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Aliases for RGS1 Gene

Aliases for RGS1 Gene

  • Regulator Of G-Protein Signaling 1 2 3
  • IER1 3 4 6
  • Regulator Of G-Protein Signalling 1 2 3
  • B-Cell Activation Protein BL34 3 4
  • Early Response Protein 1R20 3 4
  • IR20 3 6
  • 1R20 3 4
  • BL34 3 4
  • Immediate-Early Response 1, B-Cell Specific 3
  • Epididymis Secretory Protein Li 87 3
  • HEL-S-87 3

External Ids for RGS1 Gene

Previous Symbols for RGS1 Gene

  • IER1

Summaries for RGS1 Gene

Entrez Gene Summary for RGS1 Gene

  • This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

GeneCards Summary for RGS1 Gene

RGS1 (Regulator Of G-Protein Signaling 1) is a Protein Coding gene. Diseases associated with RGS1 include chronic lymphocytic leukemia. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include calmodulin binding and GTPase activator activity. An important paralog of this gene is RGS18.

UniProtKB/Swiss-Prot for RGS1 Gene

  • Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation

Gene Wiki entry for RGS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RGS1 Gene

Genomics for RGS1 Gene

Genomic Location for RGS1 Gene

Start:
192,575,727 bp from pter
End:
192,580,031 bp from pter
Size:
4,305 bases
Orientation:
Plus strand

Genomic View for RGS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RGS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RGS1 Gene

Regulatory Elements for RGS1 Gene

Proteins for RGS1 Gene

  • Protein details for RGS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08116-RGS1_HUMAN
    Recommended name:
    Regulator of G-protein signaling 1
    Protein Accession:
    Q08116
    Secondary Accessions:
    • B2RDM9
    • B4DZY0
    • Q07918
    • Q9H1W2

    Protein attributes for RGS1 Gene

    Size:
    209 amino acids
    Molecular mass:
    23858 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB26289.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH15510.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG37976.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG64242.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA51826.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RGS1 Gene

    Alternative splice isoforms for RGS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RGS1 Gene

Proteomics data for RGS1 Gene at MOPED

Post-translational modifications for RGS1 Gene

  • Could be phosphorylated. Might be functionally regulated by protein kinase(s)
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RGS1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RGS1 Gene

Domains for RGS1 Gene

Gene Families for RGS1 Gene

HGNC:
  • RGS :Regulators of G-protein signaling

Protein Domains for RGS1 Gene

Suggested Antigen Peptide Sequences for RGS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08116

UniProtKB/Swiss-Prot:

RGS1_HUMAN
Domain:
  • Contains 1 RGS domain.:
    • Q08116
genes like me logo Genes that share domains with RGS1: view

Function for RGS1 Gene

Molecular function for RGS1 Gene

GENATLAS Biochemistry: negative regulator of G-protein signaling 1,23kDa,functioning as GTPase-activating protein for G protein alpha subunits,G alpha i and G alpha o,abundantly expressed in B cells,C elegans EGL-10 and yeast SST2 homolog
UniProtKB/Swiss-Prot Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation
UniProtKB/Swiss-Prot Induction: In response to several B-cell activation signals

Gene Ontology (GO) - Molecular Function for RGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0005516 calmodulin binding TAS 10747990
genes like me logo Genes that share ontologies with RGS1: view

Phenotypes for RGS1 Gene

genes like me logo Genes that share phenotypes with RGS1: view

Animal Models for RGS1 Gene

MGI Knock Outs for RGS1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RGS1 Gene

Localization for RGS1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RGS1 Gene COMPARTMENTS Subcellular localization image for RGS1 gene
Compartment Confidence
cytosol 3
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for RGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with RGS1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RGS1 Gene

Pathways for RGS1 Gene

genes like me logo Genes that share pathways with RGS1: view

Gene Ontology (GO) - Biological Process for RGS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 8241276
GO:0007165 signal transduction NAS 8241276
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS 10480894
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway --
GO:0038032 termination of G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with RGS1: view

Compounds for RGS1 Gene

(4) Novoseek inferred chemical compound relationships for RGS1 Gene

Compound -log(P) Hits PubMed IDs
gdp 44 1
gtp 42.5 1
cycloheximide 32.4 1
calcium 0 2
genes like me logo Genes that share compounds with RGS1: view

Transcripts for RGS1 Gene

Unigene Clusters for RGS1 Gene

Regulator of G-protein signaling 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RGS1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: -
SP2:
SP3: -
SP4: - - - - -
SP5: - -
SP6:

Relevant External Links for RGS1 Gene

GeneLoc Exon Structure for
RGS1
ECgene alternative splicing isoforms for
RGS1

Expression for RGS1 Gene

mRNA expression in normal human tissues for RGS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RGS1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (7.8) and Nerve - Tibial (4.1).

SOURCE GeneReport for Unigene cluster for RGS1 Gene Hs.75256

mRNA Expression by UniProt/SwissProt for RGS1 Gene

Q08116-RGS1_HUMAN
Tissue specificity: B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high
genes like me logo Genes that share expressions with RGS1: view

No data available for Protein expression for RGS1 Gene

Orthologs for RGS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RGS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RGS1 35
  • 100 (n)
  • 100 (a)
RGS1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RGS1 35
  • 90.91 (n)
  • 90.91 (a)
RGS1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RGS1 35
  • 89.95 (n)
  • 89 (a)
RGS1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rgs1 35
  • 87.88 (n)
  • 86.6 (a)
Rgs1 16
Rgs1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RGS1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rgs1 35
  • 88.27 (n)
  • 91.36 (a)
chicken
(Gallus gallus)
Aves RGS1 35
  • 70.41 (n)
  • 66.33 (a)
RGS1 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RGS1 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rgs1 35
  • 62.81 (n)
  • 57.37 (a)
zebrafish
(Danio rerio)
Actinopterygii rgs1 36
  • 43 (a)
ManyToMany
rgs13 35
  • 58.52 (n)
  • 53.33 (a)
rgs13 36
  • 43 (a)
ManyToMany
si:ch211-117l17.5 36
  • 48 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5036 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rgs-1 36
  • 23 (a)
ManyToMany
rgs-2 36
  • 33 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for RGS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RGS1 Gene

ENSEMBL:
Gene Tree for RGS1 (if available)
TreeFam:
Gene Tree for RGS1 (if available)

Paralogs for RGS1 Gene

Paralogs for RGS1 Gene

Selected SIMAP similar genes for RGS1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RGS1: view

Variants for RGS1 Gene

Sequence variations from dbSNP and Humsavar for RGS1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1049479 -- 192,579,386(+) TATGG(A/C)TCCCT utr-variant-3-prime
rs1049480 -- 192,579,454(+) CAGAA(C/T)GGATT utr-variant-3-prime
rs1323291 -- 192,579,413(-) ACCCA(A/C)AAAAG utr-variant-3-prime
rs1547624 -- 192,574,707(-) AGAAG(A/T)TAGTA upstream-variant-2KB
rs1923948 -- 192,578,518(+) ATAAA(A/T)ATAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RGS1 Gene

Variant ID Type Subtype PubMed ID
nsv466994 CNV Loss 19166990
nsv3954 CNV Insertion 18451855

Relevant External Links for RGS1 Gene

HapMap Linkage Disequilibrium report
RGS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RGS1 Gene

Disorders for RGS1 Gene

Relevant External Links for RGS1

Genetic Association Database (GAD)
RGS1
Human Genome Epidemiology (HuGE) Navigator
RGS1
genes like me logo Genes that share disorders with RGS1: view

No data available for UniProtKB/Swiss-Prot for RGS1 Gene

Publications for RGS1 Gene

  1. A B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein. (PMID: 8241276) Newton J.S. … Norton J.D. (Biochim. Biophys. Acta 1993) 2 3 4
  2. Isolation and characterization of a novel B cell activation gene. (PMID: 8473738) Hong J.X. … Kehrl J.H. (J. Immunol. 1993) 3 4
  3. Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. (PMID: 8602223) Druey K.M. … Kehrl J.H. (Nature 1996) 2 3
  4. Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members. (PMID: 9774420) Bowman E.P. … Butcher E.C. (J. Biol. Chem. 1998) 3 23
  5. Differential capacities of the RGS1, RGS16 and RGS-GAIP regulators of G protein signaling to enhance alpha2A-adrenoreceptor agonist-stimulated GTPase activity of G(o1)alpha. (PMID: 11520900) Hoffmann M. … Milligan G. (J. Neurochem. 2001) 3 23

Products for RGS1 Gene

Sources for RGS1 Gene

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