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Aliases for BCL3 Gene

Aliases for BCL3 Gene

  • B-Cell CLL/Lymphoma 3 2 3
  • Chronic Lymphatic Leukemia Protein 2 3
  • B-Cell Lymphoma 3-Encoded Protein 2 3
  • B-Cell Leukemia/Lymphoma 3 2 3
  • Proto-Oncogene BCL3 3 4
  • D19S37 3 4
  • BCL-3 3 4
  • BCL4 3 4
  • B-Cell Lymphoma 3 Protein 3

External Ids for BCL3 Gene

Previous Symbols for BCL3 Gene

  • D19S37
  • BCL4

Summaries for BCL3 Gene

Entrez Gene Summary for BCL3 Gene

  • This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]

GeneCards Summary for BCL3 Gene

BCL3 (B-Cell CLL/Lymphoma 3) is a Protein Coding gene. Diseases associated with BCL3 include leukemia and chronic lymphocytic leukemia. Among its related pathways are NF-KappaB Family Pathway and Atypical NF-kappaB pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein binding, bridging. An important paralog of this gene is NFKBIA.

UniProtKB/Swiss-Prot for BCL3 Gene

  • Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).

Gene Wiki entry for BCL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL3 Gene

Genomics for BCL3 Gene

Genomic Location for BCL3 Gene

Start:
44,742,817 bp from pter
End:
44,760,044 bp from pter
Size:
17,228 bases
Orientation:
Plus strand

Genomic View for BCL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL3 Gene

Regulatory Elements for BCL3 Gene

Proteins for BCL3 Gene

  • Protein details for BCL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20749-BCL3_HUMAN
    Recommended name:
    B-cell lymphoma 3 protein
    Protein Accession:
    P20749
    Secondary Accessions:

    Protein attributes for BCL3 Gene

    Size:
    454 amino acids
    Molecular mass:
    47584 Da
    Quaternary structure:
    • Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2, COPS5 and PIR. Interacts with CYLD (By similarity).
    SequenceCaution:
    • Sequence=AAA51815.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA51816.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH64993.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BCL3 Gene

neXtProt entry for BCL3 Gene

Proteomics data for BCL3 Gene at MOPED

Post-translational modifications for BCL3 Gene

  • Activated by phosphorylation.
  • Polyubiquitinated. Ubiquitination via Lys-63-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on Lys-63-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BCL3 Gene

Domains for BCL3 Gene

Gene Families for BCL3 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for BCL3 Gene

UniProtKB/Swiss-Prot:

BCL3_HUMAN
Similarity:
  • Contains 7 ANK repeats.:
    • P20749
genes like me logo Genes that share domains with BCL3: view

Function for BCL3 Gene

Molecular function for BCL3 Gene

GENATLAS Biochemistry: inhibitor of REL/NFKB transcription factors,IKB (NFKBI) family
UniProtKB/Swiss-Prot Function: Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).

Gene Ontology (GO) - Molecular Function for BCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 10362352
GO:0008134 transcription factor binding IPI 11387332
GO:0030674 protein binding, bridging TAS 16306601
genes like me logo Genes that share ontologies with BCL3: view

Phenotypes for BCL3 Gene

genes like me logo Genes that share phenotypes with BCL3: view

Animal Models for BCL3 Gene

MGI Knock Outs for BCL3:

miRNA for BCL3 Gene

miRTarBase miRNAs that target BCL3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BCL3 Gene

Localization for BCL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL3 Gene

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Ubiquitination via Lys-63-linked ubiquitin chains is required for nuclear accumulation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCL3 Gene COMPARTMENTS Subcellular localization image for BCL3 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for BCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16280327
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0032996 Bcl3-Bcl10 complex IDA 16280327
GO:0033257 Bcl3/NF-kappaB2 complex IDA 9407099
genes like me logo Genes that share ontologies with BCL3: view

Pathways for BCL3 Gene

genes like me logo Genes that share pathways with BCL3: view

Pathways by source for BCL3 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for BCL3 Gene
2 Qiagen pathways for BCL3 Gene
1 KEGG pathway for BCL3 Gene

Gene Ontology (GO) - Biological Process for BCL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IMP 16280327
GO:0002268 follicular dendritic cell differentiation IEA --
GO:0002315 marginal zone B cell differentiation IEA --
GO:0002455 humoral immune response mediated by circulating immunoglobulin IEA --
GO:0002467 germinal center formation IEA --
genes like me logo Genes that share ontologies with BCL3: view

Compounds for BCL3 Gene

(3) Novoseek inferred chemical compound relationships for BCL3 Gene

Compound -log(P) Hits PubMed IDs
[alcl] 54 5
rapamycin 8.15 3
tyrosine 0 4
genes like me logo Genes that share compounds with BCL3: view

Transcripts for BCL3 Gene

Unigene Clusters for BCL3 Gene

B-cell CLL/lymphoma 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCL3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for BCL3 Gene

GeneLoc Exon Structure for
BCL3
ECgene alternative splicing isoforms for
BCL3

Expression for BCL3 Gene

mRNA expression in normal human tissues for BCL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCL3 Gene

This gene is overexpressed in Whole Blood (6.9) and Liver (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BCL3 Gene

SOURCE GeneReport for Unigene cluster for BCL3 Gene Hs.31210

genes like me logo Genes that share expressions with BCL3: view

Orthologs for BCL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCL3 36
  • 99.63 (n)
  • 99.34 (a)
BCL3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BCL3 36
  • 89.35 (n)
  • 90.09 (a)
BCL3 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCL3 37
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcl3 36
  • 82.44 (n)
  • 82.37 (a)
Bcl3 16
Bcl3 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BCL3 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCL3 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcl3 36
  • 82.51 (n)
  • 83.04 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 13 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia BCL3 37
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489600 36
  • 59.5 (n)
  • 58.06 (a)
zebrafish
(Danio rerio)
Actinopterygii bcl3 37
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6482 37
  • 13 (a)
OneToOne
Species with no ortholog for BCL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCL3 Gene

ENSEMBL:
Gene Tree for BCL3 (if available)
TreeFam:
Gene Tree for BCL3 (if available)

Paralogs for BCL3 Gene

Paralogs for BCL3 Gene

Selected SIMAP similar genes for BCL3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BCL3: view

Variants for BCL3 Gene

Sequence variations from dbSNP and Humsavar for BCL3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs743583 -- 44,759,397(-) GTGGG(A/T)GGTGA intron-variant
rs762599 -- 44,759,229(+) ccctc(C/T)tcctt intron-variant
rs762600 -- 44,759,236(+) ccttc(A/T)gaccc intron-variant
rs873470 -- 44,747,659(-) GATGG(A/G)TGGGG upstream-variant-2KB, intron-variant
rs899091 -- 44,759,423(-) CCTGA(A/G)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL3 Gene

Variant ID Type Subtype PubMed ID
nsv912116 CNV Loss 21882294
nsv833841 CNV Loss 17160897
nsv2506 CNV Loss 18451855

Relevant External Links for BCL3 Gene

HapMap Linkage Disequilibrium report
BCL3

Disorders for BCL3 Gene

UniProtKB/Swiss-Prot

BCL3_HUMAN
  • Note=A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.

(4) University of Copenhagen DISEASES for BCL3 Gene

(24) Novoseek inferred disease relationships for BCL3 Gene

Disease -log(P) Hits PubMed IDs
leukemia lymphocytic chronic 75.2 15
lymphocytic leukemia chronic b-cell 71.4 4
lymphoma t-cell peripheral 57.4 2
trisomy 53.9 2
lymphoma b-cell 53.4 4

Genatlas disease for BCL3 Gene

B cell lymphoma with translocation t(14;19)(q32;q13.1)

Relevant External Links for BCL3

Genetic Association Database (GAD)
BCL3
Human Genome Epidemiology (HuGE) Navigator
BCL3
Tumor Gene Database (TGDB):
BCL3
genes like me logo Genes that share disorders with BCL3: view

Publications for BCL3 Gene

  1. The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. (PMID: 2180580) Ohno H. … McKeithan T.W. (Cell 1990) 2 3 4 23
  2. Genomic structure of the candidate proto-oncogene BCL3. (PMID: 7896265) McKeithan T.W. … Hume E. (Genomics 1994) 3 4 23
  3. The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. (PMID: 8453667) Bours V. … Siebenlist U. (Cell 1993) 3 4 23
  4. Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family. (PMID: 11707390) Michel F. … Muller C.W. (EMBO J. 2001) 3 4 23
  5. GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity. (PMID: 15469820) Viatour P. … Chariot A. (Mol. Cell 2004) 3 4 23

Products for BCL3 Gene

Sources for BCL3 Gene

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