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Aliases for RAD51D Gene

Aliases for RAD51D Gene

  • RAD51 Paralog D 2 3
  • Recombination Repair Protein 2 3
  • RAD51-Like Protein 3 3 4
  • RAD51 Homolog D 3 4
  • RAD51L3 3 4
  • R51H3 3 4
  • TRAD 3 4
  • DNA Repair Protein RAD51 Homolog 4 2
  • RAD51 Homolog D (S. Cerevisiae) 2
  • RAD51 (S. Cerevisiae)-Like 3 2
  • RAD51-Like 3 (S. Cerevisiae) 2
  • BROVCA4 3

External Ids for RAD51D Gene

Previous HGNC Symbols for RAD51D Gene

  • RAD51L3

Previous GeneCards Identifiers for RAD51D Gene

  • GC17M033427

Summaries for RAD51D Gene

Entrez Gene Summary for RAD51D Gene

  • The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for RAD51D Gene

RAD51D (RAD51 Paralog D) is a Protein Coding gene. Diseases associated with RAD51D include rad51d-related familial susceptibility to breast-ovarian cancer and breast-ovarian cancer, familial 4. Among its related pathways are Homologous recombination and Resolution of D-Loop Structures. GO annotations related to this gene include single-stranded DNA binding and DNA helicase activity. An important paralog of this gene is ENSG00000267618.

UniProtKB/Swiss-Prot for RAD51D Gene

  • Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.

Gene Wiki entry for RAD51D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD51D Gene

Genomics for RAD51D Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAD51D Gene

Chromosome:
17
Start:
35,092,208 bp from pter
End:
35,121,522 bp from pter
Size:
29,315 bases
Orientation:
Minus strand

Genomic View for RAD51D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAD51D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD51D Gene

No data available for Regulatory Elements for RAD51D Gene

Proteins for RAD51D Gene

  • Protein details for RAD51D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75771-RA51D_HUMAN
    Recommended name:
    DNA repair protein RAD51 homolog 4
    Protein Accession:
    O75771
    Secondary Accessions:
    • B4DJU7
    • E1P637
    • O43537
    • O60355
    • O75196
    • O75847
    • O75848
    • O76073
    • O76085
    • O94908
    • Q9UFU5

    Protein attributes for RAD51D Gene

    Size:
    328 amino acids
    Molecular mass:
    35049 Da
    Quaternary structure:
    • Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel. In the absence of DNA, the BCDX2 subcomplex XRCC2:RAD51D formed a multimeric ring structure; in the presence of single-stranded DNA it formed a filamentous structure with the ssDNA. Interacts with SWSAP1 and ZSWIM7; involved in homologous recombination repair. Interacts with BLM; required for stimulation of BLM activity by the BCDX2 subcomplex XRCC2:RAD51D.

    Three dimensional structures from OCA and Proteopedia for RAD51D Gene

    Alternative splice isoforms for RAD51D Gene

neXtProt entry for RAD51D Gene

Proteomics data for RAD51D Gene at MOPED

Post-translational modifications for RAD51D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for RAD51D Gene

Domains & Families for RAD51D Gene

Protein Domains for RAD51D Gene

Graphical View of Domain Structure for InterPro Entry

O75771

UniProtKB/Swiss-Prot:

RA51D_HUMAN :
  • Belongs to the RecA family. RAD51 subfamily.
Family:
  • Belongs to the RecA family. RAD51 subfamily.
genes like me logo Genes that share domains with RAD51D: view

No data available for Gene Families for RAD51D Gene

Function for RAD51D Gene

Molecular function for RAD51D Gene

UniProtKB/Swiss-Prot Function:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.

Gene Ontology (GO) - Molecular Function for RAD51D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000150 recombinase activity IBA --
GO:0000400 contributes_to four-way junction DNA binding IDA 20207730
GO:0003677 DNA binding TAS 9570954
GO:0003690 double-stranded DNA binding IBA --
GO:0003697 single-stranded DNA binding IDA 10871607
genes like me logo Genes that share ontologies with RAD51D: view
genes like me logo Genes that share phenotypes with RAD51D: view

Animal Models for RAD51D Gene

MGI Knock Outs for RAD51D:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAD51D

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RAD51D Gene

Localization for RAD51D Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD51D Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, telomere.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAD51D Gene COMPARTMENTS Subcellular localization image for RAD51D gene
Compartment Confidence
cytoskeleton 5
nucleus 5

Gene Ontology (GO) - Cellular Components for RAD51D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IDA 15109494
GO:0005634 nucleus TAS 9570954
GO:0005654 nucleoplasm TAS --
GO:0005657 replication fork IDA 20207730
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RAD51D: view

Pathways & Interactions for RAD51D Gene

genes like me logo Genes that share pathways with RAD51D: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RAD51D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000707 meiotic DNA recombinase assembly IBA --
GO:0000723 telomere maintenance IMP 15109494
GO:0000724 double-strand break repair via homologous recombination TAS --
GO:0006281 DNA repair TAS --
GO:0006289 nucleotide-excision repair IEA --
genes like me logo Genes that share ontologies with RAD51D: view

No data available for SIGNOR curated interactions for RAD51D Gene

Drugs & Compounds for RAD51D Gene

No Compound Related Data Available

Transcripts for RAD51D Gene

Unigene Clusters for RAD51D Gene

RAD51 homolog D (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAD51D

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAD51D Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - -
SP6: -
SP7: - - - -
SP8:
SP9: - - - -
SP10: - -
SP11: - - - - - -

Relevant External Links for RAD51D Gene

GeneLoc Exon Structure for
RAD51D
ECgene alternative splicing isoforms for
RAD51D

Expression for RAD51D Gene

mRNA expression in normal human tissues for RAD51D Gene

Protein differential expression in normal tissues from HIPED for RAD51D Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAD51D Gene



SOURCE GeneReport for Unigene cluster for RAD51D Gene Hs.631757

mRNA Expression by UniProt/SwissProt for RAD51D Gene

O75771-RA51D_HUMAN
Tissue specificity: Expressed in colon, prostate, spleen, testis, ovary, thymus and small intestine. Weakly expressed in leukocytes
genes like me logo Genes that share expression patterns with RAD51D: view

Protein tissue co-expression partners for RAD51D Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RAD51D Gene

Orthologs for RAD51D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAD51D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAD51D 35
  • 87 (n)
  • 82.66 (a)
RAD51D 36
  • 71 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RAD51D 35
  • 87.05 (n)
  • 84.71 (a)
-- 36
  • 73 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rad51d 35
  • 83.23 (n)
  • 83.23 (a)
Rad51d 16
Rad51d 36
  • 72 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RAD51L3 35
  • 99.19 (n)
  • 99.39 (a)
RAD51L3 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rad51d 35
  • 83.64 (n)
  • 83.84 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves RAD51D 35
  • 69.31 (n)
  • 69.21 (a)
RAD51D 36
  • 56 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rad51d 35
  • 62.55 (n)
  • 57.91 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.19061 35
rad51d 35
  • 60.7 (n)
  • 55.25 (a)
rad51d 36
  • 46 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2888 35
fruit fly
(Drosophila melanogaster)
Insecta Rad51C 36
  • 24 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons RAD51D 35
  • 44.79 (n)
  • 35.16 (a)
Species with no ortholog for RAD51D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAD51D Gene

ENSEMBL:
Gene Tree for RAD51D (if available)
TreeFam:
Gene Tree for RAD51D (if available)

Paralogs for RAD51D Gene

Paralogs for RAD51D Gene

(1) SIMAP similar genes for RAD51D Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with RAD51D: view

Variants for RAD51D Gene

Sequence variations from dbSNP and Humsavar for RAD51D Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_020560 -
VAR_020561 -
VAR_020562 -
VAR_020563 -
VAR_020564 -

Variation tolerance for RAD51D Gene

Residual Variation Intolerance Score: 77.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAD51D Gene

HapMap Linkage Disequilibrium report
RAD51D
Human Gene Mutation Database (HGMD)
RAD51D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RAD51D Gene

Disorders for RAD51D Gene

MalaCards: The human disease database

(4) MalaCards diseases for RAD51D Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
rad51d-related familial susceptibility to breast-ovarian cancer
  • brovca4
breast-ovarian cancer, familial 4
  • breast-ovarian cancer, familial, susceptibility to, 4
hereditary breast ovarian cancer
  • hereditary breast and ovarian cancer syndrome
fallopian tube cancer
  • malignant tumor of fallopian tube
- elite association

UniProtKB/Swiss-Prot

RA51D_HUMAN
  • Breast-ovarian cancer, familial, 4 (BROVCA4) [MIM:614291]: A condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate. {ECO:0000269 PubMed:21822267}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for RAD51D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAD51D
genes like me logo Genes that share disorders with RAD51D: view

No data available for Genatlas for RAD51D Gene

Publications for RAD51D Gene

  1. Identification, characterization, and genetic mapping of Rad51d, a new mouse and human RAD51/RecA-related gene. (PMID: 9570954) Pittman D.L. … Schimenti J.C. (Genomics 1998) 2 23 67
  2. Homologous recombination contributes to the repair of DNA double-strand breaks induced by high-energy iron ions. (PMID: 20041757) Zafar F. … Wiese C. (Radiat. Res. 2010) 23 67
  3. Functional characterization and identification of mouse Rad51d splice variants. (PMID: 19327148) Gruver A.M. … Pittman D.L. (BMC Mol. Biol. 2009) 23 67
  4. The RAD51D E233G variant and breast cancer risk: population-based and clinic-based family studies of Australian women. (PMID: 18058226) Dowty J.G. … . (Breast Cancer Res. Treat. 2008) 23 67
  5. Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cells. (PMID: 18172318) Evans J.W. … Brown J.M. (Cancer Res. 2008) 23 67

Products for RAD51D Gene

Sources for RAD51D Gene

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