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Aliases for RAD23A Gene

Aliases for RAD23A Gene

  • RAD23 Homolog A, Nucleotide Excision Repair Protein 2 3 5
  • RAD23, Yeast Homolog, A 2 3
  • HHR23A 3 4
  • HR23A 3 4
  • UV Excision Repair Protein RAD23 Homolog A 3
  • RAD23 (S. Cerevisiae) Homolog A 2
  • RAD23 Homolog A (S. Cerevisiae) 2

External Ids for RAD23A Gene

Previous GeneCards Identifiers for RAD23A Gene

  • GC19P013188
  • GC19M013321
  • GC19P012901
  • GC19P012917
  • GC19P013056
  • GC19P012628

Summaries for RAD23A Gene

Entrez Gene Summary for RAD23A Gene

  • The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]

GeneCards Summary for RAD23A Gene

RAD23A (RAD23 Homolog A, Nucleotide Excision Repair Protein) is a Protein Coding gene. Diseases associated with RAD23A include Xeroderma Pigmentosum, Variant Type and Hiv-1. Among its related pathways are Nucleotide excision repair and Deubiquitination. GO annotations related to this gene include single-stranded DNA binding and polyubiquitin binding. An important paralog of this gene is RAD23B.

UniProtKB/Swiss-Prot for RAD23A Gene

  • Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to Lys-48-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to Lys-63-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.

  • Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.

  • Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.

Gene Wiki entry for RAD23A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD23A Gene

Genomics for RAD23A Gene

Regulatory Elements for RAD23A Gene

Enhancers for RAD23A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G013160 2.1 FANTOM5 Ensembl ENCODE dbSUPER 5.1 +221.5 221482 13.8 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC CCDC130 ZNF44 ZNF799 ZNF791 WDR83OS ZNF564 TRMT1 C19orf43 ZNF709 ZNF442
GH19G012943 1.4 ENCODE dbSUPER 0.7 +1.1 1106 6.8 CREB3L1 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 MRI1 ZNF564 GCDH ZNF136 CCDC130 WDR83OS ZNF442 ZNF799 ZNF844 RPS6P25
GH19G012951 1.3 Ensembl ENCODE dbSUPER 0.4 +7.7 7707 3.9 NFIB AGO1 KLF17 ZNF121 FOS EGR2 PAF1 USF2 ZEB2 ZNF623 GCDH HOOK2 DNASE2 GADD45GIP1 RAD23A
GH19G012955 1.1 ENCODE 0.4 +11.2 11153 2.3 HDGF CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 MRI1 ZNF564 CCDC130 WDR83OS ZNF136 ZNF799 ZNF44 ZNF442 DCAF15 ZNF878
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAD23A on UCSC Golden Path with GeneCards custom track

Promoters for RAD23A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107334 386 1201 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A FEZF1

Genomic Location for RAD23A Gene

Chromosome:
19
Start:
12,945,814 bp from pter
End:
12,953,643 bp from pter
Size:
7,830 bases
Orientation:
Plus strand

Genomic View for RAD23A Gene

Genes around RAD23A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAD23A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAD23A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD23A Gene

Proteins for RAD23A Gene

  • Protein details for RAD23A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54725-RD23A_HUMAN
    Recommended name:
    UV excision repair protein RAD23 homolog A
    Protein Accession:
    P54725
    Secondary Accessions:
    • K7ESE3
    • Q59EU8
    • Q5M7Z1

    Protein attributes for RAD23A Gene

    Size:
    363 amino acids
    Molecular mass:
    39609 Da
    Quaternary structure:
    • Interacts with XPC; the interaction is suggesting the existence of a functional equivalent variant XPC complex. Interacts with PSMD4 and PSMC5. Interacts with ATXN3. Interacts with HIV-1 vpr. Interacts with UBQLN2.
    SequenceCaution:
    • Sequence=BAD92950.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BX448989; Type=Frameshift; Positions=159, 333, 339, 347; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAD23A Gene

    Alternative splice isoforms for RAD23A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAD23A Gene

Post-translational modifications for RAD23A Gene

  • Ubiquitination at isoforms=2, 38, Lys16, Lys26, isoforms=2, 347, isoforms=2, 353, Lys78, Lys80, and Lys122
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAD23A (RAD23A)
  • Santa Cruz Biotechnology (SCBT) Antibodies for RAD23A

No data available for DME Specific Peptides for RAD23A Gene

Domains & Families for RAD23A Gene

Gene Families for RAD23A Gene

Graphical View of Domain Structure for InterPro Entry

P54725

UniProtKB/Swiss-Prot:

RD23A_HUMAN :
  • The ubiquitin-like domain mediates interaction with ATXN3.
  • Belongs to the RAD23 family.
Domain:
  • The ubiquitin-like domain mediates interaction with ATXN3.
  • The ubiquitin-like (UBL) and the UBA (ubiquitin-associated) domains interact intramolecularly in a highly dynamic manner, as each UBA domain competes for an overlapping UBL domain surface. Binding of ubiquitin or proteasome subunit PSMD4 disrupt the UBL-UBA domain interactions and drive RAD23A in to an open conformation.
Family:
  • Belongs to the RAD23 family.
genes like me logo Genes that share domains with RAD23A: view

Function for RAD23A Gene

Molecular function for RAD23A Gene

GENATLAS Biochemistry:
yeast (S cerevisiae) RAD23 homolog A,ubiquitin conjugating enzyme E3A,involved in the degradation of short-lived and abnormal proteins
UniProtKB/Swiss-Prot Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to Lys-48-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to Lys-63-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.
UniProtKB/Swiss-Prot Function:
Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.
UniProtKB/Swiss-Prot Function:
Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.

Gene Ontology (GO) - Molecular Function for RAD23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003684 damaged DNA binding IEA --
GO:0003697 single-stranded DNA binding TAS 8168482
GO:0005515 protein binding IPI 10488153
GO:0019900 kinase binding IPI 26296656
GO:0031593 polyubiquitin binding IDA 12643283
genes like me logo Genes that share ontologies with RAD23A: view
genes like me logo Genes that share phenotypes with RAD23A: view

Animal Models for RAD23A Gene

MGI Knock Outs for RAD23A:

Animal Model Products

miRNA for RAD23A Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAD23A Gene

Localization for RAD23A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD23A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAD23A gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAD23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA --
GO:0005634 nucleus IEA,IDA 26296656
GO:0005654 nucleoplasm TAS,IDA --
GO:0005737 cytoplasm IDA 26296656
GO:0005815 microtubule organizing center IDA --
genes like me logo Genes that share ontologies with RAD23A: view

Pathways & Interactions for RAD23A Gene

genes like me logo Genes that share pathways with RAD23A: view

Pathways by source for RAD23A Gene

Gene Ontology (GO) - Biological Process for RAD23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006289 nucleotide-excision repair IEA,IDA 9372924
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0016032 viral process IEA --
GO:0016579 protein deubiquitination TAS --
genes like me logo Genes that share ontologies with RAD23A: view

No data available for SIGNOR curated interactions for RAD23A Gene

Drugs & Compounds for RAD23A Gene

(1) Drugs for RAD23A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RAD23A: view

Transcripts for RAD23A Gene

Unigene Clusters for RAD23A Gene

RAD23 homolog A (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAD23A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d
SP1: -
SP2: -
SP3: - -
SP4: - - -
SP5: -
SP6: - - - - -
SP7: - - -
SP8: - - - -
SP9:
SP10: - -

Relevant External Links for RAD23A Gene

GeneLoc Exon Structure for
RAD23A
ECgene alternative splicing isoforms for
RAD23A

Expression for RAD23A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAD23A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAD23A Gene

This gene is overexpressed in Muscle - Skeletal (x8.2).

