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Aliases for RHEB Gene

Aliases for RHEB Gene

  • Ras Homolog Enriched In Brain 2 3 4
  • RHEB2 3 4 6
  • Ras Homolog Enriched In Brain 2 2 3
  • GTP-Binding Protein Rheb 3

External Ids for RHEB Gene

Previous Symbols for RHEB Gene

  • RHEB2

Summaries for RHEB Gene

Entrez Gene Summary for RHEB Gene

  • This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]

GeneCards Summary for RHEB Gene

RHEB (Ras Homolog Enriched In Brain) is a Protein Coding gene. Diseases associated with RHEB include tuberous sclerosis. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RASL12.

UniProtKB/Swiss-Prot for RHEB Gene

  • Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.

Gene Wiki entry for RHEB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHEB Gene

Genomics for RHEB Gene

Genomic Location for RHEB Gene

151,466,012 bp from pter
151,520,120 bp from pter
54,109 bases
Minus strand

Genomic View for RHEB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHEB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHEB Gene

Regulatory Elements for RHEB Gene

Proteins for RHEB Gene

  • Protein details for RHEB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GTP-binding protein Rheb
    Protein Accession:
    Secondary Accessions:
    • B3KWN6
    • D3DX13
    • Q53Y56
    • Q99444

    Protein attributes for RHEB Gene

    184 amino acids
    Molecular mass:
    20497 Da
    Quaternary structure:
    • Binds to mTORC1 in a guanyl nucleotide-independent manner. Interacts directly with MTOR, MLST8 and RPTOR. Interacts with TSC2. Interacts (when prenylated) with PDE6D; this promotes release from membranes.
    • The conserved catalytic Gln-64 found in other Ras-like GTPases seems not to be involved in GTP hydrolysis in RHEB.

    Three dimensional structures from OCA and Proteopedia for RHEB Gene

neXtProt entry for RHEB Gene

Proteomics data for RHEB Gene at MOPED

Post-translational modifications for RHEB Gene

  • Farnesylation is important for efficiently activating mTORC1-mediated signaling
  • Phosphorylation by MAPKAPK5 impairs GTP-binding and inactivation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys109, Lys135, Lys151, and Lys169

Other Protein References for RHEB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RHEB Gene

Domains for RHEB Gene


  • Belongs to the small GTPase superfamily. Rheb family.:
    • Q15382
genes like me logo Genes that share domains with RHEB: view

No data available for Gene Families for RHEB Gene

Function for RHEB Gene

Molecular function for RHEB Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Alternates between an inactive form bound to GDP and an active form bound to GTP. Inactivated by TSC1-TSC2 via the GTPase activating protein (GAP) domain of TSC2
UniProtKB/Swiss-Prot Function: Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.

Gene Ontology (GO) - Molecular Function for RHEB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 8206940
GO:0005515 protein binding IPI 23559067
GO:0005525 GTP binding ISS --
GO:0019003 GDP binding IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with RHEB: view
genes like me logo Genes that share phenotypes with RHEB: view

Animal Models for RHEB Gene

MGI Knock Outs for RHEB:

miRNA for RHEB Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RHEB Gene

Localization for RHEB Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHEB Gene

Endomembrane system; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for RHEB Gene COMPARTMENTS Subcellular localization image for RHEB gene
Compartment Confidence
plasma membrane 5
cytosol 4
mitochondrion 3
nucleus 2
vacuole 2
endosome 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RHEB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular --
GO:0005681 spliceosomal complex IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with RHEB: view

Pathways for RHEB Gene

genes like me logo Genes that share pathways with RHEB: view

Gene Ontology (GO) - Biological Process for RHEB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007050 cell cycle arrest TAS --
GO:0007165 signal transduction TAS 8661031
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RHEB: view

Compounds for RHEB Gene

(1) HMDB Compounds for RHEB Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP

(2) Drugbank Compounds for RHEB Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
146-91-8 target
86-01-1 target

(6) Novoseek inferred chemical compound relationships for RHEB Gene

Compound -log(P) Hits PubMed IDs
rapamycin 86.7 23
gtp 67.3 17
phosphoinositide 36.3 1
arginine 21.1 5
serine 8.97 2
genes like me logo Genes that share compounds with RHEB: view

Transcripts for RHEB Gene

Unigene Clusters for RHEB Gene

Ras homolog enriched in brain:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHEB Gene

No ASD Table

Relevant External Links for RHEB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHEB Gene

mRNA expression in normal human tissues for RHEB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RHEB Gene

SOURCE GeneReport for Unigene cluster for RHEB Gene Hs.283521

mRNA Expression by UniProt/SwissProt for RHEB Gene

Tissue specificity: Ubiquitous. Highest levels observed in skeletal and cardiac muscle.
genes like me logo Genes that share expressions with RHEB: view

Orthologs for RHEB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHEB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RHEB 36
  • 99.82 (n)
  • 100 (a)
  • 99 (a)
(Bos Taurus)
Mammalia RHEB 36
  • 94.38 (n)
  • 98.91 (a)
  • 99 (a)
(Canis familiaris)
Mammalia RHEB 36
  • 94.93 (n)
  • 99.46 (a)
  • 99 (a)
(Mus musculus)
Mammalia Rheb 36
  • 92.57 (n)
  • 98.91 (a)
Rheb 16
Rheb 37
  • 99 (a)
(Rattus norvegicus)
Mammalia Rheb 36
  • 91.67 (n)
  • 99.46 (a)
(Gallus gallus)
Aves RHEB 36
  • 88.42 (n)
  • 98.8 (a)
(Anolis carolinensis)
Reptilia RHEB 37
  • 84 (a)
African clawed frog
(Xenopus laevis)
Amphibia rheb-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rheb 36
  • 83.7 (n)
  • 92.93 (a)
Str.2304 36
(Danio rerio)
Actinopterygii rheb 37
  • 86 (a)
zgc73144 36
zgc:73144 36
  • 79.71 (n)
  • 90.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rheb 37
  • 64 (a)
(Caenorhabditis elegans)
Secernentea rheb-1 36
  • 50.1 (n)
  • 43.93 (a)
rheb-1 37
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RHB1 36
  • 51.12 (n)
  • 40.45 (a)
RHB1 37
  • 34 (a)
RHB1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A11330g 36
  • 54.12 (n)
  • 44.94 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01444 36
  • 55.37 (n)
  • 51.37 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rhb1 36
  • 56.16 (n)
  • 52.17 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1999 36
Species with no ortholog for RHEB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHEB Gene

Gene Tree for RHEB (if available)
Gene Tree for RHEB (if available)

Paralogs for RHEB Gene

Paralogs for RHEB Gene Pseudogenes for RHEB Gene

genes like me logo Genes that share paralogs with RHEB: view

Variants for RHEB Gene

Sequence variations from dbSNP and Humsavar for RHEB Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs717775 -- 151,469,166(+) TGTTT(A/C)ATCAG intron-variant
rs736645 -- 151,511,449(-) AGATA(G/T)TGATA intron-variant
rs758666 -- 151,511,244(-) AATAA(C/T)TACCT intron-variant
rs875588 -- 151,471,744(+) AACTC(C/T)TGTTT intron-variant
rs965118 -- 151,481,337(-) TATTT(A/T)CTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHEB Gene

Variant ID Type Subtype PubMed ID
nsv6006 CNV Insertion 18451855
nsv831189 CNV Gain 17160897
nsv824394 CNV Gain 20364138
nsv818570 CNV Gain 17921354

Relevant External Links for RHEB Gene

HapMap Linkage Disequilibrium report

Disorders for RHEB Gene

(1) MalaCards Diseases for RHEB Gene

Search for RHEB Gene in MalaCards »

(5) Novoseek inferred disease relationships for RHEB Gene

Disease -log(P) Hits PubMed IDs
tuberous sclerosis 89.4 15
tumors 23.2 7
cancer 10.5 3
genetic disorder 10 1
insulin resistance 0 1

Relevant External Links for RHEB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RHEB: view

No data available for UniProtKB/Swiss-Prot for RHEB Gene

Publications for RHEB Gene

  1. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. (PMID: 12869586) Inoki K. … Guan K.-L. (Genes Dev. 2003) 3 4 23
  2. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. (PMID: 15340059) Li Y. … Guan K.-L. (Mol. Cell. Biol. 2004) 3 4 23
  3. Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. (PMID: 16098514) Tee A.R. … Proud C.G. (FEBS Lett. 2005) 3 4 23
  4. Rheb binds and regulates the mTOR kinase. (PMID: 15854902) Long X. … Avruch J. (Curr. Biol. 2005) 3 4 23
  5. Isolation of cDNA and genomic clones of a human Ras-related GTP- binding protein gene and its chromosomal localization to the long arm of chromosome 7, 7q36. (PMID: 8661031) Mizuki N. … Inoko H. (Genomics 1996) 2 3 4

Products for RHEB Gene

  • Addgene plasmids for RHEB

Sources for RHEB Gene

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