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Aliases for PXN Gene

Aliases for PXN Gene

  • Paxillin 2 3

External Ids for PXN Gene

Previous GeneCards Identifiers for PXN Gene

  • GC12M119521
  • GC12M120174
  • GC12M120431
  • GC12M119060
  • GC12M119110
  • GC12M120648
  • GC12M117656

Summaries for PXN Gene

Entrez Gene Summary for PXN Gene

  • This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]

GeneCards Summary for PXN Gene

PXN (Paxillin) is a Protein Coding gene. Diseases associated with PXN include corneal opacification and other ocular anomalies. Among its related pathways are PI-3K cascade and Signaling by FGFR. GO annotations related to this gene include protein kinase binding and beta-catenin binding. An important paralog of this gene is LDB3.

UniProtKB/Swiss-Prot for PXN Gene

  • Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion)

Gene Wiki entry for PXN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PXN Gene

Genomics for PXN Gene

Regulatory Elements for PXN Gene

Genomic Location for PXN Gene

Start:
120,210,439 bp from pter
End:
120,265,771 bp from pter
Size:
55,333 bases
Orientation:
Minus strand

Genomic View for PXN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PXN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PXN Gene

Proteins for PXN Gene

  • Protein details for PXN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49023-PAXI_HUMAN
    Recommended name:
    Paxillin
    Protein Accession:
    P49023
    Secondary Accessions:
    • B2RAI3
    • B7ZMB4
    • O14970
    • O14971
    • O60360
    • Q5HYA4

    Protein attributes for PXN Gene

    Size:
    591 amino acids
    Molecular mass:
    64505 Da
    Quaternary structure:
    • Binds in vitro to vinculin as well as to the SH3 domain of SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to PTK2/FAK1 but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to PTK2/FAK1. Interacts with GIT1, NUDT16L1/SDOS and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Interacts with PTK2/FAK1 and PTK2B/PYK2. Binds ASAP2. Interacts with unphosphorylated ITGA4. Interacts with RNF5 and PDCD10. Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with PTK6. Interacts with SORBS1, PARVA and PARVB.

    Three dimensional structures from OCA and Proteopedia for PXN Gene

    Alternative splice isoforms for PXN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PXN Gene

Proteomics data for PXN Gene at MOPED

Post-translational modifications for PXN Gene

  • Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PXN Gene

Domains for PXN Gene

Protein Domains for PXN Gene

Suggested Antigen Peptide Sequences for PXN Gene

Graphical View of Domain Structure for InterPro Entry

P49023

UniProtKB/Swiss-Prot:

PAXI_HUMAN :
  • P49023
Domain:
  • Contains 4 LIM zinc-binding domains.
Family:
  • Belongs to the paxillin family.
genes like me logo Genes that share domains with PXN: view

No data available for Gene Families for PXN Gene

Function for PXN Gene

Molecular function for PXN Gene

GENATLAS Biochemistry: focal adhesion protein (68kDa),paxillin
UniProtKB/Swiss-Prot Function: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion)

Gene Ontology (GO) - Molecular Function for PXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 10604475
GO:0008013 beta-catenin binding IPI 17513457
GO:0008270 zinc ion binding IEA --
GO:0017166 vinculin binding IPI 9054445
genes like me logo Genes that share ontologies with PXN: view
genes like me logo Genes that share phenotypes with PXN: view

Animal Models for PXN Gene

MGI Knock Outs for PXN:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PXN Gene

Localization for PXN Gene

Subcellular locations from UniProtKB/Swiss-Prot for PXN Gene

Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, cell cortex. Note=Colocalizes with integrins at the cell periphery. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PXN Gene COMPARTMENTS Subcellular localization image for PXN gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
nucleus 3
extracellular 2

Gene Ontology (GO) - Cellular Components for PXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 24036928
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PXN: view

Pathways for PXN Gene

genes like me logo Genes that share pathways with PXN: view

Gene Ontology (GO) - Biological Process for PXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0006928 movement of cell or subcellular component --
GO:0006936 muscle contraction TAS --
GO:0007010 cytoskeleton organization IEA --
GO:0007155 cell adhesion NAS 10840040
genes like me logo Genes that share ontologies with PXN: view

Compounds for PXN Gene

(82) Novoseek inferred chemical compound relationships for PXN Gene

Compound -log(P) Hits PubMed IDs
tyrosine 86.6 314
phosphotyrosine 80.6 57
cytochalasin d 76.5 18
herbimycin a 64.9 2
1-oleoyl-lyso-phosphatidic acid 60.4 3
genes like me logo Genes that share compounds with PXN: view

Transcripts for PXN Gene

Unigene Clusters for PXN Gene

Paxillin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PXN Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b
SP1: - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5:
SP6: - - - -
SP7: -
SP8: - - -
SP9: -
SP10:

Relevant External Links for PXN Gene

GeneLoc Exon Structure for
PXN
ECgene alternative splicing isoforms for
PXN

Expression for PXN Gene

mRNA expression in normal human tissues for PXN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PXN Gene

This gene is overexpressed in Whole Blood (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PXN Gene

SOURCE GeneReport for Unigene cluster for PXN Gene Hs.446336

genes like me logo Genes that share expressions with PXN: view

No data available for mRNA Expression by UniProt/SwissProt for PXN Gene

Orthologs for PXN Gene

This gene was present in the common ancestor of animals.

