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Aliases for RAD51C Gene

Aliases for RAD51C Gene

  • RAD51 Paralog C 2 3
  • RAD51-Like Protein 2 3 4
  • BROVCA3 3 6
  • RAD51L2 3 4
  • FANCO 3 6
  • R51H3 3 4
  • DNA Repair Protein RAD51 Homolog 3 3
  • RAD51 (S. Cerevisiae) Homolog C 2
  • RAD51 Homolog C (S. Cerevisiae) 2
  • Yeast RAD51 Homolog 3 3
  • RAD51 Homolog C 4

External Ids for RAD51C Gene

Previous GeneCards Identifiers for RAD51C Gene

  • GC17P056517
  • GC17P059251
  • GC17P057112
  • GC17P057244
  • GC17P054124
  • GC17P056769
  • GC17P052130

Summaries for RAD51C Gene

Entrez Gene Summary for RAD51C Gene

  • This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for RAD51C Gene

RAD51C (RAD51 Paralog C) is a Protein Coding gene. Diseases associated with RAD51C include fanconi anemia, complementation group o and breast-ovarian cancer, familial 3. Among its related pathways are Hemostasis and Homologous recombination. GO annotations related to this gene include DNA-dependent ATPase activity and crossover junction endodeoxyribonuclease activity. An important paralog of this gene is RAD51B.

UniProtKB/Swiss-Prot for RAD51C Gene

  • Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.

Gene Wiki entry for RAD51C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD51C Gene

Genomics for RAD51C Gene

Regulatory Elements for RAD51C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAD51C Gene

Start:
58,692,573 bp from pter
End:
58,735,611 bp from pter
Size:
43,039 bases
Orientation:
Plus strand

Genomic View for RAD51C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAD51C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD51C Gene

Proteins for RAD51C Gene

  • Protein details for RAD51C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43502-RA51C_HUMAN
    Recommended name:
    DNA repair protein RAD51 homolog 3
    Protein Accession:
    O43502
    Secondary Accessions:
    • O43503
    • Q3B783

    Protein attributes for RAD51C Gene

    Size:
    376 amino acids
    Molecular mass:
    42190 Da
    Quaternary structure:
    • Part of the Rad21 paralog protein complexes BCDX2 and CX3; the complexes have a ring-like structure arranged into a flat disc around a central channel. The BCDX2 complex consits of RAD51B, RAD51C, RAD51D and XRCC2; the CX3 complex consists of RAD51C and XRCC3. The BCDX2 subcomplex RAD51B:RAD51C interacts with RAD51. Interacts with SWSAP1; involved in homologous recombination repair. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3.

    Alternative splice isoforms for RAD51C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAD51C Gene

Proteomics data for RAD51C Gene at MOPED

Post-translational modifications for RAD51C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for RAD51C Gene

Domains for RAD51C Gene

Gene Families for RAD51C Gene

HGNC:
  • FANC :Fanconi anemia, complementation groups

Graphical View of Domain Structure for InterPro Entry

O43502

UniProtKB/Swiss-Prot:

RA51C_HUMAN :
  • O43502
Family:
  • Belongs to the RecA family. RAD51 subfamily.
genes like me logo Genes that share domains with RAD51C: view

Function for RAD51C Gene

Molecular function for RAD51C Gene

GENATLAS Biochemistry: yeast (S cerevisiae) RAD51 homolog 3,highly expressed in testis,involved in mitosis and meiotic recombination events
UniProtKB/Swiss-Prot Function: Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.
UniProtKB/Swiss-Prot Induction: Stress-induced increase in the mitochondrial levels is seen.

Gene Ontology (GO) - Molecular Function for RAD51C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0000400 contributes_to four-way junction DNA binding IDA 20207730
GO:0003677 DNA binding TAS 9469824
GO:0005515 protein binding IPI 11751635
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with RAD51C: view
genes like me logo Genes that share phenotypes with RAD51C: view

Animal Models for RAD51C Gene

MGI Knock Outs for RAD51C:

Animal Model Products

CRISPR Products

miRNA for RAD51C Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RAD51C Gene

Localization for RAD51C Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD51C Gene

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=DNA damage induces an increase in nuclear levels. Accumulates in DNA damage induced nuclear foci or RAD51C foci which is formed during the S or G2 phase of cell cycle. Accumulation at DNA lesions requires the presence of NBN/NBS1, ATM and RPA.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAD51C Gene COMPARTMENTS Subcellular localization image for RAD51C gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RAD51C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12966089
GO:0005654 nucleoplasm TAS --
GO:0005657 replication fork IDA 20207730
GO:0005737 cytoplasm IDA 16215984
GO:0005739 mitochondrion IDA 20413593
genes like me logo Genes that share ontologies with RAD51C: view

Pathways for RAD51C Gene

genes like me logo Genes that share pathways with RAD51C: view

Pathways by source for RAD51C Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RAD51C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 23149936
GO:0000737 DNA catabolic process, endonucleolytic IEA --
GO:0006200 obsolete ATP catabolic process --
GO:0006259 DNA metabolic process --
GO:0006281 DNA repair IDA 19451272
genes like me logo Genes that share ontologies with RAD51C: view

Compounds for RAD51C Gene

(1) Novoseek inferred chemical compound relationships for RAD51C Gene

Compound -log(P) Hits PubMed IDs
camptothecin 43.8 1
genes like me logo Genes that share compounds with RAD51C: view

Transcripts for RAD51C Gene

Unigene Clusters for RAD51C Gene

RAD51 homolog C (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAD51C

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAD51C Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - -
SP8: - - - -
SP9:
SP10: -
SP11:

Relevant External Links for RAD51C Gene

GeneLoc Exon Structure for
RAD51C
ECgene alternative splicing isoforms for
RAD51C

Expression for RAD51C Gene

mRNA expression in normal human tissues for RAD51C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAD51C Gene

SOURCE GeneReport for Unigene cluster for RAD51C Gene Hs.412587

mRNA Expression by UniProt/SwissProt for RAD51C Gene

O43502-RA51C_HUMAN
Tissue specificity: Expressed in a variety of tissues, with highest expression in testis, heart muscle, spleen and prostate
genes like me logo Genes that share expressions with RAD51C: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RAD51C Gene

Orthologs for RAD51C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAD51C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD51C 35
  • 99.4 (n)
  • 99.1 (a)
RAD51C 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAD51C 35
  • 91.3 (n)
  • 89.95 (a)
RAD51C 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAD51C 35
  • 91.85 (n)
  • 92.78 (a)
RAD51C 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rad51c 35
  • 87.67 (n)
  • 86.85 (a)
Rad51c 16
Rad51c 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAD51C 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAD51C 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rad51c 35
  • 87.76 (n)
  • 87.12 (a)
chicken
(Gallus gallus)
Aves RAD51C 35
  • 71.51 (n)
  • 73.15 (a)
lizard
(Anolis carolinensis)
Reptilia RAD51C 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rad51c 35
  • 65.08 (n)
  • 64.43 (a)
Str.18691 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2850 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14386 35
rad51c 35
  • 63.35 (n)
  • 62.95 (a)
rad51c 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta spn-D 36
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DMC1 36
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons RAD51C 35
  • 49.9 (n)
  • 40.85 (a)
rice
(Oryza sativa)
Liliopsida Os01g0578000 35
  • 49.36 (n)
  • 39 (a)
Species with no ortholog for RAD51C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAD51C Gene

ENSEMBL:
Gene Tree for RAD51C (if available)
TreeFam:
Gene Tree for RAD51C (if available)

Paralogs for RAD51C Gene

Paralogs for RAD51C Gene

genes like me logo Genes that share paralogs with RAD51C: view

Variants for RAD51C Gene

Sequence variations from dbSNP and Humsavar for RAD51C Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs149404 -- 58,697,451(-) tcaag(C/T)gattc intron-variant
rs172565 -- 58,731,635(+) TAGAA(A/T)TTTAT intron-variant
rs177319 -- 58,697,428(-) ctcct(C/G/T)agtag intron-variant
rs186204 -- 58,697,435(-) cctca(G/T)cctcc intron-variant
rs191015 -- 58,697,645(-) ATTAG(G/T)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAD51C Gene

Variant ID Type Subtype PubMed ID
dgv994e1 CNV Complex 17122850
nsv428347 CNV Gain 18775914
nsv908642 CNV Loss 21882294
nsv833498 CNV Loss 17160897
esv2674642 CNV Deletion 23128226
dgv3236n71 CNV Loss 21882294
nsv908644 CNV Loss 21882294
esv2716079 CNV Deletion 23290073
esv991006 CNV Deletion 20482838
esv1778308 CNV Deletion 17803354
esv2664231 CNV Deletion 23128226

Relevant External Links for RAD51C Gene

HapMap Linkage Disequilibrium report
RAD51C
Human Gene Mutation Database (HGMD)
RAD51C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD51C Gene

Disorders for RAD51C Gene

(2) OMIM Diseases for RAD51C Gene (602774)

UniProtKB/Swiss-Prot

RA51C_HUMAN
  • Fanconi anemia complementation group O (FANCO) [MIM:613390]: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. {ECO:0000269 PubMed:20400963}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Breast-ovarian cancer, familial, 3 (BROVCA3) [MIM:613399]: A condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate. {ECO:0000269 PubMed:20400964, ECO:0000269 PubMed:21990120}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for RAD51C Gene

(1) Novoseek inferred disease relationships for RAD51C Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2

Relevant External Links for RAD51C

Genetic Association Database (GAD)
RAD51C
Human Genome Epidemiology (HuGE) Navigator
RAD51C
genes like me logo Genes that share disorders with RAD51C: view

Publications for RAD51C Gene

  1. Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes. (PMID: 9469824) Dosanjh M.K. … Schild D. (Nucleic Acids Res. 1998) 2 3 4 23
  2. RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51. (PMID: 11744692) Miller K.A. … Albala J.S. (J. Biol. Chem. 2002) 3 4 23
  3. Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells. (PMID: 11842112) Wiese C. … Schild D. (Nucleic Acids Res. 2002) 3 4 23
  4. Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro. (PMID: 12427746) Lio Y.-C. … Chen D.J. (J. Biol. Chem. 2003) 3 4 23
  5. Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion. (PMID: 12966089) French C.A. … Thacker J. (J. Biol. Chem. 2003) 3 4 23

Products for RAD51C Gene

Sources for RAD51C Gene

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