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Aliases for RNASE3 Gene

Aliases for RNASE3 Gene

  • Ribonuclease A Family Member 3 2 3
  • Ribonuclease, RNase A Family, 3 2 3 5
  • Ribonuclease 3 3 4
  • RNase 3 3 4
  • RNS3 3 4
  • ECP 3 4
  • Eosinophil Cationic Protein 2
  • Cytotoxic Ribonuclease 3
  • EC 3.1.27.5 63
  • EC 3.1.27.- 4
  • EC 3.1.27 63
  • RAF1 3

External Ids for RNASE3 Gene

Previous HGNC Symbols for RNASE3 Gene

  • RNS3

Previous GeneCards Identifiers for RNASE3 Gene

  • GC14P018731
  • GC14P015146
  • GC14P019349
  • GC14P020429
  • GC14P021359
  • GC14P001480

Summaries for RNASE3 Gene

Entrez Gene Summary for RNASE3 Gene

  • The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]

GeneCards Summary for RNASE3 Gene

RNASE3 (Ribonuclease A Family Member 3) is a Protein Coding gene. Diseases associated with RNASE3 include allergic rhinitis and allergic conjunctivitis. Among its related pathways are Platelet activation, signaling and aggregation and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is ANG.

UniProtKB/Swiss-Prot for RNASE3 Gene

  • Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.

Gene Wiki entry for RNASE3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE3 Gene

Genomics for RNASE3 Gene

Regulatory Elements for RNASE3 Gene

Promoters for RNASE3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNASE3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNASE3 Gene

Chromosome:
14
Start:
20,891,399 bp from pter
End:
20,892,348 bp from pter
Size:
950 bases
Orientation:
Plus strand

Genomic View for RNASE3 Gene

Genes around RNASE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE3 Gene

Proteins for RNASE3 Gene

  • Protein details for RNASE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12724-ECP_HUMAN
    Recommended name:
    Eosinophil cationic protein
    Protein Accession:
    P12724
    Secondary Accessions:
    • Q4VBC1
    • Q8WTP7
    • Q8WZ62
    • Q9GZN9

    Protein attributes for RNASE3 Gene

    Size:
    160 amino acids
    Molecular mass:
    18385 Da
    Quaternary structure:
    • Interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). In vitro interacts with and insert into lipid bilayers composed of dioleoyl phosphatidylcholine and dioleoyl phosphatidylglycerol. In vitro, tends to form amyloid-like aggregates at pH 3, but not at pH 5, nor 7.

    Three dimensional structures from OCA and Proteopedia for RNASE3 Gene

neXtProt entry for RNASE3 Gene

Proteomics data for RNASE3 Gene at MOPED

Selected DME Specific Peptides for RNASE3 Gene

Post-translational modifications for RNASE3 Gene

  • Glycosylation at Asn 84, Asn 92, and Asn 119
  • Modification sites at PhosphoSitePlus

Other Protein References for RNASE3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for RNASE3

Domains & Families for RNASE3 Gene

Gene Families for RNASE3 Gene

Protein Domains for RNASE3 Gene

Suggested Antigen Peptide Sequences for RNASE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P12724

UniProtKB/Swiss-Prot:

ECP_HUMAN :
  • Belongs to the pancreatic ribonuclease family.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE3: view

Function for RNASE3 Gene

Molecular function for RNASE3 Gene

GENATLAS Biochemistry:
ribonuclease RNAse A family,3,eosinophil cationic protein
UniProtKB/Swiss-Prot Function:
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.

Enzyme Numbers (IUBMB) for RNASE3 Gene

Phenotypes for RNASE3 Gene

genes like me logo Genes that share phenotypes with RNASE3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNASE3 Gene

Localization for RNASE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE3 Gene

Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNASE3 Gene COMPARTMENTS Subcellular localization image for RNASE3 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 2
cytosol 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for RNASE3 Gene

Pathways & Interactions for RNASE3 Gene

SuperPathways for RNASE3 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 IL-2 Pathway
3 IL-7 Signaling Pathways
4 Translation Insulin regulation of translation
5 Development HGF signaling pathway
genes like me logo Genes that share pathways with RNASE3: view

Pathways by source for RNASE3 Gene

Interacting Proteins for RNASE3 Gene

Gene Ontology (GO) - Biological Process for RNASE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050830 defense response to Gram-positive bacterium IDA 12860195
genes like me logo Genes that share ontologies with RNASE3: view

No data available for SIGNOR curated interactions for RNASE3 Gene

Drugs & Compounds for RNASE3 Gene

(48) Drugs for RNASE3 Gene - From: Novoseek, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pranlukast Approved Pharma Antagonist, Target, other/unknown 3
Adenosine-2'-5'-Diphosphate Experimental Pharma Target 0
Citric Acid Nutra Agonist, Activator, Target 1001

(66) Additional Compounds for RNASE3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RNASE3: view

Transcripts for RNASE3 Gene

mRNA/cDNA for RNASE3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNASE3 Gene

Ribonuclease, RNase A family, 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE3 Gene

No ASD Table

Relevant External Links for RNASE3 Gene

GeneLoc Exon Structure for
RNASE3
ECgene alternative splicing isoforms for
RNASE3

Expression for RNASE3 Gene

mRNA expression in normal human tissues for RNASE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNASE3 Gene

This gene is overexpressed in Whole Blood (x43.3).

