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Aliases for PVR Gene

Aliases for PVR Gene

  • Poliovirus Receptor 2 3 5
  • Nectin-Like Protein 5 3 4
  • Necl-5 3 4
  • PVS 3 4
  • Nectin-Like 5 2
  • CD155 Antigen 4
  • CD155 3
  • NECL5 3
  • TAGE4 3
  • HVED 3

External Ids for PVR Gene

Previous HGNC Symbols for PVR Gene

  • PVS

Previous GeneCards Identifiers for PVR Gene

  • GC19P045791
  • GC19P045538
  • GC19P049823
  • GC19P049839
  • GC19P045147
  • GC19P041579

Summaries for PVR Gene

Entrez Gene Summary for PVR Gene

  • The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for PVR Gene

PVR (Poliovirus Receptor) is a Protein Coding gene. Diseases associated with PVR include Poliomyelitis and Paralytic Poliomyelitis. Among its related pathways are Innate Immune System and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. Gene Ontology (GO) annotations related to this gene include receptor activity and virus receptor activity. An important paralog of this gene is NECTIN2.

UniProtKB/Swiss-Prot for PVR Gene

  • Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.

  • (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport (PubMed:2538245). Acts as a receptor for pseudorabies virus (PubMed:9616127). Is prevented to reach cell surface upon infection by human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells (PubMed:15640804).

Gene Wiki entry for PVR Gene

Additional gene information for PVR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PVR Gene

Genomics for PVR Gene

GeneHancer (GH) Regulatory Elements for PVR Gene

Promoters and enhancers for PVR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I044633 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 578.8 -4.2 -4185 11.6 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF766 MXD4 REST KAT8 PVR CEACAM19 ENSG00000267114 ZNF223 ENSG00000252200 ZNF227 ZNF235 ZNF226 CEACAM22P IGSF23
GH19I044606 Enhancer 1 Ensembl ENCODE dbSUPER 22.2 -35.7 -35665 3.1 NFIA NFIB JUN MAFG NR2F2 SREBF1 NFIC POLR2A ZBTB33 FOS PVR CEACAM22P CEACAM19 IGSF23 ENSG00000224366
GH19I044622 Enhancer 0.9 Ensembl ENCODE dbSUPER 23.7 -20.4 -20425 1.6 RFX1 IKZF1 MYNN ZNF512 NFE2 PVR CEACAM22P IGSF23
GH19I044657 Enhancer 0.8 ENCODE 25.3 +13.7 13697 0.7 HDGF PKNOX1 RB1 ARID4B SIN3A RAD21 EGR1 ZNF143 CREM EGR2 PVR MIR4531 CEACAM19 ENSG00000266903
GH19I044647 Enhancer 0.9 Ensembl ENCODE dbSUPER 22.3 +5.0 4977 3.1 ZNF664 RXRA SCRT2 HNF4G ZSCAN29 HNF4A REST PVR CEACAM19 CEACAM22P MIR4531 ENSG00000266903
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PVR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PVR gene promoter:

Genomic Locations for PVR Gene

Genomic Locations for PVR Gene
chr19:44,643,798-44,666,161
(GRCh38/hg38)
Size:
22,364 bases
Orientation:
Plus strand
chr19:45,147,098-45,169,429
(GRCh37/hg19)

Genomic View for PVR Gene

Genes around PVR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PVR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PVR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PVR Gene

Proteins for PVR Gene

  • Protein details for PVR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15151-PVR_HUMAN
    Recommended name:
    Poliovirus receptor
    Protein Accession:
    P15151
    Secondary Accessions:
    • B4DTS9
    • P15152
    • Q15267
    • Q15268
    • Q96BJ1

    Protein attributes for PVR Gene

    Size:
    417 amino acids
    Molecular mass:
    45303 Da
    Quaternary structure:
    • Can form trans-heterodimers with NECTIN3. The extracellular domain interacts with VTN, CD226 and CD96. The cytoplasmic domain interacts with DYNLT1. Binds with high affinity to TIGIT.
    • (Microbial infection) Interacts with poliovirus capsid proteins.
    • (Microbial infection) Interacts with human cytomegalovirus /HHV-5 UL141 protein.
    • (Microbial infection) Interacts with pseudorabies virus gD protein.
    Miscellaneous:
    • The V-type domain is necessary and sufficient for virus binding and uptake.

