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Aliases for IL22RA1 Gene

Aliases for IL22RA1 Gene

  • Interleukin 22 Receptor, Alpha 1 2 3
  • Cytokine Receptor Class-II Member 9 3 4
  • Cytokine Receptor Family 2 Member 9 3 4
  • IL-22 Receptor Subunit Alpha-1 3 4
  • IL-22R-Alpha-1 3 4
  • ZcytoR11 3 4
  • IL-22RA1 3 4
  • CRF2-9 3 4
  • IL22R 3 4
  • Interleukin-22 Receptor Subunit Alpha-1 3
  • Interleukin 22 Receptor 2
  • IL22R1 3

External Ids for IL22RA1 Gene

Previous HGNC Symbols for IL22RA1 Gene

  • IL22R

Previous GeneCards Identifiers for IL22RA1 Gene

  • GC01M023516
  • GC01M023797
  • GC01M024191
  • GC01M024318
  • GC01M024446
  • GC01M022699

Summaries for IL22RA1 Gene

Entrez Gene Summary for IL22RA1 Gene

  • The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL22RA1 Gene

IL22RA1 (Interleukin 22 Receptor, Alpha 1) is a Protein Coding gene. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include interleukin-20 binding and interferon receptor activity. An important paralog of this gene is IL20RA.

UniProtKB/Swiss-Prot for IL22RA1 Gene

  • Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL22RA1 Gene

Genomics for IL22RA1 Gene

Regulatory Elements for IL22RA1 Gene

Genomic Location for IL22RA1 Gene

Start:
24,119,771 bp from pter
End:
24,143,285 bp from pter
Size:
23,515 bases
Orientation:
Minus strand

Genomic View for IL22RA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL22RA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL22RA1 Gene

Proteins for IL22RA1 Gene

  • Protein details for IL22RA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6P7-I22R1_HUMAN
    Recommended name:
    Interleukin-22 receptor subunit alpha-1
    Protein Accession:
    Q8N6P7
    Secondary Accessions:
    • A8K839
    • B2R9Y9
    • Q9HB22

    Protein attributes for IL22RA1 Gene

    Size:
    574 amino acids
    Molecular mass:
    63077 Da
    Quaternary structure:
    • Heterodimer with IL10RB and with IL20RB. IL22 binding to heterodimer is greater than binding to IL22RA1 alone.
    Miscellaneous:
    • Failure of medical and surgical therapy in Chronic rhinosinusitis with nasal polyps is associated with decreased expression of IL22RA1

    Three dimensional structures from OCA and Proteopedia for IL22RA1 Gene

neXtProt entry for IL22RA1 Gene

Proteomics data for IL22RA1 Gene at MOPED

Post-translational modifications for IL22RA1 Gene

  • Glycosylation at Asn80 and Asn172
  • Modification sites at PhosphoSitePlus

Other Protein References for IL22RA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IL22RA1 (IL-22 R alpha 1)

No data available for DME Specific Peptides for IL22RA1 Gene

Domains for IL22RA1 Gene

Gene Families for IL22RA1 Gene

HGNC:
  • IL :Interleukins and interleukin receptors
IUPHAR :

Protein Domains for IL22RA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL22RA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6P7

UniProtKB/Swiss-Prot:

I22R1_HUMAN :
  • Q8N6P7
Domain:
  • Contains 2 fibronectin type-III domains.
Family:
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IL22RA1: view

Function for IL22RA1 Gene

Molecular function for IL22RA1 Gene

UniProtKB/Swiss-Prot Function: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
UniProtKB/Swiss-Prot Induction: By IFNG/IFN-gamma in keratinocytes.

Gene Ontology (GO) - Molecular Function for IL22RA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IBA --
GO:0004904 interferon receptor activity TAS 10875937
GO:0005515 protein binding --
GO:0042015 interleukin-20 binding IEA --
genes like me logo Genes that share ontologies with IL22RA1: view

Phenotypes for IL22RA1 Gene

genes like me logo Genes that share phenotypes with IL22RA1: view

Animal Model Products

CRISPR Products

miRNA for IL22RA1 Gene

miRTarBase miRNAs that target IL22RA1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL22RA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IL22RA1 Gene

Localization for IL22RA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL22RA1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL22RA1 Gene COMPARTMENTS Subcellular localization image for IL22RA1 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL22RA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with IL22RA1: view

Pathways for IL22RA1 Gene

genes like me logo Genes that share pathways with IL22RA1: view

Pathways by source for IL22RA1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for IL22RA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0050829 defense response to Gram-negative bacterium IEA --
genes like me logo Genes that share ontologies with IL22RA1: view

Transcripts for IL22RA1 Gene

mRNA/cDNA for IL22RA1 Gene

Unigene Clusters for IL22RA1 Gene

Interleukin 22 receptor, alpha 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IL22RA1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL22RA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for IL22RA1 Gene

GeneLoc Exon Structure for
IL22RA1
ECgene alternative splicing isoforms for
IL22RA1

Expression for IL22RA1 Gene

mRNA expression in normal human tissues for IL22RA1 Gene

mRNA differential expression in normal tissues according to GTEx for IL22RA1 Gene

This gene is overexpressed in Pancreas (30.8), Skin - Sun Exposed (Lower leg) (5.7), and Skin - Not Sun Exposed (Suprapubic) (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IL22RA1 Gene

SOURCE GeneReport for Unigene cluster for IL22RA1 Gene Hs.110915

mRNA Expression by UniProt/SwissProt for IL22RA1 Gene

Q8N6P7-I22R1_HUMAN
Tissue specificity: Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients.
genes like me logo Genes that share expressions with IL22RA1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IL22RA1 Gene

Orthologs for IL22RA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL22RA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL22RA1 35
  • 99.3 (n)
  • 99.13 (a)
IL22RA1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL22RA1 35
  • 81.18 (n)
  • 74.22 (a)
IL22RA1 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL22RA1 35
  • 84.59 (n)
  • 79.51 (a)
IL22RA1 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Il22ra1 35
  • 78.4 (n)
  • 72.82 (a)
Il22ra1 16
Il22ra1 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL22RA1 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL22RA1 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il22ra1 35
  • 78.15 (n)
  • 72.76 (a)
chicken
(Gallus gallus)
Aves IL22RA1 35
  • 47.31 (n)
  • 36.62 (a)
IL22RA1 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL22RA1 36
  • 35 (a)
OneToOne
Species with no ortholog for IL22RA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL22RA1 Gene

ENSEMBL:
Gene Tree for IL22RA1 (if available)
TreeFam:
Gene Tree for IL22RA1 (if available)

Paralogs for IL22RA1 Gene

Paralogs for IL22RA1 Gene

genes like me logo Genes that share paralogs with IL22RA1: view

Variants for IL22RA1 Gene

Sequence variations from dbSNP and Humsavar for IL22RA1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2502450 -- 24,138,215(+) TATAA(A/T)TTTCC intron-variant
rs2502451 -- 24,141,941(+) TTGGG(C/G)GGGTG intron-variant
rs2502452 -- 24,142,181(+) CCTGG(A/G)GACGC intron-variant
rs2502453 -- 24,142,275(+) CCTGG(C/T)CGAGG intron-variant
rs2506092 -- 24,140,901(-) CGTAG(A/T)CGTGT intron-variant

Relevant External Links for IL22RA1 Gene

HapMap Linkage Disequilibrium report
IL22RA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL22RA1 Gene

Disorders for IL22RA1 Gene

Relevant External Links for IL22RA1

Genetic Association Database (GAD)
IL22RA1
Human Genome Epidemiology (HuGE) Navigator
IL22RA1
genes like me logo Genes that share disorders with IL22RA1: view

No data available for UniProtKB/Swiss-Prot for IL22RA1 Gene

Publications for IL22RA1 Gene

  1. Polymorphisms in the interleukin-22 receptor alpha-1 gene are associated with severe chronic rhinosinusitis. (PMID: 19393422) Endam L.M. … Desrosiers M. (Otolaryngol Head Neck Surg 2009) 3 23 48
  2. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. (PMID: 10875937) Xie M.-H. … Gurney A.L. (J. Biol. Chem. 2000) 2 3 4
  3. Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL- TIF) receptor complexes. (PMID: 11035029) Kotenko S.V. … Pestka S. (J. Biol. Chem. 2001) 3 4
  4. Chronic rhinosinusitis with nasal polyps is associated with decreased expression of mucosal interleukin 22 receptor. (PMID: 17906500) Ramanathan M. Jr. … Lane A.P. (Laryngoscope 2007) 3 4
  5. Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism. (PMID: 18675809) Bleicher L. … Polikarpov I. (FEBS Lett. 2008) 3 4

Products for IL22RA1 Gene

Sources for IL22RA1 Gene

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