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Aliases for ZNF350 Gene

Aliases for ZNF350 Gene

  • Zinc Finger Protein 350 2 3
  • Zinc Finger And BRCA1-Interacting Protein With A KRAB Domain 1 3 4
  • KRAB Zinc Finger Protein ZFQR 3 4
  • Zinc Finger Protein ZBRK1 3 4
  • ZBRK1 3 4
  • Zinc-Finger Protein ZBRK1 3
  • ZFQR 3

External Ids for ZNF350 Gene

Summaries for ZNF350 Gene

GeneCards Summary for ZNF350 Gene

ZNF350 (Zinc Finger Protein 350) is a Protein Coding gene. Diseases associated with ZNF350 include acoustic neuroma and neuroma. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF577.

UniProtKB/Swiss-Prot for ZNF350 Gene

  • Transcriptional repressor. Binds to a specific sequence, 5-GGGxxxCAGxxxTTT-3, within GADD45 intron 3.

Gene Wiki entry for ZNF350 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF350 Gene

Genomics for ZNF350 Gene

Genomic Location for ZNF350 Gene

Start:
51,964,340 bp from pter
End:
51,986,856 bp from pter
Size:
22,517 bases
Orientation:
Minus strand

Genomic View for ZNF350 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF350 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF350 Gene

Regulatory Elements for ZNF350 Gene

Transcription factor binding sites by QIAGEN in the ZNF350 gene promoter:

Proteins for ZNF350 Gene

  • Protein details for ZNF350 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZX5-ZN350_HUMAN
    Recommended name:
    Zinc finger protein 350
    Protein Accession:
    Q9GZX5
    Secondary Accessions:
    • Q96G73
    • Q9HAQ4

    Protein attributes for ZNF350 Gene

    Size:
    532 amino acids
    Molecular mass:
    60011 Da
    Quaternary structure:
    • Interacts with BRCA1. Interacts with RNF11.

neXtProt entry for ZNF350 Gene

Proteomics data for ZNF350 Gene at MOPED

Post-translational modifications for ZNF350 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF350 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF350 Gene

Domains for ZNF350 Gene

Gene Families for ZNF350 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF350 Gene

UniProtKB/Swiss-Prot:

ZN350_HUMAN
Domain:
  • Contains 1 KRAB domain.:
    • Q9GZX5
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q9GZX5
Similarity:
  • Contains 8 C2H2-type zinc fingers.:
    • Q9GZX5
genes like me logo Genes that share domains with ZNF350: view

Function for ZNF350 Gene

Molecular function for ZNF350 Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor. Binds to a specific sequence, 5-GGGxxxCAGxxxTTT-3, within GADD45 intron 3.

Gene Ontology (GO) - Molecular Function for ZNF350 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA 11090615
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 11090615
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IDA 11090615
GO:0005515 protein binding IPI 11090615
genes like me logo Genes that share ontologies with ZNF350: view

miRNA for ZNF350 Gene

miRTarBase miRNAs that target ZNF350

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF350 Gene

Localization for ZNF350 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF350 Gene

Nucleus. Nucleus matrix. Note=Associated with the nuclear matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF350 Gene COMPARTMENTS Subcellular localization image for ZNF350 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF350 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 23665872
GO:0005654 nucleoplasm IDA --
GO:0016363 nuclear matrix IEA --
GO:0017053 transcriptional repressor complex IDA 11090615
genes like me logo Genes that share ontologies with ZNF350: view

Pathways for ZNF350 Gene

SuperPathways for ZNF350 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF350: view

Pathways by source for ZNF350 Gene

2 Reactome pathways for ZNF350 Gene

Gene Ontology (GO) - Biological Process for ZNF350 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11090615
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 11090615
GO:0045892 negative regulation of transcription, DNA-templated IDA 11090615
genes like me logo Genes that share ontologies with ZNF350: view

