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Aliases for RNASEL Gene

Aliases for RNASEL Gene

  • Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) 2
  • RNS4 3 4 6
  • Ribonuclease L (2,5-Oligoisoadenylate Synthetase-Dependent) 2 3
  • 2-5A-Dependent RNase 3 4
  • Ribonuclease 4 3 4
  • RNase L 3 4
  • PRCA1 3 6
  • 2,5-Oligoisoadenylate Synthetase-Dependent 3
  • Interferon-Induced 2-5A-Dependent RNase 3
  • 2-5A-Dependent Ribonuclease 3
  • Prostate Cancer 1 2
  • Ribonuclease L 4
  • EC 3.1.26.- 4
  • HPC1 6

External Ids for RNASEL Gene

Previous HGNC Symbols for RNASEL Gene

  • RNS4
  • PRCA1

Previous GeneCards Identifiers for RNASEL Gene

  • GC01M180070
  • GC01M177972
  • GC01M179063
  • GC01M179782
  • GC01M179274
  • GC01M180809
  • GC01M153780

Summaries for RNASEL Gene

Entrez Gene Summary for RNASEL Gene

  • This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNASEL Gene

RNASEL (Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent)) is a Protein Coding gene. Diseases associated with RNASEL include prostate cancer 1 and chronic fatigue syndrome. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include RNA binding and endoribonuclease activity.

UniProtKB/Swiss-Prot for RNASEL Gene

  • Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover.

Gene Wiki entry for RNASEL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASEL Gene

Genomics for RNASEL Gene

Regulatory Elements for RNASEL Gene

Genomic Location for RNASEL Gene

Start:
182,573,634 bp from pter
End:
182,589,285 bp from pter
Size:
15,652 bases
Orientation:
Minus strand

Genomic View for RNASEL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNASEL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASEL Gene

Proteins for RNASEL Gene

  • Protein details for RNASEL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05823-RN5A_HUMAN
    Recommended name:
    2-5A-dependent ribonuclease
    Protein Accession:
    Q05823
    Secondary Accessions:
    • Q5W0L2
    • Q6AI46

    Protein attributes for RNASEL Gene

    Size:
    741 amino acids
    Molecular mass:
    83533 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Manganese or magnesium. Required for optimal RNA cleavage rates.;
    Quaternary structure:
    • Monomer (inactive form) or homodimer. Interacts with ABCE1; this interaction inhibits the RNASEL.

    Three dimensional structures from OCA and Proteopedia for RNASEL Gene

    Alternative splice isoforms for RNASEL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNASEL Gene

Proteomics data for RNASEL Gene at MOPED

Post-translational modifications for RNASEL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNASEL Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RNASEL Gene

Domains for RNASEL Gene

Gene Families for RNASEL Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for RNASEL Gene

Graphical View of Domain Structure for InterPro Entry

Q05823

UniProtKB/Swiss-Prot:

RN5A_HUMAN :
  • Q05823
Domain:
  • The nine ankyrin repeats also called 2-5A sensor constitute the N-terminus 2-5A binding domain
  • The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization
  • The ribonuclease domain is located in the C-terminus. A single active nuclease domain in a dimer is sufficient for ribonuclease activity (By similarity).
  • Contains 1 KEN domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily.
Similarity:
  • Contains 9 ANK repeats.
genes like me logo Genes that share domains with RNASEL: view

Function for RNASEL Gene

Molecular function for RNASEL Gene

GENATLAS Biochemistry:
ribonuclease L,2,5-oligoisoadenylate dependent,interferon regulated pathway
UniProtKB/Swiss-Prot CatalyticActivity:
Cleaves 3 of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length
UniProtKB/Swiss-Prot EnzymeRegulation:
After binding to 2-5A (5-phosphorylated 2,5-linked oligoadenylates) the homodimerization and subsequent activation occurs. Inhibited by RNASEL inhibitor ABCE1/RLI, a cytoplasmic member of the ATP-binding cassette (ABC) transporter family
UniProtKB/Swiss-Prot Function:
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover.
UniProtKB/Swiss-Prot Induction:
By interferons. Virus replication in higher vertebrates is restrained by IFNs that cause cells to transcribe genes encoding antiviral proteins, such as 2-5 oligoadenylate synthetases (OASs). oligoadenylate synthetase is stimulated by dsRNA to produce 5-phosphorylated, 2-5-linked oligoadenylates (2-5A), whose function is to activate RNASEL

Enzyme Numbers (IUBMB) for RNASEL Gene

Gene Ontology (GO) - Molecular Function for RNASEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 7514601
GO:0004521 endoribonuclease activity NAS 7514601
GO:0004540 ribonuclease activity --
GO:0004672 protein kinase activity IEA --
GO:0005515 protein binding IPI 20875083
genes like me logo Genes that share ontologies with RNASEL: view
genes like me logo Genes that share phenotypes with RNASEL: view

Animal Models for RNASEL Gene

MGI Knock Outs for RNASEL:

Animal Model Products

miRNA for RNASEL Gene

No data available for Transcription Factor Targeting and HOMER Transcription for RNASEL Gene

Localization for RNASEL Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASEL Gene

Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNASEL Gene COMPARTMENTS Subcellular localization image for RNASEL gene
Compartment Confidence
mitochondrion 5
cytosol 4
nucleus 2
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RNASEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix TAS --
GO:0005829 cytosol TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RNASEL: view

Pathways for RNASEL Gene

genes like me logo Genes that share pathways with RNASEL: view

Pathways by source for RNASEL Gene

1 BioSystems pathway for RNASEL Gene
3 KEGG pathways for RNASEL Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Polycomb & Trithorax Complexes in human,mouse,rat

