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Aliases for HIVEP3 Gene

Aliases for HIVEP3 Gene

  • Human Immunodeficiency Virus Type I Enhancer Binding Protein 3 2 3 5
  • Kappa-B And V(D)J Recombination Signal Sequences-Binding Protein 3 4
  • Human Immunodeficiency Virus Type I Enhancer-Binding Protein 3 2 4
  • Zinc Finger Protein ZAS3 3 4
  • Kappa-Binding Protein 1 3 4
  • KBP-1 3 4
  • KBP1 3 4
  • ZAS3 3 4
  • KRC 3 4
  • Kappabinding Protein-1 2
  • ZAS Family, Member 3 3
  • Schnurri-3 3
  • KIAA1555 4
  • ZNF40C 3
  • SHN3 3

External Ids for HIVEP3 Gene

Previous GeneCards Identifiers for HIVEP3 Gene

  • GC01M042003
  • GC01M040979
  • GC01M041440
  • GC01M041388
  • GC01M041644
  • GC01M041744
  • GC01M040093
  • GC01M041974
  • GC01M041985

Summaries for HIVEP3 Gene

Entrez Gene Summary for HIVEP3 Gene

  • This gene encodes a member of the human immunodeficiency virus type 1 enhancer-binding protein family. Members of this protein family contain multiple zinc finger and acid-rich (ZAS) domains and serine-threonine rich regions. This protein acts as a transcription factor and is able to regulate nuclear factor kappaB-mediated transcription by binding the kappaB motif in target genes. This protein also binds the recombination signal sequence that flanks the V, D, and J regions of immunoglobulin and T-cell receptors. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Sep 2011]

GeneCards Summary for HIVEP3 Gene

HIVEP3 (Human Immunodeficiency Virus Type I Enhancer Binding Protein 3) is a Protein Coding gene. Diseases associated with HIVEP3 include presbyopia. Among its related pathways are Notch signaling pathway (KEGG). An important paralog of this gene is HIVEP1.

UniProtKB/Swiss-Prot for HIVEP3 Gene

  • Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.

Gene Wiki entry for HIVEP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIVEP3 Gene

Genomics for HIVEP3 Gene

Regulatory Elements for HIVEP3 Gene

Enhancers for HIVEP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HIVEP3 on UCSC Golden Path with GeneCards custom track

Promoters for HIVEP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HIVEP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HIVEP3 Gene

Chromosome:
1
Start:
41,506,365 bp from pter
End:
42,035,931 bp from pter
Size:
529,567 bases
Orientation:
Minus strand

Genomic View for HIVEP3 Gene

Genes around HIVEP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIVEP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIVEP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIVEP3 Gene

Proteins for HIVEP3 Gene

  • Protein details for HIVEP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T1R4-ZEP3_HUMAN
    Recommended name:
    Transcription factor HIVEP3
    Protein Accession:
    Q5T1R4
    Secondary Accessions:
    • A7YY91
    • Q5T1R5
    • Q9BZS0
    • Q9HCL7

    Protein attributes for HIVEP3 Gene

    Size:
    2406 amino acids
    Molecular mass:
    259465 Da
    Quaternary structure:
    • Interacts with TRAF1 AND TRAF2 as well as with JUN. Forms a multimeric complex with RUNX2 and E3 ubiquitin ligase WWP1 (By similarity).
    SequenceCaution:
    • Sequence=BAB13381.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HIVEP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HIVEP3 Gene

Proteomics data for HIVEP3 Gene at MOPED

Post-translational modifications for HIVEP3 Gene

Other Protein References for HIVEP3 Gene

No data available for DME Specific Peptides for HIVEP3 Gene

Domains & Families for HIVEP3 Gene

Gene Families for HIVEP3 Gene

Protein Domains for HIVEP3 Gene

Suggested Antigen Peptide Sequences for HIVEP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T1R4

UniProtKB/Swiss-Prot:

ZEP3_HUMAN :
  • The ZAS2 domain binds DNA as dimers, tetramers, and multiple of tetramers and readily forms highly ordred DNA-protein structures.
  • Contains 5 C2H2-type zinc fingers.
Domain:
  • The ZAS2 domain binds DNA as dimers, tetramers, and multiple of tetramers and readily forms highly ordred DNA-protein structures.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with HIVEP3: view

Function for HIVEP3 Gene

Molecular function for HIVEP3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.
UniProtKB/Swiss-Prot Induction:
By 12-O-tetradecanoylphorbol-13 acetate (TPA).

Gene Ontology (GO) - Molecular Function for HIVEP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IBA --
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with HIVEP3: view
genes like me logo Genes that share phenotypes with HIVEP3: view

Animal Models for HIVEP3 Gene

MGI Knock Outs for HIVEP3:

Animal Model Products

  • Taconic Biosciences Mouse Models for HIVEP3

miRNA for HIVEP3 Gene

miRTarBase miRNAs that target HIVEP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HIVEP3 Gene

Localization for HIVEP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIVEP3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIVEP3 Gene COMPARTMENTS Subcellular localization image for HIVEP3 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for HIVEP3 Gene

Pathways & Interactions for HIVEP3 Gene

SuperPathways for HIVEP3 Gene

genes like me logo Genes that share pathways with HIVEP3: view

Pathways by source for HIVEP3 Gene

1 BioSystems pathway for HIVEP3 Gene

Gene Ontology (GO) - Biological Process for HIVEP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IBA --
GO:0045893 positive regulation of transcription, DNA-templated IDA 15790681
genes like me logo Genes that share ontologies with HIVEP3: view

