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Aliases for RAP2B Gene

Aliases for RAP2B Gene

  • RAP2B, Member Of RAS Oncogene Family 2 3
  • Ras Family Small GTP Binding Protein RAP2B 2
  • Ras-Related Protein RAP-2B 2
  • Small GTP Binding Protein 2

External Ids for RAP2B Gene

Previous GeneCards Identifiers for RAP2B Gene

  • GC03P149859
  • GC03P153724
  • GC03P154161
  • GC03P154201
  • GC03P154200
  • GC03P154362
  • GC03P152880
  • GC03P150272

Summaries for RAP2B Gene

Entrez Gene Summary for RAP2B Gene

  • This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAP2B Gene

RAP2B (RAP2B, Member Of RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAP2B include platelet storage pool deficiency. Among its related pathways are ERK Signaling and G-protein signaling G-Protein alpha-i signaling cascades. GO annotations related to this gene include GTP binding and protein domain specific binding. An important paralog of this gene is DIRAS2.

UniProtKB/Swiss-Prot for RAP2B Gene

  • Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.

Gene Wiki entry for RAP2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAP2B Gene

Genomics for RAP2B Gene

Regulatory Elements for RAP2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAP2B Gene

Start:
153,162,212 bp from pter
End:
153,170,624 bp from pter
Size:
8,413 bases
Orientation:
Plus strand

Genomic View for RAP2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAP2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAP2B Gene

Proteins for RAP2B Gene

  • Protein details for RAP2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61225-RAP2B_HUMAN
    Recommended name:
    Ras-related protein Rap-2b
    Protein Accession:
    P61225
    Secondary Accessions:
    • P17964
    • Q96EG5
    • Q9CXG0

    Protein attributes for RAP2B Gene

    Size:
    183 amino acids
    Molecular mass:
    20504 Da
    Quaternary structure:
    • Interacts with PLCE1. Interacts with SGSM1, SGSM2 and SGSM3. The GTP-bound form of RAP2B interacts with RUNDC3A (By similarity).

    Three dimensional structures from OCA and Proteopedia for RAP2B Gene

neXtProt entry for RAP2B Gene

Proteomics data for RAP2B Gene at MOPED

Post-translational modifications for RAP2B Gene

  • Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK (By similarity).
  • Ubiquitination at Lys5
  • Modification sites at PhosphoSitePlus

Other Protein References for RAP2B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RAP2B Gene

Domains for RAP2B Gene

Suggested Antigen Peptide Sequences for RAP2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61225

UniProtKB/Swiss-Prot:

RAP2B_HUMAN :
  • P61225
Domain:
  • The effector domain mediates the interaction with RUNDC3A.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RAP2B: view

No data available for Gene Families for RAP2B Gene

Function for RAP2B Gene

Molecular function for RAP2B Gene

UniProtKB/Swiss-Prot Function:
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.

Gene Ontology (GO) - Molecular Function for RAP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity --
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IDA 16213650
GO:0019003 GDP binding IDA 16213650
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with RAP2B: view
genes like me logo Genes that share phenotypes with RAP2B: view

Animal Model Products

miRNA for RAP2B Gene

miRTarBase miRNAs that target RAP2B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAP2B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAP2B Gene

Localization for RAP2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAP2B Gene

Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Note=Associated with red blood cells-released vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAP2B Gene COMPARTMENTS Subcellular localization image for RAP2B gene
Compartment Confidence
endosome 5
cytosol 3
cytoskeleton 2
golgi apparatus 2
plasma membrane 2
vacuole 2
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RAP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol IDA 18582561
GO:0005886 plasma membrane IDA 16213650
GO:0005923 bicellular tight junction IDA 23885123
GO:0016020 membrane IMP 18582561
genes like me logo Genes that share ontologies with RAP2B: view

Pathways for RAP2B Gene

genes like me logo Genes that share pathways with RAP2B: view

Pathways by source for RAP2B Gene

1 Qiagen pathway for RAP2B Gene

Gene Ontology (GO) - Biological Process for RAP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction TAS 2118648
GO:0007264 small GTPase mediated signal transduction --
GO:0015031 protein transport --
GO:0030033 NOT microvillus assembly IMP 22797597
genes like me logo Genes that share ontologies with RAP2B: view

Compounds for RAP2B Gene

(1) HMDB Compounds for RAP2B Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RAP2B: view

Transcripts for RAP2B Gene

mRNA/cDNA for RAP2B Gene

(154) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAP2B Gene

RAP2B, member of RAS oncogene family:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAP2B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAP2B Gene