Gene Ontology (GO) - Biological Process for RNASEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IEA --
GO:0006397 mRNA processing IEA --
GO:0006468 protein phosphorylation NAS 7514601
GO:0009103 lipopolysaccharide biosynthetic process --
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with RNASEL: view

Compounds for RNASEL Gene

(2) HMDB Compounds for RNASEL Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
Manganese
  • manganese
7439-96-5

(23) Novoseek inferred chemical compound relationships for RNASEL Gene

Compound -log(P) Hits PubMed IDs
2,5-oligoadenylate 96.3 111
8-methyladenosine 89.9 7
ecyd 87 11
ampligen 76.7 9
oligoribonucleotide 61.3 5
genes like me logo Genes that share compounds with RNASEL: view

Transcripts for RNASEL Gene

mRNA/cDNA for RNASEL Gene

Unigene Clusters for RNASEL Gene

Ribonuclease L (2,5-oligoisoadenylate synthetase-dependent):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNASEL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASEL Gene

No ASD Table

Relevant External Links for RNASEL Gene

GeneLoc Exon Structure for
RNASEL
ECgene alternative splicing isoforms for
RNASEL

Expression for RNASEL Gene

mRNA expression in normal human tissues for RNASEL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNASEL Gene

This gene is overexpressed in Whole Blood (4.9).

Protein differential expression in normal tissues for RNASEL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (31.5) and Cervix (12.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNASEL Gene

SOURCE GeneReport for Unigene cluster for RNASEL Gene Hs.518545

mRNA Expression by UniProt/SwissProt for RNASEL Gene

Q05823-RN5A_HUMAN
Tissue specificity: Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes
genes like me logo Genes that share expressions with RNASEL: view

Expression partners for RNASEL Gene

In Situ Assay Products

Orthologs for RNASEL Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASEL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNASEL 35
  • 80.09 (n)
  • 71.94 (a)
RNASEL 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNASEL 35
  • 80.45 (n)
  • 71.51 (a)
RNASEL 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnasel 35
  • 72.93 (n)
  • 64.71 (a)
Rnasel 16
Rnasel 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNASEL 35
  • 98.74 (n)
  • 97.3 (a)
RNASEL 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnasel 35
  • 72.82 (n)
  • 63.61 (a)
oppossum
(Monodelphis domestica)
Mammalia RNASEL 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNASEL 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNASEL 35
  • 55 (n)
  • 43.99 (a)
RNASEL 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNASEL 36
  • 44 (a)
OneToOne
Species with no ortholog for RNASEL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASEL Gene

ENSEMBL:
Gene Tree for RNASEL (if available)
TreeFam:
Gene Tree for RNASEL (if available)

Paralogs for RNASEL Gene

Selected SIMAP similar genes for RNASEL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNASEL: view

No data available for Paralogs for RNASEL Gene

Variants for RNASEL Gene

Sequence variations from dbSNP and Humsavar for RNASEL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs11072 -- 182,574,196(-) ATGTT(C/T)AATAA utr-variant-3-prime
rs486907 other, - 182,585,422(-) TGCCC(A/G)AAATG missense, reference
rs501286 -- 182,581,065(-) CTCCC(C/T)GCCGG intron-variant
rs516134 -- 182,584,558(-) TGCCT(A/G)AAAGG intron-variant
rs533259 -- 182,579,884(-) CTACA(C/T)GAAGC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RNASEL Gene

Variant ID Type Subtype PubMed ID
nsv825531 CNV Loss 20364138
nsv825564 CNV Loss 20364138
esv1010175 CNV Deletion 20482838

Relevant External Links for RNASEL Gene

HapMap Linkage Disequilibrium report
RNASEL
Human Gene Mutation Database (HGMD)
RNASEL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASEL Gene

Disorders for RNASEL Gene

(1) OMIM Diseases for RNASEL Gene (180435)

UniProtKB/Swiss-Prot

RN5A_HUMAN
  • Prostate cancer, hereditary, 1 (HPC1) [MIM:601518]: A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for RNASEL Gene

(27) Novoseek inferred disease relationships for RNASEL Gene

Disease -log(P) Hits PubMed IDs
prostate cancer, hereditary, 1 93.8 8
chronic fatigue syndrome 71.5 15
prostate cancer 65.7 95
virus infection 57.6 15
parainfluenza 43.1 2

Relevant External Links for RNASEL

Genetic Association Database (GAD)
RNASEL
Human Genome Epidemiology (HuGE) Navigator
RNASEL
genes like me logo Genes that share disorders with RNASEL: view

No data available for Genatlas for RNASEL Gene

Publications for RNASEL Gene

  1. Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer. (PMID: 11941539) Roekman A. … Schleutker J. (Am. J. Hum. Genet. 2002) 3 4 23 48
  2. Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. (PMID: 11799394) Carpten J. … Trent J. (Nat. Genet. 2002) 3 4 23
  3. Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p. (PMID: 11333017) Dong B. … Silverman R.H. (RNA 2001) 3 4 23
  4. The 2-5A/RNase L/RNase L inhibitor (RNI) pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells. (PMID: 11585831) Le Roy F. … Salehzada T. (J. Biol. Chem. 2001) 3 4 23
  5. Role of genetic polymorphisms of the RNASEL gene on familial prostate cancer risk in a Japanese population. (PMID: 12915880) Nakazato H. … Yamanaka H. (Br. J. Cancer 2003) 3 23 48

Products for RNASEL Gene

Sources for RNASEL Gene

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