Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NPS Gene

Aliases for NPS Gene

  • Neuropeptide S 2 3 5
  • Prepro-Neuropeptide S 2

External Ids for NPS Gene

Previous GeneCards Identifiers for NPS Gene

  • GC10U900621
  • GC10P129237
  • GC10P129347
  • GC10P122920

Summaries for NPS Gene

GeneCards Summary for NPS Gene

NPS (Neuropeptide S) is a Protein Coding gene. Diseases associated with NPS include epicondylitis and autonomic nervous system disease. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling.

UniProtKB/Swiss-Prot for NPS Gene

  • Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).

Gene Wiki entry for NPS Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPS Gene

Genomics for NPS Gene

Regulatory Elements for NPS Gene

Genomic Location for NPS Gene

127,549,349 bp from pter
127,552,671 bp from pter
3,323 bases
Plus strand

Genomic View for NPS Gene

Genes around NPS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPS Gene

Proteins for NPS Gene

  • Protein details for NPS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuropeptide S
    Protein Accession:

    Protein attributes for NPS Gene

    89 amino acids
    Molecular mass:
    10103 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NPS Gene

Proteomics data for NPS Gene at MOPED

Post-translational modifications for NPS Gene

No Post-translational modifications

Other Protein References for NPS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NPS Gene

Domains & Families for NPS Gene

Gene Families for NPS Gene

Protein Domains for NPS Gene


Suggested Antigen Peptide Sequences for NPS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NPS: view

No data available for UniProtKB/Swiss-Prot for NPS Gene

Function for NPS Gene

Molecular function for NPS Gene

UniProtKB/Swiss-Prot Function:
Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (PubMed:15312648, PubMed:16790440).

Animal Model Products

  • Taconic Biosciences Mouse Models for NPS

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NPS Gene

Localization for NPS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPS Gene


Subcellular locations from

Jensen Localization Image for NPS Gene COMPARTMENTS Subcellular localization image for NPS gene
Compartment Confidence
extracellular 5
nucleus 3
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 2
plasma membrane 2
endosome 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for NPS Gene

Pathways & Interactions for NPS Gene

genes like me logo Genes that share pathways with NPS: view

Interacting Proteins for NPS Gene

Gene Ontology (GO) - Biological Process for NPS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway IEA --
GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness IEA --
GO:0045760 positive regulation of action potential IEA --
GO:0051968 positive regulation of synaptic transmission, glutamatergic IEA --
genes like me logo Genes that share ontologies with NPS: view

No data available for SIGNOR curated interactions for NPS Gene

Drugs & Compounds for NPS Gene

No Compound Related Data Available

Transcripts for NPS Gene

mRNA/cDNA for NPS Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NPS Gene

No ASD Table

Relevant External Links for NPS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPS Gene

mRNA expression in normal human tissues for NPS Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NPS Gene

SOURCE GeneReport for Unigene cluster for NPS Gene Hs.643423

genes like me logo Genes that share expression patterns with NPS: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NPS Gene

Orthologs for NPS Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPS Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Nps 35
  • 81.44 (n)
  • 73.86 (a)
Nps 16
Nps 36
  • 73 (a)
(Pan troglodytes)
Mammalia NPS 35
  • 98.13 (n)
  • 95.51 (a)
NPS 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Nps 35
  • 82.58 (n)
  • 73.86 (a)
(Canis familiaris)
Mammalia NPS 36
  • 78 (a)
(Monodelphis domestica)
Mammalia NPS 36
  • 56 (a)
(Anolis carolinensis)
Reptilia NPS 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nps 35
  • 60.85 (n)
  • 61.63 (a)
Species with no ortholog for NPS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NPS Gene

Gene Tree for NPS (if available)
Gene Tree for NPS (if available)

Paralogs for NPS Gene

No data available for Paralogs for NPS Gene

Variants for NPS Gene

Sequence variations from dbSNP and Humsavar for NPS Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs990310 - 127,549,521(+) TCTGT(C/T)GCTGT reference, missense
rs4751440 - 127,552,592(+) ATGGA(A/C/G)TTGGC reference, missense
rs990311 -- 127,549,985(+) GTTAG(A/C)TCTAA intron-variant
rs995202 -- 127,551,661(+) TTTGC(A/C)TTATT intron-variant
rs1931706 -- 127,547,935(+) TAATC(C/T)TGTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NPS Gene

Variant ID Type Subtype PubMed ID
nsv7607 CNV Loss 18451855

Variation tolerance for NPS Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.26; 62.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NPS Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NPS Gene

Disorders for NPS Gene

MalaCards: The human disease database

(24) MalaCards diseases for NPS Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • andrel epicondylitis
autonomic nervous system disease
  • autonomic nervous system disorder
vasomotor rhinitis
  • rhinitis vasomotor
reflex sympathetic dystrophy
  • reflex sympathetic dystrophy syndrome
alcohol-induced mental disorder
  • psychoses, alcoholic
- elite association - COSMIC cancer census association via MalaCards
Search NPS in MalaCards View complete list of genes associated with diseases

Relevant External Links for NPS

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NPS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPS Gene

Publications for NPS Gene

  1. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. (PMID: 15312648) Xu Y.-L. … Civelli O. (Neuron 2004) 2 3 4 67
  2. Synthesis and biological activity of human neuropeptide S analogues modified in position 2. (PMID: 18181564) Camarda V. … Salvadori S. (J. Med. Chem. 2008) 2 3
  3. Neuropeptide S stimulates human monocyte chemotaxis via NPS receptor activation. (PMID: 23142110) Filaferro M. … Vitale G. (Peptides 2013) 3
  4. A single-nucleotide polymorphism of human neuropeptide s gene originated from Europe shows decreased bioactivity. (PMID: 24386135) Deng C. … Hsueh A.J. (PLoS ONE 2013) 3
  5. Non-synonymous polymorphism in the neuropeptide S precursor gene and sleep apnea. (PMID: 20405330) SA!nchez-de-la-Torre M. … BarbAc F. (Sleep Breath 2011) 3

Products for NPS Gene

Sources for NPS Gene

Back to Top