Protein differential expression in normal tissues from HIPED for RAD23A Gene

This gene is overexpressed in Lavage (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAD23A Gene



Protein tissue co-expression partners for RAD23A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAD23A Gene:

RAD23A

SOURCE GeneReport for Unigene cluster for RAD23A Gene:

Hs.643267

Evidence on tissue expression from TISSUES for RAD23A Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Pancreas(4.3)
  • Muscle(3.8)
  • Lung(3.5)
  • Eye(2.9)
  • Heart(2.6)
  • Skin(2.6)
  • Intestine(2.4)
  • Kidney(2.3)
  • Stomach(2)
genes like me logo Genes that share expression patterns with RAD23A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAD23A Gene

Orthologs for RAD23A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAD23A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD23A 34 35
  • 97.51 (n)
dog
(Canis familiaris)
Mammalia RAD23A 34 35
  • 93 (n)
cow
(Bos Taurus)
Mammalia RAD23A 34 35
  • 92.91 (n)
mouse
(Mus musculus)
Mammalia Rad23a 34 16 35
  • 89.23 (n)
rat
(Rattus norvegicus)
Mammalia Rad23a 34
  • 88.04 (n)
oppossum
(Monodelphis domestica)
Mammalia RAD23A 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAD23A 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAD23A 35
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 80 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii rad23aa 34 35
  • 67.42 (n)
zgc65951 34
fruit fly
(Drosophila melanogaster)
Insecta Rad23 36 35
  • 40 (a)
CG10694 35
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea rad-23 35
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD23 35
  • 30 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons RAD23B 34
  • 48.62 (n)
rice
(Oryza sativa)
Liliopsida Os02g0179300 34
  • 50.15 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1944 35
  • 44 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2042 34
Species where no ortholog for RAD23A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAD23A Gene

ENSEMBL:
Gene Tree for RAD23A (if available)
TreeFam:
Gene Tree for RAD23A (if available)

Paralogs for RAD23A Gene

Paralogs for RAD23A Gene

(8) SIMAP similar genes for RAD23A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RAD23A: view

Variants for RAD23A Gene

Sequence variations from dbSNP and Humsavar for RAD23A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000094984 -- 12,951,957(+) AGAGT(C/T)TCTTG intron-variant
rs1000184497 -- 12,947,562(+) GTTCT(C/T)TCATT intron-variant
rs1000786637 -- 12,946,427(+) GAGTA(A/G)TGACG intron-variant
rs1000867927 -- 12,945,610(+) TGAGC(A/G)TGAGA upstream-variant-2KB
rs1000920495 -- 12,945,761(+) ACGCG(C/T)TCGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAD23A Gene

Variant ID Type Subtype PubMed ID
nsv1160589 CNV duplication 26073780
nsv833754 CNV loss 17160897
nsv953977 CNV deletion 24416366

Variation tolerance for RAD23A Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAD23A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAD23A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD23A Gene

Disorders for RAD23A Gene

MalaCards: The human disease database

(2) MalaCards diseases for RAD23A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
xeroderma pigmentosum, variant type
  • de sanctis-cacchione syndrome
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RAD23A

Genetic Association Database (GAD)
RAD23A
Human Genome Epidemiology (HuGE) Navigator
RAD23A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAD23A
genes like me logo Genes that share disorders with RAD23A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAD23A Gene

Publications for RAD23A Gene

  1. Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins. (PMID: 18234089) Goh A.M. … Howley P.M. (BMC Biochem. 2008) 3 4 22 64
  2. Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B. (PMID: 16712842) Chen L. … Madura K. (FEBS Lett. 2006) 3 4 22 64
  3. Binding of polyubiquitin chains to ubiquitin-associated (UBA) domains of HHR23A. (PMID: 15321727) Raasi S. … Pickart C.M. (J. Mol. Biol. 2004) 3 4 22 64
  4. DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a. (PMID: 14557549) Walters K.J. … Howley P.M. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 22 64
  5. Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B. (PMID: 10915768) Wang G. … Nukina N. (Hum. Mol. Genet. 2000) 3 4 22 64

Products for RAD23A Gene

Sources for RAD23A Gene

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