Aliases for RBL2 Gene
External Ids for RBL2 Gene
Previous GeneCards Identifiers for RBL2 Gene
GeneCards Summary for RBL2 Gene
RBL2 (RB Transcriptional Corepressor Like 2) is a Protein Coding gene. Diseases associated with RBL2 include Retinoblastoma and Osteogenic Sarcoma. Among its related pathways are DNA Damage Response (only ATM dependent) and PI3K-Akt signaling pathway. An important paralog of this gene is RBL1.
UniProtKB/Swiss-Prot for RBL2 Gene
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 Lys-20 trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.