Aliases for ARID4A Gene
External Ids for ARID4A Gene
Previous HGNC Symbols for ARID4A Gene
Previous GeneCards Identifiers for ARID4A Gene
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARID4A Gene
ARID4A (AT-Rich Interaction Domain 4A) is a Protein Coding gene. Diseases associated with ARID4A include Retinoblastoma. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is ARID4B.
UniProtKB/Swiss-Prot for ARID4A Gene
Interacts with the viral protein-binding domain of the retinoblastoma protein.