Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RBP1 Gene

Aliases for RBP1 Gene

  • Retinol Binding Protein 1, Cellular 2 3
  • Retinol-Binding Protein 1, Cellular 2 3
  • Cellular Retinol-Binding Protein I 3 4
  • CRBP-I 3 4
  • CRBP1 3 4
  • CRBP 3 4
  • Cellular Retinol-Binding Protein 4
  • Retinol-Binding Protein 1 3
  • CRABP-I 3
  • CRBPI 3
  • RBPC 3
  • C 6

External Ids for RBP1 Gene

Previous GeneCards Identifiers for RBP1 Gene

  • GC03M136134
  • GC03M140065
  • GC03M140517
  • GC03M140557
  • GC03M140718
  • GC03M139236
  • GC03M136611

Summaries for RBP1 Gene

Entrez Gene Summary for RBP1 Gene

  • This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for RBP1 Gene

RBP1 (Retinol Binding Protein 1, Cellular) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include transporter activity and retinal binding. An important paralog of this gene is FABP7.

UniProtKB/Swiss-Prot for RBP1 Gene

  • Intracellular transport of retinol

Gene Wiki entry for RBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBP1 Gene

Genomics for RBP1 Gene

Regulatory Elements for RBP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RBP1 Gene

139,517,434 bp from pter
139,539,829 bp from pter
22,396 bases
Minus strand

Genomic View for RBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBP1 Gene

Proteins for RBP1 Gene

  • Protein details for RBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinol-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • A8K2Q0
    • B7Z7A0
    • E7EWV0
    • F2Z2F2
    • Q6FGX8

    Protein attributes for RBP1 Gene

    135 amino acids
    Molecular mass:
    15850 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RBP1 Gene


neXtProt entry for RBP1 Gene

Proteomics data for RBP1 Gene at MOPED

Post-translational modifications for RBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBP1 Gene

Antibody Products

No data available for DME Specific Peptides for RBP1 Gene

Domains for RBP1 Gene

Gene Families for RBP1 Gene

  • FABP :Fatty acid binding protein family

Suggested Antigen Peptide Sequences for RBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P09455
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with RBP1: view

Function for RBP1 Gene

Molecular function for RBP1 Gene

GENATLAS Biochemistry:
retinol binding protein 1,cellular (lipocalin family,Kernel group),monomer,essential for vitamin A homeostasis
UniProtKB/Swiss-Prot Function:
Intracellular transport of retinol

Gene Ontology (GO) - Molecular Function for RBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005501 retinoid binding TAS 3472205
GO:0016918 retinal binding IEA --
GO:0019841 retinol binding IEA --
genes like me logo Genes that share ontologies with RBP1: view
genes like me logo Genes that share phenotypes with RBP1: view

Animal Models for RBP1 Gene

MGI Knock Outs for RBP1:

Animal Model Products

miRNA for RBP1 Gene

miRTarBase miRNAs that target RBP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RBP1 Gene

Localization for RBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBP1 Gene


Subcellular locations from

Jensen Localization Image for RBP1 Gene COMPARTMENTS Subcellular localization image for RBP1 gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0044297 cell body --
genes like me logo Genes that share ontologies with RBP1: view

Pathways for RBP1 Gene

genes like me logo Genes that share pathways with RBP1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0002138 retinoic acid biosynthetic process --
GO:0006776 vitamin A metabolic process TAS 3472205
GO:0006810 transport IEA --
GO:0007603 phototransduction, visible light TAS --
genes like me logo Genes that share ontologies with RBP1: view

Compounds for RBP1 Gene

(2) Drugbank Compounds for RBP1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
55079-83-9 target agonist
Vitamin A
  • [11,12-3H]-Retinol
68-26-8 target

(25) Novoseek inferred chemical compound relationships for RBP1 Gene

Compound -log(P) Hits PubMed IDs
vitamin a 91.6 205
retinoid 87.8 37
retinaldehyde 87.1 8
retinoic acid 86.1 102
retinyl ester 79.5 8
genes like me logo Genes that share compounds with RBP1: view

Transcripts for RBP1 Gene

Unigene Clusters for RBP1 Gene

Retinol binding protein 1, cellular:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RBP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RBP1 Gene

No ASD Table

Relevant External Links for RBP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RBP1 Gene

mRNA expression in normal human tissues for RBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RBP1 Gene

This gene is overexpressed in Ovary (15.2), Pancreas (6.9), and Adrenal Gland (4.1).

Protein differential expression in normal tissues for RBP1 Gene

This gene is overexpressed in Ovary (14.0), Fetal ovary (12.0), and Fetal testis (11.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBP1 Gene

SOURCE GeneReport for Unigene cluster for RBP1 Gene Hs.529571

mRNA Expression by UniProt/SwissProt for RBP1 Gene

Tissue specificity: Detected in nearly all the tissues with higher expression in adult ovary, pancreas, pituitary gland and adrenal gland, and fetal liver.
genes like me logo Genes that share expressions with RBP1: view

Expression partners for RBP1 Gene

In Situ Assay Products

Orthologs for RBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RBP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Rbp1 35
  • 90.37 (n)
  • 96.3 (a)
Rbp1 16
Rbp1 36
  • 96 (a)
(Pan troglodytes)
Mammalia RBP1 35
  • 99.32 (n)
  • 98.48 (a)
RBP1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Rbp1 35
  • 90.12 (n)
  • 96.3 (a)
(Bos Taurus)
Mammalia RBP1 36
  • 97 (a)
(Canis familiaris)
Mammalia RBP1 36
  • 98 (a)
(Monodelphis domestica)
Mammalia RBP1 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia RBP1 36
  • 88 (a)
(Gallus gallus)
Aves RBP1 35
  • 74.57 (n)
  • 85.19 (a)
RBP1 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rbp1 35
  • 75.31 (n)
  • 80 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6191 35
(Danio rerio)
Actinopterygii Dr.15881 35
si:ch211-119o8.7 35
  • 71.21 (n)
  • 75.76 (a)
RBP1 (2 of 3) 36
  • 72 (a)
rbp1b 36
  • 75 (a)
rbp2b 36
  • 37 (a)
Species with no ortholog for RBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RBP1 Gene

Gene Tree for RBP1 (if available)
Gene Tree for RBP1 (if available)

Paralogs for RBP1 Gene

Selected SIMAP similar genes for RBP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RBP1: view

Variants for RBP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for RBP1 Gene

Variant ID Type Subtype PubMed ID
nsv877543 CNV Gain 21882294

Relevant External Links for RBP1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RBP1 Gene

Disorders for RBP1 Gene

(22) Novoseek inferred disease relationships for RBP1 Gene

Disease -log(P) Hits PubMed IDs
epicanthus 54.5 1
blepharophimosis 49.7 1
carcinoma endometrioid 36.9 5
endometrial hyperplasia 36.8 3
squamous cell cancer 24.1 1

Relevant External Links for RBP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RBP1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for RBP1 Gene

Publications for RBP1 Gene

  1. Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization. (PMID: 9858824) De Baere E. … Messiaen L. (Cytogenet. Cell Genet. 1998) 2 3 23
  2. Identification, retinoid binding and X-ray analysis of a human retinol-binding protein. (PMID: 11274389) Folli C. … Berni R. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 23
  3. Cellular retinol-binding protein-1 expression in normal and fibrotic/cirrhotic human liver: different patterns of expression in hepatic stellate cells and (myo)fibroblast subpopulations. (PMID: 15094224) Lepreux S. … DesmouliA"re A. (J. Hepatol. 2004) 3 23
  4. Cellular retinol-binding protein-1 in hepatocellular carcinoma correlates with beta-catenin, Ki-67 index, and patient survival. (PMID: 12883492) Schmitt-GrAoff A. … Blum H.E. (Hepatology 2003) 3 23
  5. Cellular retinol-binding protein-I inhibits PI3K/Akt signaling through a retinoic acid receptor-dependent mechanism that regulates p85-p110 heterodimerization. (PMID: 15608670) Farias E.F. … Mira-y-Lopez R. (Oncogene 2005) 3 23

Products for RBP1 Gene

Sources for RBP1 Gene

Back to Top