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Aliases for IL22RA1 Gene

Aliases for IL22RA1 Gene

  • Interleukin 22 Receptor Subunit Alpha 1 2 3 5
  • Cytokine Receptor Class-II Member 9 3 4
  • Cytokine Receptor Family 2 Member 9 3 4
  • Interleukin 22 Receptor, Alpha 1 2 3
  • IL-22 Receptor Subunit Alpha-1 3 4
  • IL-22R-Alpha-1 3 4
  • ZcytoR11 3 4
  • IL-22RA1 3 4
  • CRF2-9 3 4
  • IL22R 3 4
  • Interleukin-22 Receptor Subunit Alpha-1 3
  • Interleukin 22 Receptor 2
  • IL22R1 3

External Ids for IL22RA1 Gene

Previous HGNC Symbols for IL22RA1 Gene

  • IL22R

Previous GeneCards Identifiers for IL22RA1 Gene

  • GC01M023516
  • GC01M023797
  • GC01M024191
  • GC01M024318
  • GC01M024446
  • GC01M022699

Summaries for IL22RA1 Gene

Entrez Gene Summary for IL22RA1 Gene

  • The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL22RA1 Gene

IL22RA1 (Interleukin 22 Receptor Subunit Alpha 1) is a Protein Coding gene. Among its related pathways are Innate Immune System and TGF-Beta Pathway. GO annotations related to this gene include cytokine receptor activity and interferon receptor activity. An important paralog of this gene is IL20RA.

UniProtKB/Swiss-Prot for IL22RA1 Gene

  • Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL22RA1 Gene

Genomics for IL22RA1 Gene

Regulatory Elements for IL22RA1 Gene

Enhancers for IL22RA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G024115 1.5 Ensembl ENCODE dbSUPER 13.7 +24.2 24169 6.2 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF121 GLIS2 ELK1 FOS ZMIZ1 MYOM3 IL22RA1 LOC105376871 GRHL3 NCMAP IFNLR1 PNRC2 GC01P024142
GH01G024140 1.1 ENCODE dbSUPER 18.1 +0.5 462 4.0 ELF3 ARID4B BMI1 RAD21 YY1 KLF11 CEBPB ZFP69B CEBPA ZNF580 IL22RA1 ASAP3 GC01P024142
GH01G024188 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.9 -47.8 -47756 4.9 HDGF PKNOX1 ZNF133 SIN3A YY1 ZNF121 ZNF766 FOS NFYC JUNB IFNLR1 LOC284632 GRHL3 IL22RA1 PNRC2
GH01G024091 1.6 Ensembl ENCODE dbSUPER 7.3 +40.8 40763 21.4 FOXA2 PKNOX1 CREB3L1 SIN3A ARID4B DMAP1 ZNF2 SLC30A9 FOS ZNF263 MYOM3 IL22RA1 LOC105376864
GH01G024126 0.7 dbSUPER 16.4 +16.8 16797 2.1 ZMYM3 MAX FOSL1 ZNF316 NFE2 PRDM10 L3MBTL2 BHLHE40 MAFG JUND IL22RA1 NCMAP MYOM3 GC01P024142
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IL22RA1 on UCSC Golden Path with GeneCards custom track

Promoters for IL22RA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003152 185 601 KLF11 TFAP4 SAP130 ARID4B MAX NR3C1 FOSL1 POLR2A ZNF580 IRF1

Genomic Location for IL22RA1 Gene

Chromosome:
1
Start:
24,119,771 bp from pter
End:
24,143,285 bp from pter
Size:
23,515 bases
Orientation:
Minus strand

Genomic View for IL22RA1 Gene

Genes around IL22RA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL22RA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL22RA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL22RA1 Gene

Proteins for IL22RA1 Gene

  • Protein details for IL22RA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6P7-I22R1_HUMAN
    Recommended name:
    Interleukin-22 receptor subunit alpha-1
    Protein Accession:
    Q8N6P7
    Secondary Accessions:
    • A8K839
    • B2R9Y9
    • Q9HB22

    Protein attributes for IL22RA1 Gene

    Size:
    574 amino acids
    Molecular mass:
    63077 Da
    Quaternary structure:
    • Heterodimer with IL10RB and with IL20RB. IL22 binding to heterodimer is greater than binding to IL22RA1 alone.
    Miscellaneous:
    • Failure of medical and surgical therapy in Chronic rhinosinusitis with nasal polyps is associated with decreased expression of IL22RA1.

    Three dimensional structures from OCA and Proteopedia for IL22RA1 Gene

neXtProt entry for IL22RA1 Gene

Post-translational modifications for IL22RA1 Gene

  • Glycosylation at posLast=8080 and posLast=172172
  • Modification sites at PhosphoSitePlus

Other Protein References for IL22RA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IL22RA1 (IL-22 R alpha 1)
  • Cloud-Clone Corp. Antibodies for IL22RA1

No data available for DME Specific Peptides for IL22RA1 Gene

Domains & Families for IL22RA1 Gene

Gene Families for IL22RA1 Gene

Protein Domains for IL22RA1 Gene

Suggested Antigen Peptide Sequences for IL22RA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6P7

UniProtKB/Swiss-Prot:

I22R1_HUMAN :
  • Belongs to the type II cytokine receptor family.
Family:
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IL22RA1: view

Function for IL22RA1 Gene

Molecular function for IL22RA1 Gene

UniProtKB/Swiss-Prot Function:
Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma in keratinocytes.

