Aliases for RALB Gene
External Ids for RALB Gene
Previous GeneCards Identifiers for RALB Gene
This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]
GeneCards Summary for RALB Gene
RALB (V-Ral Simian Leukemia Viral Oncogene Homolog B) is a Protein Coding gene. Diseases associated with RALB include pancreatic cancer. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include GTP binding and ubiquitin protein ligase binding. An important paralog of this gene is HRAS.
UniProtKB/Swiss-Prot for RALB Gene
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis.