Aliases for RXFP1 Gene
External Ids for RXFP1 Gene
Previous HGNC Symbols for RXFP1 Gene
Previous GeneCards Identifiers for RXFP1 Gene
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for RXFP1 Gene
RXFP1 (Relaxin/Insulin Like Family Peptide Receptor 1) is a Protein Coding gene. Diseases associated with RXFP1 include Endometriosis and Cryptorchidism, Unilateral Or Bilateral. Among its related pathways are Peptide ligand-binding receptors and Relaxin signaling pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and hormone binding. An important paralog of this gene is RXFP2.
UniProtKB/Swiss-Prot for RXFP1 Gene
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.