External Ids for RDX Gene
Previous HGNC Symbols for RDX Gene
Previous GeneCards Identifiers for RDX Gene
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
GeneCards Summary for RDX Gene
RDX (Radixin) is a Protein Coding gene. Diseases associated with RDX include Deafness, Autosomal Recessive 24 and Nonsyndromic Hearing Loss And Deafness. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include poly(A) RNA binding and cytoskeletal protein binding. An important paralog of this gene is MSN.
UniProtKB/Swiss-Prot for RDX Gene
Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.