Aliases for RNASEL Gene
External Ids for RNASEL Gene
Previous HGNC Symbols for RNASEL Gene
Previous GeneCards Identifiers for RNASEL Gene
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]
GeneCards Summary for RNASEL Gene
RNASEL (Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent)) is a Protein Coding gene. Diseases associated with RNASEL include prostate cancer 1 and chronic fatigue syndrome. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include RNA binding and endoribonuclease activity.
UniProtKB/Swiss-Prot for RNASEL Gene
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover.