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Aliases for RARG Gene

Aliases for RARG Gene

  • Retinoic Acid Receptor Gamma 2 3
  • Retinoic Acid Receptor, Gamma 2 3 5
  • Nuclear Receptor Subfamily 1 Group B Member 3 3 4
  • RAR-Gamma 3 4
  • NR1B3 3 4
  • Retinoic Acid Nuclear Receptor Gamma Variant 1 3
  • Retinoic Acid Nuclear Receptor Gamma Variant 2 3
  • RARC 3

External Ids for RARG Gene

Previous GeneCards Identifiers for RARG Gene

  • GC12M053763
  • GC12M053518
  • GC12M053321
  • GC12M051890
  • GC12M053604
  • GC12M050646

Summaries for RARG Gene

Entrez Gene Summary for RARG Gene

  • This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for RARG Gene

RARG (Retinoic Acid Receptor Gamma) is a Protein Coding gene. Diseases associated with RARG include embryonal carcinoma and teratocarcinoma. Among its related pathways are all-trans-Retinoic Acid Mediated Apoptosis and PEDF Induced Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is NR4A2.

UniProtKB/Swiss-Prot for RARG Gene

  • Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5-AGGTCA-3 sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).

Tocris Summary for RARG Gene

  • Retinoic acid receptors (RARs) are nuclear hormone receptors of the NR1B class, which function as heterodimers with retinoid X receptors (RXRs). There are three distinct RAR subtypes: RARalpha, present in most tissue types; and RARbeta and RARgamma, with more selective expression.

Gene Wiki entry for RARG Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RARG Gene

Genomics for RARG Gene

Regulatory Elements for RARG Gene

Enhancers for RARG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RARG on UCSC Golden Path with GeneCards custom track

Promoters for RARG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RARG on UCSC Golden Path with GeneCards custom track

Genomic Location for RARG Gene

Chromosome:
12
Start:
53,210,566 bp from pter
End:
53,232,980 bp from pter
Size:
22,415 bases
Orientation:
Minus strand

Genomic View for RARG Gene

Genes around RARG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RARG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RARG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RARG Gene

Proteins for RARG Gene

  • Protein details for RARG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13631-RARG_HUMAN
    Recommended name:
    Retinoic acid receptor gamma
    Protein Accession:
    P13631
    Secondary Accessions:
    • B7Z492
    • B7Z4F1
    • B7ZAE4
    • J3KNP6
    • P22932
    • Q15281
    • Q52LZ8
    • Q9BYX8
    • Q9H1I3
    • Q9UJ38

    Protein attributes for RARG Gene

    Size:
    454 amino acids
    Molecular mass:
    50342 Da
    Quaternary structure:
    • Homodimer. Heterodimer with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Forms a complex with PUS1 and the SRA1 RNA in the nucleus.
    SequenceCaution:
    • Sequence=CAA40548.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RARG Gene

    Alternative splice isoforms for RARG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RARG Gene

Proteomics data for RARG Gene at MOPED

Post-translational modifications for RARG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for RARG (RAR gamma/NR1B3)
  • Cell Signaling Technology (CST) Antibodies for RARG (RARG)

No data available for DME Specific Peptides for RARG Gene

Domains & Families for RARG Gene

Gene Families for RARG Gene

Graphical View of Domain Structure for InterPro Entry

P13631

UniProtKB/Swiss-Prot:

RARG_HUMAN :
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
Domain:
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Contains 1 nuclear receptor DNA-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR1 subfamily.
genes like me logo Genes that share domains with RARG: view

Function for RARG Gene

Molecular function for RARG Gene

GENATLAS Biochemistry:
retinoic acid receptor binding and activated by both all-trans (T-RA) and its 9-cis isomer (9-cis-RA) retinoic acids,gamma subunit,steroid/thyroid hormone receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5-AGGTCA-3 sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).