No ASD Table

Relevant External Links for RAP2B Gene

GeneLoc Exon Structure for
RAP2B
ECgene alternative splicing isoforms for
RAP2B

Expression for RAP2B Gene

mRNA expression in normal human tissues for RAP2B Gene

Protein differential expression in normal tissues for RAP2B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.3), Bone (7.7), Platelet (7.5), and Brain (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAP2B Gene

SOURCE GeneReport for Unigene cluster for RAP2B Gene Hs.98643

mRNA Expression by UniProt/SwissProt for RAP2B Gene

P61225-RAP2B_HUMAN
Tissue specificity: Expressed in red blood cells (at protein level).
genes like me logo Genes that share expressions with RAP2B: view

Expression partners for RAP2B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RAP2B Gene

Orthologs for RAP2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAP2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAP2B 35
  • 93.81 (n)
  • 99.45 (a)
RAP2B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rap2b 35
  • 93.44 (n)
  • 100 (a)
Rap2b 16
Rap2b 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAP2B 35
  • 99.82 (n)
  • 100 (a)
RAP2B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rap2b 35
  • 93.26 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia RAP2B 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAP2B 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAP2C 36
  • 87 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia RAP2B 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rap2b 35
  • 83.52 (n)
  • 95.6 (a)
Str.6887 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1322 35
zebrafish
(Danio rerio)
Actinopterygii rap2b 35
  • 90.48 (n)
  • 96.15 (a)
srnyz128 35
rap2b 36
  • 96 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rap2l 37
  • 67 (a)
Rap2l 35
  • 62.09 (n)
  • 68.13 (a)
Rap2l 36
  • 69 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004769 35
  • 62.27 (n)
  • 68.13 (a)
worm
(Caenorhabditis elegans)
Secernentea C08F8.7 37
  • 48 (a)
C25D7.7 37
  • 60 (a)
rap-2 36
  • 69 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSR1 36
  • 36 (a)
OneToMany
Species with no ortholog for RAP2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAP2B Gene

ENSEMBL:
Gene Tree for RAP2B (if available)
TreeFam:
Gene Tree for RAP2B (if available)

Paralogs for RAP2B Gene

genes like me logo Genes that share paralogs with RAP2B: view

Variants for RAP2B Gene

Sequence variations from dbSNP and Humsavar for RAP2B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs501072 -- 153,163,559(-) CTTGG(G/T)GGGTG utr-variant-3-prime
rs523085 -- 153,163,665(+) ctttc(C/T)ttttt utr-variant-3-prime
rs728723 -- 153,168,289(+) ATTTA(C/G)AAAGT utr-variant-3-prime
rs894801 -- 153,161,049(-) GTCAC(G/T)ACTGC upstream-variant-2KB
rs894802 -- 153,160,930(-) CCACT(G/T)GGAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAP2B Gene

Variant ID Type Subtype PubMed ID
nsv820284 CNV Gain 19587683

Relevant External Links for RAP2B Gene

HapMap Linkage Disequilibrium report
RAP2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAP2B Gene

Disorders for RAP2B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RAP2B Gene in MalaCards »

(1) Diseases for RAP2B Gene including...

(1) University of Copenhagen DISEASES for RAP2B Gene

Relevant External Links for RAP2B

Genetic Association Database (GAD)
RAP2B
Human Genome Epidemiology (HuGE) Navigator
RAP2B
genes like me logo Genes that share disorders with RAP2B: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for RAP2B Gene

Publications for RAP2B Gene

  1. RAP2B: a RAS-related GTP-binding protein from platelets. (PMID: 2118648) Ohmstede C.A. … Lapetina E.G. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4
  2. Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated. (PMID: 8424780) Farrell F.X. … Lapetina E.G. (Biochem. J. 1993) 3 4
  3. Rap2B-dependent stimulation of phospholipase C-epsilon by epidermal growth factor receptor mediated by c-Src phosphorylation of RasGRP3. (PMID: 15143162) Stope M.B. … Schmidt M. (Mol. Cell. Biol. 2004) 4 23
  4. cDNA sequence of a new ras-related gene (rap2b) isolated from human platelets with sequence homology to rap2. (PMID: 2115998) Farrell F.X. … Lapetina E.G. (Nucleic Acids Res. 1990) 3 4
  5. Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B. (PMID: 11877431) Evellin S. … Schmidt M. (J. Biol. Chem. 2002) 3 4

Products for RAP2B Gene

Sources for RAP2B Gene

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