Compounds for ZNF350 Gene

(1) Novoseek inferred chemical compound relationships for ZNF350 Gene

Compound -log(P) Hits PubMed IDs
zinc 53.6 9
genes like me logo Genes that share compounds with ZNF350: view

Transcripts for ZNF350 Gene

Unigene Clusters for ZNF350 Gene

Zinc finger protein 350:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF350 Gene

No ASD Table

Relevant External Links for ZNF350 Gene

GeneLoc Exon Structure for
ZNF350
ECgene alternative splicing isoforms for
ZNF350

Expression for ZNF350 Gene

mRNA expression in normal human tissues for ZNF350 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ZNF350 Gene Hs.407694

mRNA Expression by UniProt/SwissProt for ZNF350 Gene

Q9GZX5-ZN350_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with ZNF350: view

Orthologs for ZNF350 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF350 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF350 36
  • 98.81 (n)
  • 98.5 (a)
ZNF350 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 76 (a)
OneToMany
ZNF347 36
  • 81.45 (n)
  • 73.61 (a)
ZNF350 37
  • 61 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZNF350 37
  • 46 (a)
OneToOne
Species with no ortholog for ZNF350:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF350 Gene

ENSEMBL:
Gene Tree for ZNF350 (if available)
TreeFam:
Gene Tree for ZNF350 (if available)

Paralogs for ZNF350 Gene

Paralogs for ZNF350 Gene

Selected SIMAP similar genes for ZNF350 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF350: view

Variants for ZNF350 Gene

Sequence variations from dbSNP and Humsavar for ZNF350 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1241463 -- 51,987,700(-) caggc(A/G)cggtg upstream-variant-2KB
rs7507950 -- 51,983,106(+) gctca(A/G)aaacg intron-variant
rs8102072 -- 51,985,458(+) GAAAA(C/T)GCTCC intron-variant
rs8110287 -- 51,983,591(+) gatgt(C/T)tgtgt intron-variant
rs8110542 -- 51,983,908(+) cttgc(A/G)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF350 Gene

Variant ID Type Subtype PubMed ID
esv638 CNV CNV 17122850
dgv143e55 CNV Gain 17911159
dgv1112e1 CNV Complex 17122850
dgv425n27 CNV Gain 19166990
dgv1113e1 CNV Complex 17122850
nsv833872 CNV Loss 17160897
nsv525259 CNV Loss 19592680
esv2718779 CNV Deletion 23290073
esv2242567 CNV Deletion 18987734

Relevant External Links for ZNF350 Gene

HapMap Linkage Disequilibrium report
ZNF350
Human Gene Mutation Database (HGMD)
ZNF350

Disorders for ZNF350 Gene

Relevant External Links for ZNF350

Genetic Association Database (GAD)
ZNF350
Human Genome Epidemiology (HuGE) Navigator
ZNF350
genes like me logo Genes that share disorders with ZNF350: view

No data available for UniProtKB/Swiss-Prot for ZNF350 Gene

Publications for ZNF350 Gene

  1. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. (PMID: 11090615) Zheng L. … Lee H.W. (Mol. Cell 2000) 2 3 4 23
  2. Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes. (PMID: 15113441) Sigurdson A.J. … Struewing J.P. (BMC Cancer 2004) 3 23 49
  3. Genetic variants and haplotype analyses of the ZBRK1/ZNF350 gene in high-risk non BRCA1/2 French Canadian breast and ovarian cancer families. (PMID: 17764113) Desjardins S. … Durocher F. (Int. J. Cancer 2008) 3 23 49
  4. Polymorphisms in BRCA1, BRCA1-interacting genes and susceptibility of breast cancer in Chinese women. (PMID: 19484476) Huo X. … Tang J. (J. Cancer Res. Clin. Oncol. 2009) 3 23 49
  5. Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells. (PMID: 11161714) Ran Q. … Pereira-Smith O.M. (Exp. Cell Res. 2001) 2 3 4

Products for ZNF350 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF350
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF350
    • Block miRNA regulation of ZNF350 using miScript Target Protectors

    Sources for ZNF350 Gene

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