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Aliases for ARID4A Gene

Aliases for ARID4A Gene

  • AT-Rich Interaction Domain 4A 2 3 5
  • Retinoblastoma-Binding Protein 1 2 3 4
  • AT Rich Interactive Domain 4A (RBP1-Like) 2 3
  • ARID Domain-Containing Protein 4A 3 4
  • RBBP-1 3 4
  • RBBP1 3 4
  • RBP1 3 4
  • AT-Rich Interactive Domain-Containing Protein 4A 3
  • RBP-1 3

External Ids for ARID4A Gene

Previous HGNC Symbols for ARID4A Gene

  • RBBP1

Previous GeneCards Identifiers for ARID4A Gene

  • GC14P056756
  • GC14P056757
  • GC14P057835
  • GC14P058766
  • GC14P038930

Summaries for ARID4A Gene

Entrez Gene Summary for ARID4A Gene

  • The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARID4A Gene

ARID4A (AT-Rich Interaction Domain 4A) is a Protein Coding gene. Diseases associated with ARID4A include Retinoblastoma. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is ARID4B.

UniProtKB/Swiss-Prot for ARID4A Gene

  • Interacts with the viral protein-binding domain of the retinoblastoma protein.

Gene Wiki entry for ARID4A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARID4A Gene

Genomics for ARID4A Gene

Regulatory Elements for ARID4A Gene

Enhancers for ARID4A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G058242 1.4 ENCODE dbSUPER 12.6 -53.8 -53787 3.6 HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B RNU6-341P ARID4A C14orf37 ENSG00000259969 PSMA3-AS1 ENSG00000258682 TRK-CTT1-1 PSMA3
GH14G058296 1.7 FANTOM5 ENCODE dbSUPER 7.2 +0.1 53 4.4 PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 TOMM20L PSMA3-AS1 ARID4A ACTR10 GC14P058345
GH14G058280 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.8 -16.6 -16632 2.4 PKNOX1 ATF1 FEZF1 YY1 TCF12 ZNF766 ELK1 FOS ZNF263 JUNB ACTR10 TOMM20L ENSG00000258682 ARID4A HMGB1P14 PIR55001
GH14G058238 1.8 FANTOM5 Ensembl ENCODE dbSUPER 3.2 -58.9 -58876 3.0 PKNOX1 FOXA2 ARID4B E2F7 SIN3A BRCA1 YY1 ZNF121 GTF3C2 ZNF766 PSMA3-AS1 ENSG00000258682 HMGB1P14 C14orf37 ARID4A TRK-CTT1-1 ACTR10
GH14G058748 1.6 FANTOM5 Ensembl ENCODE 3.1 +451.3 451271 2.9 PKNOX1 ATF1 ARID4B DMAP1 FEZF1 ZNF48 YY1 FOS JUNB TSHZ1 ARID4A LOC102723725 GC14P058773
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARID4A on UCSC Golden Path with GeneCards custom track

Promoters for ARID4A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000069042 -85 4201 PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Transcription factor binding sites by QIAGEN in the ARID4A gene promoter:

Genomic Location for ARID4A Gene

Chromosome:
14
Start:
58,298,385 bp from pter
End:
58,373,995 bp from pter
Size:
75,611 bases
Orientation:
Plus strand

Genomic View for ARID4A Gene

Genes around ARID4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARID4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARID4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARID4A Gene

Proteins for ARID4A Gene

  • Protein details for ARID4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29374-ARI4A_HUMAN
    Recommended name:
    AT-rich interactive domain-containing protein 4A
    Protein Accession:
    P29374
    Secondary Accessions:
    • Q15991
    • Q15992
    • Q15993

    Protein attributes for ARID4A Gene

    Size:
    1257 amino acids
    Molecular mass:
    142752 Da
    Quaternary structure:
    • Interacts with BRMS1. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, BRMS1, HDAC1 and HDAC2.

    Three dimensional structures from OCA and Proteopedia for ARID4A Gene

    Alternative splice isoforms for ARID4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARID4A Gene

Post-translational modifications for ARID4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ARID4A

No data available for DME Specific Peptides for ARID4A Gene

Domains & Families for ARID4A Gene

Gene Families for ARID4A Gene

Suggested Antigen Peptide Sequences for ARID4A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARID4A: view

No data available for UniProtKB/Swiss-Prot for ARID4A Gene

Function for ARID4A Gene

Molecular function for ARID4A Gene

UniProtKB/Swiss-Prot Function:
Interacts with the viral protein-binding domain of the retinoblastoma protein.

