylation and cell migration by controlling the ERK and p38 MAPK signalling pathways. (PMID: 25725287) Tanaka T. … Iino M. (Cell. Signal. 2015) 3

Products for EXOC4 Gene

Sources for EXOC4 Gene