No data available for SIGNOR curated interactions for HIVEP3 Gene

Drugs & Compounds for HIVEP3 Gene

No Compound Related Data Available

Transcripts for HIVEP3 Gene

Unigene Clusters for HIVEP3 Gene

Human immunodeficiency virus type I enhancer binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIVEP3 Gene

No ASD Table

Relevant External Links for HIVEP3 Gene

GeneLoc Exon Structure for
HIVEP3
ECgene alternative splicing isoforms for
HIVEP3

Expression for HIVEP3 Gene

mRNA expression in normal human tissues for HIVEP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HIVEP3 Gene

This gene is overexpressed in Tlymphocyte (15.1), Monocytes (13.9), Plasma (12.3), Blymphocyte (10.6), and Adipocyte (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HIVEP3 Gene



SOURCE GeneReport for Unigene cluster for HIVEP3 Gene Hs.403972

genes like me logo Genes that share expression patterns with HIVEP3: view

Protein tissue co-expression partners for HIVEP3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HIVEP3 Gene

Orthologs for HIVEP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HIVEP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HIVEP3 35
  • 88.04 (n)
  • 88.32 (a)
HIVEP3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HIVEP3 35
  • 88.28 (n)
  • 89.37 (a)
HIVEP3 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hivep3 35
  • 82.84 (n)
  • 81.79 (a)
Hivep3 16
Hivep3 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HIVEP3 35
  • 99.21 (n)
  • 99 (a)
HIVEP3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hivep3 35
  • 82.62 (n)
  • 81.71 (a)
oppossum
(Monodelphis domestica)
Mammalia HIVEP3 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves HIVEP3 35
  • 71.65 (n)
  • 71.92 (a)
HIVEP3 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HIVEP3 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hivep3 35
  • 48.17 (n)
  • 43.58 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101886107 35
  • 54.53 (n)
  • 54.7 (a)
hivep3a 36
  • 35 (a)
OneToMany
hivep3b 36
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta shn 37
  • 44 (a)
shn 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sma-9 36
  • 12 (a)
OneToMany
Species with no ortholog for HIVEP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIVEP3 Gene

ENSEMBL:
Gene Tree for HIVEP3 (if available)
TreeFam:
Gene Tree for HIVEP3 (if available)

Paralogs for HIVEP3 Gene

Paralogs for HIVEP3 Gene

(10) SIMAP similar genes for HIVEP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIVEP3: view

Variants for HIVEP3 Gene

Sequence variations from dbSNP and Humsavar for HIVEP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2146315 - 41,584,695(-) CCAGC(A/G)TCCCA nc-transcript-variant, reference, missense
VAR_042911 A colorectal cancer sample
rs2810566 - 41,583,074(+) TGCTG(A/C/T)GGCTC nc-transcript-variant, reference, missense
rs17363472 - 41,581,537(+) GAAAT(C/G)TGGGA nc-transcript-variant, reference, missense
rs2483689 - 41,513,154(-) TGGGC(C/G)CTCTC downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HIVEP3 Gene

Variant ID Type Subtype PubMed ID
nsv871918 CNV Loss 21882294
nsv870806 CNV Loss 21882294
nsv870871 CNV Loss 21882294
nsv633 CNV Loss 18451855
nsv871298 CNV Loss 21882294
esv21529 CNV Gain 19812545
esv2229339 CNV Deletion 18987734
esv2747463 CNV Deletion 23290073
esv2747475 CNV Deletion 23290073
esv2747486 CNV Deletion 23290073
nsv644 CNV Insertion 18451855
esv1639858 CNV Insertion 17803354
nsv518313 CNV Loss 19592680
esv2657722 CNV Deletion 23128226
nsv655 CNV Insertion 18451855
esv2747497 CNV Deletion 23290073
esv2174819 CNV Deletion 18987734
esv2747508 CNV Deletion 23290073
esv2747519 CNV Deletion 23290073
esv1535775 CNV Deletion 17803354
esv2669537 CNV Deletion 23128226
nsv461361 CNV Loss 19166990
esv2663203 CNV Deletion 23128226
nsv517842 CNV Loss 19592680
nsv666 CNV Loss 18451855
nsv871130 CNV Gain 21882294
esv27848 CNV Gain 19812545
nsv677 CNV Insertion 18451855
esv268727 CNV Insertion 20981092
esv268819 CNV Insertion 20981092
nsv829671 CNV Loss 17160897

Variation tolerance for HIVEP3 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.79; 89.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIVEP3 Gene

HapMap Linkage Disequilibrium report
HIVEP3
Human Gene Mutation Database (HGMD)
HIVEP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIVEP3 Gene

Disorders for HIVEP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HIVEP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
presbyopia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HIVEP3

Genetic Association Database (GAD)
HIVEP3
Human Genome Epidemiology (HuGE) Navigator
HIVEP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIVEP3
genes like me logo Genes that share disorders with HIVEP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HIVEP3 Gene

Publications for HIVEP3 Gene

  1. Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2. (PMID: 11161801) Hicar M.D. … Wu L.-C. (Genomics 2001) 2 3 4 67
  2. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  3. Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. (PMID: 24925725) Chung S.A. … Langefeld C.D. (J. Am. Soc. Nephrol. 2014) 3
  4. Probing nuclear pore complex architecture with proximity-dependent biotinylation. (PMID: 24927568) Kim D.I. … Roux K.J. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. Novel estrogen target gene ZAS3 is overexpressed in systemic lupus erythematosus. (PMID: 23178823) Young N.A. … Jarjour W.N. (Mol. Immunol. 2013) 3

Products for HIVEP3 Gene

Sources for HIVEP3 Gene

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