Protein differential expression in normal tissues from HIPED for RNASE3 Gene

This gene is overexpressed in Neutrophil (54.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASE3 Gene



SOURCE GeneReport for Unigene cluster for RNASE3 Gene Hs.73839

genes like me logo Genes that share expression patterns with RNASE3: view

Protein tissue co-expression partners for RNASE3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RNASE3 Gene

Orthologs for RNASE3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 51 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ear1 36
  • 49 (a)
ManyToMany
Ear10 36
  • 48 (a)
ManyToMany
Ear11 36
  • 49 (a)
ManyToMany
Ear14 36
  • 46 (a)
ManyToMany
Ear2 36
  • 47 (a)
ManyToMany
Ear5 36
  • 46 (a)
ManyToMany
Ear6 36
  • 48 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ANG 36
  • 24 (a)
ManyToMany
CL2 36
  • 20 (a)
ManyToMany
RSFR 36
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
Species with no ortholog for RNASE3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE3 Gene

ENSEMBL:
Gene Tree for RNASE3 (if available)
TreeFam:
Gene Tree for RNASE3 (if available)

Paralogs for RNASE3 Gene

Paralogs for RNASE3 Gene

(5) SIMAP similar genes for RNASE3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RNASE3: view

Variants for RNASE3 Gene

Sequence variations from dbSNP and Humsavar for RNASE3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_013149 -
VAR_014109 -
VAR_029017 -

Structural Variations from Database of Genomic Variants (DGV) for RNASE3 Gene

Variant ID Type Subtype PubMed ID
dgv607e1 CNV Complex 17122850
nsv428293 CNV Gain+Loss 18775914
dgv608e1 CNV Complex 17122850
nsv832740 CNV Gain 17160897
nsv470622 CNV Loss 18288195
nsv9121 CNV Gain+Loss 18304495
nsv817619 CNV Gain 17921354
dgv1851n71 CNV Loss 21882294
nsv517174 CNV Gain+Loss 19592680
nsv1204 CNV Loss 18451855
dgv363n67 CNV Gain 20364138
nsv1205 CNV Insertion 18451855
nsv901472 CNV Gain+Loss 21882294
nsv442680 CNV CNV 18776908
esv2421825 OTHER Complex 20811451
esv29488 CNV Loss 19812545
nsv498822 CNV Loss 21111241
dgv609e1 CNV Complex 17122850
essv941 CNV CNV 17122850
nsv436831 CNV Insertion 17901297
esv2673725 CNV Deletion 23128226
nsv433274 CNV Loss 18776910
nsv901474 CNV Gain 21882294

Variation tolerance for RNASE3 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNASE3 Gene

HapMap Linkage Disequilibrium report
RNASE3
Human Gene Mutation Database (HGMD)
RNASE3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE3 Gene

Disorders for RNASE3 Gene

MalaCards: The human disease database

(73) MalaCards diseases for RNASE3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
allergic rhinitis
  • atopic rhinitis
allergic conjunctivitis
  • conjunctivitis allergic
churg-strauss syndrome
  • allergic granulomatosis angiitis
keratoconjunctivitis
kimura disease
  • angiolymphoid hyperplasia with eosinophilia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RNASE3

Genetic Association Database (GAD)
RNASE3
Human Genome Epidemiology (HuGE) Navigator
RNASE3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNASE3
genes like me logo Genes that share disorders with RNASE3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNASE3 Gene

Publications for RNASE3 Gene

  1. Eosinophil cationic protein (ECP) polymorphisms and association with asthma, s-ECP levels and related phenotypes. (PMID: 17362255) Munthe-Kaas M.C. … Carlsen K.L. (Allergy 2007) 3 23 48 67
  2. Effects of pranlukast administration on vascular endothelial growth factor levels in asthmatic patients. (PMID: 15136379) Kanazawa H. … Yoshikawa J. (Chest 2004) 23 25 26
  3. Effects of pranlukast on aspirin-induced bronchoconstriction: differences in chemical mediators between aspirin-intolerant and tolerant asthmatic patients. (PMID: 11476469) Obase Y. … Kohno S. (Ann. Allergy Asthma Immunol. 2001) 23 25 26
  4. Effects of pranlukast hydrate on serum eosinophil cationic protein levels in patients with adult bronchial asthma. (PMID: 10028377) Horiguchi T. … Shiga M. (Arzneimittelforschung 1999) 23 25 26
  5. Pranlukast, a cysteinyl leukotriene antagonist, reduces serum eosinophil cationic protein levels in patients with asthma. (PMID: 10804983) Ishioka S. … Yamakido M. (Hiroshima J. Med. Sci. 1999) 23 25 26

Products for RNASE3 Gene

Sources for RNASE3 Gene

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