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Aliases for RGS1 Gene

Aliases for RGS1 Gene

  • Regulator Of G Protein Signaling 1 2 3
  • Regulator Of G-Protein Signaling 1 2 3 5
  • Regulator Of G-Protein Signalling 1 2 3
  • B-Cell Activation Protein BL34 3 4
  • Early Response Protein 1R20 3 4
  • IER1 3 4
  • 1R20 3 4
  • BL34 3 4
  • Immediate-Early Response 1, B-Cell Specific 3
  • Epididymis Secretory Protein Li 87 3
  • HEL-S-87 3
  • IR20 3

External Ids for RGS1 Gene

Previous HGNC Symbols for RGS1 Gene

  • IER1

Previous GeneCards Identifiers for RGS1 Gene

  • GC01P190335
  • GC01P188059
  • GC01P189011
  • GC01P189833
  • GC01P189276
  • GC01P190811
  • GC01P163781

Summaries for RGS1 Gene

Entrez Gene Summary for RGS1 Gene

  • This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS1 Gene

RGS1 (Regulator Of G Protein Signaling 1) is a Protein Coding gene. Among its related pathways are MAPK-Erk Pathway and Peptide ligand-binding receptors. GO annotations related to this gene include GTPase activator activity and calmodulin binding. An important paralog of this gene is RGS3.

UniProtKB/Swiss-Prot for RGS1 Gene

  • Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541).

Gene Wiki entry for RGS1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS1 Gene

Genomics for RGS1 Gene

Regulatory Elements for RGS1 Gene

Enhancers for RGS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G192515 1.9 FANTOM5 Ensembl ENCODE dbSUPER 25.2 -58.7 -58715 2.0 PKNOX1 FOXA2 WRNIP1 YY1 ELK1 CBX5 ZNF143 FOS JUNB TBX21 LOC105371664 RGS1 RGS2 ENSG00000236069 GC01P192448
GH01G192528 1.7 FANTOM5 Ensembl ENCODE dbSUPER 23.6 -45.4 -45356 2.9 TBP NFIB BMI1 GATA2 CBX5 FOS RELB ETV6 IKZF2 CREM LOC105371664 RGS1 ENSG00000236069
GH01G192549 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.3 -25.2 -25186 2.5 TBP PKNOX1 TBL1XR1 WRNIP1 CBX5 FOS RELB ETV6 IKZF2 CREM RGS1 ENSG00000231767 RGS2 ENSG00000236069
GH01G192476 1.5 FANTOM5 Ensembl ENCODE 24.6 -98.8 -98814 1.0 TBP ATF1 SREBF2 ZBTB40 BRCA1 RAD21 CHAMP1 RFX5 GTF3C2 ZNF366 RGS1 ZNF101P2 ENSG00000231767 RGS2 GC01P192448 ENSG00000236069
GH01G192544 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21.1 -30.0 -29976 2.9 HDGF TBP PKNOX1 TBL1XR1 BMI1 ZNF366 GATA2 CBX5 FOS RELB RGS1 LOC105371664 ENSG00000236069
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RGS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RGS1 Gene

Chromosome:
1
Start:
192,575,727 bp from pter
End:
192,580,031 bp from pter
Size:
4,305 bases
Orientation:
Plus strand

Genomic View for RGS1 Gene

Genes around RGS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RGS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RGS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS1 Gene

Proteins for RGS1 Gene

  • Protein details for RGS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08116-RGS1_HUMAN
    Recommended name:
    Regulator of G-protein signaling 1
    Protein Accession:
    Q08116
    Secondary Accessions:
    • B2RDM9
    • B4DZY0
    • Q07918
    • Q9H1W2

    Protein attributes for RGS1 Gene

    Size:
    209 amino acids
    Molecular mass:
    23858 Da
    Quaternary structure:
    • Interacts with GNAI1 and GNAQ.
    SequenceCaution:
    • Sequence=AAB26289.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH15510.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG37976.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG64242.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA51826.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RGS1 Gene

    Alternative splice isoforms for RGS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS1 Gene

Post-translational modifications for RGS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RGS1 Gene

Domains & Families for RGS1 Gene

Gene Families for RGS1 Gene

Protein Domains for RGS1 Gene

Suggested Antigen Peptide Sequences for RGS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RGS1: view

No data available for UniProtKB/Swiss-Prot for RGS1 Gene

Function for RGS1 Gene

Molecular function for RGS1 Gene

GENATLAS Biochemistry:
negative regulator of G-protein signaling 1,23kDa,functioning as GTPase-activating protein for G protein alpha subunits,G alpha i and G alpha o,abundantly expressed in B cells,C elegans EGL-10 and yeast SST2 homolog
UniProtKB/Swiss-Prot Function:
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541).
UniProtKB/Swiss-Prot Induction:
In response to several B-cell activation signals.