Gene Ontology (GO) - Molecular Function for IL22RA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004904 interferon receptor activity TAS 10875937
GO:0005515 protein binding IPI 12513909
GO:0042015 interleukin-20 binding IEA --
genes like me logo Genes that share ontologies with IL22RA1: view
genes like me logo Genes that share phenotypes with IL22RA1: view

Animal Models for IL22RA1 Gene

MGI Knock Outs for IL22RA1:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL22RA1

CRISPR Products

miRNA for IL22RA1 Gene

miRTarBase miRNAs that target IL22RA1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL22RA1 Gene

Localization for IL22RA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL22RA1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL22RA1 gene
Compartment Confidence
plasma membrane 4
extracellular 3
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IL22RA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with IL22RA1: view

Pathways & Interactions for IL22RA1 Gene

genes like me logo Genes that share pathways with IL22RA1: view

Pathways by source for IL22RA1 Gene

SIGNOR curated interactions for IL22RA1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL22RA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0019221 cytokine-mediated signaling pathway IEA --
GO:0050829 defense response to Gram-negative bacterium IEA --
genes like me logo Genes that share ontologies with IL22RA1: view

Transcripts for IL22RA1 Gene

mRNA/cDNA for IL22RA1 Gene

Unigene Clusters for IL22RA1 Gene

Interleukin 22 receptor, alpha 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL22RA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for IL22RA1 Gene

GeneLoc Exon Structure for
IL22RA1
ECgene alternative splicing isoforms for
IL22RA1

Expression for IL22RA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL22RA1 Gene

mRNA differential expression in normal tissues according to GTEx for IL22RA1 Gene

This gene is overexpressed in Pancreas (x30.8), Skin - Sun Exposed (Lower leg) (x5.7), and Skin - Not Sun Exposed (Suprapubic) (x5.0).

Protein differential expression in normal tissues from HIPED for IL22RA1 Gene

This gene is overexpressed in Adipocyte (55.2) and Pancreas (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL22RA1 Gene



Protein tissue co-expression partners for IL22RA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL22RA1 Gene:

IL22RA1

SOURCE GeneReport for Unigene cluster for IL22RA1 Gene:

Hs.110915

mRNA Expression by UniProt/SwissProt for IL22RA1 Gene:

Q8N6P7-I22R1_HUMAN
Tissue specificity: Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients.

Evidence on tissue expression from TISSUES for IL22RA1 Gene

  • Liver(4.3)
  • Adrenal gland(4)
  • Skin(2.3)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with IL22RA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL22RA1 Gene

Orthologs for IL22RA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL22RA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL22RA1 34 35
  • 99.3 (n)
dog
(Canis familiaris)
Mammalia IL22RA1 34 35
  • 84.59 (n)
cow
(Bos Taurus)
Mammalia IL22RA1 34 35
  • 81.18 (n)
mouse
(Mus musculus)
Mammalia Il22ra1 34 16 35
  • 78.4 (n)
rat
(Rattus norvegicus)
Mammalia Il22ra1 34
  • 78.15 (n)
oppossum
(Monodelphis domestica)
Mammalia IL22RA1 35
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL22RA1 35
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL22RA1 35 34
  • 47.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL22RA1 35
  • 35 (a)
OneToOne
Species where no ortholog for IL22RA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL22RA1 Gene

ENSEMBL:
Gene Tree for IL22RA1 (if available)
TreeFam:
Gene Tree for IL22RA1 (if available)

Paralogs for IL22RA1 Gene

Paralogs for IL22RA1 Gene

genes like me logo Genes that share paralogs with IL22RA1: view

Variants for IL22RA1 Gene

Sequence variations from dbSNP and Humsavar for IL22RA1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000380436 -- 24,132,754(+) CCAGC(A/G)CTTTG intron-variant
rs1000393362 -- 24,138,079(+) ACTCC(C/T)GAGCC intron-variant
rs1000518767 -- 24,140,157(+) CTCAC(A/G)ACAAC intron-variant
rs1000641306 -- 24,121,300(+) TTGCC(A/G)GAACC reference, synonymous-codon
rs1000650102 -- 24,133,778(+) TTCTG(A/G)AGAAA intron-variant

Variation tolerance for IL22RA1 Gene

Residual Variation Intolerance Score: 59.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.95; 96.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IL22RA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL22RA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL22RA1 Gene

Disorders for IL22RA1 Gene

Relevant External Links for IL22RA1

Genetic Association Database (GAD)
IL22RA1
Human Genome Epidemiology (HuGE) Navigator
IL22RA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IL22RA1

No disorders were found for IL22RA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IL22RA1 Gene

Publications for IL22RA1 Gene

  1. Polymorphisms in the interleukin-22 receptor alpha-1 gene are associated with severe chronic rhinosinusitis. (PMID: 19393422) Endam L.M. … Desrosiers M. (Otolaryngol Head Neck Surg 2009) 3 22 46 64
  2. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. (PMID: 10875937) Xie M.-H. … Gurney A.L. (J. Biol. Chem. 2000) 2 3 4 64
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  4. Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism. (PMID: 18675809) Bleicher L. … Polikarpov I. (FEBS Lett. 2008) 3 4 64
  5. Chronic rhinosinusitis with nasal polyps is associated with decreased expression of mucosal interleukin 22 receptor. (PMID: 17906500) Ramanathan M. Jr. … Lane A.P. (Laryngoscope 2007) 3 4 64

Products for IL22RA1 Gene

Sources for IL22RA1 Gene

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