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Aliases for EPS15L1 Gene

Aliases for EPS15L1 Gene

  • Epidermal Growth Factor Receptor Pathway Substrate 15-Like 1 2 3
  • Eps15-Related Protein 3 4
  • EPS15R 3 4
  • Epidermal Growth Factor Receptor Substrate 15-Like 1 3
  • Epidermal Growth Factor Receptor Substrate EPS15R 3

External Ids for EPS15L1 Gene

Summaries for EPS15L1 Gene

GeneCards Summary for EPS15L1 Gene

EPS15L1 (Epidermal Growth Factor Receptor Pathway Substrate 15-Like 1) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is EHD1.

UniProtKB/Swiss-Prot for EPS15L1 Gene

  • Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.

Gene Wiki entry for EPS15L1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPS15L1 Gene

Genomics for EPS15L1 Gene

Genomic Location for EPS15L1 Gene

Start:
16,355,239 bp from pter
End:
16,472,085 bp from pter
Size:
116,847 bases
Orientation:
Minus strand

Genomic View for EPS15L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EPS15L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPS15L1 Gene

Regulatory Elements for EPS15L1 Gene

Proteins for EPS15L1 Gene

  • Protein details for EPS15L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBC2-EP15R_HUMAN
    Recommended name:
    Epidermal growth factor receptor substrate 15-like 1
    Protein Accession:
    Q9UBC2
    Secondary Accessions:
    • A2RRF3
    • A5PL29
    • B4DKA3

    Protein attributes for EPS15L1 Gene

    Size:
    864 amino acids
    Molecular mass:
    94255 Da
    Quaternary structure:
    • Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2) (By similarity). Interacts with FCHO1. Interacts with FCHO2. Interacts (via EH domains) with DAB2.

    Alternative splice isoforms for EPS15L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPS15L1 Gene

Proteomics data for EPS15L1 Gene at MOPED

Post-translational modifications for EPS15L1 Gene

  • Phosphorylated on tyrosine residues by EGFR.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys531, Lys534, Lys604, Lys632, Lys638, Lys683, Lys694, Lys701, Lys829, Lys838, Lys851, and Lys874

No data available for DME Specific Peptides for EPS15L1 Gene

Domains for EPS15L1 Gene

Gene Families for EPS15L1 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for EPS15L1 Gene

UniProtKB/Swiss-Prot:

EP15R_HUMAN
Domain:
  • Contains 1 EF-hand domain.:
    • Q9UBC2
  • Contains 3 EH domains.:
    • Q9UBC2
genes like me logo Genes that share domains with EPS15L1: view

Function for EPS15L1 Gene

Molecular function for EPS15L1 Gene

UniProtKB/Swiss-Prot Function: Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.

Gene Ontology (GO) - Molecular Function for EPS15L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 19262564
genes like me logo Genes that share ontologies with EPS15L1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for EPS15L1 Gene

Localization for EPS15L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPS15L1 Gene

Cell membrane; Peripheral membrane protein. Nucleus. Membrane, coated pit. Note=Localized to plasma membrane coated pits. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPS15L1 Gene COMPARTMENTS Subcellular localization image for EPS15L1 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for EPS15L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0030132 clathrin coat of coated pit IEA --
genes like me logo Genes that share ontologies with EPS15L1: view

Pathways for EPS15L1 Gene

genes like me logo Genes that share pathways with EPS15L1: view

Pathways by source for EPS15L1 Gene

1 BioSystems pathway for EPS15L1 Gene

Gene Ontology (GO) - Biological Process for EPS15L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with EPS15L1: view

Compounds for EPS15L1 Gene

(1) Novoseek inferred chemical compound relationships for EPS15L1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 31.1 4
genes like me logo Genes that share compounds with EPS15L1: view

Transcripts for EPS15L1 Gene

Unigene Clusters for EPS15L1 Gene

Epidermal growth factor receptor pathway substrate 15-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EPS15L1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for EPS15L1 Gene

GeneLoc Exon Structure for
EPS15L1
ECgene alternative splicing isoforms for
EPS15L1

Expression for EPS15L1 Gene

mRNA expression in normal human tissues for EPS15L1 Gene

mRNA differential expression in normal tissues according to GTEx for EPS15L1 Gene

This gene is overexpressed in Muscle - Skeletal (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EPS15L1 Gene

SOURCE GeneReport for Unigene cluster for EPS15L1 Gene Hs.744842

genes like me logo Genes that share expressions with EPS15L1: view

Orthologs for EPS15L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EPS15L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPS15L1 36
  • 97.83 (n)
  • 97.57 (a)
EPS15L1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EPS15L1 36
  • 89.45 (n)
  • 93.99 (a)
EPS15L1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EPS15L1 36
  • 91.98 (n)
  • 95.71 (a)
EPS15L1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eps15l1 36
  • 86.99 (n)
  • 92.83 (a)
Eps15l1 16
Eps15l1 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EPS15L1 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EPS15L1 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eps15l1 36
  • 87.24 (n)
  • 93.74 (a)
chicken
(Gallus gallus)
Aves EPS15L1 36
  • 78.29 (n)
  • 85.05 (a)
EPS15L1 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EPS15L1 37
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eps15l1 36
  • 70.78 (n)
  • 77.55 (a)
zebrafish
(Danio rerio)
Actinopterygii EPS15L1 (2 of 2) 37
  • 52 (a)
OneToMany
eps15l1a 36
  • 70.54 (n)
  • 74.38 (a)
eps15l1a 37
  • 72 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009189 36
  • 49.84 (n)
  • 43.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Eps-15 36
  • 50.85 (n)
  • 44.58 (a)
Eps-15 37
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ehs-1 36
  • 41.14 (n)
  • 34.51 (a)
ehs-1 37
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EDE1 37
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 53 (a)
OneToMany
Species with no ortholog for EPS15L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EPS15L1 Gene

ENSEMBL:
Gene Tree for EPS15L1 (if available)
TreeFam:
Gene Tree for EPS15L1 (if available)

Paralogs for EPS15L1 Gene

Paralogs for EPS15L1 Gene

genes like me logo Genes that share paralogs with EPS15L1: view

Variants for EPS15L1 Gene

Sequence variations from dbSNP and Humsavar for EPS15L1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs36717 -- 16,460,241(-) AGTGG(C/T)GCCAT intron-variant
rs36718 -- 16,457,480(-) GTCTC(C/T)GGCAC intron-variant
rs36719 -- 16,456,956(-) CCCCA(G/T)GTTCT intron-variant
rs36720 -- 16,456,540(-) agctg(A/G)gatta intron-variant
rs36721 -- 16,455,090(-) GTGCA(A/G)TGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPS15L1 Gene

Variant ID Type Subtype PubMed ID
nsv911166 CNV Loss 21882294
esv2667853 CNV Deletion 23128226

Relevant External Links for EPS15L1 Gene

HapMap Linkage Disequilibrium report
EPS15L1

Disorders for EPS15L1 Gene

(1) University of Copenhagen DISEASES for EPS15L1 Gene

Relevant External Links for EPS15L1

Genetic Association Database (GAD)
EPS15L1
genes like me logo Genes that share disorders with EPS15L1: view

No data available for UniProtKB/Swiss-Prot for EPS15L1 Gene

Publications for EPS15L1 Gene

  1. Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization. (PMID: 9446614) Coda L. … Di Fiore P.P. (J. Biol. Chem. 1998) 3 23
  2. The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport. (PMID: 10613896) Doria M. … Di Fiore P.P. (J. Cell Biol. 1999) 3 23
  3. Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery. (PMID: 11381094) Martina J.A. … Bonifacino J.S. (J. Cell Biol. 2001) 3 23
  4. A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination. (PMID: 12072436) Klapisz E. … van Bergen en Henegouwen P.M. (J. Biol. Chem. 2002) 3 23
  5. Selection system for genes encoding nuclear-targeted proteins. (PMID: 9853615) Ueki N. … Muramatsu M.-A. (Nat. Biotechnol. 1998) 3 4

Products for EPS15L1 Gene

  • antibodies-online peptides for EPS15L1
  • antibodies-online antibodies for EPS15L1
  • antibodies-online kits for EPS15L1

Sources for EPS15L1 Gene

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