Aliases for RECQL Gene
External Ids for RECQL Gene
Previous GeneCards Identifiers for RECQL Gene
The protein encoded by this gene is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. The encoded protein is involved in the processing of Holliday junctions, the suppression of sister chromatid exchanges, telomere maintenance, and is required for genotoxic stress resistance. Defects in this gene have been associated with several types of cancer. [provided by RefSeq, Jan 2017]
GeneCards Summary for RECQL Gene
RECQL (RecQ Like Helicase) is a Protein Coding gene. Diseases associated with RECQL include Rothmund-Thomson Syndrome and Werner Syndrome. Among its related pathways are DNA Damage. GO annotations related to this gene include nucleic acid binding and ATP-dependent DNA helicase activity. An important paralog of this gene is BLM.
UniProtKB/Swiss-Prot for RECQL Gene
DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3-5 direction.