Aliases for RGS1 Gene
External Ids for RGS1 Gene
Previous Symbols for RGS1 Gene
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
GeneCards Summary for RGS1 Gene
RGS1 (Regulator Of G-Protein Signaling 1) is a Protein Coding gene. Diseases associated with RGS1 include chronic lymphocytic leukemia. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include calmodulin binding and GTPase activator activity. An important paralog of this gene is RGS18.
UniProtKB/Swiss-Prot for RGS1 Gene
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation