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Aliases for RALB Gene

Aliases for RALB Gene

  • RAS Like Proto-Oncogene B 2 3 5
  • V-Ral Simian Leukemia Viral Oncogene Homolog B 2
  • Ras Related GTP Binding Protein B 2

External Ids for RALB Gene

Previous GeneCards Identifiers for RALB Gene

  • GC02P118215
  • GC02P118931
  • GC02P120917
  • GC02P121105
  • GC02P120726
  • GC02P120997
  • GC02P113335

Summaries for RALB Gene

Entrez Gene Summary for RALB Gene

  • This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for RALB Gene

RALB (RAS Like Proto-Oncogene B) is a Protein Coding gene. Diseases associated with RALB include Pancreatic Cancer. Among its related pathways are RET signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and ubiquitin protein ligase binding. An important paralog of this gene is RALA.

UniProtKB/Swiss-Prot for RALB Gene

  • Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269).

Gene Wiki entry for RALB Gene

Additional gene information for RALB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALB Gene

Genomics for RALB Gene

GeneHancer (GH) Regulatory Elements for RALB Gene

Promoters and enhancers for RALB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I120251 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 595.9 +13.2 13158 3.4 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B RALB C2orf76 GLI2 MTND4P26 TMEM185B LOC105373583 PIR31138
GH02I120237 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 565.7 -1.0 -981 3.4 ELF3 NFXL1 RAD21 ZNF48 ZSCAN9 RARA EGR1 SCRT2 FOS EGR2 RALB ENSG00000224789 EPB41L5 LOC105373583 TMEM185B
GH02I120290 Enhancer 0.9 ENCODE 39.4 +51.4 51393 2.6 HDAC1 PKNOX1 CLOCK ATF1 NFIB NEUROD1 SIN3A ZBTB40 TCF12 EGR1 RALB ENSG00000224789 PIR31138 LOC105373583
GH02I120242 Enhancer 1.3 Ensembl ENCODE dbSUPER 24 +4.9 4865 3.9 PKNOX1 CLOCK SIN3A FEZF1 ZNF207 ZNF263 GLIS1 KDM1A SP7 SETDB1 LOC105373583 RALB ENSG00000224789 C2orf76
GH02I120286 Enhancer 1 Ensembl ENCODE 29 +47.5 47469 2.1 BACH1 RBBP5 BATF IRF4 FOSL1 POLR2A NFATC1 ATF7 FOSL2 ETV6 RALB ENSG00000224789 GLI2 PIR31138 LOC105373583
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RALB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RALB gene promoter:

Genomic Locations for RALB Gene

Genomic Locations for RALB Gene
chr2:120,240,064-120,294,713
(GRCh38/hg38)
Size:
54,650 bases
Orientation:
Plus strand
chr2:120,997,640-121,052,289
(GRCh37/hg19)

Genomic View for RALB Gene

Genes around RALB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RALB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RALB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALB Gene

Proteins for RALB Gene

  • Protein details for RALB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11234-RALB_HUMAN
    Recommended name:
    Ras-related protein Ral-B
    Protein Accession:
    P11234
    Secondary Accessions:
    • B4E040
    • Q53T32
    • Q6ZS74

    Protein attributes for RALB Gene

    Size:
    206 amino acids
    Molecular mass:
    23409 Da
    Quaternary structure:
    • Interacts with EXOC2/Sec5 and EXOC8/Exo84 (PubMed:14525976, PubMed:18756269, PubMed:19166349). Interacts (via effector domain) with RALBP1 (PubMed:7673236, PubMed:20696399).

    Three dimensional structures from OCA and Proteopedia for RALB Gene

    Alternative splice isoforms for RALB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RALB Gene

Post-translational modifications for RALB Gene

  • Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs).
  • The farnesylated form confers resistance to the proapoptotic and anti-anchorage-dependent growth effects of geranylgeranyltransferase I inhibitors, including GGTI-2417.

No data available for DME Specific Peptides for RALB Gene

Domains & Families for RALB Gene

Gene Families for RALB Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P11234

UniProtKB/Swiss-Prot:

RALB_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RALB: view

Function for RALB Gene

Molecular function for RALB Gene

GENATLAS Biochemistry:
simian leukemia viral (v-ral) oncogene homolog B,Ras oncogene superfamily member
UniProtKB/Swiss-Prot EnzymeRegulation:
Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
UniProtKB/Swiss-Prot Function:
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269).

Phenotypes From GWAS Catalog for RALB Gene

Gene Ontology (GO) - Molecular Function for RALB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA,IDA 19166349
GO:0005515 protein binding IPI 7673236
GO:0005525 GTP binding IMP,IEA 24056301
GO:0019003 GDP binding IDA 24056301
genes like me logo Genes that share ontologies with RALB: view
genes like me logo Genes that share phenotypes with RALB: view

Animal Models for RALB Gene

MGI Knock Outs for RALB:

miRNA for RALB Gene

miRTarBase miRNAs that target RALB

Clone Products

  • Addgene plasmids for RALB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RALB Gene

Localization for RALB Gene

Subcellular locations from UniProtKB/Swiss-Prot for RALB Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Midbody. Note=During late cytokinesis, enriched at the midbody. {ECO:0000269 PubMed:18756269}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RALB gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 3
cytoskeleton 1
nucleus 1
endosome 1

Gene Ontology (GO) - Cellular Components for RALB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 colocalizes_with exocyst IDA 24056301
GO:0005622 intracellular IEA --
GO:0005776 colocalizes_with autophagosome IDA 24056301
GO:0005886 plasma membrane IEA,IDA 17875936
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RALB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RALB Gene

Pathways & Interactions for RALB Gene

genes like me logo Genes that share pathways with RALB: view

Pathways by source for RALB Gene

SIGNOR curated interactions for RALB Gene

Other effect:

Gene Ontology (GO) - Biological Process for RALB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001928 regulation of exocyst assembly ISS --
GO:0001934 positive regulation of protein phosphorylation IMP 24056301
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction IEA,TAS 2120779
genes like me logo Genes that share ontologies with RALB: view

Drugs & Compounds for RALB Gene

(1) Additional Compounds for RALB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RALB: view

Transcripts for RALB Gene

Unigene Clusters for RALB Gene

V-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein):
Representative Sequences:

Clone Products

  • Addgene plasmids for RALB

Alternative Splicing Database (ASD) splice patterns (SP) for RALB Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: -
SP10: -

Relevant External Links for RALB Gene

GeneLoc Exon Structure for
RALB
ECgene alternative splicing isoforms for
RALB

Expression for RALB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RALB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RALB Gene

This gene is overexpressed in Whole Blood (x7.7).

Protein differential expression in normal tissues from HIPED for RALB Gene

This gene is overexpressed in Uterus (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RALB Gene



Protein tissue co-expression partners for RALB Gene

NURSA nuclear receptor signaling pathways regulating expression of RALB Gene:

RALB

SOURCE GeneReport for Unigene cluster for RALB Gene:

Hs.469820

Evidence on tissue expression from TISSUES for RALB Gene

  • Nervous system(4.8)
  • Lung(4.4)
  • Eye(4.2)
  • Adrenal gland(2)
  • Blood(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with RALB: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RALB Gene

Orthologs for RALB Gene

This gene was present in the common ancestor of animals.

Orthologs for RALB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RALB 33 34
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia RALB 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RALB 33 34
  • 91.59 (n)
cow
(Bos Taurus)
Mammalia RALB 33 34
  • 89.32 (n)
mouse
(Mus musculus)
Mammalia Ralb 33 16 34
  • 85.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RALB 34
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ralb 33
  • 84.14 (n)
chicken
(Gallus gallus)
Aves RALB 33 34
  • 83.98 (n)
lizard
(Anolis carolinensis)
Reptilia RALB 34
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7039 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5659 33
zebrafish
(Danio rerio)
Actinopterygii ralba 33 34
  • 77.83 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9969 33
fruit fly
(Drosophila melanogaster)
Insecta Rala 35 34
  • 75 (a)
worm
(Caenorhabditis elegans)
Secernentea Y53G8AR.3 35
  • 68 (a)
ral-1 34
  • 52 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10753 34
  • 65 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12282 33
Species where no ortholog for RALB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RALB Gene

ENSEMBL:
Gene Tree for RALB (if available)
TreeFam:
Gene Tree for RALB (if available)

Paralogs for RALB Gene

Paralogs for RALB Gene

genes like me logo Genes that share paralogs with RALB: view

Variants for RALB Gene

Sequence variations from dbSNP and Humsavar for RALB Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000110488 -- 120,280,944(+) T/C intron_variant
rs1000113281 -- 120,242,794(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000178048 -- 120,282,133(+) C/A intron_variant
rs1000181983 -- 120,238,557(+) GGCCTGGGTGAGGGG/G upstream_transcript_variant
rs1000182575 -- 120,293,610(+) C/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for RALB Gene

Variant ID Type Subtype PubMed ID
dgv2226e59 CNV duplication 20981092
nsv1000477 CNV gain 25217958
nsv1109282 CNV deletion 24896259
nsv2894 CNV deletion 18451855
nsv508164 CNV deletion 20534489
nsv834346 CNV gain 17160897

Variation tolerance for RALB Gene

Residual Variation Intolerance Score: 37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RALB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RALB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RALB Gene

Disorders for RALB Gene

MalaCards: The human disease database

(1) MalaCards diseases for RALB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pancreatic cancer
  • pancreatic carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search RALB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RALB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RALB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RALB Gene

Publications for RALB Gene

  1. Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding. (PMID: 19166349) Fenwick RB … Owen D (Biochemistry 2009) 3 4 22 58
  2. Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs. (PMID: 18756269) Cascone I … Camonis J (The EMBO journal 2008) 3 4 22 58
  3. Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. (PMID: 17875936) Falsetti SC … Sebti SM (Molecular and cellular biology 2007) 3 4 22 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells. (PMID: 18227351) de Gorter DJ … Spaargaren M (Blood 2008) 3 22 58

Products for RALB Gene

Sources for RALB Gene

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