Orthologs for PXN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PXN 35
  • 99.55 (n)
  • 99.66 (a)
PXN 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PXN 35
  • 89.93 (n)
  • 93.34 (a)
PXN 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PXN 35
  • 91.79 (n)
  • 96.3 (a)
PXN 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pxn 35
  • 88.56 (n)
  • 93.45 (a)
Pxn 16
Pxn 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PXN 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PXN 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pxn 35
  • 88.16 (n)
  • 94.51 (a)
chicken
(Gallus gallus)
Aves PXN 35
  • 81.26 (n)
  • 89.74 (a)
PXN 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PXN 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397826 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pxn 35
  • 73.19 (n)
  • 81.94 (a)
Str.15031 35
zebrafish
(Danio rerio)
Actinopterygii LOC565130 35
  • 69.65 (n)
  • 73.93 (a)
PXN (1 of 3) 36
  • 33 (a)
OneToMany
pxna 36
  • 89 (a)
OneToMany
pxna 36
  • 91 (a)
OneToMany
sbcb631 35
fruit fly
(Drosophila melanogaster)
Insecta Pax 36
  • 45 (a)
OneToMany
Pax 37
  • 70 (a)
worm
(Caenorhabditis elegans)
Secernentea pxl-1 36
  • 42 (a)
OneToMany
C28H8.6 37
  • 54 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11495 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9134 36
  • 54 (a)
OneToMany
Species with no ortholog for PXN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PXN Gene

ENSEMBL:
Gene Tree for PXN (if available)
TreeFam:
Gene Tree for PXN (if available)

Paralogs for PXN Gene

genes like me logo Genes that share paralogs with PXN: view

Variants for PXN Gene

Sequence variations from dbSNP and Humsavar for PXN Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs25662 -- 120,214,855(-) CCGCG(A/C/G/T)TGCTA synonymous-codon, reference, downstream-variant-500B, nc-transcript-variant
rs1151821 -- 120,239,474(+) ctact(C/T)gggag intron-variant
rs1151822 -- 120,239,577(+) actcc(A/G)tctca intron-variant
rs1151823 -- 120,239,608(+) caggc(A/G)tggtg intron-variant
rs1151824 -- 120,240,578(+) CAAGC(A/G)GATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PXN Gene

Variant ID Type Subtype PubMed ID
nsv899555 CNV Loss 21882294
nsv519657 CNV Loss 19592680
nsv832530 CNV Loss 17160897
nsv7238 OTHER Inversion 18451855
nsv905 CNV Insertion 18451855
nsv899556 CNV Gain 21882294

Relevant External Links for PXN Gene

HapMap Linkage Disequilibrium report
PXN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PXN Gene

Disorders for PXN Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PXN Gene including...

Search for PXN Gene in MalaCards »

(1) University of Copenhagen DISEASES for PXN Gene

(42) Novoseek inferred disease relationships for PXN Gene

Disease -log(P) Hits PubMed IDs
neurofibromatosis type 2 47.7 2
metastasis 40 24
tumors 31.3 46
glioblastoma 27.2 2
cancer 24.2 17

Relevant External Links for PXN

Genetic Association Database (GAD)
PXN
Human Genome Epidemiology (HuGE) Navigator
PXN
genes like me logo Genes that share disorders with PXN: view

No data available for UniProtKB/Swiss-Prot for PXN Gene

Publications for PXN Gene

  1. Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL. (PMID: 7534286) Salgia R. … Griffin J.D. (J. Biol. Chem. 1995) 2 3 4 23
  2. Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins. (PMID: 9054445) Mazaki Y. … Sabe H. (J. Biol. Chem. 1997) 3 4 23
  3. A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration. (PMID: 10749932) Kondo A. … Sabe H. (Mol. Biol. Cell 2000) 3 4 23
  4. RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization. (PMID: 12861019) Didier C. … Ronai Z. (Mol. Cell. Biol. 2003) 3 4 23
  5. No somatic genetic change in the paxillin gene in nonsmall-cell lung cancer. (PMID: 19353596) Pallier K. … Blons H. (Mol. Carcinog. 2009) 3 23 48

Products for PXN Gene

Sources for PXN Gene

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