Gene Ontology (GO) - Molecular Function for RARG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10428834
genes like me logo Genes that share ontologies with RARG: view
genes like me logo Genes that share phenotypes with RARG: view

Animal Models for RARG Gene

MGI Knock Outs for RARG:

Animal Model Products

  • Taconic Biosciences Mouse Models for RARG
Targeted motifs for RARG Gene
HOMER Transcription Factor Regulatory Elements motif RARG
  • Consensus sequence: AGGTCAAGGTCA Submotif: canonical Cell Type: ES GEO ID: GSE30538

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for RARG Gene

Localization for RARG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RARG Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RARG Gene COMPARTMENTS Subcellular localization image for RARG gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RARG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005667 transcription factor complex ISS --
genes like me logo Genes that share ontologies with RARG: view

Pathways & Interactions for RARG Gene

genes like me logo Genes that share pathways with RARG: view

SIGNOR curated interactions for RARG Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for RARG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0002063 chondrocyte development IEA --
GO:0002068 glandular epithelial cell development IEA --
GO:0003406 retinal pigment epithelium development IEA --
GO:0003417 growth plate cartilage development IEA --
genes like me logo Genes that share ontologies with RARG: view

Drugs & Compounds for RARG Gene

(32) Drugs for RARG Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adapalene Approved Pharma binder, Target, agonist RAR尾 and RAR纬 agonist 74
Tazarotene Approved, Investigational Pharma binder, Target, agonist Topical retinoid;antiproliferative;inducer of TIG3 tumor suppressor 36
Tretinoin Approved, Investigational Nutra Full agonist, Agonist, binder, Target, agonist 215
Acitretin Approved Pharma Target, agonist Metabolite of etretinate 30
Alitretinoin Approved, Investigational Pharma agonist, Target 15

(7) Additional Compounds for RARG Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cd 437
125316-60-1
retinoic acid
302-79-4
9-cis-retinoic acid
  • 15-Apo-beta-caroten-15-oate
  • 15-Apo-beta-caroten-15-oic acid
  • 9-cis-Retinoate
  • 9-cis-Retinoic acid
  • 9-cis-Tretinoin
Agonist
Am 580
102121-60-8
Ch 55
110368-33-7

(5) Tocris Compounds for RARG Gene

Compound Action Cas Number
AM 580 Retinoic acid analog; RARalpha agonist 102121-60-8
CD 437 RARgamma-selective agonist 125316-60-1
Ch 55 Potent RAR agonist 110368-33-7
Retinoic acid Endogenous retinoic acid receptor agonist 302-79-4
TTNPB Retinoic acid analog; RAR agonist 71441-28-6

(6) ApexBio Compounds for RARG Gene

Compound Action Cas Number
Acitretin Metabolite of etretinate 55079-83-9
Adapalene RAR尾 and RAR纬 agonist 106685-40-9
Tazarotene Topical retinoid;antiproliferative;inducer of TIG3 tumor suppressor 118292-40-3
Tretinoin (Aberela) 302-79-4
TTNPB (Arotinoid Acid) Potent RAR agonist 71441-28-6
Vitamin A Acetate Unsaturated nutritional hydrocarbons 127-47-9
genes like me logo Genes that share compounds with RARG: view

Drug Products

Transcripts for RARG Gene

Unigene Clusters for RARG Gene

Retinoic acid receptor, gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RARG Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - -
SP4: -
SP5: - - - - - - - - - - - - - -
SP6: - - -
SP7: - -
SP8: - - -
SP9: - - - - - - - -
SP10: - - - - -
SP11: - - - - - -
SP12:
SP13:
SP14:

ExUns: 11 ^ 12 ^ 13a · 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for RARG Gene

GeneLoc Exon Structure for
RARG
ECgene alternative splicing isoforms for
RARG

Expression for RARG Gene

mRNA expression in normal human tissues for RARG Gene

mRNA differential expression in normal tissues according to GTEx for RARG Gene

This gene is overexpressed in Esophagus - Mucosa (x6.4), Skin - Sun Exposed (Lower leg) (x5.0), and Skin - Not Sun Exposed (Suprapubic) (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RARG Gene



SOURCE GeneReport for Unigene cluster for RARG Gene Hs.1497

genes like me logo Genes that share expression patterns with RARG: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RARG Gene

Orthologs for RARG Gene

This gene was present in the common ancestor of animals.

