Aliases for RBL2 Gene
External Ids for RBL2 Gene
GeneCards Summary for RBL2 Gene
RBL2 (Retinoblastoma-Like 2) is a Protein Coding gene. Diseases associated with RBL2 include unilateral retinoblastoma and retinoblastoma. Among its related pathways are PI3K-Akt signaling pathway and Cell Cycle, Mitotic. An important paralog of this gene is RB1.
UniProtKB/Swiss-Prot for RBL2 Gene
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 Lys-20 trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor