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Aliases for RAD51B Gene

Aliases for RAD51B Gene

  • RAD51 Paralog B 2 3
  • RAD51L1 3 4 6
  • RAD51 Homolog B 3 4
  • R51H2 3 4
  • REC2 3 4
  • DNA Repair Protein RAD51 Homolog 2 3
  • RAD51 Homolog B (S. Cerevisiae) 2
  • RAD51 (S. Cerevisiae)-Like 1 2
  • RAD51-Like 1 (S. Cerevisiae) 2
  • Recombination Repair Protein 3
  • RAD51-Like Protein 1 4
  • RecA-Like Protein 3
  • Rad51B 4

External Ids for RAD51B Gene

Previous HGNC Symbols for RAD51B Gene

  • RAD51L1

Previous GeneCards Identifiers for RAD51B Gene

  • GC14P068287

Summaries for RAD51B Gene

Entrez Gene Summary for RAD51B Gene

  • The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Jul 2011]

GeneCards Summary for RAD51B Gene

RAD51B (RAD51 Paralog B) is a Protein Coding gene. Among its related pathways are Hemostasis and Homologous recombination. GO annotations related to this gene include DNA-dependent ATPase activity. An important paralog of this gene is RAD51C.

UniProtKB/Swiss-Prot for RAD51B Gene

  • Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.

Gene Wiki entry for RAD51B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD51B Gene

Genomics for RAD51B Gene

Genomic Location for RAD51B Gene

Start:
67,819,779 bp from pter
End:
68,730,218 bp from pter
Size:
910,440 bases
Orientation:
Plus strand

Genomic View for RAD51B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAD51B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD51B Gene

No data available for Regulatory Elements for RAD51B Gene

Proteins for RAD51B Gene

  • Protein details for RAD51B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15315-RA51B_HUMAN
    Recommended name:
    DNA repair protein RAD51 homolog 2
    Protein Accession:
    O15315
    Secondary Accessions:
    • O60914
    • O75210
    • Q3Y4F8
    • Q6FHX8
    • Q86SY3
    • Q86SY4
    • Q86TR0
    • Q86U92
    • Q86U93
    • Q86U94
    • Q8N6H4
    • Q9UPL5

    Protein attributes for RAD51B Gene

    Size:
    384 amino acids
    Molecular mass:
    42196 Da
    Quaternary structure:
    • Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel. The BCDX2 subcomplex RAD51B:RAD51C interacts with RAD51. Interacts with SWSAP1; involved in homologous recombination repair.
    SequenceCaution:
    • Sequence=CAD62357.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD66573.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RAD51B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAD51B Gene

Proteomics data for RAD51B Gene at MOPED

Post-translational modifications for RAD51B Gene

Other Protein References for RAD51B Gene

Antibody Products

No data available for DME Specific Peptides for RAD51B Gene

Domains for RAD51B Gene

Graphical View of Domain Structure for InterPro Entry

O15315

UniProtKB/Swiss-Prot:

RA51B_HUMAN :
  • O15315
Family:
  • Belongs to the RecA family. RAD51 subfamily.
genes like me logo Genes that share domains with RAD51B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for RAD51B Gene

Function for RAD51B Gene

Molecular function for RAD51B Gene

UniProtKB/Swiss-Prot Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.

Gene Ontology (GO) - Molecular Function for RAD51B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0000400 contributes_to four-way junction DNA binding IDA 20207730
GO:0003677 DNA binding TAS 9512535
GO:0003678 DNA helicase activity --
GO:0003690 double-stranded DNA binding IDA 12441335
genes like me logo Genes that share ontologies with RAD51B: view
genes like me logo Genes that share phenotypes with RAD51B: view

Animal Models for RAD51B Gene

MGI Knock Outs for RAD51B:

Animal Model Products

CRISPR Products

miRNA for RAD51B Gene

miRTarBase miRNAs that target RAD51B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RAD51B Gene

Localization for RAD51B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD51B Gene

Gene Ontology (GO) - Cellular Components for RAD51B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9512535
GO:0005654 nucleoplasm TAS --
GO:0005657 replication fork IDA 20207730
GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex IDA 11751635
genes like me logo Genes that share ontologies with RAD51B: view

No data available for Subcellular locations from COMPARTMENTS for RAD51B Gene

Pathways for RAD51B Gene

genes like me logo Genes that share pathways with RAD51B: view

Pathways by source for RAD51B Gene

1 KEGG pathway for RAD51B Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RAD51B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 23149936
GO:0006200 obsolete ATP catabolic process --
GO:0006259 DNA metabolic process --
GO:0006260 DNA replication --
GO:0006281 DNA repair TAS 9512535
genes like me logo Genes that share ontologies with RAD51B: view

Transcripts for RAD51B Gene

Unigene Clusters for RAD51B Gene

RAD51 homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAD51B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAD51B Gene

No ASD Table

Relevant External Links for RAD51B Gene

GeneLoc Exon Structure for
RAD51B
ECgene alternative splicing isoforms for
RAD51B

Expression for RAD51B Gene

mRNA expression in normal human tissues for RAD51B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAD51B Gene

SOURCE GeneReport for Unigene cluster for RAD51B Gene Hs.172587

mRNA Expression by UniProt/SwissProt for RAD51B Gene

O15315-RA51B_HUMAN
Tissue specificity: Expressed in a wide range of tissues
genes like me logo Genes that share expressions with RAD51B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RAD51B Gene

Orthologs for RAD51B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAD51B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD51B 36
  • 92 (a)
OneToOne
RAD51L1 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RAD51B 35
  • 92.58 (n)
  • 91.91 (a)
RAD51B 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAD51B 35
  • 90.74 (n)
  • 90.54 (a)
RAD51B 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rad51b 35
  • 86.18 (n)
  • 85.8 (a)
Rad51b 16
Rad51b 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAD51B 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rad51b 35
  • 84.39 (n)
  • 83.1 (a)
chicken
(Gallus gallus)
Aves RAD51B 35
  • 72.93 (n)
  • 73.7 (a)
RAD51B 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAD51B 36
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rad51b 35
  • 59.84 (n)
  • 58.75 (a)
rad51b 36
  • 53 (a)
OneToOne
wufd07f04 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DMC1 36
  • 28 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons RAD51B 35
  • 45.7 (n)
  • 31.16 (a)
rice
(Oryza sativa)
Liliopsida Os05g0121700 35
  • 44.54 (n)
  • 36.01 (a)
Species with no ortholog for RAD51B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAD51B Gene

ENSEMBL:
Gene Tree for RAD51B (if available)
TreeFam:
Gene Tree for RAD51B (if available)

Paralogs for RAD51B Gene

Paralogs for RAD51B Gene

genes like me logo Genes that share paralogs with RAD51B: view

Variants for RAD51B Gene

Sequence variations from dbSNP and Humsavar for RAD51B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2679 -- 68,557,282(+) TCTGT(A/G)GCTTA intron-variant
rs365934 -- 68,123,035(-) ACCCC(C/T)CCCTG intron-variant
rs372143 -- 68,120,621(-) AGCAG(A/G)AGACC intron-variant
rs373918 -- 68,106,502(-) CTTGA(C/T)ATTGT intron-variant
rs377771 -- 68,109,493(-) TCTAG(A/T)AAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAD51B Gene

Variant ID Type Subtype PubMed ID
esv272299 CNV Insertion 20981092
nsv518669 CNV Gain 19592680
esv2666318 CNV Deletion 23128226
esv2748809 CNV Deletion 23290073
esv2748810 CNV Deletion 23290073
dgv36n6 CNV Loss 16902084
esv2658077 CNV Deletion 23128226
esv2439284 CNV Deletion 19546169
nsv85157 CNV Loss 16902084
nsv85709 CNV Insertion 16902084
esv2489967 CNV Deletion 19546169
nsv512364 CNV Loss 21212237
esv2315033 CNV Deletion 18987734
esv2663782 CNV Deletion 23128226
esv2748811 CNV Deletion 23290073
esv1003046 CNV Deletion 20482838
nsv85056 CNV Loss 16902084
esv9245 CNV Loss 19470904
esv1205109 CNV Deletion 17803354
nsv510383 CNV Loss 20534489
nsv1324 CNV Insertion 18451855
esv274001 CNV Insertion 20981092
esv270991 CNV Insertion 20981092
nsv1325 CNV Insertion 18451855
nsv85374 CNV Loss 16902084
esv1361357 CNV Insertion 17803354
dgv399e199 CNV Deletion 23128226
nsv832822 CNV Loss 17160897
nsv1326 CNV Insertion 18451855
esv28449 CNV Loss 19812545
nsv525928 CNV Loss 19592680
nsv1327 CNV Insertion 18451855
esv2748812 CNV Deletion 23290073
esv2198876 CNV Deletion 18987734
esv2748813 CNV Deletion 23290073
esv2748814 CNV Deletion 23290073
esv999446 CNV Deletion 20482838
esv2748815 CNV Deletion 23290073
esv1041303 CNV Deletion 17803354
nsv521761 CNV Gain 19592680
nsv516239 CNV Gain 19592680
nsv1328 CNV Insertion 18451855

Relevant External Links for RAD51B Gene

HapMap Linkage Disequilibrium report
RAD51B
Human Gene Mutation Database (HGMD)
RAD51B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD51B Gene

Disorders for RAD51B Gene

UniProtKB/Swiss-Prot

RA51B_HUMAN
  • Note=A chromosomal aberration involving RAD51B is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with HMGA1.
  • Note=A chromosomal aberration involving RAD51B is found in uterine leiomyoma. Translocation t(12;14)(q15;q23-24) with HMGA2.

(4) Novoseek inferred disease relationships for RAD51B Gene

Disease -log(P) Hits PubMed IDs
uterine leiomyoma 64.9 5
benign tumor 32.6 1
chromosomal aberrations 30.2 1
tumors 0 1
genes like me logo Genes that share disorders with RAD51B: view

Publications for RAD51B Gene

  1. RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51. (PMID: 11744692) Miller K.A. … Albala J.S. (J. Biol. Chem. 2002) 3 4 23
  2. Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells. (PMID: 11842112) Wiese C. … Schild D. (Nucleic Acids Res. 2002) 3 4 23
  3. Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro. (PMID: 12427746) Lio Y.-C. … Chen D.J. (J. Biol. Chem. 2003) 3 4 23
  4. Holliday junction binding activity of the human Rad51B protein. (PMID: 12441335) Yokoyama H. … Shibata T. (J. Biol. Chem. 2003) 3 4 23
  5. Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15. (PMID: 12649198) Quade B.J. … Morton C.C. (Cancer Res. 2003) 3 4 23

Products for RAD51B Gene

Sources for RAD51B Gene

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