Orthologs for RARG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RARG 35
  • 93.29 (n)
  • 98.67 (a)
RARG 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RARG 35
  • 93.52 (n)
  • 98.45 (a)
RARG 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rarg 35
  • 89.9 (n)
  • 98.89 (a)
Rarg 16
Rarg 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RARG 35
  • 99.56 (n)
  • 100 (a)
RARG 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rarg 35
  • 89.16 (n)
  • 98 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia RARG 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RARG 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485387 35
  • 73.19 (n)
  • 84.89 (a)
zebrafish
(Danio rerio)
Actinopterygii rargb 35
  • 79.16 (n)
  • 88.63 (a)
rarga 36
  • 73 (a)
OneToMany
rargb 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Eip75B 37
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea sex-1 37
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8261 36
  • 38 (a)
OneToMany
Species with no ortholog for RARG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RARG Gene

ENSEMBL:
Gene Tree for RARG (if available)
TreeFam:
Gene Tree for RARG (if available)

Paralogs for RARG Gene

Paralogs for RARG Gene

genes like me logo Genes that share paralogs with RARG: view

Variants for RARG Gene

Sequence variations from dbSNP and Humsavar for RARG Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_036061 A breast cancer sample
rs2229774 - 53,211,761(-) CTCCT(C/T)GCAGC reference, missense
rs12817110 -- 53,218,776(+) CGCAC(C/T)CCCCC intron-variant
rs7305456 -- 53,218,238(+) AAGCA(C/G)CCTTC intron-variant
rs28539481 -- 53,214,948(+) GGGGG(G/T)GGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RARG Gene

Variant ID Type Subtype PubMed ID
nsv517066 CNV Loss 19592680
nsv832417 CNV Gain 17160897
nsv470295 CNV Gain 18288195
nsv469404 CNV Loss 19166990

Variation tolerance for RARG Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.20; 69.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RARG Gene

HapMap Linkage Disequilibrium report
RARG
Human Gene Mutation Database (HGMD)
RARG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RARG Gene

Disorders for RARG Gene

MalaCards: The human disease database

(4) MalaCards diseases for RARG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
embryonal carcinoma
  • primary extragonadal embryonal carcinoma
teratocarcinoma
  • mixed embryonal carcinoma and teratoma
exfoliative ichthyosis
  • autosomal recessive exfoliative ichthyosis
urethral stricture
- elite association - COSMIC cancer census association via MalaCards
Search RARG in MalaCards View complete list of genes associated with diseases

Relevant External Links for RARG

Genetic Association Database (GAD)
RARG
Human Genome Epidemiology (HuGE) Navigator
RARG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RARG
genes like me logo Genes that share disorders with RARG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RARG Gene

Publications for RARG Gene

  1. Genomic organization of the retinoic acid receptor gamma gene. (PMID: 1849262) Lehmann J.M. … Pfahl M. (Nucleic Acids Res. 1991) 2 3 4 23 67
  2. HACE1: A novel repressor of RAR transcriptional activity. (PMID: 19350571) Zhao J. … Soprano D.R. (J. Cell. Biochem. 2009) 3 23
  3. A unique cytoplasmic localization of retinoic acid receptor-gamma and its regulations. (PMID: 19416983) Han Y.H. … Zhang X.K. (J. Biol. Chem. 2009) 3 23
  4. Retinoic acid increases aquaporin 3 expression in normal human skin. (PMID: 17943189) BellemA"re G. … Oddos T. (J. Invest. Dermatol. 2008) 3 23
  5. Functional characterization of hypertrophy in chondrogenesis of human mesenchymal stem cells. (PMID: 18438858) Mueller M.B. … Tuan R.S. (Arthritis Rheum. 2008) 3 23

Products for RARG Gene

Sources for RARG Gene

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