Gene Ontology (GO) - Molecular Function for RGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IPI 18434541
GO:0005096 GTPase activator activity IDA,TAS 10480894
GO:0005516 calmodulin binding TAS 10747990
genes like me logo Genes that share ontologies with RGS1: view
genes like me logo Genes that share phenotypes with RGS1: view

Animal Models for RGS1 Gene

MGI Knock Outs for RGS1:

Animal Model Products

  • Taconic Biosciences Mouse Models for RGS1

CRISPR Products

miRNA for RGS1 Gene

miRTarBase miRNAs that target RGS1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RGS1 Gene

Localization for RGS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RGS1 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RGS1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
extracellular 1

Gene Ontology (GO) - Cellular Components for RGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,IDA 10480894
GO:0005886 plasma membrane TAS 10480894
GO:0016020 membrane IEA --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA 10480894
genes like me logo Genes that share ontologies with RGS1: view

Pathways & Interactions for RGS1 Gene

genes like me logo Genes that share pathways with RGS1: view

Gene Ontology (GO) - Biological Process for RGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 8241276
GO:0007165 signal transduction NAS,IDA 10480894
GO:0007186 G-protein coupled receptor signaling pathway IDA 10480894
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS 10480894
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA --
genes like me logo Genes that share ontologies with RGS1: view

No data available for SIGNOR curated interactions for RGS1 Gene

Drugs & Compounds for RGS1 Gene

(1) Drugs for RGS1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for RGS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RGS1: view

Transcripts for RGS1 Gene

Unigene Clusters for RGS1 Gene

Regulator of G-protein signaling 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RGS1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: -
SP2:
SP3: -
SP4: - - - - -
SP5: - -
SP6:

Relevant External Links for RGS1 Gene

GeneLoc Exon Structure for
RGS1
ECgene alternative splicing isoforms for
RGS1

Expression for RGS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RGS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.8) and Nerve - Tibial (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of RGS1 Gene:

RGS1

SOURCE GeneReport for Unigene cluster for RGS1 Gene:

Hs.75256

mRNA Expression by UniProt/SwissProt for RGS1 Gene:

Q08116-RGS1_HUMAN
Tissue specificity: Detected in peripheral blood monocytes (PubMed:10480894). Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high (PubMed:8473738).

Evidence on tissue expression from TISSUES for RGS1 Gene

  • Nervous system(4.3)
  • Muscle(4.2)
  • Skin(4)
  • Lymph node(2.7)
  • Intestine(2.2)
  • Gall bladder(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with RGS1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RGS1 Gene

Orthologs for RGS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS1 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia RGS1 34 35
  • 90.91 (n)
dog
(Canis familiaris)
Mammalia RGS1 34 35
  • 89.95 (n)
rat
(Rattus norvegicus)
Mammalia Rgs1 34
  • 88.27 (n)
mouse
(Mus musculus)
Mammalia Rgs1 34 16 35
  • 87.88 (n)
oppossum
(Monodelphis domestica)
Mammalia RGS1 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 73 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves RGS1 34 35
  • 70.41 (n)
lizard
(Anolis carolinensis)
Reptilia RGS1 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs1 34
  • 62.81 (n)
zebrafish
(Danio rerio)
Actinopterygii rgs13 34 35
  • 58.52 (n)
si:ch211-117l17.5 35
  • 48 (a)
ManyToMany
rgs1 35
  • 43 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5036 35
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rgs-2 35
  • 33 (a)
ManyToMany
rgs-1 35
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
OneToMany
Species where no ortholog for RGS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS1 Gene

ENSEMBL:
Gene Tree for RGS1 (if available)
TreeFam:
Gene Tree for RGS1 (if available)

Paralogs for RGS1 Gene

Paralogs for RGS1 Gene

(17) SIMAP similar genes for RGS1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RGS1: view

Variants for RGS1 Gene

Sequence variations from dbSNP and Humsavar for RGS1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1001387889 -- 192,576,983(+) AGTAT(A/G)CCTCT intron-variant
rs1002090470 -- 192,576,952(+) GTTTG(C/T)CTGTA intron-variant
rs1002156812 -- 192,575,426(+) TAATA(C/T)GCCAA intron-variant, upstream-variant-2KB
rs1002450473 -- 192,576,008(+) GGAAG(A/G)GAGTG intron-variant
rs1004118617 -- 192,576,564(+) TCTAT(C/T)TGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS1 Gene

Variant ID Type Subtype PubMed ID
nsv3954 CNV insertion 18451855
nsv466994 CNV loss 19166990
nsv548658 CNV loss 21841781

Variation tolerance for RGS1 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RGS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RGS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS1 Gene

Disorders for RGS1 Gene

Relevant External Links for RGS1

Genetic Association Database (GAD)
RGS1
Human Genome Epidemiology (HuGE) Navigator
RGS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RGS1

No disorders were found for RGS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RGS1 Gene

Publications for RGS1 Gene

  1. A B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein. (PMID: 8241276) Newton J.S. … Norton J.D. (Biochim. Biophys. Acta 1993) 2 3 4 64
  2. Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois P.C. … van Heel D.A. (Nat. Genet. 2010) 3 46 64
  3. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro A.P. … Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort. (PMID: 19693089) Amundsen S.S. … Sollid L.M. (Genes Immun. 2010) 3 46 64

Products for RGS1 Gene

Sources for RGS1 Gene

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