External Ids for IL21 Gene
Previous GeneCards Identifiers for IL21 Gene
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for IL21 Gene
IL21 (Interleukin 21) is a Protein Coding gene. Diseases associated with IL21 include Immunodeficiency, Common Variable, 11 and Mikulicz Disease. Among its related pathways are Th17 Differentiation Pathway and ERK Signaling. GO annotations related to this gene include cytokine activity and interleukin-2 receptor binding.
UniProtKB/Swiss-Prot for IL21 Gene
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.