Aliases for BCL3 Gene
External Ids for BCL3 Gene
Previous HGNC Symbols for BCL3 Gene
Previous GeneCards Identifiers for BCL3 Gene
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]
GeneCards Summary for BCL3 Gene
BCL3 (B-Cell CLL/Lymphoma 3) is a Protein Coding gene. Diseases associated with BCL3 include Lymphoma and Chronic Lymphocytic Leukemia. Among its related pathways are TNF signaling pathway and Apoptosis-related network due to altered Notch3 in ovarian cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein binding, bridging. An important paralog of this gene is NFKBIE.
UniProtKB/Swiss-Prot for BCL3 Gene
Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).