Gene Ontology (GO) - Molecular Function for ARID4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 15640446
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 8414517
GO:0004407 histone deacetylase activity TAS --
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with ARID4A: view
genes like me logo Genes that share phenotypes with ARID4A: view

Animal Models for ARID4A Gene

MGI Knock Outs for ARID4A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARID4A Gene

Localization for ARID4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARID4A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARID4A gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for ARID4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8414517
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0017053 transcriptional repressor complex IDA 11283269
genes like me logo Genes that share ontologies with ARID4A: view

Pathways & Interactions for ARID4A Gene

genes like me logo Genes that share pathways with ARID4A: view

Pathways by source for ARID4A Gene

1 GeneGo (Thomson Reuters) pathway for ARID4A Gene

SIGNOR curated interactions for ARID4A Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ARID4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006349 regulation of gene expression by genetic imprinting IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter TAS 8414517
genes like me logo Genes that share ontologies with ARID4A: view

Drugs & Compounds for ARID4A Gene

(1) Drugs for ARID4A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ARID4A: view

Transcripts for ARID4A Gene

Unigene Clusters for ARID4A Gene

AT rich interactive domain 4A (RBP1-like):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARID4A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6: - -
SP7: -
SP8: -
SP9:

Relevant External Links for ARID4A Gene

GeneLoc Exon Structure for
ARID4A
ECgene alternative splicing isoforms for
ARID4A

Expression for ARID4A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARID4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARID4A Gene

This gene is overexpressed in Adrenal (23.4), Peripheral blood mononuclear cells (10.3), CD8 Tcells (9.3), and Blymphocyte (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARID4A Gene



Protein tissue co-expression partners for ARID4A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARID4A Gene:

ARID4A

SOURCE GeneReport for Unigene cluster for ARID4A Gene:

Hs.161000

Evidence on tissue expression from TISSUES for ARID4A Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with ARID4A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARID4A Gene

Orthologs for ARID4A Gene

This gene was present in the common ancestor of animals.

Orthologs for ARID4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARID4A 34 35
  • 99.81 (n)
cow
(Bos Taurus)
Mammalia ARID4A 34 35
  • 93.44 (n)
dog
(Canis familiaris)
Mammalia ARID4A 34 35
  • 92.87 (n)
mouse
(Mus musculus)
Mammalia Arid4a 16 35 34
  • 84.99 (n)
rat
(Rattus norvegicus)
Mammalia Arid4a 34
  • 82.61 (n)
oppossum
(Monodelphis domestica)
Mammalia ARID4A 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARID4A 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARID4A 34 35
  • 78.7 (n)
lizard
(Anolis carolinensis)
Reptilia ARID4A 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arid4a 34
  • 68.01 (n)
Str.10513 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.32170 34
zebrafish
(Danio rerio)
Actinopterygii arid4a 35
  • 52 (a)
OneToOne
wufi14h03 34
worm
(Caenorhabditis elegans)
Secernentea arid-1 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6900 34
Species where no ortholog for ARID4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARID4A Gene

ENSEMBL:
Gene Tree for ARID4A (if available)
TreeFam:
Gene Tree for ARID4A (if available)

Paralogs for ARID4A Gene

Paralogs for ARID4A Gene

(1) SIMAP similar genes for ARID4A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ARID4A: view

Variants for ARID4A Gene

Sequence variations from dbSNP and Humsavar for ARID4A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs62621193 Uncertain significance 58,365,301(+) GAAGG(A/C/G)TAAGG reference, missense, splice-donor-variant
rs1000019501 -- 58,314,697(+) GCACC(A/G)GGATT intron-variant
rs1000071242 -- 58,357,315(+) TTATC(A/T)GGACA intron-variant
rs1000103401 -- 58,298,215(+) TCCAT(G/T)GGACA upstream-variant-2KB
rs1000154005 -- 58,298,069(+) TTCTC(A/G/T)CCAGA nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARID4A Gene

Variant ID Type Subtype PubMed ID
esv26881 CNV loss 19812545

Variation tolerance for ARID4A Gene

Residual Variation Intolerance Score: 10.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARID4A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARID4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARID4A Gene

Disorders for ARID4A Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARID4A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retinoblastoma
  • retinoblastoma, trilateral
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARID4A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARID4A
genes like me logo Genes that share disorders with ARID4A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARID4A Gene

Publications for ARID4A Gene

  1. Alternative splicing of the RBP1 gene clusters in an internal exon that encodes potential phosphorylation sites. (PMID: 8455946) Otterson G.A. … Kaye F.J. (Oncogene 1993) 2 3 4 22 64
  2. Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. (PMID: 1857421) Defeo-Jones D. … Oliff A. (Nature 1991) 2 3 4 22 64
  3. Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. (PMID: 14581478) Meehan W.J. … Welch D.R. (J. Biol. Chem. 2004) 3 4 22 64
  4. Characterization of the retinoblastoma binding proteins RBP1 and RBP2. (PMID: 8414517) Fattaey A.R. … Jones R.E. (Oncogene 1993) 3 4 22 64
  5. Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements. (PMID: 16873370) Monroe D.G. … Spelsberg T.C. (J. Biol. Chem. 2006) 3 22 64

Products for ARID4A Gene

Sources for ARID4A Gene

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