    Three dimensional structures from OCA and Proteopedia for PVR Gene

    Alternative splice isoforms for PVR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PVR Gene

Post-translational modifications for PVR Gene

  • N-glycosylated. N-glycan at Asn-120: Hex5HexNAc4.
  • Phosphorylated by Src kinases on tyrosine residues in the ITIM motif upon ligation. Interaction with TIGIT is required for Phosphorylation.
  • Glycosylation at Asn105, Asn120, Asn188, isoforms=2, 4, 3218, Asn237, Asn278, isoforms=2, 4, 3307, and isoforms=2, 4, 3313

No data available for DME Specific Peptides for PVR Gene

Domains & Families for PVR Gene

Gene Families for PVR Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for PVR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15151

UniProtKB/Swiss-Prot:

PVR_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the nectin family.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Family:
  • Belongs to the nectin family.
genes like me logo Genes that share domains with PVR: view

Function for PVR Gene

Molecular function for PVR Gene

GENATLAS Biochemistry:
poliovirus sensitivity,receptor
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=72 nM for VTN;
UniProtKB/Swiss-Prot Function:
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport (PubMed:2538245). Acts as a receptor for pseudorabies virus (PubMed:9616127). Is prevented to reach cell surface upon infection by human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells (PubMed:15640804).
UniProtKB/Swiss-Prot Induction:
Transcriptionally regulated by SHH.

Phenotypes From GWAS Catalog for PVR Gene

Gene Ontology (GO) - Molecular Function for PVR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004872 receptor activity TAS 2538245
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 19011627
GO:0042803 protein homodimerization activity IBA --
genes like me logo Genes that share ontologies with PVR: view
genes like me logo Genes that share phenotypes with PVR: view

miRNA for PVR Gene

miRTarBase miRNAs that target PVR

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PVR Gene

Localization for PVR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PVR Gene

Isoform Alpha: Cell membrane; Single-pass type I membrane protein.
Isoform Delta: Cell membrane; Single-pass type I membrane protein.
Isoform Beta: Secreted.
Isoform Gamma: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PVR gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 3
endoplasmic reticulum 2
lysosome 2
endosome 2
cytoskeleton 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PVR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 2170108
GO:0005737 cytoplasm TAS 2170108
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with PVR: view

Pathways & Interactions for PVR Gene

genes like me logo Genes that share pathways with PVR: view

Pathways by source for PVR Gene

Gene Ontology (GO) - Biological Process for PVR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP 12913096
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA --
GO:0008037 cell recognition IBA --
genes like me logo Genes that share ontologies with PVR: view

No data available for SIGNOR curated interactions for PVR Gene

Drugs & Compounds for PVR Gene

(34) Drugs for PVR Gene - From: DrugBank and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Colchicine Approved Pharma Antagonist Tubulin Inhibitor 118
Dalteparin Approved Pharma 341
Dexamethasone Approved, Investigational, Vet_approved Pharma Agonist 2314
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1970
Heparin Approved, Investigational Pharma Antagonist 905,282
genes like me logo Genes that share compounds with PVR: view

Transcripts for PVR Gene

Unigene Clusters for PVR Gene

Poliovirus receptor:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PVR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5: - - -

Relevant External Links for PVR Gene

GeneLoc Exon Structure for
PVR
ECgene alternative splicing isoforms for
PVR

Expression for PVR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PVR Gene

Protein differential expression in normal tissues from HIPED for PVR Gene

This gene is overexpressed in Amniocyte (15.7), Cerebrospinal fluid (12.6), Serum (8.5), and Urine (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PVR Gene



Protein tissue co-expression partners for PVR Gene

NURSA nuclear receptor signaling pathways regulating expression of PVR Gene:

PVR

SOURCE GeneReport for Unigene cluster for PVR Gene:

Hs.171844

Evidence on tissue expression from TISSUES for PVR Gene

  • Liver(4.5)
  • Nervous system(4.3)
  • Pancreas(4.2)
  • Bone marrow(4.1)
  • Heart(3.7)
  • Lung(3.7)
  • Kidney(3.6)
  • Muscle(2.6)
  • Intestine(2.5)
  • Blood(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PVR Gene

Germ Layers:
  • mesoderm
Systems:
  • immune
Organs:
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with PVR: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PVR Gene

Orthologs for PVR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PVR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PVR 33 34
  • 98.24 (n)
dog
(Canis familiaris)
Mammalia PVR 33 34
  • 72.07 (n)
cow
(Bos Taurus)
Mammalia PVR 33
  • 67.47 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 43 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia PVR 34
  • 42 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pvr 34
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 30 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch73-22o12.1 34
  • 27 (a)
ManyToMany
pvrl2l 34
  • 24 (a)
ManyToMany
si:ch211-141e20.2 34
  • 22 (a)
ManyToMany
si:ch211-222f23.6 34
  • 22 (a)
ManyToMany
si:dkey-281i8.1 34
  • 22 (a)
ManyToMany
si:ch211-214p13.3 34
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 13 (a)
OneToMany
Species where no ortholog for PVR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PVR Gene

ENSEMBL:
Gene Tree for PVR (if available)
TreeFam:
Gene Tree for PVR (if available)

Paralogs for PVR Gene

(1) SIMAP similar genes for PVR Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PVR: view

Variants for PVR Gene

Sequence variations from dbSNP and Humsavar for PVR Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000114397 -- 44,653,791(+) C/G intron_variant
rs1000155746 -- 44,661,660(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000311658 -- 44,656,030(+) T/C intron_variant
rs1000492793 -- 44,652,397(+) G/A intron_variant
rs1000620113 -- 44,644,459(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PVR Gene

Variant ID Type Subtype PubMed ID
nsv1062812 CNV gain 25217958
nsv1134797 CNV deletion 24896259
nsv483005 CNV loss 15286789
nsv9736 CNV loss 18304495

Variation tolerance for PVR Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PVR Gene

Human Gene Mutation Database (HGMD)
PVR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PVR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PVR Gene

Disorders for PVR Gene

MalaCards: The human disease database

(17) MalaCards diseases for PVR Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
poliomyelitis
  • infantile paralysis
paralytic poliomyelitis
  • poliomyelitis, paralytic
heart conduction disease
  • heart rhythm disease
basilar artery insufficiency
  • basilar artery syndrome
cardiac tamponade
  • pericardial tamponade
- elite association - COSMIC cancer census association via MalaCards
Search PVR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PVR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PVR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PVR Gene

Publications for PVR Gene

  1. PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis. (PMID: 15607800) Pende D … Moretta A (Molecular immunology 2005) 3 4 22 58
  2. Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141. (PMID: 15640804) Tomasec P … Wilkinson GW (Nature immunology 2005) 3 4 22 58
  3. Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). (PMID: 15034010) Fuchs A … Colonna M (Journal of immunology (Baltimore, Md. : 1950) 2004) 3 4 22 58
  4. Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). (PMID: 15039383) Tahara-Hanaoka S … Shibuya A (International immunology 2004) 3 4 22 58
  5. Ligand stimulation of CD155alpha inhibits cell adhesion and enhances cell migration in fibroblasts. (PMID: 15194502) Oda T … Nomoto A (Biochemical and biophysical research communications 2004) 3 4 22 58

Products for PVR Gene

Sources for PVR Gene

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