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Aliases for IL21 Gene

Aliases for IL21 Gene

  • Interleukin 21 2 3
  • IL-21 3 4
  • Za11 3 4
  • Interleukin-21 Isoform 3
  • Interleukin-21 3
  • CVID11 3

External Ids for IL21 Gene

Summaries for IL21 Gene

Entrez Gene Summary for IL21 Gene

  • This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for IL21 Gene

IL21 (Interleukin 21) is a Protein Coding gene. Diseases associated with IL21 include immunodeficiency, common variable, 11 and dacryoadenitis. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include cytokine activity and interleukin-2 receptor binding.

UniProtKB/Swiss-Prot for IL21 Gene

  • Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.

Gene Wiki entry for IL21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL21 Gene

Genomics for IL21 Gene

Genomic Location for IL21 Gene

Start:
122,612,628 bp from pter
End:
122,621,069 bp from pter
Size:
8,442 bases
Orientation:
Minus strand

Genomic View for IL21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL21 Gene

Regulatory Elements for IL21 Gene

Proteins for IL21 Gene

  • Protein details for IL21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBE4-IL21_HUMAN
    Recommended name:
    Interleukin-21
    Protein Accession:
    Q9HBE4
    Secondary Accessions:
    • A5J0L4

    Protein attributes for IL21 Gene

    Size:
    155 amino acids
    Molecular mass:
    17923 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG29348.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH66258.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH66259.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH66260.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH66261.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH66262.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH69124.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAU88182.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=ABG36529.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL21 Gene

    Alternative splice isoforms for IL21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL21 Gene

Proteomics data for IL21 Gene at MOPED

Post-translational modifications for IL21 Gene

Other Protein References for IL21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL21 Gene

Domains for IL21 Gene

Gene Families for IL21 Gene

HGNC:
  • IL :Interleukins and interleukin receptors

Protein Domains for IL21 Gene

UniProtKB/Swiss-Prot:

IL21_HUMAN
Family:
  • Belongs to the IL-15/IL-21 family.:
    • Q9HBE4
genes like me logo Genes that share domains with IL21: view

Function for IL21 Gene

Molecular function for IL21 Gene

UniProtKB/Swiss-Prot Function: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.

Gene Ontology (GO) - Molecular Function for IL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005126 cytokine receptor binding TAS 15546387
GO:0005134 interleukin-2 receptor binding IPI 12504082
genes like me logo Genes that share ontologies with IL21: view
genes like me logo Genes that share phenotypes with IL21: view

Animal Models for IL21 Gene

MGI Knock Outs for IL21:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for IL21 Gene

Localization for IL21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL21 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL21 Gene COMPARTMENTS Subcellular localization image for IL21 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for IL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space NAS 11081504
genes like me logo Genes that share ontologies with IL21: view

Pathways for IL21 Gene

genes like me logo Genes that share pathways with IL21: view

Gene Ontology (GO) - Biological Process for IL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IDA 19322899
GO:0002729 positive regulation of natural killer cell cytokine production IEA --
GO:0006955 immune response IEA --
GO:0007165 signal transduction NAS 11081504
GO:0008284 positive regulation of cell proliferation IDA 17673207
genes like me logo Genes that share ontologies with IL21: view

Compounds for IL21 Gene

(4) Novoseek inferred chemical compound relationships for IL21 Gene

Compound -log(P) Hits PubMed IDs
cytidine 37 3
con a 31.9 2
rantes 5.24 1
tyrosine 0 4
genes like me logo Genes that share compounds with IL21: view

Transcripts for IL21 Gene

mRNA/cDNA for IL21 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL21 Gene

Interleukin 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL21 Gene

No ASD Table

Relevant External Links for IL21 Gene

GeneLoc Exon Structure for
IL21
ECgene alternative splicing isoforms for
IL21

Expression for IL21 Gene

mRNA expression in normal human tissues for IL21 Gene

mRNA differential expression in normal tissues according to GTEx for IL21 Gene

This gene is overexpressed in Testis (41.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL21 Gene

SOURCE GeneReport for Unigene cluster for IL21 Gene Hs.567559

mRNA Expression by UniProt/SwissProt for IL21 Gene

Q9HBE4-IL21_HUMAN
Tissue specificity: Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.
genes like me logo Genes that share expressions with IL21: view

Orthologs for IL21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL21 36
  • 99.59 (n)
  • 100 (a)
IL21 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL21 36
  • 87.92 (n)
  • 81.88 (a)
IL21 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL21 36
  • 89.04 (n)
  • 80.82 (a)
IL21 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il21 36
  • 76.94 (n)
  • 63.01 (a)
Il21 16
Il21 37
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL21 37
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il21 36
  • 75.8 (n)
  • 60.96 (a)
chicken
(Gallus gallus)
Aves IL21 37
  • 30 (a)
OneToOne
Species with no ortholog for IL21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL21 Gene

ENSEMBL:
Gene Tree for IL21 (if available)
TreeFam:
Gene Tree for IL21 (if available)

Paralogs for IL21 Gene

No data available for Paralogs for IL21 Gene

Variants for IL21 Gene

Sequence variations from dbSNP and Humsavar for IL21 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs907715 -- 122,613,898(-) AATGC(A/G)AGTTA intron-variant
rs1849428 -- 122,615,312(-) gatct(C/T)ctgac intron-variant
rs1849429 -- 122,615,250(-) gccac(C/T)gcacc intron-variant
rs2390350 -- 122,613,542(+) agacc(A/G)ggttt intron-variant
rs4833837 -- 122,615,808(+) TGAAA(A/G)CAGGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for IL21 Gene

Variant ID Type Subtype PubMed ID
nsv879866 CNV Gain 21882294

Relevant External Links for IL21 Gene

HapMap Linkage Disequilibrium report
IL21
Human Gene Mutation Database (HGMD)
IL21

Disorders for IL21 Gene

UniProtKB/Swiss-Prot

IL21_HUMAN
  • Immunodeficiency, common variable, 11 (CVID11) [MIM:615767]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269 PubMed:24746753}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(21) Novoseek inferred disease relationships for IL21 Gene

Disease -log(P) Hits PubMed IDs
severe combined immunodeficiency, x-linked 66.9 3
autoimmune diseases 58.3 12
autoimmunity 57.8 6
metastatic melanoma 47.7 5
encephalomyelitis 44.9 2

Relevant External Links for IL21

Genetic Association Database (GAD)
IL21
Human Genome Epidemiology (HuGE) Navigator
IL21
genes like me logo Genes that share disorders with IL21: view

Publications for IL21 Gene

  1. IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells. (PMID: 15178704) Strengell M. … Matikainen S. (J. Leukoc. Biol. 2004) 3 4 23
  2. Cloning and characterization of an isoform of interleukin-21. (PMID: 17673207) Rahman M. … Asao H. (FEBS Lett. 2007) 3 4 23
  3. Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus. (PMID: 17720724) Sawalha A.H. … Harley J.B. (Ann. Rheum. Dis. 2008) 3 23 49
  4. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. (PMID: 11081504) Parrish-Novak J. … Foster D. (Nature 2000) 2 3 4
  5. IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice. (PMID: 20190192) Markley J.C. … Sadelain M. (Blood 2010) 3 23

Products for IL21 Gene

Sources for IL21 Gene

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